Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
  • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
  • A61F2/02—Prostheses implantable into the body
  • A61F2/30—Joints
  • A61F2/3094—Designing or manufacturing processes
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B17/00—Surgical instruments, devices or methods
  • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
  • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements
  • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
  • A61B17/80—Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
  • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
  • A61F2/02—Prostheses implantable into the body
  • A61F2/30—Joints
  • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
  • A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B17/00—Surgical instruments, devices or methods
  • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
  • A61B2017/561—Implants with special means for releasing a drug
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
  • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
  • A61F2/02—Prostheses implantable into the body
  • A61F2/30—Joints
  • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
  • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
  • A61F2002/30004—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
  • A61F2002/30011—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis differing in porosity
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
  • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
  • A61F2/02—Prostheses implantable into the body
  • A61F2/30—Joints
  • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
  • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
  • A61F2002/3006—Properties of materials and coating materials
  • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
  • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
  • A61F2/02—Prostheses implantable into the body
  • A61F2/30—Joints
  • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
  • A61F2002/30108—Shapes
  • A61F2002/3011—Cross-sections or two-dimensional shapes
  • A61F2002/30112—Rounded shapes, e.g. with rounded corners
  • A61F2002/3013—Rounded shapes, e.g. with rounded corners figure-"8"- or hourglass-shaped
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
  • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
  • A61F2/02—Prostheses implantable into the body
  • A61F2/30—Joints
  • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
  • A61F2002/3092—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth having an open-celled or open-pored structure
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
  • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
  • A61F2/02—Prostheses implantable into the body
  • A61F2/30—Joints
  • A61F2/3094—Designing or manufacturing processes
  • A61F2002/30971—Laminates, i.e. layered products
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
  • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
  • A61F2310/00005—The prosthesis being constructed from a particular material
  • A61F2310/00179—Ceramics or ceramic-like structures
  • A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite

Definitions

• the present disclosure relates to a surgical insert and a bone cement, in particular a surgical insert comprising a first layer and a second layer comprising octomorphic shaped orifices as well as a bone cement comprising a powdery solid phase comprising natural or derived polysaccharides of natural compounds and a ceramic filler and an acrylate in liquid phase.
• a fracture of the orbital structure can also have aesthetic repercussions when it is associated with a fracture of the orbital rim, the nose or the zygomatic body by modifying the bony reliefs of the face.
• the main objective of reconstructing the orbital structure is to reconstruct the shape and volume of the orbit specific to the anatomy of each patient.
• reduction of thin bone fragments from the orbital floor is sometimes not sufficient or even impossible. It is therefore necessary to cover or fill the defect to avoid complications such as tissue displacement around the eye.
• a biocompatible material also called an orbital implant
• this orbital implant must be adapted to the anatomy of each patient in order to function optimally.
• a material used as a bone substitute include: its biocompatibility, chemical and mechanical, its osteoconductivity, the capacity to allow the different cellular elements to reach the bone area to be repaired, its mechanical resistance which must be close to that of the bone and its macroporosity in order to allow the colonization of the cells and the revascularization of the graft.
• a first material used is autologous bone.
• Autologous bone is a sample of bone material from another part of the body such as the calvarium, the bone of the cranial vault, the iliac crest, one of the bones of the coxal bone, or the microvascularized bones in cases of extensive reconstructions. This material is useful for reconstruction and augmentation of the contours of the orbit, particularly after resection of a tumor using ionizing radiation treatment.
• the bony parts cannot be of true anatomical shape and there appears a reduction in bone volume by bone resorption. It is also possible to use chondrocostal cartilage.
• a second material that can be used is based on resorbable polymer membranes. They are ideal for small defects with a surface area of less than 1 cm 2 . However, for larger defects, resorbable polymer membranes do not have sufficient mechanical characteristics to support and stabilize the orbital walls.
• a third commonly used material is titanium and its alloys. It has been used for around fifteen years and demonstrates excellent biocompatibility and excellent integration into the bone site. Titanium is a material with excellent corrosion resistance, a useful property knowing that the human body is particularly corrosive, as well as high mechanical resistance. It is easily shaped which makes it usable in many types of implants.
• a therapeutic solution to bioceramics are bone substitutes in the form of cements.
