EP4582121A1 - Installation de thérapie par aérosol comprenant un nébuliseur et un dispositif de compression d'air - Google Patents

Installation de thérapie par aérosol comprenant un nébuliseur et un dispositif de compression d'air Download PDF

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Publication number
EP4582121A1
EP4582121A1 EP24150304.4A EP24150304A EP4582121A1 EP 4582121 A1 EP4582121 A1 EP 4582121A1 EP 24150304 A EP24150304 A EP 24150304A EP 4582121 A1 EP4582121 A1 EP 4582121A1
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EP
European Patent Office
Prior art keywords
nebulizer
air
chamber
installation according
aerosol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP24150304.4A
Other languages
German (de)
English (en)
Other versions
EP4582121B1 (fr
Inventor
Alessandra RUOCCO
Luca Alberici
Alice SIGNORINI
Giuseppe Sandoni
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Air Liquide Medical Systems SRL
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Air Liquide Medical Systems SRL
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Publication date
Application filed by Air Liquide Medical Systems SRL filed Critical Air Liquide Medical Systems SRL
Priority to EP24150304.4A priority Critical patent/EP4582121B1/fr
Publication of EP4582121A1 publication Critical patent/EP4582121A1/fr
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Publication of EP4582121B1 publication Critical patent/EP4582121B1/fr
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A61M11/002—Particle size control by flow deviation causing inertial separation of transported particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/07—General characteristics of the apparatus having air pumping means

