EP4652510A1 - Système automatisé de distribution et de dosage de volume - Google Patents

Système automatisé de distribution et de dosage de volume

Info

Publication number
EP4652510A1
EP4652510A1 EP24745069.5A EP24745069A EP4652510A1 EP 4652510 A1 EP4652510 A1 EP 4652510A1 EP 24745069 A EP24745069 A EP 24745069A EP 4652510 A1 EP4652510 A1 EP 4652510A1
Authority
EP
European Patent Office
Prior art keywords
fluid
distribution system
stopcock
container
containers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24745069.5A
Other languages
German (de)
English (en)
Inventor
James Gregory MADSEN
Christopher J. WEGENER
Kyungyoon Min
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fenwal Inc
Original Assignee
Fenwal Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fenwal Inc filed Critical Fenwal Inc
Publication of EP4652510A1 publication Critical patent/EP4652510A1/fr
Pending legal-status Critical Current

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B13/00—Pumps specially modified to deliver fixed or variable measured quantities
    • F04B13/02—Pumps specially modified to deliver fixed or variable measured quantities of two or more fluids at the same time
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B49/00—Control, e.g. of pump delivery, or pump pressure of, or safety measures for, machines, pumps, or pumping installations, not otherwise provided for, or of interest apart from, groups F04B1/00 - F04B47/00
    • F04B49/22—Control, e.g. of pump delivery, or pump pressure of, or safety measures for, machines, pumps, or pumping installations, not otherwise provided for, or of interest apart from, groups F04B1/00 - F04B47/00 by means of valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B9/00—Piston machines or pumps characterised by the driving or driven means to or from their working members
    • F04B9/08—Piston machines or pumps characterised by the driving or driven means to or from their working members the means being fluid
    • F04B9/12—Piston machines or pumps characterised by the driving or driven means to or from their working members the means being fluid the fluid being elastic, e.g. steam or air
    • F04B9/123—Piston machines or pumps characterised by the driving or driven means to or from their working members the means being fluid the fluid being elastic, e.g. steam or air having only one pumping chamber

Definitions

  • the present disclosure is generally directed to systems and methods for distributing fluid(s) between a plurality of containers, and more particularly, to systems and methods that distribute, with high accuracy, amounts of fluid between a plurality of containers.
  • Some blood products and cell therapy applications require very accurate volume distribution of fluids between containers.
  • this type of volume distribution requires highly trained personnel using handheld syringes, and sometimes scales, to accurately distribute fluid volumes between containers.
  • the user exacts a specific volume of fluid from a vial or bag and then distributes, such as by dosing, that volume into another container.
  • the user uses a handheld syringe, and optionally a scale, to extract an amount of an additive solution from an additive container.
  • the user then uses the syringe to deliver the amount of additive to a product or pooling container.
  • Several applications require a high accuracy in the volume of fluid transferred between the containers. For example, there are applications that require an accuracy of 0.5 ml or less.
  • the manual use of a handheld syringe is an open transfer system.
  • Such open transfer systems can have an undesirable risk of contamination.
  • the transfer and dosing may be performed within a biosafety cabinet.
  • manual dosing may be performed in a biosafety cabinet to reduce the risk of possible hazards associated with the handling of toxic fluids.
  • Using a biosafety cabinet adds an extra expense and working within such a cabinet can affect the ability to transfer an accurate volume of fluid.
  • a fluid distribution system comprises a fluid circuit that includes a manifold including a plurality of stopcocks and distribution pump in fluid communication with the manifold.
  • the system also includes a set of containers comprising a plurality of supply containers, wherein each of the supply containers contain an additive fluid and each of the supply containers is in communication with a respective stopcock of the manifold.
  • the system further includes a product container containing a product, wherein the product container is in communication with another stopcock of the manifold. The stopcocks being configured to be moved to different positions to distribute additive fluid from the supply containers to the product container.
  • FIG. 1 is a perspective view of a system for distributing volumes of fluid between a plurality of containers.
  • FIG. 2 is a perspective view of one alternative embodiment of a system for distributing volumes of fluid between a plurality of containers.
  • Fig. 3 perspective view of one alternative embodiment of a system for distributing volumes of fluid between a plurality of containers.
