Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q15/00—Anti-perspirants or body deodorants
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
  • A61K8/0295—Liquid crystals
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
  • A61K8/04—Dispersions; Emulsions
  • A61K8/06—Emulsions
  • A61K8/062—Oil-in-water emulsions
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
  • A61K8/27—Zinc; Compounds thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/34—Alcohols
  • A61K8/342—Alcohols having more than seven atoms in an unbroken chain
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/34—Alcohols
  • A61K8/345—Alcohols containing more than one hydroxy group
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/34—Alcohols
  • A61K8/347—Phenols
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
  • A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/37—Esters of carboxylic acids
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
  • A61K8/41—Amines
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
  • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
  • A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
  • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
  • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
  • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
  • A61K8/9783—Angiosperms [Magnoliophyta]
  • A61K8/9794—Liliopsida [monocotyledons]
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P17/00—Drugs for dermatological disorders
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
  • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
  • A61K2800/30—Characterized by the absence of a particular group of ingredients
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
  • A61K2800/74—Biological properties of particular ingredients
  • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
  • A61K2800/782—Enzyme inhibitors; Enzyme antagonists
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K31/00—Medicinal preparations containing organic active ingredients
  • A61K31/12—Ketones
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K31/00—Medicinal preparations containing organic active ingredients
  • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
  • A61K31/19—Carboxylic acids, e.g. valproic acid
  • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
  • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K33/00—Medicinal preparations containing inorganic active ingredients
  • A61K33/24—Heavy metals; Compounds thereof
  • A61K33/30—Zinc; Compounds thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
  • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Definitions

• the present invention is in the field of antiperspirancy, in particular methods of reducing perspiration without the use of aluminium and/or zirconium salts.
• WO 02/011690 discloses an antiperspirancy method whereby calcium channels within the secretory coil cells of the eccrine glands are blocked, thereby controlling sweat production at its source.
• Certain anticholinergic drugs have also been used to treat hyperhidrosis, with varying degrees of success. These drugs include Ditropan® (oxybutynin), Probanthine® (propantheline bromide) and Cogentin® (benzotropine).
• US 2008/0207737 discloses a topical composition for antiperspirant benefit comprising varying levels of oxybutynin.
• an antiperspirant composition comprising; a non-aluminium, non-zirconium, gel-forming, film-forming or water absorbing agent; an agent that affects the secretory coil of eccrine glands in such a manner as to reduce secretions therefrom, termed a sweat secretory coil affecter, and a cosmetically acceptable carrier.
• a cosmetic method of reducing perspiration comprising the topical application of an antiperspirant composition according to the first aspect of the invention.
• the second aspect of the invention described immediately above may alternatively be expressed as the use of an antiperspirant composition according to the first aspect of the invention for reducing perspiration on the surface of the human body,
• a method manufacture of an antiperspirant composition comprising the bringing together of a non-aluminium, non-zirconium, gel-forming, film forming or water absorbing agent and an agent that affects the secretory coil of eccrine glands in such a manner as to reduce secretions therefrom, termed a sweat secretory coil affecter, and a cosmetically acceptable carrier.
• a composition according to the first aspect of the invention for the topical treatment of hyperhidrosis.
• an antiperspirant composition according to the first aspect of the invention and a dispenser for said composition comprising containment means and application means for the composition.
• references to an amount of a compound or an active refer to the total amount of compounds or actives of the type indicated.
• application and “applied” relate to application to the surface of the human body, in particular the underarm regions, unless the context dictates otherwise.
• preferred, particularly preferred and especially preferred features of the invention are particularly preferred when used in combination with other preferred, particularly preferred and especially preferred features of the invention. This is particularly the case with combinations of a non-aluminium, non-zirconium, gel-forming agent and the sweat secretory coil affecter.
• ambient conditions refer to 20°C and 1 atmosphere pressure, unless otherwise indicated.
• Use of the invention typically involves the topical application of the antiperspirant composition to the underarm regions of the human body, otherwise known as the axillae.
• An essential component of the invention is a non-aluminium, non-zirconium, gel-forming, film-forming or water absorbing agent. Such agents have an effect on the skin of the human body when applied thereto and typically reduce the amount of perspiration thereon.