Definitions

  • the characteristics of the aerosol or mist provided by the nebulizer such as the droplet or particle size, depend on various features of both the nebulizer and of the compressing device, which are not straightforward to determine. Further, power consumption of the air-compressing device, in particular of the electric motor, may also be an issue from time to time.
  • a solution according to the present invention concerns an aerosoltherapy installation useable for aerosolizing, i.e. nebulizing, a liquid, such as a drug-containing solution, comprising :
  • the air-compressing device i.e. also called compressor device
  • the air-compressing device of the aerosoltherapy installation according to the present invention can comprise one or several of the following additional features:
  • Figure 1 represents shows an aerosoltherapy installation 1 comprising a nebulizer 10 and an air-compressing device 20, also called an air compressor, according to the present invention fluidly connected by a flexible hose 30 or the like that conveys the compressed-air flow provided by the air-compressing device 20 to the nebulizer 10.
  • a nebulizer 10 and an air-compressing device 20, also called an air compressor, according to the present invention fluidly connected by a flexible hose 30 or the like that conveys the compressed-air flow provided by the air-compressing device 20 to the nebulizer 10.
  • the compressed-air flow is used for atomizing a liquid, typically a drug-containing solution to be aerosolized, that is subsequently delivered to a patient in need thereof by means of a respiratory interface 19, such as a mouthpiece (as shown) or a nasal or facial mask (not shown), or the like, as detailed below.
  • a respiratory interface 19 such as a mouthpiece (as shown) or a nasal or facial mask (not shown), or the like, as detailed below.
  • the air-compressing device 20 comprises a rigid casing 27 containing in its inner volume 28, compressing elements 22 driven by an electric motor 21 that are used for compressing ambient air (i.e. air at atmospheric pressure) thereby delivering a flow of compressed air, typically at a pressure of less than 5 bar abs, typically of between 1.2 et 3.5 bar abs, or any suitable pressure.
  • a pivotable cover 29 gives access to the inner volume 28 of the casing 27.
  • the air-compressing device 20 further comprises other classical components, such as an on/off button, a power connection to the Mains (110/220 V) or the like...
  • Compressing elements 22 can comprise an air compression chamber, a compressor element, such as a mobile piston element or the like, driven by the electric motor 21, and preferably a manifold block cooperating together for sucking and compressing ambient air. Ambient air sucked by the compressor element driven by the electric motor 21, passes through the manifold block, then enters into the air compression chamber where it is compressed by the compressor element and, once compressed, exits the air compression chamber and is conveyed to the nebulizer 10, via the compressed air port 25 and the flexible hose 30.
  • a compressor element such as a mobile piston element or the like
  • the compressor element such as a piston element or the like, can be -directly or indirectly- fixed to the rotatable shaft (i.e. axis) 211 of the electric motor 21 as shown in Fig. 2 , so as to be, in use, driven by the electric motor 21.
  • the electric motor 21 is powered by a power source (not shown) providing electric current, such as the mains, i.e. 110/220V.
  • the stator 220 of the motor 21 comprises a laminated core 223 having a thickness T greater than 18.5 mm, preferably of between 19 mm and 21 mm, typically of about 20 mm.
  • the wire winding 221 comprises a number of turns of between 1900 and 2200, preferably of between 2000 and 2100 turns, typically of about 2050 turns.
  • the wire 222 used in said wire winding 221 is a copper wire, i.e. pure copper or a copper alloy, having a wire diameter of less than 0.30 mm, preferably of between 0,25 mm and 0.29 mm, typically of about 0,27 mm.
  • FIG. 3A &3B that represent partial sectional views of two possible embodiments of the nebulizer 10 of the aerosoltherapy installation 1 according to the present invention of Fig. 1 .
  • the main body 100 is closed by a top cover 120 (cf. Fig. 3A &3B), such as a detachable cover, that forms a top or roof of the nebulization body 100.
  • a top cover 120 cf. Fig. 3A &3B
  • a detachable cover that forms a top or roof of the nebulization body 100.
  • the top cover 120 carries an elongated tubular element 121 that axially projects in the nebulizer's body 100, i.e. along the vertical axis XX.
  • the top cover 120 and the elongated tubular element 121 are made one piece as shown in Fig. 4 . According to other embodiments, they can be made of two or more sub-units or parts attached together.
  • the elongated tubular element 121 comprises an upper end 121.1 and a lower end 121.2, namely two opposite ends, and an internal passage 122, i.e. a lumen, that communicates, on the one hand, with the ambient atmosphere via a top aperture 123 located at its upper end 121.1, and, on the other hand, with the aerosol chamber 112 via a bottom aperture 124 located at its lower end 121.2.
  • the elongated tubular element 121 traverses the top cover 120 at its upper end 121.1.
  • the impactor 104 of the aerosol-generating system 101 is arranged in the internal passage 122 of the elongated tubular element 121, preferably in the region of its lower end 121.2 as shown in Fig. 3A &3B.
  • the impactor 104 can also be arranged outside of the internal passage 122 but so as to face the bottom aperture 124 located at the lower end 121.2 of the elongated tubular element 121.
  • the ampoule chamber 111 i.e. inner chamber, is delimited by peripheral and bottom walls forming a reservoir or tank that receives and stores the liquid to be aerosolized, e.g. a liquid drug.
  • the ampoule chamber 111 has a "cup-like" shape.
  • the ampoule chamber 111 is further traversed by an inner conduit 113, preferably arranged at the center of the ampoule chamber 111, namely at the center of the cup-like" shape.
  • Said inner conduit 113 projects axially (axis XX) and upwardly into the ampoule chamber 111 of the nebulizer 10.
  • the downstream portion 113.1 of the inner conduit 113 that is located in the ampoule chamber 111 has a conical outer shape, whereas its upstream portion 113.2 has a cylindrical outer shape.
  • the ampoule chamber 111 can be arranged in the main body 100 of the nebulizer 10 or be detachable, for instance it can constitute a removable reservoir that is inserted into and detachably fixed to the main body 100 of the nebulizer 10.
  • the ampoule chamber 111 comprises an inner volume for storing/containing the liquid to be aerosolized, typically a drug-containing solution or the like, that is of less than 70 cm 3 , preferably of between 30 cm 3 and 60 cm 3 , more preferably of between 40 cm 3 and 55 cm 3 , for instance of about 44.50 cm 3 to 51.55 cm 3 .
  • Such a reduced volume allows limiting the size of the ampoule chamber 111 thereby better controlling the quantity of liquid drug, without negatively affecting the characteristics of the nebulization.
  • the inner conduit 113 traversing the ampoule chamber 111 comprises an inner passage 115, i.e. a lumen, in fluid communication with the air inlet 15 of the nebulizer 10, at its upstream end, and with a compressed air outlet 14, at its downstream end.
  • the air outlet 14 of the inner conduit 113 faces the delivery orifice 103 of the jet nozzle 102, preferably they are coaxially (XX) arranged.
  • the aerosol provided by the tubular hollow expansion 130 can thereafter be inhaled by the patient.
  • a respiratory interface can be a mouthpiece, or a mouth, nasal or facial respiratory mask, or any other suitable respiratory device.
  • the choice of the most suitable interface depends on the type of medication to be taken and on the type of patients, for instance a facial mask is advocated for pediatric patients, for instance children or toddlers, while a mouthpiece or a mouth mask is more suitable for adults.
  • the assembly comprising the tubular elongated element 122, the top cap 120, the jet nozzle 102 and the impactor 104 of the aerosol-generating system 101, is removably attached to the main body 100 so that it can be removed for cleaning operations or the like.
  • the installation 1 of the present invention is usable for nebulizing a liquid or solution, typically a drug- or medication-containing solution, and thus obtaining a mist or aerosol containing droplets of medication having suitable sizes so as to be able to reach the lower airways of the patient(s) that has/have to inhale said mist in the course of their aerosoltherapy.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nozzles (AREA)
EP24150304.4A 2024-01-04 2024-01-04 Installation de thérapie par aérosol comprenant un nébuliseur et un dispositif de compression d'air Active EP4582121B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP24150304.4A EP4582121B1 (fr) 2024-01-04 2024-01-04 Installation de thérapie par aérosol comprenant un nébuliseur et un dispositif de compression d'air