  • Fig. 4 is a block diagram of an embodiment of the processing or hardware of the systems of Figs. 1 -3.
  • Fig. 5 is a schematic illustration of the stopcock positions.
  • Figs. 6A-6K are schematic illustrations of the stopcock configurations showing the different stages of operation of the system.
  • FIG. 1 an embodiment of a system 100 for distributing fluids between a plurality of containers 1 16a-c, 118 is illustrated.
  • the system 100 may be used to distribute fluid from (i) one container to another, (ii) from several containers to one container, or (iii) from one container to several containers. Furthermore, the system may distribute a volumes of fluid between the containers at an accuracy of 5 ml or less.
  • the system 100 is a substantially closed fluid system in that the containers 116a-c, 118 may be in fluid communication with each other via a substantially closed fluid circuit 102.
  • the system 100 has fluid circuit 102 that includes a manifold 104 having a plurality of stopcocks 105, 106a-d, fluid lines 108a-d, 110, 112, and a vent 1 14. These components of the fluid circuit 102 may be fluidly connected.
  • the system also includes the plurality of containers 1 16a-d, 118 that are connectable to the fluid circuit 102 via respective fluid lines 108a-d, 110.
  • the system 100 includes a distribution pump 120 for moving/distributing fluid from one of the containers through the fluid circuit 102 and into another container.
  • the system 100 may further include at least one gas and fluid sensor.
  • system 100 may include air fluid sensors 122a, 122b for detecting liquid and gas (air) within the fluid circuit 102.
  • the system 100 also includes a user control interface 124 and a controller processor/hardware 126 (Fig. 4) for controlling the distribution/movement of fluid through the system 100.
  • the system 100 has fluid circuit 102 that includes a manifold 104 having a plurality of stopcocks 105, 106a-d, fluid lines 108a-d, 110, 112, and a vent 1 14. These components of the fluid circuit 102 may be fluidly connected.
  • the system also includes the plurality of containers 1 16a-d, 118 that are connectable to the fluid circuit 102 via respective fluid lines 108a-d, 110.
  • the system 100 includes a distribution pump 120 for moving/distributing fluid from one of the containers through the fluid circuit 102 and into another container.
  • the system 100 further includes air fluid sensors 122a, 122b for detecting liquid and gas (air) within the fluid circuit 102.
  • the system 100 also includes a user control interface 124 and a controller processor/hardware 126 (Fig. 4) for controlling the distribution/movement of fluid through the system 100.
  • the illustrated system 100 includes five containers 116a-c, 118, but the system 100 may include more or less than five containers, depending on the application.
  • Containers 116a-c, 1 18 may be welded containers, such as flexible bags made from welded plastic films.
  • the containers 116a-c, 118 may be vials, jars, or any other suitable container.
  • the containers may be a mix of different types of container, wherein the type of each container depends on the particular application or the type of fluid in the container.
  • the set of containers 116 may include container 116a, 1 16b, 116c and 116d.
  • containers 116a-d are each supply containers and container 118 is a product or pooling container which receives fluid from the set of containers 116.
  • Each of the supply containers 116a-d contain fluid (such as a solution or suspension) that is distributed from the respective container 116a-d and dosed into the product or pooling container 1 18.
  • the supply containers 116a-d may be additive containers that contain additives, such as but not limited to, Platelet Additive Solution (PAS), Cryoprotectant (i.e., Glycerol, Dimethyl Sulfoxide), Human Serum Albumin (HSA), etc.
  • the product or pooling container 1 18 may contain a blood product (such as whole, blood, plasma, etc.) or cell solution (such as a cell culture).
  • the system may include support members 117a-d, such as hangers or hooks, that support the containers 116a-d.
  • one end of the containers 116a-d includes an opening 119a-d for receiving the hangers 117a-d so that the containers 116a-d hang therefrom. In this position and due to the forces of gravity, the fluid pools at the other end of the container.
  • One or more of the hangers 117a-d may be operatively connected to one or more scales (127 shown schematically in Fig. 4) which calculate and/or monitor the weight of the respective container 116a-d.
  • the scales may be used to monitor the volume of fluid exiting and entering the container.
  • the system 100 may include a tray 128 that holds container 1 18.
