EP4493057A1 - Dispositif de perfusion de médicament hautement intégré - Google Patents

Dispositif de perfusion de médicament hautement intégré

Info

Publication number
EP4493057A1
EP4493057A1 EP22931676.5A EP22931676A EP4493057A1 EP 4493057 A1 EP4493057 A1 EP 4493057A1 EP 22931676 A EP22931676 A EP 22931676A EP 4493057 A1 EP4493057 A1 EP 4493057A1
Authority
EP
European Patent Office
Prior art keywords
infusion
area
elastic
conductive
highly integrated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP22931676.5A
Other languages
German (de)
English (en)
Other versions
EP4493057A4 (fr
Inventor
Cuijun YANG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medtrum Technologies Inc
Original Assignee
Medtrum Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medtrum Technologies Inc filed Critical Medtrum Technologies Inc
Publication of EP4493057A1 publication Critical patent/EP4493057A1/fr
Publication of EP4493057A4 publication Critical patent/EP4493057A4/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0015—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by features of the telemetry system
    • A61B5/002—Monitoring the patient using a local or closed circuit, e.g. in a room or building
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14503—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1473—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/683—Means for maintaining contact with the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/683—Means for maintaining contact with the body
    • A61B5/6838—Clamps or clips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6848—Needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6848—Needles
    • A61B5/6849—Needles in combination with a needle set
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/505—Flexible containers without fluid transport within
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
    • H01M50/00—Constructional details or processes of manufacture of the non-active parts of electrochemical cells other than fuel cells, e.g. hybrid cells
    • H01M50/20—Mountings; Secondary casings or frames; Racks, modules or packs; Suspension devices; Shock absorbers; Transport or carrying devices; Holders
    • H01M50/247—Mountings; Secondary casings or frames; Racks, modules or packs; Suspension devices; Shock absorbers; Transport or carrying devices; Holders specially adapted for portable devices, e.g. mobile phones, computers, hand tools or pacemakers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
    • H01M50/00—Constructional details or processes of manufacture of the non-active parts of electrochemical cells other than fuel cells, e.g. hybrid cells
    • H01M50/20—Mountings; Secondary casings or frames; Racks, modules or packs; Suspension devices; Shock absorbers; Transport or carrying devices; Holders
    • H01M50/271—Lids or covers for the racks or secondary casings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02—Operational features
    • A61B2560/0204—Operational features of power management
    • A61B2560/0214—Operational features of power management of power generation or supply
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/04—Constructional details of apparatus
    • A61B2560/0443—Modular apparatus
    • A61B2560/045—Modular apparatus with a separable interface unit, e.g. for communication
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/04—Constructional details of apparatus
    • A61B2560/0462—Apparatus with built-in sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/04—Constructional details of apparatus
    • A61B2560/0462—Apparatus with built-in sensors
    • A61B2560/0468—Built-in electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/08—Sensors provided with means for identification, e.g. barcodes or memory chips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/16—Details of sensor housings or probes; Details of structural supports for sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/22—Arrangements of medical sensors with cables or leads; Connectors or couplings specifically adapted for medical sensors
    • A61B2562/225—Connectors or couplings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/22—Arrangements of medical sensors with cables or leads; Connectors or couplings specifically adapted for medical sensors
    • A61B2562/225—Connectors or couplings
    • A61B2562/227—Sensors with electrical connectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0216—Materials providing elastic properties, e.g. for facilitating deformation and avoid breaking
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0233—Conductive materials, e.g. antistatic coatings for spark prevention
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A61M2205/502—User interfaces, e.g. screens or keyboards
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/023—Sending and receiving of information, e.g. using Bluetooth®
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0609—Holders integrated in container to position an object
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0663—Whole sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E60/00—Enabling technologies; Technologies with a potential or indirect contribution to GHG emissions mitigation
    • Y02E60/10—Energy storage using batteries

