Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
  • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
  • A61K8/25—Silicon; Compounds thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/35—Ketones, e.g. benzophenone
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/37—Esters of carboxylic acids
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/37—Esters of carboxylic acids
  • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
  • A61K8/41—Amines
  • A61K8/415—Aminophenols
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
  • A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
  • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
  • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
  • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
  • A61K8/496—Triazoles or their condensed derivatives, e.g. benzotriazoles
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
  • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
  • A61K8/4966—Triazines or their condensed derivatives

Definitions

• UV filters are octocrylene and homosalate.
• UV filters are also being questioned in terms of human health and aquatic organisms.
• the present invention is directed to new cosmetic sunscreen compositions comprising
• a UV filter system comprising phenylbenzimidazole sulfonic acid, ethylhexyl salicylate, terephthalylidene dicamphor sulfonic acid, butyl methoxydibenzoylmethane, ethylhexyl triazone, bis-ethylhexyloxyphenol methoxyphenyl triazine, diethylamino hydroxybenzoyl hexyl benzoate, methylene bis- benzotriazolyl tetramethylbutylphenol (and) polyglyceryl-10 laurate; and
• an emollient system comprising isopropyl myristate, isononyl isononanoate, and diisopropyl sebacate.
• the present invention is also directed to the use of a cosmetic sunscreen composition.
• an UV filter system comprising phenylbenzimidazole sulfonic acid, ethylhexyl salicylate, terephthalylidene dicamphor sulfonic acid, butyl methoxydibenzoylmethane, ethylhexyl triazone, bis-ethylhexyloxyphenol methoxyphenyl triazine, diethylamino hydroxybenzoyl hexyl benzoate, methylene bis- benzotriazolyl tetramethylbutylphenol (and) polyglyceryl-10 laurate; and
• an emollient system comprising isopropyl myristate, isononyl isononanoate, and diisopropyl sebacate
• the amount of the UV filter system of present invention ranges from about 15.0 to about 31.0 %, from about 17.5 to about
• said UV filter system comprises from about 1 .0 to about 3.0 % by weight of phenylbenzimidazole sulfonic acid, from about 3.0 to about 5.5 % by weight of ethylhexyl salicylate, from about 0.5 to about 1 .5 % by weight of terephthalylidene dicamphor sulfonic acid, from about 3.0 to about 5.0 % by weight of butyl methoxydibenzoylmethane, from about 3.0 to about 4.5 % by weight of ethylhexyl triazone, from about 3.0 to about 6.0 % by weight of bisethylhexyloxyphenol methoxyphenyl triazine, from about 0.5 to about 2.5 % by weight of diethylamino hydroxybenzoyl hexyl benzoate, and from about 1.0 to about 3.0 % by weight of methylene bis-benzotriazolyl tetra
• the amount of the emollient system of present invention ranges from about 5.0 to about 15.0 %, from about 7.5 to about
• said emollient system comprises from about 0.5 to about 3.0 % by weight of isopropyl myristate, from about 2.0 to about 5.5 % by weight of isononyl isononanoate, and from about 2.5 to about 7.5 % by weight of diisopropyl sebacate, including all ranges and sub-ranges there between, based on the total weight of the composition.
• the cosmetic sunscreen composition further comprises silica silylate, in an amount that ranges from about 0.1 to about 2.5 %, from about 0.2 to about 2.3 %, from about 0.3 to about 1.5 %, from about 0.5 to about 1 .0 % by weight, including all ranges and sub-ranges there between, based on the total weight of the composition.
• the cosmetic sunscreen composition of the present invention presents a Sun Protection Factor (SPF) ranging from 30 to 99, preferably from 40 to 80, more preferably about 80.
• SPF Sun Protection Factor
• the cosmetic sunscreen composition of the present invention may present a Sun Protection Factor of 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95 or 99.
• the cosmetic sunscreen composition of the present invention can be used as a daily product for the photoprotection of keratinous materials with high SPF, with dry touch, oil control and reduction, and good stability.