  • the tray 128 may be an agitation tray, which moves to mix/agitate the fluids in container 118.
  • tray 128 also may be temperature controlled. That is, tray 128 may be configured to heat or cool the contents of container 1 18, depending on the desired application and fluid contained in container 1 18.
  • tray 128 may include a scale 130 for weighing and monitoring the weight of container 1 18. For example, the scale may be used to monitor the volume of fluid entering and exiting container 118.
  • Each of the containers 1 16a-d, 118 are connected to and in fluid communication with the fluid lines of the fluid circuit 102.
  • Container 1 18 is connected to one end 11 1 of fluid line 1 10, and containers 1 16a-d are connected to one end 109a-d of respective fluid lines 108a-d.
  • the containers are releasably connected to the fluid lines.
  • the containers 116a-d, 1 18 each have a port that includes a male luer lock which engages a respective female luer lock at the ends 1 1 1 , 109a-d of fluid lines 108a-d, 110.
  • one or more of the containers 116a-c, 118 may be permanently connected to the fluid line(s)/system. Such permanent connection may be via a sterile tubing weld, which provides closed-system transfers.
  • some of the containers may be permanently connected to the fluid line(s)/system, while others are releasably connected.
  • the container(s) containing the additive may be permanently connected to the fluid line(s), while the container(s) receiving dosing of the additive(s) may be releasably connected to the fluid line(s). After a container(s) has received the selected dosing, the container may be disconnected and a new container(s) is connected to receive dosing.
  • containers 116a-d may be connected to the fluid line(s)/system via welding, while container 118 may be releasably connected via a luer lock. Such a configuration would allow for dosing solution into multiple containers 118.
  • first container 1 18 may be disconnected and a second, different container 118 may be connected to the system for dosing.
  • container 1 18 may include an additive that is dosed into one or more of the containers 116.
  • container 118 may be permanently attached to the fluid line(s)/system.
  • Each of the containers 116a-d may be releasably attached to the fluid line(s)/system. After the additive is transferred from container 118 and dosed into containers 116a-d, the containers 116a-d may be disconnected and new containers 116a-d may be connected for dosing.
  • the other end 113 of fluid line 110 and the other ends 107a-d of fluid lines 108a-d are connected to and in fluid communication with manifold 104.
  • the manifold includes stopcocks 105, 106a-d for controlling the flow of fluid through the system 100.
  • the stopcocks are motorized and the position of each stopcock is controlled by motorized stopcock actuator 115 (shown schematically in Fig. 4).
  • End 113 of fluid line 110 is in fluid communication with stopcock 105.
  • Ends 107a-d of fluid lines 108a-d are in fluid communication with stopcocks 106a-d.
  • fluid lines 108a-c, 1 10 are integral with respective containers 116a-d, 118, and ends 107a-d, 113 of fluid lines 108a-c, 110 are releasably attached to a respective stopcock 106a-d, 105 with, for example, luer fittings.
  • the stopcocks 105, 106a-d have different positions, depending on the desired flow through the fluid circuit 102.
  • each of the stopcocks 105, 106a-d has at least three positions.
  • position A the stopcock closes off fluid communication to and from the container. In other words, in this position, the stopcock prevents fluid from entering and exiting the container.
  • position B the stopcock opens fluid communication to and from the container. Fluid may enter or exit the container, depending on the operation of the distribution pump 120.
  • the by-pass is closed.
  • position C the stopcock closes off fluid communication to and from the container and the fluid by-pass is open.
  • the fluid of fluid through the system 100 and fluid circuit 102 will be explained in more detail below.
  • the fluid circuit 102 includes vent 114 that is in fluid communication with manifold 104.
  • vent 114 may be connected to one of the stopcocks of the manifold 104.
  • vent 114 is in fluid communication with manifold 104 via fluid line 132.
  • Fluid line 132 has one end attached to and in fluid communication with vent 114 and another end in fluid communication with stopcock 106d.
  • a flow controller 131 such as an in-line pinch valve, may be associated with the fluid line 132.
  • the pinch valve may, optionally, include a sealing head.
  • the flow controller 131 opens and closes the flow of fluid to and the from the vent 114.
  • Vent 1 14 may include a filter, such as a sterilizing filter.
