EP4529480A1 - Dispositif de distribution de principes actifs ou de substances pouvant être transportées de manière ciblée, contrôlable et régulable à l'aide d'une cellule génératrice de gaz - Google Patents

Dispositif de distribution de principes actifs ou de substances pouvant être transportées de manière ciblée, contrôlable et régulable à l'aide d'une cellule génératrice de gaz

Info

Publication number
EP4529480A1
EP4529480A1 EP23718001.3A EP23718001A EP4529480A1 EP 4529480 A1 EP4529480 A1 EP 4529480A1 EP 23718001 A EP23718001 A EP 23718001A EP 4529480 A1 EP4529480 A1 EP 4529480A1
Authority
EP
European Patent Office
Prior art keywords
gas
conveyable
liquid
active ingredient
targeted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP23718001.3A
Other languages
German (de)
English (en)
Inventor
Matthias Meier
Hans Gfeller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SIMATEC AG
Original Assignee
SIMATEC AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SIMATEC AG filed Critical SIMATEC AG
Publication of EP4529480A1 publication Critical patent/EP4529480A1/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16N—LUBRICATING
    • F16N7/00—Arrangements for supplying oil or unspecified lubricant from a stationary reservoir or the equivalent in or on the machine or member to be lubricated
    • F16N7/30—Arrangements for supplying oil or unspecified lubricant from a stationary reservoir or the equivalent in or on the machine or member to be lubricated the oil being fed or carried along by another fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14526—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons the piston being actuated by fluid pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F1/00—Treatment of water, waste water, or sewage
    • C02F1/46—Treatment of water, waste water, or sewage by electrochemical methods
    • C02F1/461—Treatment of water, waste water, or sewage by electrochemical methods by electrolysis
    • C02F1/467—Treatment of water, waste water, or sewage by electrochemical methods by electrolysis by electrochemical disinfection; by electrooxydation or by electroreduction
    • C02F1/4676—Treatment of water, waste water, or sewage by electrochemical methods by electrolysis by electrochemical disinfection; by electrooxydation or by electroreduction by electroreduction
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F1/00—Treatment of water, waste water, or sewage
    • C02F1/68—Treatment of water, waste water, or sewage by addition of specified substances, e.g. trace elements, for ameliorating potable water
    • C02F1/685—Devices for dosing the additives
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B1/00—Electrolytic production of inorganic compounds or non-metals
    • C25B1/01—Products
    • C25B1/02—Hydrogen or oxygen
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16N—LUBRICATING
    • F16N11/00—Arrangements for supplying grease from a stationary reservoir or the equivalent in or on the machine or member to be lubricated; Grease cups
    • F16N11/10—Arrangements for supplying grease from a stationary reservoir or the equivalent in or on the machine or member to be lubricated; Grease cups by pressure of another fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M2005/14204—Pressure infusion, e.g. using pumps with gas-producing electrochemical cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3368—Temperature
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F2201/00—Apparatus for treatment of water, waste water or sewage
    • C02F2201/46—Apparatus for electrochemical processes
    • C02F2201/461—Electrolysis apparatus
    • C02F2201/46105—Details relating to the electrolytic devices
    • C02F2201/46115—Electrolytic cell with membranes or diaphragms
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F2201/00—Apparatus for treatment of water, waste water or sewage
    • C02F2201/46—Apparatus for electrochemical processes
    • C02F2201/461—Electrolysis apparatus
    • C02F2201/46105—Details relating to the electrolytic devices
    • C02F2201/4616—Power supply
    • C02F2201/46165—Special power supply, e.g. solar energy or batteries
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F2209/00—Controlling or monitoring parameters in water treatment
    • C02F2209/30—H2
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F2307/00—Location of water treatment or water treatment device
    • C02F2307/02—Location of water treatment or water treatment device as part of a bottle
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16N—LUBRICATING
    • F16N2270/00—Controlling
    • F16N2270/20—Amount of lubricant

