EP4457356A4 - Zusammensetzungen und verfahren zur identifizierung von genfusionen - Google Patents

Zusammensetzungen und verfahren zur identifizierung von genfusionen

Info

Publication number
EP4457356A4
EP4457356A4 EP22910350.2A EP22910350A EP4457356A4 EP 4457356 A4 EP4457356 A4 EP 4457356A4 EP 22910350 A EP22910350 A EP 22910350A EP 4457356 A4 EP4457356 A4 EP 4457356A4
Authority
EP
European Patent Office
Prior art keywords
genfusions
identifying
compositions
methods
identifying genfusions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP22910350.2A
Other languages
English (en)
French (fr)
Other versions
EP4457356A1 (de
Inventor
David Thomas Mulder
Pedro Feijao
Melissa Kathleen Mcconechy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pacbridge Partners Ii Investment Co Ltd
Pacbridge Partners Ii Invest Co Ltd
Original Assignee
Pacbridge Partners Ii Investment Co Ltd
Pacbridge Partners Ii Invest Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pacbridge Partners Ii Investment Co Ltd, Pacbridge Partners Ii Invest Co Ltd filed Critical Pacbridge Partners Ii Investment Co Ltd
Publication of EP4457356A1 publication Critical patent/EP4457356A1/de
Publication of EP4457356A4 publication Critical patent/EP4457356A4/de
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1089Design, preparation, screening or analysis of libraries using computer algorithms
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701Specific hybridization probes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP22910350.2A 2021-12-24 2022-12-23 Zusammensetzungen und verfahren zur identifizierung von genfusionen Pending EP4457356A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163293711P 2021-12-24 2021-12-24
PCT/IB2022/062748 WO2023119252A1 (en) 2021-12-24 2022-12-23 Compositions and methods for identification of gene fusions

Publications (2)

Publication Number Publication Date
EP4457356A1 EP4457356A1 (de) 2024-11-06
EP4457356A4 true EP4457356A4 (de) 2025-10-29

Family

ID=86901551

Family Applications (1)

Application Number Title Priority Date Filing Date
EP22910350.2A Pending EP4457356A4 (de) 2021-12-24 2022-12-23 Zusammensetzungen und verfahren zur identifizierung von genfusionen

Country Status (4)

Country Link
EP (1) EP4457356A4 (de)
AU (1) AU2022422775A1 (de)
CA (1) CA3242158A1 (de)
WO (1) WO2023119252A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118398081B (zh) * 2024-06-26 2024-10-22 杭州联川生物技术股份有限公司 一种基于rna测序分析融合基因类型的方法、系统、设备和介质
CN119091966A (zh) * 2024-09-03 2024-12-06 浙江洛兮医学检验实验室有限公司 一种用于检测高通量测序数据中融合基因的方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2914743B1 (de) * 2012-11-02 2019-08-07 Life Technologies Corporation Erfassung, detektion und quantifizierung von kleiner rna
WO2020106893A1 (en) * 2018-11-21 2020-05-28 Karius, Inc. Direct-to-library methods, systems, and compositions
US20210222161A1 (en) * 2018-06-06 2021-07-22 The Regents Of The University Of California Methods of Producing Nucleic Acid Libraries and Compositions and Kits for Practicing Same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8790873B2 (en) * 2009-01-16 2014-07-29 Affymetrix, Inc. DNA ligation on RNA template
US10597710B2 (en) * 2012-12-21 2020-03-24 New England Biolabs, Inc. Ligase activity
US10597650B2 (en) * 2012-12-21 2020-03-24 New England Biolabs, Inc. Ligase activity
US10964410B2 (en) * 2017-05-25 2021-03-30 Koninklijke Philips N.V. System and method for detecting gene fusion
CN115136241A (zh) * 2020-02-14 2022-09-30 夸登特健康公司 用于确定融合事件的方法和系统

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2914743B1 (de) * 2012-11-02 2019-08-07 Life Technologies Corporation Erfassung, detektion und quantifizierung von kleiner rna
US20210222161A1 (en) * 2018-06-06 2021-07-22 The Regents Of The University Of California Methods of Producing Nucleic Acid Libraries and Compositions and Kits for Practicing Same
WO2020106893A1 (en) * 2018-11-21 2020-05-28 Karius, Inc. Direct-to-library methods, systems, and compositions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SEAN MAGUIRE ET AL: "A low-bias and sensitive small RNA librarypreparation method using randomized splint ligation", NUCLEIC ACIDS RESEARCH, vol. 48, no. 14, 4 June 2020 (2020-06-04), GB, pages e80 - e80, XP055725025, ISSN: 0305-1048, DOI: 10.1093/nar/gkaa480 *

Also Published As

Publication number Publication date
AU2022422775A1 (en) 2024-08-08
AU2022422775A9 (en) 2024-08-15
WO2023119252A1 (en) 2023-06-29
EP4457356A1 (de) 2024-11-06
CA3242158A1 (en) 2023-06-29

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Ipc: C12Q 1/6806 20180101AFI20250701BHEP

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