• the expression “at least” is interchangeable with the expression “one or more” and thus includes individual components as well as mixtures/combinations.
• a mixture thereof also relates to “mixtures thereof.”
• A-F represent the elements: “one or more elements selected from the group consisting of A, B, C, D, E, F, and a mixture thereof.”
• A-F represent the elements: “one or more elements selected from the group consisting of A, B, C, D, E, F, and a mixture thereof.”
• the term, “a mixture thereof” does not require that the mixture include all of A, B, C, D, E, and F (although all of A, B, C, D, E, and F may be included). Rather, it indicates that a mixture of any two or more of A, B, C, D, E, and F can be included. In other words, it is equivalent to the phrase “one or more elements selected from the group consisting of A, B, C, D, E, F, and a mixture of any two or more of A, B, C, D, E, and F.”
• “Substituted,” as used herein, means comprising at least one substituent.
• substituents include atoms, such as oxygen atoms and nitrogen atoms, as well as functional groups, such as hydroxyl groups, ether groups, alkoxy groups, acyloxyalkyl groups, oxyalkylene groups, polyoxyalkylene groups, carboxylic acid groups, amine groups, acylamino groups, amide groups, halogen containing groups, ester groups, thiol groups, sulphonate groups, thiosulphate groups, siloxane groups, and polysiloxane groups.
• the substituent(s) may be further substituted.
• a salt thereof also relates to “salts thereof.”
• the disclosure refers to “an element selected from the group consisting of A, B, C, D, E, F, a salt thereof, and a mixture thereof,” it indicates that that one or more of
• A, B, C, D, and F may be included, one or more of a salt of A, a salt of B, a salt of C, a salt of D, a salt of E, and a salt of F may be included, or a mixture of any two of A,
• B, C, D, E, F, a salt of A, a salt of B, a salt of C, a salt of D, a salt of E, and a salt of F may be included.
• the salts referred to throughout the disclosure may include salts having a counter-ion such as an alkali metal, alkaline earth metal, or ammonium counter-ion. This list of counter-ions, however, is non-limiting.
• compositions of the instant disclosure can be free or essentially free of all components and elements positively recited throughout the instant disclosure.
• the silica silylate which could also be mentioned as “silica aerogel”
• silica aerogel is a porous material obtained by replacing (by drying) the liquid component of a silica gel with air.
• Silica aerogels are generally synthesized via a sol-gel process in a liquid medium and then dried, usually by extraction with a supercritical fluid, such as, but not limited to, supercritical carbon dioxide (CO2). This type of drying makes it possible to avoid shrinkage of the pores and of the material.
• a supercritical fluid such as, but not limited to, supercritical carbon dioxide (CO2).
• the silica silylate e.g., hydrophobic silica silylate particles
• the specific surface area per unit of mass may be determined via the BET (Brunauer-Emmett-Teller) nitrogen absorption method described in the Journal of the American Chemical Society, vol. 60, page 309, February 1938, corresponding to the international standard ISO 5794/1 .
• the BET specific surface area corresponds to the total specific surface area of the particles under consideration.
• the size of the particles may be measured by static light scattering using a commercial granulometer such as the MasterSizer 2000 machine from Malvern.
• the data are processed on the basis of the Mie scattering theory.
• This theory which is exact for isotropic particles, makes it possible to determine, in the case of non-spherical particles, an "effective" particle diameter. This theory is especially described in the publication by Van de Hulst, H.C., "Light Scattering by Small Particles," Chapters 9 and 10, Wiley, New York, 1957.
• the particles used in the present invention may advantageously have a tamped (or tapped) density ranging from about 0.04 g/cm 3 to about 0.10 g/cm 3 ’ or alternatively from about 0.05 g/cm 3 to about 0.08 g/cm 3 .
• this density may be assessed according to the following protocol: 40 g of powder are poured into a measuring cylinder; the measuring cylinder is then placed on a Stav 2003 machine from Stampf Volumeter; the measuring cylinder is then subjected to a series of 2500 packing motions (this operation is repeated until the difference in volume between two consecutive tests is less than 2%); the final volume Vf of packed powder is then measured directly on the measuring cylinder.