Definitions

  • the present invention relates to a device for the targeted, controllable and regulatable delivery of active ingredients or substances that can be conveyed by means of a delivery pressure built up by one or more gas development cells.
  • Devices available on the market for conveying active substances or other substances that can be conveyed in humanitarian or veterinary medicine function electromechanically, by means of spring tension or on the basis of elastomers.
  • Peristaltic pumps are also known.
  • the electromechanical systems are characterized by precisely controllable dosage, but these systems are relatively large compared to the volume conveyed.
  • the spring-driven systems as well as the elastomer pumps are inaccurate and not sufficiently reliable due to their design and the lack of electronics.
  • the present invention is therefore based on the object of specifying a device for the targeted, controllable and regulatable delivery of active ingredients or substances that can be conveyed by means of a conveying pressure built up by a gas development cell, which is characterized by a compact size, its comparatively easy-to-control conveying technology and the Achievable conveying accuracy and controllable conveying are distinguished.
  • the advantages over current systems are the smaller size, the simpler design, the increased mobility and independence, the lower complexity, the improved accuracy, the electronic controllability, the functional monitoring, the digital communication and the easier filling of the system.
  • the system is characterized by its position-independent functionality, which is independent of the prevailing gravitational force and also works in weightlessness.
  • the invention is based on the object of using the conveying principle of displacement by means of gas, which is produced by one or more gas development cells, to specifically, control, regulate and monitor a conveyable medium, which can be gaseous, liquid, viscous or powdery, for example in an organism (human, animal, plant) or to hand over a technical system such as machines or systems.
  • Medications or active ingredients in liquid, dissolved or viscous form are conceivable as the medium that can be conveyed, but also any type of supporting substances and liquids that can be conveyed with the system, as well as lubricants (fat, oil) or reagents when used in the technical area.
  • the system should be able to be manufactured cost-effectively and be suitable for efficient mass production, and consumables and wear parts should also be easy to replace.
  • the operation and correct setting of the device as well as starting, pausing or stopping the dispensing process should be simple, understandable and designed in such a way that the probability of errors is minimized and the safety of the patient is maximized. reliable and safe operation of the technical system is guaranteed.
  • the system essentially consists of the following parts: a) an operating, control, regulation, monitoring and communication unit (A); b) a gas drive unit (B); c) a reservoir for active ingredient or producible substance (C); and d) a connection system (D).
  • Operating unit operating, controlling, regulating, monitoring and communication unit
  • the operating unit consists of a housing, a display (e.g. LCD), controls (e.g. buttons), an energy source (e.g. button battery or rechargeable battery), components for wireless communication and electronic components that fulfill the functionalities described below.
  • a display e.g. LCD
  • controls e.g. buttons
  • an energy source e.g. button battery or rechargeable battery
  • the most important functions include one or more of the following properties: a) a start function for an optimal start-up b) an indirect control of the delivery quantity by means of temperature, pressure and current measurement over time, and c) a bolus function for reacting to short-term higher required dosages.
  • the latter can be realized through a controlled discharge current or through a defined gas pressure accumulator with a release valve.
  • the time required until the next pressure build-up can be used to naturally prevent over-bolus delivery.
  • the device can be easily set (dispensing rate ml/h, total quantity ml, etc.) and started using the controls and the display.
  • the control unit has electronics that enable wireless communication, e.g. B. with a PC, tablet or smartphone. This means that all the necessary values can be set precisely and, if necessary, a time course can also be programmed.
  • the device can also be started, stopped or paused contactlessly. Safe monitoring of the delivery and networking of the patient, e.g. B. via blockchain technology is possible.
  • the system can also be expanded to include a device for troubleshooting or troubleshooting, e.g. B. can clear a blockage using a pressure pulse.
  • a pressure pulse can be realized with the help of appropriately switched valves, pistons and springs or detectors.
  • a constant dosage of active ingredient can be achieved through intelligent control of the gas development cell using pressure and temperature measurement with a corresponding control algorithm and a corresponding control of the gas development cell.
  • the donation volume/active ingredient dosage is regulated indirectly via pressure and temperature measurement.
  • the gas production, or Discharge current in mAh is "normalized" (normal pressure @ 20°C) to integrated.
  • the gas production of the gas evolution cells is known and controllable.
  • a combination with a separate level measuring system is also conceivable, such as the Piston position measurement or flow measurement of the delivery quantity.
  • control electronics and firmware can assume that there is a new, completely filled active ingredient reservoir in the device. All counters/integrators can be set to "zero", i.e. a fill level of 100% is assumed.