• the cement is less invasive, practical to handle and easily adapts to the volume to be treated.
• the first family is that of phosphocalcic cements. They are mainly composed of calcium phosphate which gives them many advantages such as biocompatibility, bioresorption and bone regrowth properties. However, they have the drawback of being fragile and brittle.
• the second family of cements is represented by acrylic cements. They are mainly made of polymethyl methacrylate, formed by polyaddition and used for fixing prostheses. They have good biocompatibility as well as excellent mechanical resistance. However, they have the drawback of having a withdrawal behavior after setting in situ, resulting in a void between the implant and the bone. This behavior can cause serious problems such as the loosening of certain prostheses.
• a first type of implant is a manually shaped flat implant.
• the surgeon uses replicas of the patient's skull sterilized in ABS (acrylonitrile butadiene styrene) to place and shape the implant to adapt it to the patient's anatomy.
• ABS acrylonitrile butadiene styrene
• This implant almost completely respects the patient's anatomy and thus improves the precision of surgical repairs.
• this solution requires prerequisites: to be able to manufacture and sterilize the patient's skull in ABS, to desterilize and re-sterilize the implant, to have the time to carry out this operation and to be in a structure that has access to this technology. .
• a second solution is to design implants for most individuals by anatomically preforming an implant covering the orbital floor and medial wall. These implants have “average” dimensions, that is to say, their dimensions are not specific to an individual but are suitable for the different anatomical shapes of the orbit. These implants are available in two different sizes. They allowed a clear improvement compared to standard implants.
• a surgical insert comprising:
• first layer and the second layer comprise orifices having an octomorphic shape.
• the surgical insert according to the first aspect of the invention has an internal architecture optimized for better circulation of fluids and bone regrowth.
• the first layer and the second layer ensure that the surgical insert has sufficient mechanical support properties, in particular by a significant reduction in maximum stresses.
• This surgical insert can be used as a bone substitute, particularly for human or veterinary use. Its general form can be adapted to result in an anatomically shaped bone implant. Thus, it could be used, for example, to replace a part of the skeleton such as the orbital floor, serve as an osteosynthesis plate or form a joint prosthesis.
• This surgical insert, or surgical implant can also be used for human or animal surgery, in particular vertebrates. It can be implanted or replace all or part of the structures of the human or animal body, for example a limb, the skull, the trunk, etc. It can be used in particular in reconstructive surgery of the limbs (lower and upper), the face (including the jaws, teeth) or the trunk (for example the spine). It can also be used in vascular, abdominal or digestive surgery.
• a bone substitute is proposed in the form of bone cement (also called bone cement) comprising:
• the bone cement according to the second aspect of the invention has advantageous properties, in particular excellent biocompatibility with the human body, excellent osteo-conductivity and mechanical strength close to that of human bone. It also has a macroporosity property allowing the colonization of cells and the revascularization of the graft.
• FIG. 4 schematically shows a top view of octomorphic shaped orifices arranged in a hexagonal pattern
• FIG. 7 schematically shows a top view of an example of a surgical insert according to the invention, of round shape
• FIG. 9 shows the two sides of an example of a surgical insert according to the invention.