Definitions

  • the present invention mainly relates to the field of medical instruments, in particular to a highly integrated drug infusion device.
  • Diabetes is mainly a metabolic disease caused by abnormal human pancreatic function. Diabetes is a lifelong disease. At present, medical technology cannot cure diabetes. It can only control the occurrence and development of diabetes and its complications by stabilizing blood glucose. The normal human pancreas automatically monitors changes in the body's blood glucose levels and automatically secretes the required insulin. At present, the medical device for stabilizing blood glucose works by dynamically monitoring the blood glucose changes of the human body by a glucose sensor implanted in the subcutaneous tissue of the human body; and continuously accurately infusing insulin into the subcutaneous tissue of the human body through a medical cannula implanted in the subcutaneous tissue of the human body.
  • the detection and infusion can be completed at the same time by puncturing at one position.
  • the electrode contacting point (PAD) set on the surface of the infusion cannula is slidingly connected with the electrical connection area of the program unit to receive the body fluid analyte parameter signal, and the PAD is very thin, will be damaged easily during the sliding process, thus affecting the electrical connection stability and service life of the integrated drug infusion device.
  • Embodiments of the present invention disclose a highly integrated drug infusion device, the infusion device is provided with a conductor, one end of the conductor is fixed and electrically connected to the PAD, and the other end is slidably connected to the electrical connection area of the program unit.
  • the PAD is no longer slidably connected to the electrical connection area and will not be damaged, thereby improving the stability of the electrical connection of the drug infusion device and prolonging the service life.
  • the invention discloses a highly integrated drug infusion device, comprising: an infusion unit configured to deliver drugs; a program unit comprises an input end and an output end, and the input end comprises a plurality of electrically connection areas for receiving the signal of analyte data in the body fluid, after the output end is electrically connected to the infusion unit, and the program unit controls the drug delivering of the infusion unit; an infusion cannula provided with electrodes and electrode contact point; and a conductor, one end is fixed and electrically connected to the electrode contact point, and the other end is slidably and electrically connected to the electrical connection area, when the infusion cannula is installed in the working position, the infusion cannula is connected with the infusion unit, the drug can be injected into the body through the infusion cannula, and the conductor is electrically connected to the electrical connection area, inputting signal of analyte data in the body fluid to the program unit.
  • the conductor is an elastic conductor.
  • the elastic conductor is elastic pins.
  • the elastic conductor is an elastic conductive member that comprises spaced conductive area and insulating area.
  • the elastic conductive member is a hollow elastic conductive column, which is in interference fit with the infusion cannula.
  • the elastic conductive member is rectangular solid.
  • the elastic conductive member at least partially surrounds the infusion cannula.
  • the conductive area and the insulating area pass through the elastic conductive member in the transverse direction, respectively.
  • the conductive area and the insulating area surround the surface of the elastic conductive member.
  • the conductive areas are elastic conductive members distributed at intervals, and the insulating area is the spaced air area of the conductive area.
  • the electrical connection area is a metal conductive contact.
  • the elastic conductor is one of conductive adhesive strips, conductive foam or conductive bubble.
  • the highly integrated drug infusion device consists of multiple parts, the infusion unit and the program unit are arranged in different parts, and the different parts are electrically connected through a plurality of electrical contact.
  • the conductor comprises an elastic pin and an elastic conductor including a spaced conductive area and an insulating area.
  • the infusion device is provided with a conductor, one end of the conductor is fixed and electrically connected to the PAD. The other end is slidably connected to the electrical connection area of the program unit. The sliding connection between the conductor and the electrical connection area replaces the sliding connection between the PAD and the electrical connection area. Thus the PAD will not be damaged.
  • the conductor’s thickness is much larger than that of PAD, and its wear resistance is also much larger than that of PAD, so it increases the electrical connection stability and prolongs the service life of the highly integrated drug infusion device.
  • the conductor is an elastic conductor, and the elastic material deforms to lock after being squeezed.
  • the elastic conductor can enhance the stability of the contact and act as a buffer. Therefore, the elastic conductors can be connected to each other more closely as a conductive member or as an auxiliary member of an electrical connection position, thereby improving the reliability of the electrical connection.
  • the elastic conductor is an elastic conductive member that comprises conductive areas and insulating areas distributed at intervals, which can realize the conduction between circuits and the insulation between different circuits at the same time, making the deployment of the infusion device more compact and convenient for the integrated design of the infusion device.
  • the conductor comprises elastic pins and/or an elastic conductor, including a spaced conductive area and an insulating area, which can be flexibly selected according to actual needs.
  • the elastic conductive member is a hollow elastic conductive column, the interference fit between the elastic conductive column and the infusion cannula can prevent poor contact, and the electrical connection stability of the PAD and the elastic conductor 170 can be maintained even if no external pressure.
  • the infusion unit comprises a plurality of infusion subunits, the plurality of infusion subunits being electrically connected to the output end, respectively, and the program unit controlling whether each infusion subunit delivers drugs. Different drugs are reserved in different infusion subunits, and the program unit sends different drug infusion instructions to different infusion subunits to achieve precise control of the analyte level in body fluid.
  • FIG. 1 is a flow chart of the operation of a highly integrated drug infusion device according to an embodiment of the present invention.
  • FIG. 2a is a schematic cross-sectional view of an infusion cannula of a highly integrated drug infusion device in a pre-installation position according to one embodiment of the present invention.
  • FIG. 2b is a schematic cross-sectional view showing the infusion cannula of the integrated drug infusion device in a working position according to an embodiment of the present invention.
  • FIG. 3a is the section view of an elastic conductor, PAD and electrical connection area of FIG. 2b according to the embodiment of the invention.
  • FIG. 3b is the side view of the elastic conductor in FIG. 3a according to the embodiment of the invention.
  • FIG. 3c is another section view of an elastic conductor PAD and electrical connection area according to another embodiment of the invention.
  • FIG. 3d and FIG. 3e are different section view of elastic conductors, PADs and electrical connection areas in different embodiments of the invention.
  • FIG. 4 is the schematic diagram of an elastic conductor, a PAD and an electrical connection area according to another embodiment of the invention.
  • FIG. 5a-FIG. 5b are schematic diagrams of the electrical connection positions of the electrical connection area and the elastic conductor in different embodiments of the invention.
  • FIG. 6a-FIG. 6b are schematic diagrams of the infusion cannula, PAD and the elastic conductor in different embodiments of the invention.
  • FIG. 7a is a top view of a highly integrated drug infusion device 100 in accordance with another embodiment of the present invention.
  • FIG. 7b is a top view of a highly integrated drug infusion device 100 in accordance with another embodiment of the present invention.
  • FIG. 8 is a schematic view of a highly integrated drug infusion device and a remote device according to still another embodiment of the present invention.
  • PAD set on the surface of the infusion cannula is slidingly connected with the electrical connection area of the program unit to receive the body fluid analyte parameter signal, and PAD will be damaged easily during the sliding process, thus affecting the electrical connection stability and service life of the integrated drug infusion device.
  • the present invention provides a highly integrated drug infusion device, the infusion device is provided with a conductor, one end of the conductor is fixed and electrically connected to the PAD, and the other end is slidably connected to the electrical connection area of the program unit.
  • the PAD is no longer slidably connected to the electrical connection area and will not be damaged, thereby improving the stability of the electrical connection of the drug infusion device and prolonging the service life.
  • FIG. 1 is a flow chart showing the operation of a highly integrated drug infusion device according to an embodiment of the present invention.
  • the highly integrated drug infusion device of the embodiment of the invention comprises three basic parts: electrodes, a program unit and an infusion unit.
  • the body fluid analyte data is obtained by the electrodes and converted into an electrical signal. Electrical signals are passed to the program unit via electrodes and/or electrode leads.
  • the program unit After analyzing the body fluid analyte data signal, the program unit sends a signal to the infusion unit controlling whether to perform a drug infusion, thereby stabilizing the body fluid parameters.
  • the body fluid analyte data are detected by the electrodes in real time, and the cycle of detection and infusion is without interruption. This process does not require human intervention and is done directly through program analysis to control the stability of body fluid parameters.
  • the program unit after receiving the analyte parameter information, the program unit only uses the analyte parameter information as a comparison parameter index for the program unit to control whether the alarm unit issues an alarm, for example, when the detected analyte parameter information exceeds the preset threshold, the program unit controls the alarm unit to send an alarm.
  • the program unit sends a signal to the infusion unit whether to perform drug infusion according to the preset program, to stabilize body fluid parameters.
  • FIG. 2a-2b are cross-sectional views of a highly integrated drug infusion device 100 according to an embodiment of the present invention, and the highly integrated drug infusion device 100 is an integral structure.
  • FIG. 2a shows the infusion cannula 130 in the pre-installation position while FIG. 2b shows the infusion cannula 130 in the working position.
  • Program unit 120 includes an input end 121 and an output end 122.
  • the input end 121 is used for receiving a body fluid analyte data signal.
  • the input end 121 includes electrically connective regions 121a1, 121b and 121c.
  • the input end121 is electrically connected to the electrode contact point (PAD) 140 through the electrical conductor 170 to receive the parameter signal, wherein the electrical conductor 170 is fixed connected to the PAD 140, so only one part is shown in FIG. 2a and FIG. 2b.
  • the specific connection method of the input end 121 and the PAD 140 will be described in detail below.
  • the input end 121 may only include two also electrically connective regions or include more electrically connective regions depending on the number of electrodes.
  • the output end 122 is electrically coupled to the infusion unit 110, allowing the program unit 120 to effectively control the infusion unit 110.
  • the infusion cannula 130 is mounted on the mounting unit 150.
  • the mounting unit 150 protrudes from the outer surface of the integrated drug infusion device 100, as shown in FIG. 2a.
  • the mounting unit 150 is pressed into the integrated drug infusion device 100 with the top portion integral with the integrated drug infusion device 100 housing, as shown in FIG. 2b.
  • the mounting unit 150 holds the infusion cannula 130 in the pre-installation position.
  • the mounting unit 150 is pressed to insert the infusion cannula under skin, and the integrated drug infusion device can start operation.
  • the installation method of the embodiment of the invention reduces the steps required for installation, makes the installation more convenient and flexible and improves the user experience.
  • the manner of setting the infusion cannula 130 in the mounting unit 150 can be various, and is not specifically limited herein. Specifically, in the embodiment of the present invention, the other side of the mounting unit 150 also protrudes from the partial infusion cannula 130 (shown by a dotted line in FIG. 2a and FIG. 2b) for subsequent connection with the outlet of the infusion unit 110 to achieve drug circulation.
  • electrical conductor 170 is not electrically coupled to the input end 121 when the infusion cannula 130 is in the pre-installation position. And the other end of the infusion cannula 130 is also not connected with the infusion unit 110 outlet.
  • FIG. 2b when the infusion cannula 130 is mounted in the working position, one end of the infusion cannula 130 is inserted subcutaneously (indicated by the solid line portion of the infusion cannula in FIG. 2b) and the other end (illustrated by the dotted portion of the infusion cannula in FIG. 2b) is connected with the outlet of the infusion unit 110, thereby establishing a flow path for the drug from the infusion unit 110 to the body tissue fluid.
  • the electrical contact region 140 and the electrical conductor 170 reach the electrically connective region of the input end 121, enabling electrical connection between the program unit 120 and the electrical contact region 140.
  • the program unit 120 will not enter working mode, so that the integrated drug infusion device does not generate any analyte data signal, nor does it issue an instruction to inject drug or send alarm. Therefore, in other embodiments of the present invention, when the infusion cannula 130 is in the pre-installation position, the electrical conductor 170 may also be electrically connected to the electrically connective region of the input end 121 or the infusion cannula 130 may be coupled to the outlet of the infusion unit 110. And there are no specific restrictions herein.
  • a medical tape 160 for attaching the integrated drug infusion device 100 to the skin surface is used to paste the program unit 120, the infusion unit 110, the electrode and the infusion cannula 130 as a whole on the skin.
  • the portion of the infusion cannula 130 that is inserted into the skin is 13.
  • FIG. 3a is the section view of an elastic conductor, PAD and electrical connection area of FIG. 2b according to the embodiment of the invention.
  • FIG. 3b is the side view of the elastic conductor in FIG. 3a.
  • FIG. 3c is another section view of an elastic conductor PAD and electrical connection area according to another embodiment of the invention.
  • FIG. 3d and FIG. 3e are different section view of elastic conductors, PADs and electrical connection areas in different embodiments of the invention.
  • the infusion cannula 130 and the input end 121 will slide relative to each other. Since no additional electrical conductor is provided on the infusion cannula, the electrode contacting point (PAD) 140 will directly rub against the electrical connection area of the input end 121, while the PAD 140 is very thin and is easily damaged in the process of rubbing with the input end 121, affecting the stability of the electrical connection between the PAD 140 and the input end 121, thereby affecting the service life of highly integrated drug infusion devices.
  • PAD electrode contacting point