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP24150304.4A EP4582121B1 (fr) 2024-01-04 2024-01-04 Installation de thérapie par aérosol comprenant un nébuliseur et un dispositif de compression d'air

Publications (2)

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EP4582121A1 true EP4582121A1 (fr) 2025-07-09
EP4582121B1 EP4582121B1 (fr) 2026-04-15

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Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5054477A (en) * 1986-09-22 1991-10-08 Omron Tateisi Electronics Co. Nebulizer
DE19902847C1 (de) 1999-01-20 2000-05-18 Kendall Med Erzeugnisse Gmbh Medikamentenvernebler zur Inhalationsbehandlung mit kombiniertem Ein-/Ausatmungsventil
EP3459577A1 (fr) 2017-09-22 2019-03-27 Air Liquide Medical Systems S.p.A. Nébuliseur pour l'aérosolisation d'une solution médicamenteuse à structure interne évasée limitant les déchets d'aérosol
EP3678719A1 (fr) 2017-09-06 2020-07-15 3A Health Care S.R.L. Dispositif de thérapie par aérosol
EP3721928A1 (fr) 2019-04-08 2020-10-14 Air Liquide Medical Systems S.R.L. Atomiseur pour pulvériser un liquide avec une partie avant confortable
EP3912662A1 (fr) 2020-05-19 2021-11-24 Air Liquide Medical Systems S.r.l. Nébuliseur pour pulvériser un liquide comprenant un capuchon pivotant disposé sur le couvercle supérieur comprenant le système de soupape
EP4206467A1 (fr) 2022-01-04 2023-07-05 Air Liquide Medical Systems S.R.L. Dispositif de compresseur pour fournir de l'air comprimé à un dispositif médical
WO2023199573A1 (fr) * 2022-04-12 2023-10-19 オムロンヘルスケア株式会社 Nébuliseur et procédé d'atomisation chimique

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5054477A (en) * 1986-09-22 1991-10-08 Omron Tateisi Electronics Co. Nebulizer
DE19902847C1 (de) 1999-01-20 2000-05-18 Kendall Med Erzeugnisse Gmbh Medikamentenvernebler zur Inhalationsbehandlung mit kombiniertem Ein-/Ausatmungsventil
EP3678719A1 (fr) 2017-09-06 2020-07-15 3A Health Care S.R.L. Dispositif de thérapie par aérosol
EP3678719B1 (fr) * 2017-09-06 2023-04-05 3A Health Care S.R.L. Dispositif de thérapie par aérosol
EP3459577A1 (fr) 2017-09-22 2019-03-27 Air Liquide Medical Systems S.p.A. Nébuliseur pour l'aérosolisation d'une solution médicamenteuse à structure interne évasée limitant les déchets d'aérosol
EP3721928A1 (fr) 2019-04-08 2020-10-14 Air Liquide Medical Systems S.R.L. Atomiseur pour pulvériser un liquide avec une partie avant confortable
EP3912662A1 (fr) 2020-05-19 2021-11-24 Air Liquide Medical Systems S.r.l. Nébuliseur pour pulvériser un liquide comprenant un capuchon pivotant disposé sur le couvercle supérieur comprenant le système de soupape
EP4206467A1 (fr) 2022-01-04 2023-07-05 Air Liquide Medical Systems S.R.L. Dispositif de compresseur pour fournir de l'air comprimé à un dispositif médical
WO2023199573A1 (fr) * 2022-04-12 2023-10-19 オムロンヘルスケア株式会社 Nébuliseur et procédé d'atomisation chimique

Also Published As

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