• FIG. 10a schematically shows a top view of a first layer of a surgical insert according to the invention
• FIG. 10b schematically shows a top view of a second layer of the same surgical insert as Figure 10a;
• FIG. 11 schematically shows an example of a surgical insert according to the invention, in three dimensions comprising two layers separated from each other by a plurality of separators;
• FIG. 12 schematically shows an example of a pillar with a straight longitudinal axis and perpendicular to the mean plane of the first or second layer;
• FIG. 13 shows the evolution of the weighting coefficient C 2 as a function of the twist angle 0 of the pillars of the surgical insert according to the invention
• FIG. 14 schematically shows an example of a pillar with a vertical longitudinal axis of helical shape with a twist angle different from 0;
• FIG. 15 shows the evolution of the weighting coefficient C 3 as a function of the angle of inclination Q of the straight pillars of the surgical insert according to the invention
• FIG. 16 schematically shows an example of a pillar with a longitudinal axis having a non-zero angle of inclination Q relative to the vertical;
• FIG. 18 schematically shows an example of a pillar with a right longitudinal axis of helical shape having pores at its lateral surface
• FIG. 19 schematically shows an example of a section of a layer of the surgical insert according to the invention and having an orifice of octomorphic shape and transverse orifices of octomorphic shape;
• FIG. 20 schematically shows an example of a surgical insert according to the invention, in three dimensions having three layers separated by a plurality of pillars of vertical longitudinal axis of helical shape having pores at its lateral surface;
• FIG. 21 shows an example of a Bézier curve or function
• FIG. 22 shows a distribution of octomorphic shaped orifices along a Bézier curve
• FIG. 23 is an enlargement of part of the Bézier curve of Figure 22 at an extremum
• FIG. 24 shows overlapping sections induced by a homothetic duplication of the first layer leading to the second layer
• FIG. 25 shows octomorphic orifices arranged in a partial rectangular pattern
• FIG. 26 shows octomorphic orifices arranged partially along the contours of an octagon
• FIG. 27 shows an example of a surgical insert according to the invention and its limit box
• FIG. 28 shows the simulation results of two inserts both having octomorphic shaped orifices, one having mechanical reinforcement, the other being free;
• FIG. 29 shows the ternary diagram of variation of the cellulose acetate, the ceramic filler and the starch included in the bone cement according to the invention
• FIG. 30 shows the evolution of the Young modulus in the field of study of bone cement according to the invention
• FIG. 31 shows the evolution of the shear modulus in the field of study of bone cement according to the invention
• FIG. 32 shows the evolution of swelling in the field of study of bone cement according to the invention
• FIG. 33 shows the evolution of the temperature as a function of time for the three formulations of bone cement according to the invention
• FIG. 34 shows the evolution of the setting time of an acrylic cement as a function of the mass proportion of vitamin C in the bone cement according to the invention
• FIG. 35 shows the evolution of the maximum temperature reached of an acrylic cement as a function of the mass proportion of vitamin C of the bone cement according to the invention
• FIG. 37 shows the evolution of the swelling of Example 2.2 of the bone cement according to the invention in different liquid media as a function of the number of days of immersion;
• FIG. 38 shows the evolution of the swelling of Example 2.3 of the bone cement according to the invention in different liquid media as a function of the number of days of immersion;
• FIG. 41 shows the cell survival rate as a function of each formulation of the bone cement according to the invention and two controls, a first based on 100% alumina, and the second based on tissue culture polystyrene (TCPS), a material constituting the culture plates;
• TCPS tissue culture polystyrene
• FIG. 42 shows the total quantities of ciprofloxacin (CFX) present in the different formulations of bone cement according to the invention.
• the present invention relates, according to a first aspect, to a surgical insert which will be described below with reference to Figures 1 to 28.
• the surgical insert 1 comprises:
• first layer 11 and the second layer 12 comprise orifices 111, 121 having an octomorphic shape.
• Figure 1 shows a top view diagram of an orifice 111, 121 of octomorphic shape.
• length we understand a dimension taken in a direction extending between the two lobes, the direction corresponding in particular to one of the axes of symmetry if present.
• width we mean a dimension perpendicular to the length.
• the thickness of the surgical insert is understood as a distance between the two extreme faces of the insert in the direction of superposition of the layers. Unless otherwise indicated, we mean the average thickness on the insert. The distance between two orifices is taken between the centers of these orifices.
• the total length, L o can be between 200 pm and 50 mm. In certain cases (for example for orbital floors), this length is preferably
• the ratio of the total length, L o , to the total width, t o can be between
• (ptot is the total porosity of the surgical insert 1
• (pi is the porosity of the first layer 11
• ⁇ p 2 is the porosity of the second layer 12
• Si is the total surface of the first layer 11
• S 2 is the total surface area of the second layer 12.
• the porosity is the ratio between the surface area occupied by the octomorphic orifices and the total surface area of the layer.
• the insert 1 has a total porosity greater than or equal to 0.6 and less than or equal to 0.93.
• the insert 1 has a ratio between the total surface occupied by the orifices of a layer and the total surface of this layer greater than or equal to 0.09 and less than or equal to 0.92.
• the ratio between the total surface occupied by the orifices of a layer and the total surface of this layer is greater than or equal to 0.111 and less than or equal to 0.923.