  • an electrical conductor 170 is further provided on the infusion cannula 130 to realize electrical connection between the PAD 140 on the infusion cannula and the electrical connection areas 121a, 121b and 121c.
  • the infusion cannula 130 and the input end 121 slide relative to each other, since the conductor 170 is fixed connected to the PAD 140 on the infusion cannula 130, the component that actually rubs against the input end 121 is the electrical conductor 170, and the thickness of the electrical conductor 170 can be selected. It can be much larger than the PAD, and its degree of friction resistance is much larger than that of the PAD140, so the stability of the electrical connection between the PAD140 and the input end 121 can be increased.
  • the conductor 170 is an elastic conductor, and the elastic material deforms to lock after being squeezed.
  • the use of the elastic conductor can be better electrical contacted, and at the same time it can be used as a buffer. Therefore, the elastic conductors can be connected to each other more closely as a conductive member or as an auxiliary member of an electrical connection position, thereby improving the reliability of the electrical connection.
  • the elastic conductor is an elastic pin, the position and number of which correspond to the position and number of the PAD.
  • the number of elastic conductors is set to one, and the provision of only one elastic conductor reduces the number of internal components of the highly integrated drug infusion device.
  • the elastic conductor 170 is an elastic conductive member that comprises at least two conductive area 170a and at least one insulating area 170b.
  • the conductive area 170a and the insulating area 170b function as conductive conduction and electrical insulation, respectively.
  • the conductive area 170a and the insulating area 170b cannot be separated from each other, that is, the conductive area 170a and the insulating area 170b belong to an integral part of the elastic conductor 170, respectively.
  • An insulating area 170b is arranged between adjacent conductive area 170a.
  • Different PAD 140 or different electrical connection areas are electrically connected with different conductive area 170a respectively, so that any two PAD 140 or any two electrical connection areas are electrically insulated from each other.
  • the conductive area 170a and the insulating area 170b pass through the elastic conductor 170 in the transverse direction, as shown in FIG. 3b.
  • the transverse direction refers to the direction from the PAD 140 to the corresponding electrical connection area, or the direction of the current between the PAD 140 and the electrical connection area.
  • the PAD 140 is electrically connected with the electrical connection area, transverse conduction of the elastic conductor 170 can be ensured, not longitudinal conduction.
  • the elastic conductor 170 electrically connects the PAD 140 with the corresponding electrical connection are, it also electrically insulates different PADs 140 or different electrical connection area.
  • the conductive area and the insulating area of the elastic conductor 170 may also surround the surrounding surface of the electrical insulating material of the elastic conductor, or the conductive area may be an elastic conductor distributed at intervals, and the insulating area may be the middle space of the conductive area, such as air or vacuum.
  • An elastic conductor 170 plays the role of conduction and electrical insulation at the same time. The complexity of the internal design of the infusion device is reduced, the internal deployment is more compact, and the electrical connection reliability of the infusion device is improved.
  • the elastic conductor 170 can be one of the materials of conductive adhesive strip, conductive foam or conductive bubble, because these materials such as rubber strip, foam, bubble and so on is electrically insulating, which can ensure good insulation effect between different circuits, and set up a conductive area on the surface of rubber strip, foam and bubble.
  • the conductive area passes through the insulating material in the transverse direction of the interval, and the circuit conduction can be realized on all surfaces of the elastic conductor 170.
  • the conductive area 170a or the insulating area 170b can also have a certain inclination, or be arranged inside the elastic conductor 170 in other directions or ways. There is no specific limitation here, as long as the above conditions of conductive conduction and electrical insulation can be met.
  • the conductive area 170a and the insulating area 170b are arranged at intervals and pass through the elastic conductor 170 respectively.
  • different conductive area 170a are arranged in the same insulating area 170b, that is, surrounded by the same insulating area 170b, as shown in FIG. 3d.
  • the top view of the elastic conductor 170 may be circular, as shown in FIG. 3e. In another embodiment of the invention, the top view of the elastic conductor 170 may also be circular.
  • the elastic conductor 170 can also have other shapes, which are not specifically limited here, as long as the conditions for realizing the above functions of the elastic conductor 170 can be met.
  • the elastic conductor 170 is electrically connected with the PAD 140 and the electrical connection area respectively, there is an insulating area 170b between any two PAD 140 connected with the elastic conductor 170.
  • the insulating area 170b separated between any two PAD 140 comprises a part of an insulating area 170b (between 140a and 140b of FIG. 3a and FIG. 3b) , or an insulating area 170b, or more than one insulating area 170b (between 140c and 140b of FIG. 3a and FIG. 3b) .
  • the insulating area 170b separated between any two electrical connection area connected to the elastic conductor 170 comprises a part of one insulating area 170b, one insulating area 170b, or more than one insulating area 170b.
  • the PAD and the corresponding electrical connection area (such as between 140a and 121a, between 140b and 121b, or between 140c and 121c) share a common part of the conductive area 170a to realize the conductivity of the two.
  • the conductive area of the common part comprises a part of a conductive area 170a (as between 140c and 121c in FIG. 3a and FIG. 3b) , or a conductive area 170a, or more than one conductive area 170a.
  • a part of an insulating area or conductive area, an insulating area or conductive area, and more than one insulating area or conductive area can also represent the coverage of the PAD or electrical connection area to the insulating area or conductive area in the two-dimensional direction (in area) , as shown in FIG. 3c.
  • the dotted line in FIG. 3c represents the partial outline of the pin.
  • the PAD 140 can cover a part of an insulating area or conductive area, or an insulating area or conductive area, or more than one insulating area or conductive area.
  • the elastic conductor 170 only comprises two conductive area 170a and an insulating area 170b arranged between the two conductive area 170a. That is, two pairs of different PADs and electrical connection areas are electrically connected through different conductive area 170a to realize conductivity. At the same time, two PADs or two electrical connection areas are separated by insulation areas to achieve electrical insulation.
  • FIG. 4 is the schematic diagram of an elastic conductor, a PAD and an electrical connection area according to another embodiment of the invention.
  • the other embodiments of the invention may also comprise more electrodes. Therefore, the elastic conductor 170 comprises more conductive areas and insulating areas arranged at intervals, and the mode of electrical connection will be more flexible, as shown in FIG. 4.
  • the embodiment of the invention does not limit the connection mode or connection principle.
  • only the working electrode and the counter electrode are electrically connected with the electrical connection area through the above elastic conductor through the corresponding PADs, while the reference electrode is electrically connected with the electrical connection area through other ways, such as through the aforementioned elastic pins to connect with the electrical connection area.
  • FIG. 5a-FIG. 5b are schematic diagrams of the electrical connection positions of the electrical connection area and the elastic conductor in different embodiments of the invention.
  • the electrical connection area 121a, 121b, 121c is a convex spherical crown metal conductive contact.
  • the elastic conductor 170 is provided with a concave part at the position connected with the convex metal conductive contact to make the connection closer.
  • the connection between the convex part and the concave part also plays a role in fixing the position of the elastic conductor 170, that is, no matter what external force the infusion device receives, the position of the elastic conductor 170 is always fixed without displacement, so as to ensure that the elastic conductor 170 performs normal conduction and insulation work.
  • the elastic conductor 170 may not design a concave part. When pressed by the protruding metal conductive contact, the concave part matching with the metal conductive contact will automatically appear on the elastic conductor 170 to ensure the function of electrical connection or electrical insulation.
  • the electrical connection area is arranged inside the input end 121.
  • the elastic conductor 170 is correspondingly provided with a convex part, which can enter the interior of the input end 121 and be electrically connected with the corresponding electrical connection area.
  • FIG. 6a-FIG. 6b are schematic diagrams of the infusion cannula, PAD and the elastic conductor in different embodiments of the invention.
  • the infusion device is a highly integrated infusion device, the electrodes are formed on the circular infusion cannula 130, and the PAD 140 is also formed on the infusion cannula 130 with a certain arc. Therefore, in an embodiment of the present invention, the elastic conductive member is a hollow elastic conductive column, the interference fit between the elastic conductive column and the infusion cannula can prevent poor contact, and the electrical connection stability of the PAD140 and the elastic conductor 170 can be maintained even if no external pressure, as shown in the FIG. 6a.
  • the elastic conductor 170 is a rectangular solid, which surrounds the infusion cannula 130, that is, a deployment similar to that the infusion cannula 130 inserted into the elastic conductor 170 is formed, so that the PAD 140 and the elastic conductor 170 are completely fitted. Under the pressure of the input end 121 or other components such as the housing, the PAD 140, the elastic conductor 170 and the electrical connection area are locked to achieve stable electrical connection.
  • the elastic conductor 170 only partially surrounds the infusion cannula 130, and the contact length between the elastic conductor 170 and the infusion cannula 130 is not less than the length of the PAD 140, that is, the elastic conductor 170 completely covers the PAD 140, as shown in FIG. 6b, under the pressure of the input end 121 or other components such as the housing, the PAD 140 , the elastic conductor 170 and the electrical connection area can also be locked to achieve stable electrical connection
  • FIG. 7a is a top view of a highly integrated drug infusion device 100 in accordance with another embodiment of the present invention.
  • the integrated drug infusion device 100 comprises two parts.
  • the program unit 120 is disposed in one part, the infusion unit 110 is disposed in another part, and the two parts are electrically connected by the multiple electrical contacts 123.
  • the contact area of the electrical contact is much smaller, which provides more flexibility to the structure design, and can effectively reduce the volume of the control structure.
  • these smaller electrical contacts can be directly electrically connected to the internal circuit or electrical components, or can be directly soldered on the circuit board, which helps to optimize the design of the internal circuit and effectively reduce the complexity of the circuit, thereby, saving costs and reducing the volume of the infusion device.
  • the type of electrical contact 123 includes rigid metal pins or elastic conductive members, and the type of the elastic conductive member includes conductive spring, conductive silica gel, conductive rubber, or conductive leaf spring.
  • FIG. 7b is a top view of a highly integrated drug infusion device 100 in accordance with another embodiment of the present invention.
  • the integrated drug infusion device 100 comprises two parts, and the infusion unit 110 comprises two infusion subunits 110a and 110b.
  • the infusion subunits 110a and 110b can be used to reserve different drugs such as insulin, glucagon, antibiotics, nutrient solution, analgesics, morphine, anticoagulants, gene therapy drugs, cardiovascular drugs or chemotherapeutic drugs, etc.
  • Infusion subunits 110a and 110b are electrically coupled to outputs 122a and 122b, respectively, allowing the program unit 120 to effectively control the infusion unit 110.
  • the outlets of infusion subunits 110a and 110b can be connected with the 130a portion and 130b portion of infusion cannula respectively.
  • 130a and 130b are connected with the 130c portion of infusion cannula, respectively.
  • the 130c portion of the infusion cannula is used to penetrate the skin, thereby establishing a path for the two drugs to flow from the infusion unit 110 into the body fluid. That is, the integrated drug infusion device still penetrates the skin only in one position.
  • program unit 120 can output different infusion signals to different infusion subunits to control whether infusion of drug is required. This method realizes accurate detection and control of body fluid analyte level to stabilize the physiological state of the user.
  • infusion subunits there may be more infusion subunits according to actual needs, and multiple infusion subunits may be disposed in different parts of the integrated drug infusion device 100. There are no specific restrictions herein.
  • signals are transmitted between the remote device 200 and the integrated drug infusion device 100.
  • the embodiment of the invention also includes a remote device 200.
  • the remote device 200 includes but is not limited to a handset, a mobile terminal, or the like.
  • the remote device 200 and the program unit 120 transmit wireless signals to each other.
  • Program unit 120 may send body fluid analyte data or drug infusion information (including infusion or no infusion) or warning information to remote device 200.
  • the remote device 200 can receive, record, store, display body fluid information or infusion information or warning information, as well as other functional options.
  • the user can view historical or real-time information at any time from the remote device 200. Through the remote device 200, the user can also manually set the infusion instructions or warning information and transmit the information wirelessly to the program unit 120.
  • the program unit 120 guarantees the communication security and infusion security, the infusion unit is controlled to perform the drug infusion, thereby realizing remote manual control.
  • the present invention discloses A highly integrated drug infusion device, one end of the conductor is fixed and electrically connected to the PAD, and the other end is slidably connected to the electrical connection area of the program unit.
  • the sliding connection between the conductor and the electrical connection area replaces the sliding connection between the PAD and the electrical connection area, thus the PAD will not be damaged.
  • the conductor’s thickness is much larger than that of PAD, and its wear resistance is also much larger than that of PAD, so it increases the electrical connection stability and prolongs the service life of the highly integrated drug infusion device.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Pathology (AREA)
  • Chemical & Material Sciences (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Electrochemistry (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Emergency Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Computer Hardware Design (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Arrangements For Transmission Of Measured Signals (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)