• Preferred components of this type are gel-forming agents.
• non-aluminium, non-zirconium gel-forming agents absorb water and form a gel like structure on application to the surface of the human body.
• the non-aluminium, non-zirconium, gel-forming, film-forming or water absorbing agent may be present in the composition at a level of from 0.5 to 30%, preferably from 1 to 25% and more preferably from 2 to 20%, these figures excluding any propellant that may also be present in the composition.
• Preferred non-aluminium, non-zirconium gel-forming agents are selected from a list consisting of: (i) an amphiphilic material that forms a water-insoluble, liquid crystal phase of greater than one dimensional periodicity upon contact with perspiration; (ii) a lamellar phase stabilised oil-in-water emulsion; (iii) a C18-C22 fatty acid soap; (iv) a mixture of a C10-C22 liquid fatty acid and a water-soluble calcium or zinc salt capable of forming a water-insoluble salt with the C10-C22 fatty acid at a pH of greater than 6; (v) an oil-in- water emulsion comprising lipophilic material having a melting point greater than 40°C and (vi) a complex of a zinc salt with a b-amino alcohol.
• Suitable amphiphilic materials that forms a water-insoluble, liquid crystal phase of greater than one dimensional periodicity upon contact with perspiration are described in EP 550,960 A1 (Unilever, 1992) and WO 94/024993 (Unilever, 1994).
• a preferred amphiphilic material of this type is a mixture consisting of isostearyl alcohol and glycerol monolaurate at a ratio of from 25: 75 to 45: 55.
• Suitable lamellar phase stabilised oil-in-water emulsions and their use as antiperspirants are described in EP 2442779 B1 (Unilever, 2013).
• Preferred lamellar phase stabilised oil- in-water emulsions comprise an oil selected from hydrocarbon oils and ester oils, particularly triglyceride oils, such as sunflower seed oil.
• Other particular oils that might be used are C12-15 alkyl benzoate esters, hydrogenated polybutene, PPG-14 butyl ether, triethyl citrate, isopropyl palmitate, and isopropyl myristate.
• the lamellar phase is preferably comprised of two non-ionic surfactants, one having a relatively low HLB (less than 8 and preferably less than 5) and one having a relatively high HLB (more than 12 and preferably more than 15).
• the ratio high HLB surfactant to low HLB surfactant is chosen so as to give a stable dispersion, preferred ratios being from 1:1 to 1:6, respectively.
• a blend of steareth-2 and steareth-20 has been found to be particularly preferred, especially when used in combination with sunflower seed oil. Steareth-2 and steareth-20 are most preferably used at a ratio of from 1 :4 to 1 :5.
• Suitable C18-C22 fatty acid soaps and their use as antiperspirants are described in W02020/078931 A1.
• Sodium stearate is a preferred fatty acid soap of this type.
• Suitable mixtures of a C10-C22 liquid fatty acid and a water-soluble calcium or zinc salt capable of forming a water-insoluble salt with the C10-C22 fatty acid at a pH of greater than 6 are described in W02020/094568 A1 (Unilever, 2020). Preferred mixtures of this are emulsions. Zinc salts are particularly preferred and preferred liquid fatty acids are oleic and ricinoleic acid.
• Suitable oil-in-water emulsions comprising lipophilic material having a melting point greater than 40°C are described in WO 2021/073988 (Unilever, 2021).
• Preferred lipophilic materials having a melting point greater than 40°C for incorporation in the oil-in- water emulsion are selected from hydrogenated oils, fatty alcohols, fatty esters, petroleum oil and wax.
• a particularly preferred lipophilic material is a hydrogenated oil selected from hydrogenated soybean oil, hydrogenated palm oil, hydrogenated corn oil, hydrogenated peanut oil, hydrogenated cottonseed oil, hydrogenated olive oil, hydrogenated avocado oil, hydrogenated castor oil, or any mixture thereof.
• Especially preferred hydrogenated oils are selected from hydrogenated soybean oil, hydrogenated palm oil, hydrogenated peanut oil, hydrogenated cottonseed oil, beeswax, tribehenin, or a mixture thereof.
• Suitable complexes of a zinc salt with a b-amino alcohol are described in WO 2020/03414 A1 (Unilever, 2020).