  • the active ingredient reservoir size can be recognized automatically (HW coding on the reservoir) or is determined via the Uo voltage of the respective gas development cell package.
  • the state of charge of the cell can be checked at the same time by monitoring the voltage when starting
  • Figure 2 outlines the initial start of the active ingredient dosing device, during which the gas development cells are quickly discharged until an “individual cell voltage” of less than 0.4V is achieved (conditioning) . From this voltage point onwards, the gas development cell only enters the process of hydrogen gas production. The rapid discharge of the gas development cells now continues up to a pressure of 0. 15bar, here, for example, the piston friction of a delivery piston is overcome. The pressure increase (slope) can be monitored in the starting position, and dead volume can also be compensated for.
  • the pressure is increased until the pressure equilibrium ("dispense active substance") is achieved. This pressure is recorded as "system pressure" and is used as a control basis in further evaluations. If the device later encounters one or more error states, the learning cycle could be triggered again. It can also be monitored whether the maximum system pressure (final pressure) has already been exceeded in the starting phase and whether perfect function is therefore impossible from the outset.
  • control system can be trained to assume that the system is clogged and consequently sends an error message or signals this error on the device itself.
  • control can be designed in such a way that it assumes the presence of a leak.
  • the active ingredient dispenser signals this error and/or issues an error message.
  • Figure 5 shows the case in which the gas development cell is controlled in “pulse operation” (approx. 1 ml in 22 minutes). Discharge at 180 ohms results in a gas rate of 2.7 ml/h.
  • the pressure measurement signal should increase and decrease again as the active ingredient flows.
  • the piston movement can be determined in this way.
  • the stick-slip effect of the piston static friction/sliding friction
  • the gas diffusion through a syringe housing or an outer bag can also be continuously compensated for by the control by realizing an increasing gas rate.
  • the gas drive unit forms the actual drive of the dispensing system and can be connected to the control unit (A).
  • the gas drive unit consists at least of a housing, one or more gas development cells and contact elements.
  • the gas drive unit is mechanically and electrically connected to the control unit and the active ingredient reservoir (C).
  • the gas drive unit controls the entire controlling, regulating and monitoring electronics including. Sensors, communication elements (e.g. radio) and energy source (e.g. battery).
  • the gas development is controlled via a programmable current discharge.
  • the sensors and intelligent electronics which are located either in the gas drive unit or the control unit, enable reliable delivery of the active ingredient.
  • the delivery can also be paused if necessary, for example if you feel unwell due to the painkiller dosage being set too high.
  • the delivery rate can also be adjusted at any time adjust during delivery. For example, the delivery quantity could also follow a pre-programmed dosage profile.
  • the gas drive unit could either be connected or welded to a housing 6 or an active ingredient container 4 during production. But they will only be connected to it when it is made available.
  • the connection should be designed in such a way that unwanted gas escape is prevented and that the connection can withstand the necessary gas pressure generated to extract the active ingredient.
  • a passive overpressure safety device which enables controlled venting of the gas space in the event of critical overpressure, could also be integrated.
  • the active ingredient reservoir contains the medium to be pumped. This is either already pre-filled or is filled by the provider (pharmacist, nursing service, etc.) or by the patient themselves.
  • the filling is made maximally simple and safe by an appropriately designed construction design or a separate auxiliary device, mixing or This makes it easy to mix medications shortly before dispensing the medication.
  • the active substance reservoir can be designed in the form of a syringe available on the market (FIG. 8a).
  • the piston acts as a media separator between the gas and the medium to be pumped, but other possible forms for separating the pumped medium and gas are also possible, such as “bag in bag”, “bag in a dimensionally stable housing”, or “bag in a flexible shape housing”. and volume-stable housing” ( Figure 8b).
  • An inflatable membrane or a type of bubble or balloon as a displacer is also technically conceivable ( Figure 9b and Figure 9c).
  • the active ingredient reservoir should meet various requirements depending on the application, in particular its material should have optimized compatibility with the active ingredient and a minimum or have no gas diffusion at all.
  • the passage of gas through The flow through the media separator into the medium to be conveyed should always be minimal and must not exceed any set maximum values. This can be achieved through a suitable choice of material or coating or a multilayer structure. It can also provide protection from light or UV radiation.
  • the active ingredient reservoir can also be protected from heating by an additional cold protection system or kept warm by a warming system.
  • connection system A standard system that has already established itself on the market is preferably used as the connection system. This makes handling the device easier for nursing staff, for example.