Abstract

Est divulgué ici un dispositif de perfusion de médicament (100) hautement intégré, comprenant : une unité de perfusion (110) conçue pour administrer des médicaments ; une unité de programme (120) comprenant une extrémité d'entrée (121) et une extrémité de sortie (122), et l'extrémité d'entrée (121) comprend une pluralité de zones de connexion électrique destinées à recevoir le signal de données d'analyte dans le fluide corporel, après connexion électrique de l'extrémité de sortie (122) à l'unité de perfusion (110), et l'unité de programme (120) commandant l'administration de médicament de l'unité de perfusion (110) ; une canule (130) de perfusion pourvue d'électrodes et d'un point de contact d'électrode ; et un conducteur (170), une extrémité étant fixée et connectée électriquement au point de contact d'électrode (PAD) (140), et l'autre extrémité étant connectée en coulissement et électriquement à la zone de connexion électrique, lorsque la canule (130) de perfusion est installée dans la position de fonctionnement, la canule (130) de perfusion étant reliée à l'unité de perfusion (110), le médicament pouvant être injecté dans le corps à travers la canule (130) de perfusion, et le conducteur (170) étant électriquement connecté à la zone de connexion électrique, introduisant l'unité de programme (120) un signal de données d'analyte dans le fluide corporel. Le PAD (140) n'est plus relié en coulissement à la zone de connexion électrique et ne sera pas endommagé, ce qui permet d'améliorer la stabilité de la connexion électrique du dispositif de perfusion de médicament (100) et de prolonger la durée de vie.
EP22931676.5A 2019-08-19 2022-08-03 Dispositif de perfusion de médicament hautement intégré Pending EP4493057A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/CN2019/101271 WO2021031057A1 (fr) 2019-08-19 2019-08-19 Dispositif de détection
PCT/CN2022/080845 WO2022252744A1 (fr) 2019-08-19 2022-03-15 Dispositif de détection d'analyte
PCT/CN2022/110056 WO2023173654A1 (fr) 2019-08-19 2022-08-03 Dispositif de perfusion de médicament hautement intégré

Publications (2)

Publication Number Publication Date
EP4493057A1 true EP4493057A1 (fr) 2025-01-22
EP4493057A4 EP4493057A4 (fr) 2025-12-17

Family

ID=74603809

Family Applications (11)

Application Number Title Priority Date Filing Date
EP19942547.1A Withdrawn EP4017357A4 (fr) 2019-08-19 2019-08-19 Dispositif de détection
EP20854011.2A Active EP4017360B1 (fr) 2019-08-19 2020-02-20 Dispositif de détection d'analyte hautement intégré
EP20854350.4A Active EP4017361B1 (fr) 2019-08-19 2020-02-20 Dispositif de détection de micro-analyte
EP20920724.0A Pending EP4106628A4 (fr) 2019-08-19 2020-07-07 Dispositif de détection d'analyte intelligent hautement intégré
EP20919852.2A Active EP4106613B1 (fr) 2019-08-19 2020-08-03 Dispositif de détection d'analyte de fluide corporel
EP20920622.6A Pending EP4107526A4 (fr) 2019-08-19 2020-10-14 Dispositif de détection d'analyte à fonction d'identification intelligente
EP21843300.1A Active EP4183339B1 (fr) 2019-08-19 2021-05-31 Dispositif de détection d'analyte de fiabilité élevée
EP21854556.4A Pending EP4190237A4 (fr) 2019-08-19 2021-05-31 Dispositif de détection d'analytes de liquides organiques
EP21842391.1A Active EP4182677B1 (fr) 2019-08-19 2021-07-08 Dispositif de détection d'analyte hautement intégré
EP22814792.2A Pending EP4346593A4 (fr) 2019-08-19 2022-03-15 Dispositif de détection d'analyte
EP22931676.5A Pending EP4493057A4 (fr) 2019-08-19 2022-08-03 Dispositif de perfusion de médicament hautement intégré

Family Applications Before (10)

Application Number Title Priority Date Filing Date
EP19942547.1A Withdrawn EP4017357A4 (fr) 2019-08-19 2019-08-19 Dispositif de détection
EP20854011.2A Active EP4017360B1 (fr) 2019-08-19 2020-02-20 Dispositif de détection d'analyte hautement intégré
EP20854350.4A Active EP4017361B1 (fr) 2019-08-19 2020-02-20 Dispositif de détection de micro-analyte
EP20920724.0A Pending EP4106628A4 (fr) 2019-08-19 2020-07-07 Dispositif de détection d'analyte intelligent hautement intégré
EP20919852.2A Active EP4106613B1 (fr) 2019-08-19 2020-08-03 Dispositif de détection d'analyte de fluide corporel
EP20920622.6A Pending EP4107526A4 (fr) 2019-08-19 2020-10-14 Dispositif de détection d'analyte à fonction d'identification intelligente
EP21843300.1A Active EP4183339B1 (fr) 2019-08-19 2021-05-31 Dispositif de détection d'analyte de fiabilité élevée
EP21854556.4A Pending EP4190237A4 (fr) 2019-08-19 2021-05-31 Dispositif de détection d'analytes de liquides organiques
EP21842391.1A Active EP4182677B1 (fr) 2019-08-19 2021-07-08 Dispositif de détection d'analyte hautement intégré
EP22814792.2A Pending EP4346593A4 (fr) 2019-08-19 2022-03-15 Dispositif de détection d'analyte

Country Status (5)

