Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/60—Sugars; Derivatives thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/67—Vitamins
  • A61K8/676—Ascorbic acid, i.e. vitamin C
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
  • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
  • A61Q19/08—Anti-ageing preparations

Definitions

• Sialyllactoses are acidic human milk oligosaccharides (HMOs) comprising sialic acid (N-acetyl neuraminic acid) in their molecular structures. Sialyllactoses have been reported to be effective anti-viral and anti-bacterial agents. Furthermore, recent publications evidenced that 3'-sialyllactose and 6'-sialyllactose exhibit whitening and moisturizing activities in the skin. Thus, sialylated HMOs currently attract a lot of attention in the cosmetic industry. Sialyllactoses tend, however, to discolor in the presence of water and thus often lead to an unpleasant optical appearance of the final cosmetic products, which is highly unwanted by the end consumers.
• HMOs acidic human milk oligosaccharides
• sialic acid N-acetyl neuraminic acid
• the present invention relates to cosmetic compositions comprising at least one sialyllactose and a Vitamin C derivative
• the present invention relates to a method for reducing discoloration of compositions containing at least one sialyllactose, said method comprising preparing a composition comprising said sialyllactose, a Vitamin C derivative and a cosmetically acceptable carrier, which carrier preferably comprises water, and optionally storing the respective composition for at least 1 , more preferably for at least 2 weeks.
• suppress/ suppressing discoloration refers to a reduced discoloration of the composition according to the present invention compared to control.
• the suppression of discoloration according to the present invention is reflected by reduced a-values (according to the Cl ELAB colorspace) compared to the respective control not comprising Vitamin C or a derivative thereof upon storage such as upon storage for at least 2 weeks at 50°C, at daylight in clear glass vials/ containers as outlined in the example.
• sialyllactoses according to the present invention are 3’sialyllactose (3’SL) and 6’ sialyllactose (6’SL) as well as salts thereof such as in particular the respective sodium salts (CAS Nos: 35890-39-2 (3’sialyllactose); 128596- 80-5 (3’sialyllactose sodium salt); 35890-39-2 (6’sialyllactose); 157574-76-0 (6’sialyllactose sodium salt)).
• the water content in the compositions according to the present invention is selected in the range from 30 to 90 wt.-%, preferably from 40 to 90 wt.-%, more preferably from 45 to 90 wt.-%, most preferably from 50 to 90 wt.-%, based on the total weight of the composition. Further suitable ranges are from 30 to 75 wt.-%, from 30 to 70 wt.-%, from 30 to 60 wt.-% and from 40 to 60 wt.-%.
• compositions according to the present invention are cosmetic compositions intended to be topically applied to mammalian keratinous tissue such as in particular to human skin or the human scalp.
• Such compositions are also called dermatological compositions.
• the cosmetic compositions are topical cosmetic (i.e. dermatological) compositions with all the definitions and preferences as given herein.
• compositions according to the invention intended for topical application comprise a physiologically acceptable medium, i.e. a medium compatible with keratinous substances, such as the skin, mucous membranes, and keratinous fibers.
• physiologically acceptable medium is a cosmetically acceptable carrier.
• the carrier comprises water.
• compositions of the present invention are formulated as an aerosol and applied to the skin as a spray-on product, a propellant is added to the composition.
• the cosmetic composition may comprise further ingredients, which may form part of the carrier.
• ingredients are particularly surfactants, emulsifiers, thickeners, and oils.
• surfactants, emulsifiers, thickeners, and oils are well known to a person skilled in the art.
• Examples of functional preparations are cosmetic compositions containing active ingredients such as hormone preparations, vitamin preparations, vegetable extract preparations, anti-ageing preparations, and/or antimicrobial (antibacterial or antifungal) preparations without being limited thereto.
• the ratio of oily phase to aqueous phase is selected in the range of 40:60 to 30 to 70.
• the cosmetic composition according to the invention is an O/W emulsion
• it contains advantageously at least one O/W- or Si/W-emulsifier selected from the list of, glyceryl stearate citrate, glyceryl stearate SE (self-emulsifying), stearic acid, salts of stearic acid, polyglyceryl-3-methylglycosedistearate.
• O/W- or Si/W-emulsifiers selected from the list of, glyceryl stearate citrate, glyceryl stearate SE (self-emulsifying), stearic acid, salts of stearic acid, polyglyceryl-3-methylglycosedistearate.
• phosphate esters and the salts thereof such as cetyl phosphate (e.g. as Amphisol® A from DSM Nutritional Products Ltd.), diethanolamine cetyl phosphate (e.g.