  • vent 114 may include a 0.2 pm sterilizing filter or any other suitable sterilizing filter. Vent 114 enables, priming of the fluid circuit or lines of the fluid circuit, airchases, burping of containers, etc.
  • the system 100 includes distribution pump 120 that is in fluid communication with manifold 104.
  • pump 120 may be connected to one of the stopcocks of the manifold 104.
  • pump 120 is in fluid communication with manifold 104 via fluid line 112.
  • Fluid line 112 has one end attached to and in fluid communication with pump 120 and another end attached to and in fluid communication with stopcock 105.
  • Pump 120 may be pneumatic syringe pump, such as these disclosed in U.S. Published Application No. 2021/0121827, which is hereby incorporated herein by reference.
  • the distribution pump 120 may be a pneumatic syringe pump is configured to use a syringe 150 with a syringe barrel 152 (which may be made of cyclic olefin copolymer, or other materials such as may be inert, optically clear) and a piston or plunger head assembly 154.
  • the piston head assembly 154 is moveable (translatable) between a first end 156 and a second end 158 of the barrel 152.
  • the pump 120 may include a detection system that detects or determines the amount of fluid taken into the pump, within the pump or pushed out of the pump.
  • the detection system may include a position detector that detects the position of the piston, thereby detecting the amount of fluid taken into the syringe, within the syringe or pushed out of the syringe.
  • the piston head assembly 154 includes the piston and an infrared reflector 162, which defines one part of a position detector.
  • the position detector also includes a plurality of transmitter/sensor pairs 164, which may be in the form of infrared light emitting diodes, and the sensors may be in the form of infrared sensors.
  • the transmitters/sensors may use visible or ultraviolet light, for example.
  • the transmitter/sensor pairs 164 are disposed along the length of the barrel 152 between the first end 156 and the second end 158.
  • the reflector 162 may be in the form of a reflective strip that is attached opposite the piston.
  • the position detector would use the interaction between the transmitter/sensor pairs 164 and the reflector 162 to determine the position of the piston head assembly 154 along the barrel 152.
  • light emitted from the transmitter would be received by the sensor (or would be received over a threshold amount) if the light contacts the reflector 162. Otherwise, the light would not be received by the sensor (or would not be received below the threshold amount).
  • a signal generated by the sensor would vary.
  • the controller 126 may determine the position of the piston head assembly 154 along the barrel 152 between the first and second ends 156, 158.
  • the piston head assembly 154 starts at a first position.
  • the controller 126 causes the vacuum/pressure source 172 to operate and draw vacuum behind the piston head assembly 154 (i.e., in space 176).
  • the piston head assembly 154 moves in the direction of the end 158 (i.e., from the end 156 to the end 158) and draws fluid into the space 178.
  • the controller 126 may subsequently operate the vacuum/pressure source to pump pressurized air into the space 176. This causes the piston head assembly 154 to move in the direction of the end 156 (i.e., from the end 158 to the end 156) and push fluid from the space 178.
  • the system also includes sensors 122a, 122b that sense and monitor liquid and gas flow through the fluid circuit 102.
  • sensors 122a and 122b may be in-line air bubble detectors, which sense when the fluid in fluid lines 112, 132 has changed from liquid to air or vise- versa.
  • Sensor 122a monitors the I iqu id/air interface in fluid line 112 through which fluid to and from the distribution pump 120 flows.
  • the piston head 154 when drawing liquid into the syringe 150 from one of the containers 116a-d, 118 the piston head 154 will move up and initially draw air from the fluid line into the syringe 150. This air will be followed by the desired liquid.
  • the syringe 150 Upon liquid reaching the syringe 150 the sensor 122a it will detect the interface and the system will record the position of the piston head 154/reflector 162 to use as the zero value for liquid within the syringe 150. This is used to determine the liquid volume within the syringe 150.
  • Sensor 122a may be used to determine when the liquid volume of the syringe 150 is emptied as it detects the liquid/air interface as fluid flows through out of syringe 150 through fluid line 112.
  • Sensor 122b monitors fluid line 110 connected to the vent 114 to prevent the filter of the vent from becoming wet. For example, if sensor 112b senses liquid, it will close flow controller 131 to prevent liquid from flowing to the vent 114.