• the L/h ratio is less than 4. Subsequently, the characteristics will be described in the case of an L/h ratio less than 4. Furthermore, the fluid flows are then generally complex.
• the second layer 12 may have two zones, a first zone 122 with orifices 1221 having a first maximum length l_ 2 and a second zone 123 with second orifices 1231 having a second maximum length.
• the ratio between the first maximum length l_ 3 and the second maximum length l_ 2 can be between 1.6 and 2, preferably between 1.7 and 1.9, preferably between 1.75 and
• the arrangement of the octomorphic orifices 121 on the second layer 12 can correspond to a homothetic duplication of the arrangement of the orifices octomorphs 111 of the first layer 11. That is to say that the orifices undergo a translation and a rotation (duplication) then a homogeneous scaling (homothety).
• This homothetic duplication can be described by the following formulas: with :
• the homothetic duplication induces a minimum overlap section SR of 0.2 mm 2 between the orifice 111 of the first layer 11 and the orifice 121 of the second layer 12 which results from it (see figure 24) .
• the covering is worth a maximum of a quarter of the surface of the orifice 111 of the first layer 11.
• a plurality of separators 15 can be arranged between the first layer 11 and the second layer 12.
• Each separator 15 can be in the form of a pillar 15.
• Figure 11 shows a three-dimensional surgical insert comprising two layers separated from each other by a plurality of pillars of octomorphic section.
• the pillar 15 may have a longitudinal axis.
• This longitudinal axis can be straight (figures 12, 14 and 16) or curved (figure 17). When the longitudinal axis is straight, it can extend perpendicularly from the average plane formed by the first layer 11 or by the second layer 12. It can also be understood as forming a non-right angle with this average plane. When the longitudinal axis is curved, it follows the curve of a parametric equation between the first layer 11 and the second layer 12.
• Each separator 15 among the plurality of separators 15 may have a cross section which has an octomorphic shape as described above.
• pillar 15 can be obtained by translation of the octomorphic shape along the longitudinal axis ( Figures 12, 16).
• the pillar 15 can be obtained by a combination of translation and rotation of the octomorphic shape along the longitudinal axis so as to give the lateral surface of the pillar 15 a helical shape (figure 14).
• the number of rotations of the octomorphic shape between the first layer 11 and the second layer 12 can be 1 /4+k, 1 /2+k, 3 /4+k or 1 -ik, where k is a number greater than or equal to 0; for example 0, 1, 2, 3.
• the number of rotations is 1 /4+k or 3 /4+k
• the number of rotations is 1 /2+k or 1 -ik
• the pillar 15 is chosen as being a pillar 15 of helical shape with a twist angle p
• said angle p can be between 0 and 180°, preferably less than 90° .

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• Health & Medical Sciences (AREA)
• Orthopedic Medicine & Surgery (AREA)
• Life Sciences & Earth Sciences (AREA)
• Engineering & Computer Science (AREA)
• Animal Behavior & Ethology (AREA)
• Veterinary Medicine (AREA)
• Public Health (AREA)
• Biomedical Technology (AREA)
• Heart & Thoracic Surgery (AREA)
• General Health & Medical Sciences (AREA)
• Cardiology (AREA)
• Surgery (AREA)
• Oral & Maxillofacial Surgery (AREA)
• Transplantation (AREA)
• Vascular Medicine (AREA)
• Molecular Biology (AREA)
• Medical Informatics (AREA)
• Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
• Neurology (AREA)
• Manufacturing & Machinery (AREA)
• Prostheses (AREA)

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• 2023
  • 2023-08-31 CA CA3265826A patent/CA3265826A1/fr active Pending
  • 2023-08-31 CA CA3265881A patent/CA3265881A1/fr active Pending
  • 2023-08-31 EP EP23772307.7A patent/EP4580555A1/de active Pending
  • 2023-08-31 WO PCT/FR2023/051318 patent/WO2024047317A1/fr not_active Ceased
  • 2023-08-31 WO PCT/FR2023/051319 patent/WO2024047318A1/fr not_active Ceased
  • 2023-08-31 EP EP23772554.4A patent/EP4580556A1/de active Pending

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