Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
  • A61Q17/005—Antimicrobial preparations
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
  • A61K8/20—Halogens; Compounds thereof
  • A61K8/21—Fluorides; Derivatives thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
  • A61K8/25—Silicon; Compounds thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
  • A61K8/27—Zinc; Compounds thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/34—Alcohols
  • A61K8/345—Alcohols containing more than one hydroxy group
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
  • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
  • A61K2800/30—Characterized by the absence of a particular group of ingredients

Definitions

• the present invention relates to oral care compositions in particular oral care that are free from preservatives.
• a key attribute for oral care products is that they are free from microbial and fungal contamination.
• oral care products that provide consistent and reproducible resistance to bacterial growth and mould, while maintaining their efficacy and consumer acceptability.
• Oral care products having a high water content and a silica abrasive can be difficult to preserve, especially in the absence of preservatives.
• WO 2013/095370 provides oral care compositions comprising: greater than 50 weight % water; an effective amount of benzyl alcohol; and a silica abrasive that are said to provide adequate preservation.
• WO 2018/145988 discloses compositions oral care comprising low levels of sodium fluoride.
• WO 2014/100930 discloses the use of a water-soluble source of stannous ions for improving the robustness towards microbial challenge of oral care compositions.
• Toothpastes that contain higher levels of water are desirable from both a cost and sustainability point of view. There is now a consumer preference for products that minimise the use of preservatives and lower the level of fluoride, thus products that are self-preserving are desirable.
• the present invention relates to a toothpaste composition
• a toothpaste composition comprising: i) 40 wt% or greater of the total composition of water, ii) silica abrasive, iii) from 0.05 wt% to 0.15 wt%, of the total composition of sodium fluoride, iv) 0.4 wt% of the total composition of zinc sulphate.
• the invention further relates to the use of zinc sulphate to mitigate fungal contamination in a toothpaste composition comprising 40wt% or greater of water of the total composition of water and from 0.05 wt% to 0.15 wt% the total composition of fluoride.
• free from can be interpretated as comprising less than 0.05 wt% of the total composition of an ingredient, preferably less than 0.01wt %.
• compositions according to the invention comprise 0.4 wt% of the total composition of zinc sulphate, preferably the level zinc sulphate is from 0.5 to 3 wt%, more preferably from 0.6 to 1 .5 wt% of the total composition of the total composition. It is preferred if the zinc sulphate is zinc sulphate hepthydrate.
• metal salts may be present but preferably zinc sulphate is present at all level of 60 wt% or greater the amount of zinc salts, more preferably it is the only zinc salt present. If present other metal salts include zinc chloride, zinc fluoride, zinc citrate, zinc lactate, zinc oxide, zinc monoglycerolate, zinc tartrate, zinc pyrophosphate and zinc maleate. Stannous ions such as stannous fluoride and stannous chloride may also be suitable for use with the invention.
• Toothpaste compositions may further comprise a polyol at a level from 5 to 35, preferably 10 to 30 wt% of the total composition.
• the polyol is selected from glycerol, sorbitol mixtures thereof. Particularly preferred is sorbitol.
• compositions of the invention comprises is sodium fluoride at a level rorm 0.05 wt% 0.15 wt% the total composition of sodium fluoride., preferably from 0,07wt% to 0.13wt% of the total composition.
• level of fluoride is below 800ppm, more preferably from 300 to 600 ppm.
• the toothpaste is free from sodium benzoate and/or benzoic acid.
• a composition according to the invention will generally contain further ingredients to enhance performance and/or consumer acceptability, in addition to the ingredients specified above.
• the composition particularly if a toothpaste preferably comprises an inorganic or a natural or synthetic thickener or gelling agent in proportions of about 0.10 to about 15% by weight depending on the material chosen.
• Suitable thickeners or gelling agents useful in the practice of the present invention include inorganic thickening silicas such as amorphous silicas available from Huber Corporation under the trade designation Zeodent 165, Irish moss, iota-carrageenan, gum tragacanth, and polyvinylpyrrolidone.
• inorganic thickening silicas such as amorphous silicas available from Huber Corporation under the trade designation Zeodent 165, Irish moss, iota-carrageenan, gum tragacanth, and polyvinylpyrrolidone.
• compositions according to the invention preferably comprise a polymeric deposition aid.
• the composition comprises acid anhydride polymers, particularly preferred are copolymers of maleic anhydride with methyl vinylether, in which the anhydride moiety may be in a partially or fully hydrolysed or alcoholysed form.
• Preferred copolymers include Gantrez(R) polymers such as:
• Gantrez S-95 molecular weight 216,000; free acid
• Gantrez S-96 molecular weight 700,000; free acid