  • the sensors 122a, 122b send signals to the controller 126 so that the controller can adjust the process as needed or provide a signal to the user.
  • the system includes user interface 124 which may include a video display 123 and a touch screen 125 (Fig. 4) to program the distribution system.
  • the interface 124 sends signals to the controller 126.
  • the system 200 includes several of the same or similar features of that of system 100.
  • system 200 includes a fluid circuit 202, manifold 204, stopcocks 205 and 206, fluid lines, vent 214, one or more containers 216, 218, pump 220, user control interface 224, etc.
  • System 200 also operates in substantially the same manner as system 100.
  • the system 200 also includes a gravity flow container 240, a flow controller 242 and a sensor 244.
  • the system may include a pole 246 from which container 240 hangs. Pole 246 holds container 240 above container 218 so that liquid within the container 240 may drain directly into container 218.
  • a fluid line 241 has one end 243 attached to container 240 and the other end 245 in fluid communication with container 218.
  • end 245 is attached to a Y-connector 247.
  • the Y-connector 247 has three ports. One port attached to end 245 of fluid line 241 , another port attached to container 218, and the third port attached to line 212.
  • the flow controller 242 and sensor 244 are in-line with fluid line 241 and in communication with controller 126 Fig. 4.
  • the controller opens flow controller 242, which allows liquid to flow under the force of gravity into container 218.
  • the sensor 244 senses the flow of the liquid and sends a signal to the controller.
  • flow controller 242 closed and stops the flow of liquid.
  • the fluid containers may be any suitable fluid container.
  • the fluid containers 118 and 218 of systems 100 and 200 shown in Figs. 1 and 2 may by a cell culture or gene therapy container 318.
  • controller 126 is configured to control operation of the system 100.
  • the controller 126 may include a microprocessor 153 (which, in fact may include multiple physical and/or virtual processors). According to other embodiments, the controller 126 may include one or more electrical circuits designed to conduct the actions described herein. In fact, the controller 126 may include a microprocessor 153 and other circuits or circuitry. In addition, the controller 126 may include one or more memories 155.
  • the instructions by which the microprocessor 153 is programmed may be stored on the one or more memories 155 associated with the microprocessor 153, which memory /memories 155 may include one or more tangible non-transitory computer readable memories, having computer executable instructions stored thereon, which when executed by the microprocessor 153, may cause the microprocessor 153 to carry out one or more actions as described below.
  • the controller 126 may be coupled (i.e., directly, or indirectly connected) to the equipment of the system 100 and control such equipment, such as stopcock actuators 115, pump 120, scales associated with containers 116a-d, tray table 128 (scale, temperature control members), sensors, 122a, 122b, flow controller 131 , and user control interface 124.
  • equipment such as stopcock actuators 115, pump 120, scales associated with containers 116a-d, tray table 128 (scale, temperature control members), sensors, 122a, 122b, flow controller 131 , and user control interface 124.
  • Fig. 5 provides a schematic illustration of possible configurations of the stopcocks.
  • the stopcock closes fluid flow to/from the container and closes the stopcock by- pass.
  • the stopcock opens fluid flow to/from the container and closes the stopcock by-pass.
  • the stopcock closes fluid flow to/from the container and opens fluid flow through the by-pass.
  • Container 1 18 contains a blood product or cell culture and containers 116a-116d contain additive fluids (e.g., liquids) for distribution/dosing into container 1 18.
  • additive fluids e.g., liquids
  • the system may commence with taking in air for the creation of an air chaser that may be used to push liquid through the system at various times during the operation of the system.
  • This step is optional and is not necessary to begin the operation of the system.
  • the flow control 131 e.g., pinch valve
  • the stopcocks 105, 106a-d are in position C (fluid flow to the respective container is closed and the stopcock by-pass is opened).
  • the controller 126 activates the distribution pump 120 to draw air through fluid lines 132, the stopcock by-passes of stopcocks 105, 106a-d, fluid line 112 and into the space 178 of syringe 150 (Fig. 1 ).
  • the air flows into syringe 150 until a selected amount of air has been drawn into space 178.
  • the syringe 150 includes a detection system that sends signals to the controller 126 to stop the operation of the pump 120 when the selected amount of air has been drawn into space 178.