• Preferred complexes of a zinc salt with a b-amino alcohol have a molar ratio of zinc salt to b-amino alcohol of from 1 : 0.5 to 1 : 3.
• Particularly preferred complexes of this type are selected from mono ethanol amine, di-ethanol amine, tri-ethanol amine or 2-amino-1 -butanol.
• Suitable zinc salts for forming the complex are zinc chloride, formate, acetate, propionate, gluconate and citrate. These complexes are preferably used in anhydrous formulations.
• preferred non-aluminium, non-zirconium, gel-forming, film-forming or water absorbing agents are film-forming agents that are cellulosic film forming polymers (FFPs).
• FFPs cellulosic film forming polymers
• a particularly preferred agent of this type is a C1-C7 alkyl cellulose, preferably used in combination with an organic solvent and (i) a plasticizer selected from one or more of triethyl citrate, polypropylene oxide (with Tg lower than 25°C), glycerol monostearate, stearic acid, cetyl alcohol, triethyl phosphate, or mineral oil or (ii) a particulate filler which is MQ resin.
• a particularly preferred agent of this type is ethyl cellulose.
• Particularly preferred gel-forming agents are selected from a list consisting of: (i) a mixture consisting of isostearyl alcohol and glycerol monolaurate at a ratio of from 25: 75 to 45: 55 by weight; (ii) a lamellar phase stabilised oil-in-water emulsion; (iii) a C18-C22 fatty acid soap; (iv) ) a mixture of oleic or ricinoleic acid and a water-soluble zinc salt; (v) an oil-in-water emulsion comprising lipophilic material having a melting point greater than 40°C and (vi) a complex of a zinc salt with a b-amino alcohol.
• Especially preferred gel-forming agents are selected from a list consisting of: (i) a mixture consisting of isostearyl alcohol and glycerol monolaurate at a ratio of from 25: 75 to 45:
• a further essential component of the invention is an agent that affects the secretory coil of eccrine glands in such a manner as to reduce secretions therefrom, termed a “secretory coil affecter” hereinafter.
• the secretory coil affecter reduces sweat production at its source, the secretory coils of sweat glands themselves. It is understood that the secretory coil affecter permeates to the secretory coil of the sweat glands, said permeation generally being enhanced by other components with which the affecter is formulated.
• Preferred secretory coil affecters are cosmetic actives, i.e. they are suitable for cosmetic use. Particularly preferred secretory coil affecters are natural or naturally derived.
• the secretory coil affecter may be present in the composition at a level of from 0.1 to 20%, preferably from 0.2 to 10% and more preferably from 0.5 to 5%, these figures excluding any propellant that may also be present in the composition.
• the secretory coil affecter is formulated with a skin penetration enhancer (SPE).
• SPEs are short chain polyhydric alcohols, in particular C2-C5 alcohols with 2-5 hydroxy groups, especially glycerol and propylene glycol.
• the SPE may be present at a level of from 0.5 to 90%, preferably from 1 to 50%, more preferably from 2 to 30% and most preferably from 3 to 12%, these figures excluding any propellant that may also be present in the composition.
• the ratio of the non-aluminium, non-zirconium, gel-forming, film-forming or water absorbing agent to the sweat secretory coil affecter is preferably from 1: 1 to 1000: 1, more preferably from 5: 1 to 1000: 1 and especially from 10: 1 to 1000: 1.
• Preferred secretory coil affecters are selected from a list consisting of (i) calcium channel blocking agents (CCBAs), particularly voltage-gated CCBAs; (ii) anticholinergic materials; (iii) store operated calcium entry (SOCE) protein affecters; (iv) electroneutral cation- chloride cotransporter (ECCC) inhibitors and (v) calcium-activated chloride channel (CACC) inhibitors.
• CCBAs calcium channel blocking agents
• SOCE store operated calcium entry
• ECCC electroneutral cation- chloride cotransporter
• CACC calcium-activated chloride channel
• Suitable CCBAs are described in US 6,632,422 B2 (Unilever, 2003) as having a molecular weight of less than 750, this being thought to enhance skin penetration.