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Organic Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Water Supply & Treatment (AREA)
  • Environmental & Geological Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Hydrology & Water Resources (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Combustion & Propulsion (AREA)
  • Fluid Mechanics (AREA)
  • Metallurgy (AREA)
  • Medicinal Chemistry (AREA)
  • Materials Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Electrolytic Production Of Non-Metals, Compounds, Apparatuses Therefor (AREA)

Abstract

L'objet de l'invention est de distribuer un milieu pouvant être transporté, qui peut être gazeux, liquide, visqueux, pâteux ou pulvérulent, dans un organisme (humain, animal, végétal) ou sur un système technique par exemple de manière ciblée, contrôlée, régulée et surveillée au moyen d'un principe de pompage par déplacement à l'aide d'un gaz produit par une cellule génératrice de gaz. Il est possible d'utiliser des médicaments ou des principes actifs sous une forme liquide, dissoute ou visqueuse en tant que milieux pouvant être transportés, mais aussi tout type de substance et de liquide de support qui peut être transporté par le système, ainsi que des lubrifiants ou des agents protecteurs (graisse, huile) ou réactifs, en tant que milieux pouvant être transportés. Le système devrait être peu coûteux à produire et approprié pour une production économique en masse, et de plus des pièces consommables et des pièces d'usure devraient être faciles à remplacer. Le fonctionnement et la mise en place correcte du dispositif ainsi que le démarrage, la mise en pause ou l'arrêt du processus de distribution devraient être faciles, compréhensibles et conçus de sorte que la probabilité de défauts soit réduite au minimum et que la sécurité du patient soit maximisée ou que le fonctionnement fiable du système technique soit assuré. Ceci est obtenu par le système décrit ci-dessous, tel que divulgué dans la revendication de brevet indépendante (1) et les revendications de brevet dépendantes (2) à (4). Le système comprend essentiellement les pièces suivantes : a) une unité de commande, de contrôle, de régulation, de surveillance et de communication (A) ; b) une unité d'entraînement par gaz (B) ; c) un réservoir de principe actif (C) ; et d) un système de raccordement (D).
EP23718001.3A 2022-05-23 2023-04-24 Dispositif de distribution de principes actifs ou de substances pouvant être transportées de manière ciblée, contrôlable et régulable à l'aide d'une cellule génératrice de gaz Pending EP4529480A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP22174862 2022-05-23
EP22184015 2022-07-11
EP22184010 2022-07-11
PCT/EP2023/060666 WO2023227307A1 (fr) 2022-05-23 2023-04-24 Dispositif de distribution de principes actifs ou de substances pouvant être transportées de manière ciblée, contrôlable et régulable à l'aide d'une cellule génératrice de gaz

Publications (1)

Publication Number Publication Date
EP4529480A1 true EP4529480A1 (fr) 2025-04-02

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EP23718001.3A Pending EP4529480A1 (fr) 2022-05-23 2023-04-24 Dispositif de distribution de principes actifs ou de substances pouvant être transportées de manière ciblée, contrôlable et régulable à l'aide d'une cellule génératrice de gaz

Country Status (4)

Country Link
US (1) US20250297705A1 (fr)
EP (1) EP4529480A1 (fr)
CN (1) CN119255830A (fr)
WO (2) WO2023227307A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4656061A1 (fr) * 2024-05-31 2025-12-03 simatec ag Procédé et système de libération contrôlée d'un principe actif pour l'obtention et/ou l'amélioration de la capacité de stockage et/ou de transport de produits végétaux et/ou animaux
CH721705B1 (de) 2024-07-31 2025-10-15 Vizdun Gmbh Vorrichtung und verfahren zur bekämpfung der tigermücke

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5242406A (en) * 1990-10-19 1993-09-07 Sil Medics Ltd. Liquid delivery device particularly useful for delivering drugs
WO1996041159A1 (fr) * 1995-06-07 1996-12-19 Ceramatec, Inc. Dispositif d'amplification gazeuse
US6413238B1 (en) * 1999-09-17 2002-07-02 Baxter International Inc Fluid dispenser with stabilized fluid flow
JP2006255613A (ja) * 2005-03-17 2006-09-28 Seiki Shiga 活性水素溶存水の生成方法、生成器および生成用の石こう供給部材、並びに活性水素の生成性物質とその製造方法
US20130184640A1 (en) * 2010-04-20 2013-07-18 Minipumps, Llc Accurate flow control in drug pump devices
JP6564466B2 (ja) * 2015-11-09 2019-08-21 バイオコーク技研株式会社 水素富加装置、水素富加方法及び水素富加液体の製造方法
JP6010716B1 (ja) * 2016-06-10 2016-10-19 浩章 皆川 水素水製造装置及び水素水製造方法
KR101875023B1 (ko) * 2016-12-19 2018-07-05 김규현 휴대용 수소수 분무기
CN209547790U (zh) * 2018-12-04 2019-10-29 佛山市宇泉水处理设备有限公司 多功能即饮式富氢饮水机
CN110935076B (zh) * 2019-12-23 2025-02-25 上海点明医疗器械有限公司 一种富氢水排便清肠器

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WO2023227308A3 (fr) 2024-01-25

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