  • the selected amount of air may be an amount to create an air chaser used later in the operation, as will be explained in more detail below.
  • the controller 126 activates the stopcock actuators 1 15 to move stopcock 106a into position B so that fluid flow out of container 1 16a is open. Controller 126 also activates the actuators 115 to move stopcock 105 to position C so that the stopcock by-pass is open.
  • the controller 126 actives the distribution pump 120 to draw liquid out of container 1 16a, through fluid lines 108a, stopcock 106a, by-pass of stopcock 105, fluid line 112 and into the space 178 of syringe 150.
  • the sensor 122a senses the transition from air to liquid flowing through the fluid line 112. The liquid flows into syringe 150 until a desired amount of liquid has been drawn into space 178.
  • the syringe 150 includes detection system that sends signals to the controller 126 to stop the operation of the pump 120 when a selected amount of liquid has been drawn into space 178.
  • the controller 126 actives the actuators 115 to move stopcock 105 into position B so that fluid flow into container 118 is open and the by-pass is closed.
  • the controller 126 activates the pump 120 to push the liquid through fluid line 112, stopcock 105, fluid line 110 and into container 1 18.
  • the system optionally, air chases residual liquid from the fluid lines, if needed. For example, if the optional step described above in association with Fig. 6B was performed, then the syringe already includes a sufficient amount of air for an air chaser. If the optional step was not performed, the controller actives the actuators 115 to move all of the stopcocks to position C and to open flow controller 131 as shown in Fig. 6B. The controller 126 opens flow controller 131 and actives the distribution pump 120 to draw air through the vent 114, through the manifold 104 and line 112. The sensor 122a senses any liquid flowing into syringe 150 and then the transition to air.
  • the syringe 150 includes detection system that sends signals to the controller 126 to stop the operation of the pump 120 when the desired amount of air has been drawn into space 178.
  • the tray may agitate container 1 18 to mix the original fluid and added liquids within container 118. This may occur continuously or after each dose of additive fluid is added to container 118. Additionally, the tray 128 may have a scale that ways the container 118 and sends a signal to the controller 126. The controller compares this weight to the container’s previous weight and determines whether an accurate volume of additive liquid has been dosed to container 118. Weighing of the container 1 18 may occur after each dose.
  • the controller 126 activates the stopcock actuators 1 15 to move each of stopcocks 105 and 106a into position C and stopcock 106b into position B so that fluid flow out of container 116b is open.
  • the controller 126 actives the distribution pump 120 to draw liquid out of container 116b, through fluid lines 108b, stopcock 106b, by-passes of stopcock 106a, 105, fluid line 112 and into the space 178 of syringe 150.
  • the liquid flows into syringe 150 until a desired amount of fluid has been drawn into space 178.
  • the controller 126 actives actuator 1 15 to move stopcock 105 into position B so that fluid flow into container 118 is open and the by-pass is closed.
  • the controller 126 activates the pump 120 to push the liquid through fluid line 112, stopcock 105, fluid line 1 10 and into container 1 18.
  • the system uses an air chaser, as described above with respect to Fig. 6B, to flow any residual liquid in fluid lines 1 10 and 1 12 into container 1 18.
  • the controller 126 activates the stopcock actuator 115 to move each of stopcocks 105, 106a, 106b into position C and stopcock 106c into position B so that fluid flow out of container 1 16c is open.
  • the controller 126 actives the distribution pump 120 to draw liquid out of container 116c, through fluid lines 108c, stopcock 106c, by-passes of stopcock 106a, 106b, 105, fluid line 1 12 and into the space 178 of syringe 150.
  • the liquid flows into syringe 150 until a desired amount of liquid has been drawn into space 178.
  • the controller 126 actives actuator 115 to move stopcock 105 into position B so that fluid flow into container 118 is open and the by-pass is closed.
  • the controller 126 activates the pump 120 to push the liquid through fluid line 112, stopcock 105, fluid line 1 10 and into container 1 18.
  • the system uses an air chaser, as described above with respect to Fig. 6B, to flow any residual liquid in fluid lines 1 10 and 1 12 into container 1 18.
  • the controller 126 activates the stopcock actuator 115 to move each of stopcocks 105, 106a, 106b, 106c into position C and stopcock 106d into position B so that fluid flow out of container 1 16d is open.