• Gantrez S-97 molecular weight 1 ,500,000; free acid
• Gantrez MS-955 molecular weight 1,060,000; calcium/sodium salt.
• Particularly preferred co-polymers of maleic acid and methyl vinylether have a molecular weight of 1,000,000 or greater and an especially preferred material is Gantrez S-97.
• compositions according to the invention may comprise a tooth whitening agent.
• the whitening agent preferably comprises a green and/or a blue pigment.
• a pigment is generally understood to be a shade/material which is insoluble in the relevant medium, at the relevant temperature. This is in contrast to dyes which are soluble.
• the "relevant medium” is human saliva, the liquid medium in which the composition is used, at the temperature of the oral cavity during brushing of the teeth, i.e. up to 37 Degrees C. As a reasonable approximation, the relevant medium may be considered to be water and the relevant temperature to be 25 Degrees C.
• the blue pigment is Pigment Blue 15, more preferably Pigment Blue 15:1 , 15:2, 15:3, 15:4, 15:5 or 15:6, most preferably 15:1.
• a preferred pigment is blue pigment is Phthalocyanine Blue Pigment, Cl No. 74160, blue covarine.
• the preferred Green pigment is Phthalocyanine Green, preferably Phthalocyanine Green CI- 74260.
• the total level of pigment in the composition is from 0.01 wt% to 3 wt, more preferably from 0.02 to 2 wt%.
• composition is a toothpaste it may be a dual phase paste, with the whitening pigments present in one phase.
• compositions according to the invention may comprise oral care enzyme systems such as hydrogen peroxide producing enzyme systems (e.g. the oxidoreductase enzyme glucose oxidase), amyloglucosidase, dextranase and/or mutanase, (optionally in the presence of zinc ion providing compounds and/or 8- hydroxyquinoline derivatives), lactoperoxidase, lactoferrin, lysozyme and mixtures thereof.
• hydrogen peroxide producing enzyme systems e.g. the oxidoreductase enzyme glucose oxidase
• amyloglucosidase e.g. the oxidoreductase enzyme glucose oxidase
• dextranase and/or mutanase e.g. the oxidoreductase enzyme glucose oxidase
• mutanase e.g. the mutanase
• lactoperoxidase e.g. the
• a preferred class of oral care active for inclusion in the compositions of the invention includes agents for the remineralisation of teeth.
• remineralisation in the context of the present invention means the in situ generation of hydroxyapatite on teeth.
• a specific example of a suitable agent for the remineralisation of teeth is a mixture of a calcium source and a phosphate source which, when delivered to the teeth results in the in situ generation of hydroxyapatite on teeth.
• remineralising calcium sources include, for example, calcium phosphate, calcium gluconate, calcium oxide, calcium lactate, calcium glycerophosphate, calcium carbonate, calcium hydroxide, calcium sulphate, calcium carboxymethyl cellulose, calcium alginate, calcium salts of citric acid, calcium silicate and mixtures thereof.
• the remineralising calcium source is calcium silicate.
• the amount of remineralising calcium source(s) (e.g. calcium silicate) in the composition of the invention typically ranges from 1 to 30%, preferably from 5 to 20% by total weight remineralising calcium source based on the total weight of the oral care composition.
• remineralising phosphate sources include, for example, monosodium dihydrogen phosphate, disodium hydrogen phosphate, sodium pyrophosphate, tetrasodium pyrophosphate, sodium tripolyphosphate, sodium hexametaphosphate, potassium dihydrogenphosphate, trisodium phosphate, tripotassium phosphate and mixtures thereof.
• the remineralising phosphate source is a mixture of trisodium phosphate and sodium dihydrogen phosphate.
• the amount of remineralising phosphate source(s) (e.g. trisodium phosphate and sodium dihydrogen phosphate) in the composition of this invention typically ranges from 2 to 15%, preferably from 4 to 10% by total weight remineralising phosphate source based on the total weight of the oral care composition.
• starch starch, sucrose, water or water/alcohol systems etc.
• surfactants such as anionic, nonionic, cationic and zwitterionic or amphoteric surfactants
• Humectants such as glycerol, sorbitol, propyleneglycol, xylitol, lactitol etc.
• binders and thickeners such as sodium carboxymethyl-cellulose, hydroxyethyl cellulose (Natrosol®), xanthan gum, gum arabic etc.
• bleaching agents such as peroxy compounds e.g. potassium peroxydiphosphate, effervescing systems such as sodium bicarbonate/citric acid systems, colour change systems, and so on.
• Example according to the invention are illustrated by a number, comparative Examples by a letter.

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• Health & Medical Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Veterinary Medicine (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Birds (AREA)
• Epidemiology (AREA)
• Chemical & Material Sciences (AREA)
• Inorganic Chemistry (AREA)
• Oral & Maxillofacial Surgery (AREA)
• Emergency Medicine (AREA)
• Dermatology (AREA)
• Cosmetics (AREA)

Applications Claiming Priority (2)

Publications (1)

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• 2023
  • 2023-04-12 CN CN202380041886.1A patent/CN119317421A/zh active Pending
  • 2023-04-12 EP EP23715190.7A patent/EP4532037A1/de active Pending
  • 2023-04-12 WO PCT/EP2023/059538 patent/WO2023227282A1/en not_active Ceased

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