• CCBAs are voltage-gated CCBAs, particularly preferred are those selected from verapamil and methoxy-verapamil.
• Safrole, tanshinone and magnolol may also be suitable for use as CCBAs.
• Suitable anticholinergic materials and their use as antiperspirants are described in numerous publications.
• US 8,618,160 B2 (Rose U, 2013) discloses wipes containing glycopyrrolate, a muscarinic anticholinergic, as a treatment for hyperhidrosis.
• US 2008/0207737 (Zinger, 2008) discloses a topical composition for antiperspirant benefit comprising varying levels of oxybutynin, a further muscarinic anticholinergic.
• Preferred anticholinergic materials are muscarinic anticholinergic materials.
• Preferred anticholinergic materials are selected from oxybutynin, tolterodine, sulpiride, glycopyrrolate, benztropine and propanetheline.
• SOCE protein affecters are materials that effect SOCE proteins, generally moderating their operation and thereby reducing Ca 2+ entry into the eccrine cells and causing an antiperspirant effect.
• Particular SOCE protein affecters are described in EP 3,270,881 B1 (Unilever, 2018).
• SOCE proteins of particular relevance are Orai 1, SUM 1, Orai 3, TRPC1 and SUM 2 proteins and affecters of these SOCE proteins are particularly preferred secretory coil affecters.
• Preferred SOCE protein affecters are 6-gingerol, 6-gingerdiol, ethyl cinnamate, 1E,6E)- 1 ,7-bis(3,4-dimethoxyphenyl)-4,4-dimethylhepta-1 ,6-diene-3,5-dione, 1 ,7-bis(4-hydroxy-3- methoxyphenyl) heptane-3, 5-diol, 1,7-bis (3,4-dimethoxyphenyl)-4,4-dimethylheptane- 3,5-diol, benzaldehyde, honokiol and capsaicin.
• Preferred ECCC protein inhibitors are inhibitors of the sodium-potassium-2 chloride cotransporter 1 (NKCC1) in eccrine sweat glands. Such materials are described in DE102004052707 A (Beiersdorf, 2004).
• NKCC1 ECCC protein inhibitors are bumetanide, furosemide, azosemide and torasemide.
• An especially preferred NKCC1 ECCC is ARN23746: 3- (dimethylsulfamoyl)-4-(8,8,8-trifluorooctylamino)benzoic acid (see Savardi etai, Chem 6, 2073-2096, Aug. 06, 2020).
• Preferred CACC inhibitors are inhibitors of the TMEM16a channel (also known as anoctamin-1 [ANO-1]). Particularly preferred inhibitors of this sort are selected from the list di-gallic acid, tannic acid, T16Ainh-A01 , Ani9, MONNA and Silibinin.
• T16Ainh-A01 is 6-tert-butyl-2-(furan-2-carboxamido)-4,5,6,7-tetrahydrobenzo[b]- thiophene-3-carboxylic acid.
• Ani9 is known as (4-chloro-2-methylphenoxy)-acetic acid [(2-methoxyphenyl)- methylene]hydrazide, 2-(4-chloro-2-methylphenoxy)-N-[(2-methoxyphenyl)- methylideneamino]-acetamide, or 2-(4-chloro-2-methylphenoxy)-acetic acid 2-[(2- methoxyphenyl)methylene]hydrazide.
• MONNA is N-((4-methoxy)-2-naphthyl)-5-nitroanthranilic acid.
• Particularly preferred secretory coil affecters are selected from a list consisting of (i) inhibitors of Orai 1, SUM 1, Orai 3, TRPC1 or SUM 2 proteins and (ii) muscarinic anticholinergics.
• Especially preferred secretory coil affecters are selected from a list consisting of glycopyrrolate, oxybutynin, propantheline bromide, benzotropine, 6-gingerol, 6-gingerdiol, ethyl cinnamate, 1 E,6E)-1 ,7-bis(3,4-dimethoxyphenyl)-4,4-dimethylhepta-1 ,6-diene-3,5- dione, 1,7-bis(4-hydroxy-3-methoxyphenyl) heptane-3, 5-diol, 1,7-bis (3,4- dimethoxyphenyl)-4,4-dimethylheptane-3,5-diol, benzaldehyde, honoki
• the carrier used in conjunction with the present invention should be cosmetically acceptable and aid in the delivery of the antiperspirants agent to the surface of the human body.