  • the controller 126 actives the distribution pump 120 to draw liquid out of container 116d, through fluid lines 108d, stopcock 106d, by-passes of stopcock 106a, 106b, 106c, 105, fluid line 112 and into the space 178 of syringe 150.
  • the liquid flows into syringe 150 until a desired amount of fluid has been drawn into space 178.
  • the controller 126 actives actuator 1 15 to move stopcock 105 into position B so that fluid flow into container 118 is open and the by-pass is closed.
  • the controller 126 activates the pump 120 to push the fluid through fluid line 1 12, stopcock 105, fluid line 1 10 and into container 1 18.
  • the system uses an air chaser, as described above with respect to Fig. 6B, to flow any residual liquid in fluid lines 1 10 and 1 12 into container 1 18.
  • Fig. 6K after the container 118 has been dosed with the fluids from one or more of the containers 1 16a-d, the controller 126 actives stopcock actuator 115 to place all of the stopcocks 105, 106a-d into position A and the product container 118 is removed from the system. A new container 1 18 may then be connected to the system.
  • the system may open fluid flow controller 242 at selected times during operation to dose the liquid from container 240 into containers 1 18, 218, 318.
  • the liquid may be dosed from container 240 at any point during operation of the system.
  • the liquid from container 240 may be dosed simultaneously with the dosing from the other containers or it may be dosed separately.
  • container 118 may contain an additive that is dosed to containers 116a-d.
  • the system may optionally start by drawing air into the syringe 150 for air chasing. Then, the controller 126 activates the stopcock actuators 115 to move stopcock 105 into position B so that fluid flow out of container 118 is open and the by-pass is closed (Fig. 6D).
  • the controller 126 actives the distribution pump 120 to draw liquid out of container 118, through fluid line 1 10, stopcock 105, fluid line 112 and into the space 178 of syringe 150.
  • the sensor 122a senses the transition from air to liquid flowing through the fluid line 1 12.
  • the liquid flows into syringe 150 until a desired amount of liquid has been drawn into space 178.
  • the syringe 150 includes detection system that sends signals to the controller 126 to stop the operation of the pump 120 when a selected amount of liquid has been drawn into space 178.
  • the selected amount of liquid may be an amount to dose one of the containers 116a-d or an amount to dose all of the containers 1 16a-d.
  • the controller 126 activates the stopcock actuators 115 to move stopcock 105 into position C so that the by-pass is open.
  • the actuators also move stopcock 106a into position B so that fluid flow into container 116a is open (Fig. 6B).
  • the controller 126 activates the pump 120 to push the fluid liquid through fluid line 112, by-pass of stopcock 105, stopcock 106a, fluid line 108a and into container 116a.
  • the system uses an air chaser, as described above with respect to Fig. 6B, to flow any residual liquid in fluid lines 110 and 1 12 into container 118.
  • the system moves stopcock 105 into position B and repeats the step of drawing liquid from container 1 18 into syringe 150.
  • the system then activates stopcock actuators 115 to move stopcock 105 and 106a to position C.
  • the actuators 115 also move stopcock 106b to position B.
  • the controller 126 activates the pump 120 to push the fluid liquid through fluid line 112, by-pass of stopcocks 105, 106a, stopcock 106b, fluid line 108b and into container 1 16b.
  • the system uses an air chaser, as described above with respect to Fig. 6B, to flow any residual liquid in fluid lines into container 1 16b. This process continues to dose containers 116c and 116d.
  • the system then activates stopcock actuators 1 15 to move stopcock 105 and 106a to position C.
  • the actuators 115 also move stopcock 106b to position B.
  • the controller 126 activates the pump 120 to push the fluid liquid through fluid line 1 12, by-pass of stopcocks 105, 106a, stopcock 106b, fluid line 108b and into container 116b.
  • the system uses an air chaser, as described above with respect to Fig. 6B, to flow any residual liquid in fluid lines into container 1 16b. This process continues to dose containers 1 16c and 116d.
  • the system moves stopcock 106B to position C and stopcock 106C to position B.
  • the system then delivers a dose of liquid to container 116C.
  • the stopcock associated with the previously dosed container is moved to position C and the stopcock of the container be filed next is moved to position B.
