EP4472941A4 - Procédé de production de lipides ionisables ou d'intermédiaires pour la synthèse de tels lipides - Google Patents

Procédé de production de lipides ionisables ou d'intermédiaires pour la synthèse de tels lipides

Info

Publication number
EP4472941A4
EP4472941A4 EP23749311.9A EP23749311A EP4472941A4 EP 4472941 A4 EP4472941 A4 EP 4472941A4 EP 23749311 A EP23749311 A EP 23749311A EP 4472941 A4 EP4472941 A4 EP 4472941A4
Authority
EP
European Patent Office
Prior art keywords
lipids
synthesis
production
intermediate products
ionizable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP23749311.9A
Other languages
German (de)
English (en)
Other versions
EP4472941A1 (fr
Inventor
N D Prasad Atmuri
Deaglan Arnold
Fariba Saadati
Daniel Kurek
Jayesh Kulkarni
Dominik Witzigmann
Marco A Ciufolini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanovation Therapeutics Inc
Original Assignee
Nanovation Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanovation Therapeutics Inc filed Critical Nanovation Therapeutics Inc
Publication of EP4472941A1 publication Critical patent/EP4472941A1/fr
Publication of EP4472941A4 publication Critical patent/EP4472941A4/fr
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/26Catalysts comprising hydrides, coordination complexes or organic compounds containing in addition, inorganic metal compounds not provided for in groups B01J31/02 - B01J31/24
    • B01J31/38Catalysts comprising hydrides, coordination complexes or organic compounds containing in addition, inorganic metal compounds not provided for in groups B01J31/02 - B01J31/24 of titanium, zirconium or hafnium
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/377Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C07C51/38Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups by decarboxylation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C7/00Purification; Separation; Use of additives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Analytical Chemistry (AREA)
  • Water Supply & Treatment (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP23749311.9A 2022-02-02 2023-01-31 Procédé de production de lipides ionisables ou d'intermédiaires pour la synthèse de tels lipides Pending EP4472941A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202263305827P 2022-02-02 2022-02-02
PCT/CA2023/050129 WO2023147657A1 (fr) 2022-02-02 2023-01-31 Procédé de production de lipides ionisables ou d'intermédiaires pour la synthèse de tels lipides

Publications (2)

Publication Number Publication Date
EP4472941A1 EP4472941A1 (fr) 2024-12-11
EP4472941A4 true EP4472941A4 (fr) 2026-02-25

Family

ID=87553118

Family Applications (1)

Application Number Title Priority Date Filing Date
EP23749311.9A Pending EP4472941A4 (fr) 2022-02-02 2023-01-31 Procédé de production de lipides ionisables ou d'intermédiaires pour la synthèse de tels lipides

Country Status (4)

Country Link
US (1) US20250162968A1 (fr)
EP (1) EP4472941A4 (fr)
CA (1) CA3243452A1 (fr)
WO (1) WO2023147657A1 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013086322A1 (fr) * 2011-12-07 2013-06-13 Alnylam Pharmaceuticals, Inc. Lipides biodégradables ramifiés à terminaisons alkyle et cycloalkyle destinés à l'administration d'agents actifs

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013086322A1 (fr) * 2011-12-07 2013-06-13 Alnylam Pharmaceuticals, Inc. Lipides biodégradables ramifiés à terminaisons alkyle et cycloalkyle destinés à l'administration d'agents actifs

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CLEMENT ET AL: "Sur une m�thode de pr�paration du nonad�canedio�que-1,19", COMPTES RENDUS DES S�ANCES DE L'ACAD�MIE DES SCIENCES / C,, vol. 254, 30 November 1961 (1961-11-30), pages 2794 - 2795, XP009548067 *
See also references of WO2023147657A1 *

Also Published As

Publication number Publication date
WO2023147657A1 (fr) 2023-08-10
CA3243452A1 (fr) 2023-08-10
US20250162968A1 (en) 2025-05-22
EP4472941A1 (fr) 2024-12-11

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A4 Supplementary search report drawn up and despatched

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RIC1 Information provided on ipc code assigned before grant

Ipc: C07C 45/57 20060101AFI20260120BHEP

Ipc: C07C 49/17 20060101ALI20260120BHEP

Ipc: C07C 51/09 20060101ALI20260120BHEP

Ipc: C07C 59/347 20060101ALI20260120BHEP

Ipc: C07C 51/38 20060101ALI20260120BHEP

Ipc: C07C 7/00 20060101ALI20260120BHEP

Ipc: C07F 7/18 20060101ALI20260120BHEP