Country Link
US (12) US20220218240A1 (fr)
EP (11) EP4017357A4 (fr)
CN (16) CN112386251B (fr)
ES (1) ES3058746T3 (fr)
WO (18) WO2021031057A1 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4017357A4 (fr) * 2019-08-19 2023-04-19 Medtrum Technologies Inc. Dispositif de détection
WO2021146902A1 (fr) 2020-01-21 2021-07-29 Medtrum Technologies Inc. Dispositif médical avec vérification de sécurité et procédé de vérification de sécurité de celui-ci
WO2021242266A1 (fr) * 2020-05-29 2021-12-02 Hewlett-Packard Development Company, L.P. Dispositif microfluidique consommable
CN115474931B (zh) * 2021-05-31 2025-10-31 上海移宇科技股份有限公司 体液分析物检测器件
US20240237926A1 (en) * 2021-05-31 2024-07-18 Medtrum Technologies Inc. Highly integrated analyte detection device
WO2022252002A1 (fr) * 2021-05-31 2022-12-08 上海移宇科技股份有限公司 Dispositif de détection d'analytes de liquides organiques
US20240266661A1 (en) * 2021-05-31 2024-08-08 Medtrum Technologies Inc. Battery shell integrated analyte detection device
US20240366127A1 (en) * 2021-07-08 2024-11-07 Medtrum Technologies Inc. Micro analyte sensor and continuous analyte monitoring device
CN115704820B (zh) * 2021-08-06 2025-08-05 上海移宇科技股份有限公司 体液分析物检测器件
WO2023019453A1 (fr) * 2021-08-18 2023-02-23 Medtrum Technologies Inc. Dispositif de détection intelligent
CN115886803B (zh) * 2021-08-18 2025-11-25 上海移宇科技股份有限公司 智能检测装置
WO2023044891A1 (fr) * 2021-09-27 2023-03-30 Medtrum Technologies Inc. Unité d'installation d'un dispositif de détection d'analyte
EP4408278B1 (fr) * 2021-09-27 2026-03-18 Medtrum Technologies Inc. Système de détection d'analyte
WO2023102778A1 (fr) * 2021-12-08 2023-06-15 Medtrum Technologies Inc. Plaque d'électrode positive pour batterie de dispositif médical et son procédé de préparation
CN114886422A (zh) * 2022-05-20 2022-08-12 湖州美奇医疗器械有限公司 一种传感器和发射器的卡合结构
US12594031B2 (en) * 2022-06-03 2026-04-07 Oura Health Oy Detachable battery in a wearable ring device
CN114711765B (zh) * 2022-06-07 2022-10-14 苏州百孝医疗科技有限公司 连续分析物浓度监测系统
WO2025152019A1 (fr) * 2024-01-16 2025-07-24 上海移宇科技有限公司 Dispositif de test d'analyte de fluide corporel
CN121985906A (zh) * 2024-01-16 2026-05-05 上海移宇科技有限公司 体液分析物检测器件
CN121985909A (zh) * 2024-01-16 2026-05-05 上海移宇科技有限公司 分析物检测系统
CN121969306A (zh) * 2024-01-16 2026-05-01 上海移宇科技有限公司 紧凑型体液分析物检测器件