• emulsifiers are sorbitan oleate, sorbitan sesquioleate, sorbitan isostearate, sorbitan trioleate, cetearyl glucoside, lauryl glucoside, decyl glucoside, sodium stearoyl glutamate, sucrose polystearate and hydrated polyisobutene.
• one or more synthetic polymers may be used as an emulsifier. For example, PVP eicosene copolymer, acrylates/C 10-30 alkyl acrylate crosspolymer, and mixtures thereof.
• Particular suitable O/W emulsifiers to be used in the cosmetic compositions according to the invention encompass phosphate ester emulsifiers such as advantageously 8-10 alkyl ethyl phosphate, 09-15 alkyl phosphate, ceteareth-2 phosphate, ceteareth-5 phosphate, ceteth-8 phosphate, ceteth-10 phosphate, cetyl phosphate, C6-10 pareth- 4 phosphate, C12-15 pareth-2 phosphate, C12-15 pareth-3 phosphate, DEA- ceteareth-2 phosphate, DEA-cetyl phosphate, DEA-oleth-3 phosphate, potassium cetyl phosphate, deceth-4 phosphate, deceth-6 phosphate and trilaureth-4 phosphate.
• phosphate ester emulsifiers such as advantageously 8-10 alkyl ethyl phosphate, 09-15 alkyl phosphate, ceteareth-2 phosphate, ceteareth-5
• a particular suitable O/W emulsifier to be used in the cosmetic compositions according to the invention is potassium cetyl phosphate e.g. commercially available as Amphisol® K at DSM Nutritional Products Ltd Kaiseraugst.
• the invention relates to cosmetic compositions with all the definitions and preferences given herein in the form of O/W emulsions comprising an oily phase dispersed in an aqueous phase in the presence of an O/W emulsifier wherein the O/W emulsifier is potassium cetyl phosphate.
• the amount of oily phase in such O/W emulsions is preferably at least 10 wt.-%, more preferably in the range of 10 to 60 wt.-%, most preferably in the range of 15 to 50 wt.-%, such as in the range of 15 to 40 wt.-%, based on the total weight of the composition.
• the cosmetic compositions according to the invention further comprise at least one fatty alcohol (co-emulsifier), such as in particular cetyl alcohol, cetearyl alcohol and/ or behenyl alcohol.
• fatty alcohol co-emulsifier
• the total amount of one or several fatty alcohols on the topical compositions according to the invention is preferably selected in the range of about 0.1 to 10.0 wt.-%, in particular in the range of about 0.5 to 6.0 wt.-% with respect to the total weight of the topical composition.
• the topical compositions according to the invention comprise a thickener in particular if the topical composition is in the form of an emulsion to assist in making the consistency of a product suitable.
• Preferred thickeners are aluminiumsilicates, xanthan gum, hydroxypropylmethylcellulose, hydroxyethylcellulose, polyacrylates such as carbopole® (e.g. Carbopole 980, 981 , 1382, 2984, 5984) or mixtures thereof.
• Further preferred thickeners encompass acrylate/Cio-3o alkyl acrylate copolymers (such as e.g. Pemulen TR 1 , Pemulen TR 2, Carbopol 1328 by.
• the cosmetic compositions according to the present invention advantageously comprise a preservative.
• the preservative is preferably used in an amount of 0.1 to 2 wt.-%, more preferably in an amount of 0.5 to 1 .5 wt.-%, based on the total weight of the composition.
• the cosmetic compositions according to the invention in general have a pH in the range of 3 to 10, preferably a pH in the range of 3 to 8 and most preferably a pH in the range of 3 to 7.5 such as in the range of 3 to 6.5.
• the pH can easily be adjusted as desired with suitable acids, such as e.g. citric acid, or bases, such as sodium hydroxide (e.g. as aqueous solution), triethanolamine (TEA Care), Tromethamine (Trizma Base) and Aminomethyl Propanol (AMP-Ultra PC 2000), according to standard methods in the art. It is well understood, that ascorbic acid may be present in the composition as a salt, dependent on the final pH of the composition.
• compositions according to the present invention are free of any parabenes, benzethoniumchlorid, piroctone olamine, lauroylarginat, methylisothiazolinon, chlormethylisothiazolinon, bronopol, benzalkoniumchloride, formaldehyd releasing compounds, salicylic acid, triclosan, DMDM hydantoin, chlorphenesin and IPBC (lodopropinylbutyl carbamate), such as in particular free of methylchloroisothiazolinone.
• the amount of the cosmetic composition to be applied to the skin is not critical and can easily be adjusted by a person skilled in the art.
• the amount is selected in the range of 0.1 to 3 mg/cm 2 skin, such as preferably in the range of 0.1 to 2 mg/cm 2 skin and most preferably in the range of 0.5 to 2 mg/cm 2 skin.

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• Health & Medical Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Dermatology (AREA)
• Birds (AREA)
• Epidemiology (AREA)
• Gerontology & Geriatric Medicine (AREA)
• Cosmetics (AREA)

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• 2022
  • 2022-08-23 EP EP22772426.7A patent/EP4392008A1/de active Pending
  • 2022-08-23 CN CN202280057140.5A patent/CN117835959A/zh active Pending
  • 2022-08-23 WO PCT/EP2022/073481 patent/WO2023025800A1/en not_active Ceased

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