• the antiperspirant agents are typically suspended or dissolved in the carrier.
• the carrier is typically a fluid, i.e. a liquid or gas at ambient temperature and pressure.
• the carrier preferably comprises from 10 to 99% of the composition.
• a preferred additional component of the carrier is ethanol. This may comprise up to 80% of the total composition, but is typically restricted to less than 70%, and often less than 60%. When employed ethanol typically comprises at least 10%, preferably at least 20%, and more preferably at least 40% by weight of total composition. Each of these preferred minimum levels of ethanol may be limited by the aforementioned maximum levels of ethanol. In some compositions, ethanol may serve as a skin penetration enhancer for the secretory coil affecter.
• a preferred additional component of the carrier is water, especially when employed in conjunction with ethanol, to give an aqueous ethanol carrier.
• Water may comprise up to 90% of the total composition, but is typically restricted to less than 60%, and often less than 50%.
• employed water typically comprises at least 10%, preferably at least 20%, and more preferably at least 30% by weight of total composition. Each of these preferred minimum levels of water may be limited by the aforementioned maximum levels of water.
• a preferred additional component is a fragrance, typically at a level of from 0.1 to 5% of the total composition.
• the fragrance is preferably accompanied by a fragrance solubiliser, typically a non-ionic surfactant used a concentration of from 0.1 to 5% of the total composition.
• a further optional component is an organic anti-microbial agent. Such agents may be selected from any of those known in the art, provided reasonable skill is used to avoid any incompatibilities.
• An organic anti-microbial agent is a particularly preferred additional component. When employed, organic anti-microbial agents are typically used at a level of from 0.1 to 5% by weight of the composition.
• Thickening agents may be employed in compositions of the invention. Such agents increase the viscosity of or solidify the carrier in which the antiperspirant agent is typically suspended or dissolved.
• Thickening agents may be selected from any of those known in the art, provided reasonable skill is used to avoid any incompatibilities.
• a preferred class of thickeners, especially for compositions also comprising water, are hydroxyalkyl celluloses, such as hydroxypropyl cellulose. When employed, thickening agents are typically used at a level of from 0.1 to 40%. When a hydroxyalkyl cellulose thickening agent is employed, this is typically used at a level of from 0.2 to 10% by weight.
• Dispensers suitable for use with the present invention comprise containment means and application means for the composition. They also typically comprise means for getting the composition from its containment means to its application means.
• Preferred dispensers are able to function without the consumer needing to touch the composition with his or her hands in order for it to be applied, this feature enhancing efficient delivery.
• the composition of the invention can be applied cosmetically and topically to the skin by “contact” or non-contact” application”.
• contact methods a composition is wiped across the surface of the skin, depositing a fraction of the composition as it passes.
• non- contact methods the composition is sprayed from a dispenser held proximate to the skin, onto the skin surface, the dispenser commonly being called an aerosol dispenser.
• Contact application generally involves (i) a liquid composition, which is usually applied using a roll-on dispenser or possibly absorbed into or onto a wipe, or (ii) a solid or soft solid composition typically comprising a carrier liquid that that is thickened by a structuring agent.
• the topically acceptable carrier comprises a hydrophobic carrier or an aqueous carrier.
• the hydrophobic carrier in such cases may comprise a silicone compound, low boiling alcohol or a wax.
• the composition comprises a propellant, it is delivered as an aerosol.
• composition of the present invention can comprise a wide range of other optional components.
• CTFA Personal Care Ingredient Handbook Second Edition, 1992, which is incorporated by reference herein in its entirety, describes a wide variety of non limiting personal care and pharmaceutical ingredients commonly used in the skin care industry, which are suitable for use in the compositions of the present invention. Examples include: antioxidants, binders, biological additives, buffering agents, colorants, thickeners, polymers, astringents, conditioners, exfoliating agents, pH adjusters, preservatives, natural extracts, essential oils, skin sensates, skin soothing agents, and skin healing agents.
• compositions according to the invention are illustrated in Table 1 to 3. These may be prepared by method known in the art.

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