• the tamped density is determined by the ratio m/Vf, in this instance 40/Vf (Vf being expressed in cm 3 and m in g).
• the silica silylate particles have a specific surface area per unit of volume Sv ranging from about 5 to about 60 m 2 /cm 3 , or alternatively from about 10 to about 50 m 2 /cm 3 , or alternatively from about 15 to about 40 m 2 /cm 3 .
• the silica silylate particles have an oil-absorbing capacity, measured at the wet point, ranging from about 5 to about 18 ml/g, or alternatively from about 6 to about 15 ml/g, or alternatively from about 8 to about 12 ml/g.
• the oil-absorbing capacity measured at the wet point, noted Wp corresponds to the amount of water that needs to be added to 100 g of particle in order to obtain a homogeneous paste. Wp is measured according to the wet point method or the method for determining the oil uptake of a powder described in standard NF T 30- 022.
• Wp corresponds to the amount of oil adsorbed onto the available surface of the powder and/or absorbed by the powder by measuring the wet point, described below:
• An amount 2 g of powder is placed on a glass plate, and the oil (isononyl isonanoate) is then added dropwise.
• mixing is performed using a spatula, and addition of oil is continued until a conglomerate of oil and powder has formed.
• the oil is added one drop at a time and the mixture is then triturated with the spatula.
• the addition of oil is stopped when a firm, smooth paste is obtained. This paste must be able to be spread on the glass plate without cracking or forming lumps.
• the volume Vs (expressed in ml) of oil used is then noted.
• the oil uptake corresponds to the ratio Vs/m.
• the silica silylate is a "hydrophobic silica", meaning any silica whose surface is treated with silylating agents, for example, halogenated silanes, such as alkylchlorosilanes, siloxanes, in particular dimethylsiloxanes, such as hexamethyldisiloxane, or silazanes, so as to functionalize the OH groups with silyl groups Si-Rn, for example, trimethylsilyl groups.
• silylating agents for example, halogenated silanes, such as alkylchlorosilanes, siloxanes, in particular dimethylsiloxanes, such as hexamethyldisiloxane, or silazanes, so as to functionalize the OH groups with silyl groups Si-Rn, for example, trimethylsilyl groups.
• silylating agents for example, halogenated silanes, such as alkylchlorosilanes, siloxanes
• hydrophobic silica silylate may include, but are not limited to, the aerogels sold under the tradenames of VM-2260 (INCI name: Silica silylate) and VM-2270 (INCI name: Silica silylate), both available from Dow Corning Corporation (Midland, Michigan).
• the particles of VM-2260 have a mean size of about 1000 microns and a specific surface area per unit of mass ranging from 600 to 800 m 2 /g.
• the particles of VM-2270 have a mean size ranging from 5 to 15 microns and a specific surface area per unit of mass ranging from 600 to 800 m 2 /g.
• hydrophobic silica aerogel may include, but is not limited to, the aerogels commercially available from Cabot Corporation (Billerica, Massachusetts) under the tradename of Aerogel TLD 201 , Aerogel OGD 201 and Aerogel TLD 203, Enova Aerogel MT 1100 and Enova Aerogel MT 1200.
• said composition may comprise at least one additional UV filter selected from commonly used UV filters, excluding octocrylene and homosalate.
• the concentration of the at least one additional UV filter ranges from about 15.0 to about 35.0 %, from about 16.0 to about 34.0 %, from about 17.0 to about 33.0 %, from about 18.0 to about 32.0 %, from about 19.0 to about 31 .0 %, from about 20.0 to about 21 .%, from about 20.0 to about 28.0 %, from about 21.0 to about 27.0 %, from about 22.0 to about 26.0 %, from about 23.0 to about 25.0 % by weight, including all ranges and sub-ranges there between, based on the total weight of the composition.