Family Cites Families (199)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4449774A (en) * 1981-02-05 1984-05-22 Shin-Etsu Polymer Co., Ltd. Electroconductive rubbery member and elastic connector therewith
GB8414036D0 (en) * 1984-06-01 1984-07-04 Emi Ltd Field effect devices
DE3885858T2 (de) * 1987-06-13 1994-03-17 Tdk Corp Wasserdichte elektrodenanschluss-vorrichtung für lebende organismen.
EP0443073A1 (fr) * 1990-02-23 1991-08-28 Kabushiki Kaisha Fine Rubber Kenkyuusho Capteur de pression utilisant du caoutchouc conducteur sensible à une extension
FR2675124A1 (fr) * 1991-04-15 1992-10-16 Sincoplas Boite d'emballage perdu destinee notamment a contenir une recharge de produit cosmetique.
JPH05205531A (ja) * 1992-01-27 1993-08-13 Nitto Denko Corp 異方性導電膜及びその製造方法
US6175752B1 (en) * 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US8974386B2 (en) * 1998-04-30 2015-03-10 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8688188B2 (en) * 1998-04-30 2014-04-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US7113069B1 (en) * 1999-11-30 2006-09-26 Smiths Detection Inc. Aligned particle based sensor elements
JP2001281197A (ja) * 2000-03-30 2001-10-10 Matsushita Electric Ind Co Ltd バイオセンサ測定装置
US20050176084A1 (en) * 2001-12-17 2005-08-11 Burkoth Terry L. Non-or minimally invasive monitoring methods
CN2542206Y (zh) * 2002-06-03 2003-04-02 古鹏飞 破坏型一次性安全自动采血针
US7494465B2 (en) 2004-07-13 2009-02-24 Dexcom, Inc. Transcutaneous analyte sensor
US20140121989A1 (en) * 2003-08-22 2014-05-01 Dexcom, Inc. Systems and methods for processing analyte sensor data
JP4530333B2 (ja) * 2003-11-14 2010-08-25 日立マクセル株式会社 密閉型電池
US9247900B2 (en) * 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
JP2005251654A (ja) * 2004-03-05 2005-09-15 Jst Mfg Co Ltd 異方導電性シート及びその製造方法
US8277713B2 (en) * 2004-05-03 2012-10-02 Dexcom, Inc. Implantable analyte sensor
US8792955B2 (en) * 2004-05-03 2014-07-29 Dexcom, Inc. Transcutaneous analyte sensor
EP4111962B1 (fr) * 2004-07-13 2023-08-30 Dexcom, Inc. Capteur d'analyte transcutanée
US8989833B2 (en) * 2004-07-13 2015-03-24 Dexcom, Inc. Transcutaneous analyte sensor
ES2334671T3 (es) * 2004-08-13 2010-03-15 Egomedical Technologies Ag Sistema de ensayo de analitos para determinar la concentracion de un analito en un fluido fisiologico o acuoso.
CN101091114A (zh) * 2004-08-31 2007-12-19 生命扫描苏格兰有限公司 制造自动校准传感器的方法
US7418285B2 (en) * 2004-12-29 2008-08-26 Abbott Laboratories Analyte test sensor and method of manufacturing the same
US20090105569A1 (en) * 2006-04-28 2009-04-23 Abbott Diabetes Care, Inc. Introducer Assembly and Methods of Use
DE202005002650U1 (de) * 2005-02-18 2005-08-11 TaiDoc Technology Corp., Ltd., San-Chung Intelligentes Biosensormessgerät
US20090076360A1 (en) * 2007-09-13 2009-03-19 Dexcom, Inc. Transcutaneous analyte sensor
US9072476B2 (en) * 2005-09-23 2015-07-07 Medtronic Minimed, Inc. Flexible sensor apparatus
WO2007071562A1 (fr) * 2005-12-19 2007-06-28 F. Hoffmann La-Roche Ag Capteur en sandwich destine a determiner une concentration d'analyte
US20090142483A1 (en) * 2005-12-27 2009-06-04 Edelbrock Andrew J Process of Making Electrolessly Plated Auto-Calibration Circuits for Test Sensors
JP2007281013A (ja) * 2006-04-03 2007-10-25 Seiko Epson Corp 半導体装置
JP2006318923A (ja) * 2006-06-16 2006-11-24 Jsr Corp 導電性ゴムシートならびにそれを用いたコネクターおよび回路基板の電気的検査用冶具、ならびに導電性ゴムシートの製造方法
US9119582B2 (en) * 2006-06-30 2015-09-01 Abbott Diabetes Care, Inc. Integrated analyte sensor and infusion device and methods therefor
US7918121B2 (en) * 2006-08-14 2011-04-05 Bayer Healthcare, Llc Meter system designed to run singulated test sensors
CN102743179B (zh) * 2006-12-22 2016-03-16 F·霍夫曼-拉罗氏股份公司 带体内电化学分析物感测的流体传输
AU2008227870B2 (en) * 2007-03-19 2013-10-17 Insuline Medical Ltd. Method and device for drug delivery
EP1987761B1 (fr) * 2007-05-03 2019-10-23 F. Hoffmann-La Roche AG Capteur tubulaire destiné à la détection d'un analyte
EP2152895A2 (fr) * 2007-05-11 2010-02-17 Sigmed, Inc. Caractérisation non invasive d'un paramètre physiologique
US20100268043A1 (en) * 2007-11-07 2010-10-21 Ofer Yodfat Device and Method for Preventing Diabetic Complications
JP2011504129A (ja) * 2007-11-21 2011-02-03 メディンゴ・リミテッド アナライト監視及び流体分注システム
CA2968779C (fr) * 2008-03-17 2020-02-25 Waveform Technologies, Inc. Sous-ensemble de detection d'analytes et procedes et appareils pour inserer un detecteur d'analytes lui etant associes
US8396528B2 (en) * 2008-03-25 2013-03-12 Dexcom, Inc. Analyte sensor
JP4919093B2 (ja) * 2008-03-31 2012-04-18 Ｊｓｒ株式会社 異方導電性シート
US20110151310A1 (en) * 2008-08-14 2011-06-23 Balan Biomedical, Inc. High energy density battery for use in implantable medical devices and methods of manufacture
KR101179364B1 (ko) * 2008-09-22 2012-09-03 파나소닉 주식회사 휴대전자기기
CN102238911A (zh) * 2008-12-04 2011-11-09 创业有限公司 采血装置
US9402544B2 (en) * 2009-02-03 2016-08-02 Abbott Diabetes Care Inc. Analyte sensor and apparatus for insertion of the sensor
JP4900534B2 (ja) * 2009-02-24 2012-03-21 パナソニック株式会社 電池モジュールとそれを用いた電池モジュール集合体
TW201031384A (en) 2009-02-25 2010-09-01 Micro Star Int Co Ltd A portable physiological information measurement device
CN104825171B (zh) * 2009-02-26 2017-08-04 雅培糖尿病护理公司 改进的分析物传感器及其制造和使用方法
US20100277119A1 (en) * 2009-05-01 2010-11-04 Medtronic Minimed, Inc. Medical Device Charging System
WO2010146579A1 (fr) * 2009-06-14 2010-12-23 Medingo Ltd. Dispositifs et procédés de reconnaissance de dysfonctionnements dans un dispositif d'administration thérapeutique
CN201522508U (zh) * 2009-11-13 2010-07-07 沁业科技有限公司 矩阵列式导接模块
DK2353628T3 (da) * 2010-01-28 2021-04-19 Hoffmann La Roche Modulært infusionssæt med integreret elektrisk drevet funktionel komponent
US10448872B2 (en) * 2010-03-16 2019-10-22 Medtronic Minimed, Inc. Analyte sensor apparatuses having improved electrode configurations and methods for making and using them
JP2013524888A (ja) * 2010-04-16 2013-06-20 アボット ダイアベティス ケア インコーポレイテッド アナライト監視装置および方法
US20110256024A1 (en) * 2010-04-16 2011-10-20 Abbott Diabetes Care Inc. Modular Analyte Monitoring Device
WO2011141753A1 (fr) * 2010-05-13 2011-11-17 Aircraft Medical Limited Gestion de puissance pour dispositif électrique
EP2400292A1 (fr) * 2010-06-24 2011-12-28 Roche Diagnostics GmbH Système destiné à la mesure d'une concentration en analytes dans un échantillon de liquide corporel
SI2422693T1 (sl) * 2010-08-27 2019-02-28 Roche Diabetes Care Gmbh Naprava in postopek za izvajanje vsaj ene medicinske funkcije
US8507119B2 (en) * 2010-09-17 2013-08-13 Panasonic Corporation Battery block and battery module
EP2649191B1 (fr) * 2010-12-09 2021-06-16 Abbott Diabetes Care, Inc. Capteurs d'analytes avec une surface de détection ayant de petits points de détection
AU2012271333B2 (en) * 2011-06-17 2016-05-19 Abbott Diabetes Care Inc. Connectors for making connections between analyte sensors and other devices
US20130060106A1 (en) * 2011-09-06 2013-03-07 Medtronic Minimed, Inc. Optical sensing systems and methods
WO2013035455A1 (fr) * 2011-09-09 2013-03-14 テルモ株式会社 Dispositif d'insertion de capteur et procédé de fonctionnement de celui-ci
CN202266572U (zh) * 2011-09-21 2012-06-06 深圳市理邦精密仪器股份有限公司 一种密封装配结构
CN102579054B (zh) * 2012-03-06 2014-07-16 北京超思电子技术股份有限公司 一种防水壳体及血氧测量仪
US9451912B2 (en) * 2012-03-13 2016-09-27 Terumo Kabushiki Kaisha Sensor insertion device and method for operating said device
US9931065B2 (en) * 2012-04-04 2018-04-03 Dexcom, Inc. Transcutaneous analyte sensors, applicators therefor, and associated methods
US9493807B2 (en) * 2012-05-25 2016-11-15 Medtronic Minimed, Inc. Foldover sensors and methods for making and using them
EP2668902A1 (fr) * 2012-05-31 2013-12-04 Roche Diagniostics GmbH Cartouche de capteur et dispositif d'insertion
EP2880432A4 (fr) * 2012-08-05 2016-03-02 Univ Ramot Capteur pouvant être positionné et son procédé d'utilisation
EP2898828B1 (fr) * 2012-09-24 2019-04-03 Terumo Kabushiki Kaisha Dispositif d'insertion de capteur
JP6112338B2 (ja) * 2012-10-24 2017-04-12 トヨタ自動車株式会社 二次電池
US9344777B2 (en) * 2012-12-20 2016-05-17 Abbott Diabetes Care Inc. Wireless communication authentication for medical monitoring device
US10426383B2 (en) * 2013-01-22 2019-10-01 Medtronic Minimed, Inc. Muting glucose sensor oxygen response and reducing electrode edge growth with pulsed current plating
GB2510600B (en) * 2013-02-08 2015-05-20 R & D Core Ltd Calibration of Contact Sensor
KR20140123007A (ko) * 2013-04-11 2014-10-21 주식회사 엘지화학 라운드 코너를 포함하는 전지셀
WO2014179343A1 (fr) * 2013-04-30 2014-11-06 Abbott Diabetes Care Inc. Systèmes, dispositifs et procédés pour activation de dispositif électrique efficace en énergie
WO2014176753A1 (fr) * 2013-04-30 2014-11-06 成都领御生物技术有限公司 Système de détection de bande d'essai immunochromatographique à points quantiques et utilisation associée
CN203707530U (zh) * 2013-07-09 2014-07-09 古河电气工业株式会社 旋转连接器
CN103367797A (zh) * 2013-07-23 2013-10-23 耀安电池电源科技（深圳）有限公司 可充电的纽扣式锂离子电池及其制造方法
CN103462615B (zh) * 2013-09-13 2015-12-16 上海移宇科技有限公司 微米尺度葡萄糖传感器微电极
CN203576512U (zh) * 2013-11-04 2014-05-07 理康互联科技(北京)有限公司 分析物传感装置
CN104904053B (zh) * 2013-11-27 2017-10-24 株式会社Lg化学 电极组件和包含其的电化学装置
KR101519742B1 (ko) * 2013-11-28 2015-05-12 율촌화학 주식회사 내충격성 및 안정성을 갖는 셀 파우치 및 그 제조방법
CN103750818B (zh) * 2013-12-25 2016-03-30 浙江凯立特医疗器械有限公司 用于植入式生物传感器的快速植入器
CN103750819B (zh) * 2013-12-25 2016-08-31 浙江凯立特医疗器械有限公司 可控制植入角度的皮下组织内传感器装置
CN104749228B (zh) * 2013-12-30 2018-07-06 深圳先进技术研究院 同时检测血糖和血脂的试纸条及方法
CN104739444B (zh) * 2013-12-31 2018-04-27 深圳迈瑞生物医疗电子股份有限公司 超声探头及含有该超声探头的超声检测装置
US9848779B2 (en) * 2014-02-24 2017-12-26 Medtronic Monitoring, Inc. Separable monitoring device and method
US20150238118A1 (en) * 2014-02-27 2015-08-27 Biorasis, Inc. Detection of the spatial location of an implantable biosensing platform and method thereof
CN104887242B (zh) * 2014-03-07 2018-08-28 上海移宇科技股份有限公司 分析物传感系统
EP3129777B1 (fr) * 2014-04-11 2023-08-16 Ascensia Diabetes Care Holdings AG Adaptateurs d'émetteur sans fil pour dispositifs de mesure à biocapteur alimentés par batterie et leur procédé de production
EP3169219B1 (fr) * 2014-07-15 2019-01-30 Comftech S.r.L. Capteur pour la mesure de signaux électriques physiologiques
