EP4355909A4 - Dispositifs, systèmes et procédés d'analyse d'acides nucléiques - Google Patents
Dispositifs, systèmes et procédés d'analyse d'acides nucléiquesInfo
- Publication number
- EP4355909A4 EP4355909A4 EP22825944.6A EP22825944A EP4355909A4 EP 4355909 A4 EP4355909 A4 EP 4355909A4 EP 22825944 A EP22825944 A EP 22825944A EP 4355909 A4 EP4355909 A4 EP 4355909A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- systems
- methods
- nucleic acid
- acid analysis
- analysis devices
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6823—Release of bound markers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/16—Reagents, handling or storing thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/041—Connecting closures to device or container
- B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0663—Whole sensors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0672—Integrated piercing tool
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0883—Serpentine channels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
- B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0644—Valves, specific forms thereof with moving parts rotary valves
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Dispersion Chemistry (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Fluid Mechanics (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163211555P | 2021-06-17 | 2021-06-17 | |
| US202163293564P | 2021-12-23 | 2021-12-23 | |
| US202263336959P | 2022-04-29 | 2022-04-29 | |
| US202263348672P | 2022-06-03 | 2022-06-03 | |
| PCT/US2022/034110 WO2022266513A2 (fr) | 2021-06-17 | 2022-06-17 | Dispositifs, systèmes et procédés d'analyse d'acides nucléiques |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP4355909A2 EP4355909A2 (fr) | 2024-04-24 |
| EP4355909A4 true EP4355909A4 (fr) | 2025-06-11 |
Family
ID=84526727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP22825944.6A Withdrawn EP4355909A4 (fr) | 2021-06-17 | 2022-06-17 | Dispositifs, systèmes et procédés d'analyse d'acides nucléiques |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US20240359180A1 (fr) |
| EP (1) | EP4355909A4 (fr) |
| WO (1) | WO2022266513A2 (fr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230167487A2 (en) | 2021-07-12 | 2023-06-01 | Labsimply, Inc. | Crispr cascade assay |
| EP4423263A4 (fr) * | 2021-10-29 | 2026-03-04 | Mammoth Biosciences Inc | Protéines effectrices, compositions, systèmes, dispositifs, kits et leurs procédés d'utilisation |
| US11820983B2 (en) | 2021-12-13 | 2023-11-21 | Labsimply, Inc. | Tuning cascade assay kinetics via molecular design |
| US20230279375A1 (en) | 2021-12-13 | 2023-09-07 | Labsimply, Inc. | Signal boost cascade assay |
| WO2024073114A1 (fr) | 2022-09-30 | 2024-04-04 | Vedabio, Inc. | Administration d'agents thérapeutiques in vivo par l'intermédiaire d'un système en cascade basé sur crispr |
| US11982677B2 (en) | 2022-10-02 | 2024-05-14 | Vedabio, Inc. | Dimerization screening assays |
| US11965205B1 (en) | 2022-10-14 | 2024-04-23 | Vedabio, Inc. | Detection of nucleic acid and non-nucleic acid target molecules |
| WO2024102720A2 (fr) * | 2022-11-07 | 2024-05-16 | Shennon Biotechnologies Inc. | Dispositifs microfluidiques pour le criblage à haut débit d'interactions cellule-cellule |
| WO2024141622A1 (fr) * | 2022-12-30 | 2024-07-04 | Quantoom Biosciences S.A. | Procédé et dispositif de mise en œuvre en continu d'une réaction biochimique liquide |
| WO2024253707A2 (fr) | 2023-01-07 | 2024-12-12 | Vedabio, Inc. | Nucléases guidées par acide nucléique modifié |
| US12060602B2 (en) | 2023-01-10 | 2024-08-13 | Vedabio, Inc. | Sample splitting for multiplexed detection of nucleic acids without amplification |
| EP4689092A1 (fr) * | 2023-03-31 | 2026-02-11 | Mammoth Biosciences, Inc. | Protéines effectrices modifiées, compositions, systèmes et leurs procédés d'utilisation |
| CN119757745A (zh) * | 2025-03-05 | 2025-04-04 | 北京市农林科学院 | 基于G4二聚体增强的CRISPR/Cas12a微流控芯片适配体传感器及其应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017044710A1 (fr) * | 2015-09-11 | 2017-03-16 | Corning Incorporated | Compositions et procédés pour la purification des acides nucléiques d'échantillons de sang |
| US20210102242A1 (en) * | 2018-08-01 | 2021-04-08 | Mammoth Biosciences, Inc. | Programmable nuclease compositions and methods of use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013181616A1 (fr) * | 2012-06-02 | 2013-12-05 | Health & Bliss Llc | Auto-analyse diagnostique |
| WO2020041280A1 (fr) * | 2018-08-21 | 2020-02-27 | Waters Technologies Corporation | Collecteur fluidique reconfigurable pour un système de chromatographie liquide |
| KR20220035376A (ko) * | 2019-06-18 | 2022-03-22 | 매머드 바이오사이언시즈 인크. | 핵산 검출을 위한 분석 및 방법 |
-
2022
- 2022-06-17 EP EP22825944.6A patent/EP4355909A4/fr not_active Withdrawn
- 2022-06-17 WO PCT/US2022/034110 patent/WO2022266513A2/fr not_active Ceased
-
2023
- 2023-12-15 US US18/541,650 patent/US20240359180A1/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017044710A1 (fr) * | 2015-09-11 | 2017-03-16 | Corning Incorporated | Compositions et procédés pour la purification des acides nucléiques d'échantillons de sang |
| US20210102242A1 (en) * | 2018-08-01 | 2021-04-08 | Mammoth Biosciences, Inc. | Programmable nuclease compositions and methods of use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| EP4355909A2 (fr) | 2024-04-24 |
| WO2022266513A3 (fr) | 2023-02-02 |
| US20240359180A1 (en) | 2024-10-31 |
| WO2022266513A2 (fr) | 2022-12-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
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| 17P | Request for examination filed |
Effective date: 20240115 |
|
| AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
| DAV | Request for validation of the european patent (deleted) | ||
| DAX | Request for extension of the european patent (deleted) | ||
| A4 | Supplementary search report drawn up and despatched |
Effective date: 20250514 |
|
| RIC1 | Information provided on ipc code assigned before grant |
Ipc: C12Q 1/6823 20180101ALI20250508BHEP Ipc: B01L 3/00 20060101ALI20250508BHEP Ipc: C12N 9/22 20060101ALI20250508BHEP Ipc: C12Q 1/6834 20180101ALI20250508BHEP Ipc: C12Q 1/6844 20180101AFI20250508BHEP |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
| 18D | Application deemed to be withdrawn |
Effective date: 20251205 |