• Suitable UV filters of the present invention could be as follows: Oil-soluble organic sunscreen ingredient
• oil-soluble organic sunscreen ingredient means any organic compound for screening out UV radiation, which can be fully dissolved in molecular form or miscible in an oil phase or which can be dissolved in colloidal form (for example in micellar form) in an oil fatty phase.
• Cinnamic derivatives As examples of other suitable oil-soluble organic sunscreen ingredients, mention may be made of those denoted herein below under their INCI name: Cinnamic derivatives:
• cinnamic derivatives include, but are not limited to, ethylhexyl methoxycinnamate, isopropyl methoxycinnamate, isoamyl methoxycinnamate, DEA methoxycinnamate, diisopropyl methylcinnamate, glyceryl ethylhexanoate dimethoxycinnamate.
• Suitable dibenzoylmethane derivatives include, but are not limited to, isopropyl dibenzoylmethane.
• suitable salicylic derivatives include, but are not limited to, dipropylene glycol salicylate and TEA salicylate.
• Beta, beta -Diphenylacrylate derivatives
• beta, beta -diphenylacrylate derivatives examples include, but are not limited to, etocrylene.
• Suitable benzylidenecamphor derivatives include, but are not limited to, 3-benzylidene camphor manufactured, 4-methylbenzylidene camphor, polyacrylamidomethyl benzylidene camphor manufactured.
• the oil-soluble organic sunscreen ingredient is preferably present in the composition according to the invention in an amount of from about 15.0 to about 25.0 %, from about 16.0 to about 24.0 %, from about 17.0 to about 23.0 %, from about 18.0 to about 22.0 %, from about 19.0 to about 21.0 %, from about 20.0 to about 20.5%, from about 20.0 to about 22.0 %, from about 20.0 to about 25.0 %,by weight, and most preferably about 18.0 to about 21.0 %,by weight, based on the total weight of the composition.
• Suitable additional actives include, but are not limited to, triethanolamine, and mixtures thereof.
• the composition may also comprise at least one filler, such as silica and/or cellulose.
• An example of a suitable cosmetic sunscreen composition according to the present invention comprises:
• phenylbenzimidazole sulfonic acid ethylhexyl salicylate, terephthalylidene dicamphor sulfonic acid, butyl methoxydibenzoylmethane, ethylhexyl triazone, bis-ethylhexyloxyphenol methoxyphenyl triazine, diethylamino hydroxybenzoyl hexyl benzoate, and methylene bis-benzotriazolyl tetramethylbutylphenol (and) polyglyceryl-10 laurate;
• compositions from about 25.0 to about 30.0 % by weight, based on the total weight of the composition, of additional cosmetically acceptable ingredients selected from active compounds, fatty compounds, fillers, fragrances, polymers, solvents, vitamins, preserving agents, surfactants and mixtures thereof.
• Inventive cosmetic sunscreen compositions according to Ex. 5 and Ex. 6 were tested to measure its SPF according to the ISO 24444-2019 method (SPF), in two phases.
• phase 1 the cosmetic sunscreen composition according to Ex. 5 demonstrated an average in vivo UVA-PF of 29.0 ( ⁇ 0.0), and the cosmetic sunscreen composition according to Ex. 6 had an average in vivo UVA-PF of 26.7 ( ⁇ 4.0).
• phase 2 only the composition according to Ex. 5 was tested with a broader group of subjects, and demonstrated an in vivo UVA-PF of 27.8 ( ⁇ 1 .8).
• the cosmetic sunscreen composition of the present invention according to Ex. 4 was compared to a state-of-the-art cosmetic sunscreen composition according to Ex. 1 , which comprises octocrylene and homosalate, as well as titanium dioxide.
• compositions were tested on a group of women, ages 18 to 55 years old, which were daily users of cosmetic sunscreen compositions for at least 1 year and 6 months, with oily or combination skin.

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• 2022
  • 2022-06-10 EP EP22735761.3A patent/EP4536176A1/de active Pending
  • 2022-06-10 WO PCT/BR2022/050213 patent/WO2023235942A1/en not_active Ceased
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