US10194842B2 (en) * 2014-09-03 2019-02-05 Nova Biomedical Corporation Subcutaneous sensor inserter and method
US9872633B2 (en) * 2014-09-29 2018-01-23 Becton, Dickinson And Company Cannula insertion detection
US10119993B2 (en) * 2014-10-30 2018-11-06 Tongfu Microelectronics Co., Ltd. Testing probe and semiconductor testing fixture, and fabrication methods thereof
CN105651980A (zh) * 2014-11-14 2016-06-08 厚美德生物科技股份有限公司 具有一体成型顶盖的生化数值检测仪
EP3258848B1 (fr) * 2015-02-16 2021-05-12 Verily Life Sciences LLC Capteur électrochimique pour système de surveillance de glucose en continu de type bandage
US10251605B2 (en) * 2015-02-16 2019-04-09 Verily Life Sciences Llc Bandage type of continuous glucose monitoring system
US9985255B2 (en) * 2015-03-05 2018-05-29 Medtronic, Inc. Battery encasement for implantable devices
CN204542144U (zh) * 2015-03-12 2015-08-12 深圳市光聚通讯技术开发有限公司 微型动态血糖仪
KR101848417B1 (ko) * 2015-04-27 2018-04-12 주식회사 아모그린텍 웨어러블 장치
CN204606554U (zh) * 2015-05-09 2015-09-02 杜启明 一种基于一次性卡扣的安全箱袋
US9839382B2 (en) * 2015-05-18 2017-12-12 Pacesetter, Inc. Device and method for sensing blood glucose
CN204833208U (zh) * 2015-07-28 2015-12-02 南昌欧菲光科技有限公司 触控产品及其电连接装置
CN105615841A (zh) * 2015-10-08 2016-06-01 上海温尔信息科技有限公司 连接器及温度计探头、温度计主体和防水型分体式温度计
CN112932477A (zh) * 2015-10-19 2021-06-11 中国农业大学 植于活鱼眼球巩膜组织间液内的血糖传感器及制备方法
CN108024716B (zh) * 2015-10-21 2022-04-29 德克斯康公司 经皮分析物传感器、其施加器以及相关联方法
EP3170453B1 (fr) * 2015-11-19 2021-03-17 Roche Diabetes Care GmbH Ensemble capteur pour détecter au moins un analyte dans un fluide corporel et procédé d'assemblage d'un ensemble capteur
EP3610791A1 (fr) * 2015-11-19 2020-02-19 Roche Diabetes Care GmbH Ensemble capteur et capteur pour la détection d'un analyte dans un fluide corporel
JP2017118911A (ja) * 2015-12-28 2017-07-06 セイコーエプソン株式会社 センサー基板、分析素子、グルコース測定装置およびインスリン供給装置
EP3804611B1 (fr) * 2015-12-30 2024-07-17 Dexcom, Inc. Systèmes et procédés de capteur d'analyte transcutané
US10362975B2 (en) * 2015-12-30 2019-07-30 Dexcom, Inc. System and method for factory calibration or reduced calibration of an indwelling sensor based on sensitivity profile and baseline model of sensors
US10436773B2 (en) * 2016-01-18 2019-10-08 Jana Care, Inc. Mobile device based multi-analyte testing analyzer for use in medical diagnostic monitoring and screening
EP3195795B1 (fr) * 2016-01-19 2023-08-23 Roche Diabetes Care GmbH Ensemble capteur pour détecter au moins un analyte dans un fluide corporel
EP3203396A1 (fr) * 2016-02-02 2017-08-09 Roche Diabetes Care GmbH Système et procédé d'analyse de données de surveillance du glucose indiquant un niveau de glucose et produit de programme informatique
SI3909506T1 (sl) * 2016-02-05 2023-09-29 F. Hoffmann - La Roche Ag Medicinski pripomoček za odkrivanje vsaj enega analita v telesni tekočini
ITUA20161345A1 (it) * 2016-03-04 2017-09-04 Eltek Spa Dispositivo sensore per contenitori di sostanze liquide
ITUA20161342A1 (it) * 2016-03-04 2017-09-04 Eltek Spa Dispositivo sensore per contenitori di sostanze liquide
US10413183B2 (en) * 2016-04-08 2019-09-17 Medtronic Minimed, Inc. Insertion device
US20170290535A1 (en) * 2016-04-08 2017-10-12 Medtronic Minimed, Inc. Analyte sensor with indicators
US10765348B2 (en) * 2016-04-08 2020-09-08 Medtronic Minimed, Inc. Sensor and transmitter product
US10765369B2 (en) * 2016-04-08 2020-09-08 Medtronic Minimed, Inc. Analyte sensor
US11369412B2 (en) * 2016-04-27 2022-06-28 Phc Holdings Corporation Sensor insertion device and biosensor
US20170325725A1 (en) * 2016-05-13 2017-11-16 Percusense, LLC Vivo sensing and infusion devices
CN106025366A (zh) * 2016-07-13 2016-10-12 深圳市秸川材料科技有限公司 一种锂离子纽扣电池
EP3278729B1 (fr) 2016-08-04 2020-06-24 Roche Diabetes Care GmbH Dispositif médical pour détecter au moins un analyte dans un fluide corporel
CN106137214A (zh) * 2016-08-12 2016-11-23 上海移宇科技股份有限公司 一种经皮分析物传感设备及其安装方法
WO2018027940A1 (fr) * 2016-08-12 2018-02-15 Medtrum Technologies Inc. Système de détection d'analyte transcutané et ses procédés d'installation
KR102589016B1 (ko) * 2016-08-25 2023-10-16 삼성전자주식회사 반도체 소자
JP6738247B2 (ja) * 2016-09-08 2020-08-12 Ykk Ap株式会社 開閉制御装置及び建具
WO2018057318A1 (fr) * 2016-09-21 2018-03-29 Cardiac Pacemakers, Inc. Dispositif de stimulation sans fil muni d'un boîtier qui abrite des composants interne du dispositif de stimulation sans fil et fonctionne comme boîtier de batterie et borne d'une batterie interne
KR102588428B1 (ko) * 2016-10-10 2023-10-12 삼성전자주식회사 안테나 장치 및 그것을 포함하는 전자 장치
US20180115017A1 (en) * 2016-10-20 2018-04-26 Johnson & Johnson Vision Care, Inc. Biomedical energization elements with polymer electrolytes
EP3500854B1 (fr) * 2016-11-09 2025-06-18 Dexcom, Inc. Systèmes et procédés d'assistance technique de contrôle d'analyte en continu et systèmes de capteurs
CN108078569B (zh) * 2016-11-21 2024-06-25 南通九诺医疗科技有限公司 一种手机app直接监控的动态血糖监测仪及其控制方法
CN206576873U (zh) * 2016-11-21 2017-10-24 南通九诺医疗科技有限公司 一种手机app直接监控的动态血糖监测仪
CN108078570B (zh) * 2016-11-21 2024-06-25 南通九诺医疗科技有限公司 一种内置加速度传感器的动态血糖监测电路及其控制方法
MX394407B (es) * 2016-12-22 2025-03-24 Sanvita Medical Corp Sistema y método de monitoreo continuo de glucosa.
AU2017388066B9 (en) * 2016-12-27 2021-04-01 Dexcom, Inc. Systems and methods for patient monitoring using an HCP - specific device
CN108281200A (zh) * 2016-12-30 2018-07-13 上海移宇科技股份有限公司 一种在动态血糖监测系统中调整算法的方法及应用该方法的动态血糖监测系统
CN106949988A (zh) * 2017-03-13 2017-07-14 泉州市小新智能科技有限公司 一种纽扣式温感器及其工作方法
CA3047218C (fr) * 2017-03-21 2023-08-29 F. Hoffmann-La Roche Ag Dispositif medical et methode de fabrication d'un dispositif medical utiule pour la surveillance continue d'analytes et/ou d'autres fonctions corporelles
CN207662531U (zh) * 2017-04-21 2018-07-27 深圳市爱立康医疗股份有限公司 一种体温计
CN206772463U (zh) * 2017-04-21 2017-12-19 深圳市爱立康医疗股份有限公司 一种超薄体温计
HUE057712T2 (hu) * 2017-05-23 2022-05-28 Hoffmann La Roche Érzékelõrendszer és eljárás annak elõállítására
CN207898483U (zh) * 2017-05-27 2018-09-25 北京怡唐生物科技有限公司 动态连续血糖监测系统的一次性监测装置信号发送器
CN107014877B (zh) * 2017-05-27 2023-06-20 北京怡唐生物科技有限公司 一种动态连续血糖监测系统
DK4154802T3 (da) * 2017-06-19 2024-03-25 Dexcom Inc Applikatorer til anbringelse af transkutane analytsensorer
EP3928688B1 (fr) * 2017-06-23 2022-06-01 Dexcom, Inc. Capteurs de substance à analyser transcutanés, applicateurs correspondants et moyeu d'aiguille comprenant une fonction anti-rotation
CN107361775A (zh) 2017-07-24 2017-11-21 湖州美奇医疗器械有限公司 一种血糖仪
EP3928687B1 (fr) * 2017-10-24 2024-06-26 Dexcom, Inc. Dispositif portable avec un capteur d'analyte préconnecté
TWI640296B (zh) * 2017-12-12 2018-11-11 研能科技股份有限公司 血糖偵測裝置
US11656195B2 (en) * 2018-05-03 2023-05-23 Dexcom, Inc. Automatic analyte sensor calibration and error detection
CA3092649A1 (fr) * 2018-05-04 2019-11-07 Dexcom, Inc. Systemes et procedes de gestion d'energie dans un systeme de capteurs d'analyte
CN208142255U (zh) * 2018-05-21 2018-11-23 青岛迈金智能科技有限公司 一种心率检测模块及心率带
CN109085329A (zh) * 2018-07-23 2018-12-25 青岛厚美德生物科技有限公司 一种免调码生物传感试纸及其免调码识别处理方法
KR102200138B1 (ko) * 2018-07-31 2021-01-11 주식회사 아이센스 연속 혈당 측정 장치
CN109199400B (zh) * 2018-09-10 2021-08-31 中山大学 基于微针阵列的血糖电化学传感器
US11239668B2 (en) * 2018-09-21 2022-02-01 Google Llc Charger case for wearable electronics
CN109148786A (zh) * 2018-10-18 2019-01-04 天津中聚新能源科技有限公司 一种具有灭火防护功能的电池
CN109350079A (zh) * 2018-11-14 2019-02-19 贝生(广州)传感科技有限公司 一种持续葡萄糖监测系统的植入装置
US20200194749A1 (en) * 2018-12-14 2020-06-18 TeraWatt Technolgy Inc. Prelithiated anode in battery cells for electric vehicles
CN109730674B (zh) * 2019-01-31 2024-04-30 青岛光电医疗科技有限公司 一次性防水型心电电极及移动式心电监测设备
CN210204726U (zh) * 2019-01-31 2020-03-31 青岛光电医疗科技有限公司 一次性防水型心电电极及移动式心电监测设备
CN218852699U (zh) * 2019-04-22 2023-04-14 德克斯康公司 分析物感测装置
CN109998560B (zh) * 2019-04-30 2023-12-22 苏州百孝医疗科技有限公司 分离供电动态血糖监测发射器、系统及信号采样方法
CN210056040U (zh) * 2019-04-30 2020-02-14 苏州百孝医疗科技有限公司 分离供电动态血糖监测发射器及其系统
CN109998555B (zh) 2019-04-30 2023-12-15 苏州百孝医疗科技有限公司 一种受体生理参数测量系统
CN210541578U (zh) * 2019-04-30 2020-05-19 三诺生物传感股份有限公司 一种新型动态血糖监测仪发射器和动态血糖监测仪
TWI699189B (zh) * 2019-05-29 2020-07-21 華廣生技股份有限公司 生物感測裝置及生物感測裝置啟動方法
CN110370738A (zh) * 2019-06-28 2019-10-25 佛山佛塑科技集团股份有限公司 一种锂离子电池用软包装膜
EP4631429A3 (fr) * 2019-07-19 2025-12-03 Medtrum Technologies Inc. Dispositif de perfusion de médicament intégré
CN112237658B (zh) * 2019-07-19 2022-10-04 上海移宇科技股份有限公司 集成型药物输注装置
CN211014024U (zh) * 2019-08-02 2020-07-14 普乐药业有限公司 便携式血糖测量仪
CN110296970A (zh) * 2019-08-02 2019-10-01 普乐药业有限公司 便携式血糖测量仪
TWI735138B (zh) * 2019-08-02 2021-08-01 華廣生技股份有限公司 生理訊號傳感裝置
CN110584676A (zh) * 2019-08-19 2019-12-20 上海移宇科技股份有限公司 传感装置
EP4017357A4 (fr) * 2019-08-19 2023-04-19 Medtrum Technologies Inc. Dispositif de détection
CN110680343A (zh) * 2019-09-11 2020-01-14 杭州瀚科医疗科技有限公司 新型皮下葡萄糖传感器电路导通方法
CN110722863B (zh) * 2019-10-15 2021-10-08 界首市天鸿新材料股份有限公司 一种锂电池用耐腐蚀软包装膜制备方法
US12303261B2 (en) * 2019-11-08 2025-05-20 Ascensia Diabetes Care Holdings Ag Devices, systems, and methods for measuring analytes in interstitial fluid
CN110881983B (zh) * 2019-11-20 2025-05-06 浙江大学 一种柔性微创血糖传感器
CN211749634U (zh) * 2019-12-03 2020-10-27 华东数字医学工程研究院 分析物传感器模块和分析物传感器系统
CN210868333U (zh) * 2019-12-03 2020-06-26 华东数字医学工程研究院 分析物传感系统
EP3851037A1 (fr) * 2020-01-14 2021-07-21 Bionime Corporation Dispositif de chargement pour un émetteur de signal physiologique et son procédé de chargement
EP4106627A4 (fr) * 2020-02-20 2024-05-01 Medtrum Technologies Inc. Dispositif de détection d'analyte hautement intégré
CN111244381A (zh) * 2020-03-05 2020-06-05 清华大学 一种全极耳型纽扣电池及其制造方法
US20230157577A1 (en) * 2020-03-06 2023-05-25 Chulalongkorn University Non-invasive wearable sensor device for detecting biomarkers in secretion
CN115715168A (zh) * 2020-06-10 2023-02-24 赞思健康科技有限公司 气体灭菌的连续代谢监测仪
US12082924B2 (en) * 2020-07-31 2024-09-10 Medtronic Minimed, Inc. Sensor identification and integrity check design
CN112120709A (zh) * 2020-09-27 2020-12-25 微泰医疗器械(杭州)有限公司 一种血糖监测装置
CN214632156U (zh) * 2020-11-27 2021-11-09 浙江凯立特医疗器械有限公司 一种可充电式发射器
CN113363592A (zh) * 2021-06-08 2021-09-07 四川启睿克科技有限公司 一种芯片与电池一体化集成方法及设备
US20240366127A1 (en) * 2021-07-08 2024-11-07 Medtrum Technologies Inc. Micro analyte sensor and continuous analyte monitoring device
EP4408278B1 (fr) * 2021-09-27 2026-03-18 Medtrum Technologies Inc. Système de détection d'analyte

Also Published As

Publication number Publication date
CN113281382A (zh) 2021-08-20
EP4017357A1 (fr) 2022-06-29
US20220225900A1 (en) 2022-07-21
WO2021031541A1 (fr) 2021-02-25
EP4190237A1 (fr) 2023-06-07
WO2022028070A1 (fr) 2022-02-10
EP4346593A4 (fr) 2025-05-07
CN115483485B (zh) 2023-11-21
EP4183339A1 (fr) 2023-05-24
US12402815B2 (en) 2025-09-02
CN112394097A (zh) 2021-02-23
CN113274003A (zh) 2021-08-20
CN115474928A (zh) 2022-12-16
US20230263433A1 (en) 2023-08-24
US20250195759A1 (en) 2025-06-19
WO2021164183A1 (fr) 2021-08-26
US20220218240A1 (en) 2022-07-14
WO2022252744A1 (fr) 2022-12-08
US20220234039A1 (en) 2022-07-28
EP4017360A4 (fr) 2023-09-06
EP4346593A1 (fr) 2024-04-10
EP4182677A4 (fr) 2024-08-14
WO2021164085A1 (fr) 2021-08-26
ES3058746T3 (en) 2026-03-12
EP4183339A4 (fr) 2024-07-24
EP4017357A4 (fr) 2023-04-19
EP4190237A4 (fr) 2024-08-14
US20230210408A1 (en) 2023-07-06
WO2023173654A1 (fr) 2023-09-21
WO2021164207A1 (fr) 2021-08-26
EP4017361A1 (fr) 2022-06-29
CN115474932A (zh) 2022-12-16
EP4106613A4 (fr) 2024-04-17
EP4493057A4 (fr) 2025-12-17
CN115483489B (zh) 2023-11-21
WO2021164278A1 (fr) 2021-08-26
CN112386251B (zh) 2024-08-20
CN113274002B (zh) 2023-04-28
CN115474928B (zh) 2025-10-31
CN114052728A (zh) 2022-02-18
EP4106628A4 (fr) 2024-05-01
WO2022252549A1 (fr) 2022-12-08
WO2021031542A1 (fr) 2021-02-25
CN116785528A (zh) 2023-09-22
WO2022252550A1 (fr) 2022-12-08
US12622610B2 (en) 2026-05-12
CN113274003B (zh) 2023-09-12
CN115474932B (zh) 2025-09-02
US12521044B2 (en) 2026-01-13
EP4182677A1 (fr) 2023-05-24
EP4017361B1 (fr) 2025-06-18
CN113285268A (zh) 2021-08-20
CN113285268B (zh) 2023-09-12
WO2022012400A1 (fr) 2022-01-20
EP4106628A1 (fr) 2022-12-28
WO2021164185A1 (fr) 2021-08-26
WO2021031057A1 (fr) 2021-02-25
WO2022012187A1 (fr) 2022-01-20
CN115483489A (zh) 2022-12-16
EP4017361A4 (fr) 2023-06-07
US20230255517A1 (en) 2023-08-17
CN113274005B (zh) 2024-02-13
US20240225492A1 (en) 2024-07-11
EP4017360A1 (fr) 2022-06-29
US20230092945A1 (en) 2023-03-23
CN113274005A (zh) 2021-08-20
EP4107526A1 (fr) 2022-12-28
CN113274002A (zh) 2021-08-20
WO2021164184A1 (fr) 2021-08-26
CN113281382B (zh) 2025-01-28
CN114052728B (zh) 2025-06-03
US20230066226A1 (en) 2023-03-02
CN113274006B (zh) 2023-09-26
CN113274013B (zh) 2023-07-04
EP4107526A4 (fr) 2024-05-22
US12484810B2 (en) 2025-12-02
US20240245327A1 (en) 2024-07-25
WO2022252548A1 (fr) 2022-12-08
EP4106613B1 (fr) 2025-04-09
CN115483485A (zh) 2022-12-16
EP4182677B1 (fr) 2025-12-31
EP4106613A1 (fr) 2022-12-28
CN112386251A (zh) 2021-02-23
WO2021164206A1 (fr) 2021-08-26
US20230066019A1 (en) 2023-03-02
CN113940673B (zh) 2024-02-13
CN113274013A (zh) 2021-08-20
CN113940673A (zh) 2022-01-18
EP4017360B1 (fr) 2025-08-13
EP4183339B1 (fr) 2026-04-01
CN113274006A (zh) 2021-08-20

Similar Documents

Publication Publication Date Title
WO2023173654A1 (fr) Dispositif de perfusion de médicament hautement intégré
EP3999144B1 (fr) Dispositif de perfusion de médicament intégré
CN114432537B (zh) 贴片式药物输注装置
US12471810B2 (en) Highly integrated analyte detection device
CN112237658B (zh) 集成型药物输注装置
CN113225915B (zh) 一种双面传感器结构及血糖监测装置
US20230390488A1 (en) Patch-type drug infusion device

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20240910

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20251114

RIC1 Information provided on ipc code assigned before grant

Ipc: A61B 5/145 20060101AFI20251110BHEP