  • the process continues until the containers are dosed.
  • the dosed containers may be removed from the system as other containers are being dosed or the containers may be removed after all the containers have been dosed.
  • a new container or new set of containers are then attached to the system, but for example, a luer lock.
  • the system may be programmable so that a user can choose a dosing protocol.
  • the protocol may be preprogrammed or may be custom, depending on the desired use.
  • the system may include preprogrammed or saved protocols that the user may choose through the user interface.
  • the system may allow the user to program in a custom protocol.
  • the protocols may vary by amount of liquid dosed, the timing of the dosing, the order of dosing, etc.
  • a fluid distribution system comprising: a fluid circuit comprising: manifold including a plurality of stopcocks; and distribution pump in fluid communication with the manifold; a set of containers comprising a plurality of supply containers, wherein each of the supply containers contain an additive fluid and each of the supply containers is in communication with a respective stopcock of the manifold; a product container containing a product, wherein the product container is in communication with another stopcock of the manifold; and wherein the stopcocks are configured to be moved to different positions to distribute additive fluid from the supply containers to the product container.
  • Aspect 2 The fluid distribution system according to Aspect 1 , wherein the different positions of the stopcocks comprise: a first position in which the stopcock closes fluid flow to and from the respective supply/product container and closes a stopcock by-pass; a second position in which the stopcock opens fluid flow to and from the respective supply/product container and closes the stopcock by-pass; a third position in which the stopcock closes fluid flow to and from the respective supply/product container and opens the stopcock by-pass.
  • Aspect 3 The fluid distribution system according to any one of Aspects 1 and 2, further including a motorized actuator for moving the plurality of stopcocks into the different positions.
  • Aspect 4 The fluid distribution system according to Aspect 3, further including a controller for controlling distribution of fluid through the fluid distribution system.
  • Aspect 5 The fluid distribution system according to Aspect 4, wherein the controller activates the motorized actuator to move the stopcocks into the different positions.
  • Aspect 6 The fluid distribution system according to any one of Aspects 4 and 5, wherein the controller controls the distribution pump.
  • Aspect 7 The fluid distribution system according to any one of Aspects 1 -6, wherein the fluid circuit further includes fluid lines.
  • Aspect 8 The fluid distribution system according to Aspect 7, wherein the fluid lines are in fluid communication with the supply containers and the manifold.
  • Aspect 10 The fluid distribution system according to Aspect 9, wherein the at least one of the fluid lines fluidly connects the distribution pump to another stopcock in communication with the product container.
  • Aspect 1 1 The fluid distribution system according to any one of Aspects 1 -10, wherein the fluid circuit includes a vent.
  • Aspect 12 The fluid distribution system according to any one of Aspects 1 -11 , further including a tray for holding the product container.
  • Aspect 13 The fluid distribution system according to Aspect 12, wherein the tray includes a scale for weighing the product container.
  • Aspect 14 The fluid distribution system according to any one of Aspects 12 and 13, wherein the tray agitates to mix the product and a dose of additive fluid within the product container.
  • Aspect 15 The fluid distribution system according to any one of Aspects 12-14, wherein the tray is configured to heat or cool the product in the product container.
  • Aspect 16 The fluid distribution system according to any one of Aspects 1 -15, further including hangers for hanging the plurality of supply containers.
  • Aspect 17 The fluid distribution system according to 16, further including scales associated with the hangers for weighing the plurality of supply containers.
  • Aspect 18 The fluid distribution system according to any one of Aspects 1 -17, wherein the pump is a pneumatic syringe pump.
  • Aspect 19 The fluid distribution system according to Aspect 18, further including a detection system for detecting a position of the pneumatic syringe pump.
  • Aspect 20 The fluid distribution system according to Aspect 19, further including at least one gas and fluid sensor for sensing gas and fluid within the fluid circuit, wherein amount of fluid in the syringe pump is determined by the position of the pump and the gas and fluid sensors.
  • Aspect 21 The fluid distribution system according to any one of Aspects 1 -18, further including at least one gas and fluid sensor for sensing gas and fluid within the fluid circuit.
  • Aspect 22 The fluid distribution system according to any one of Aspects 1 -21 , wherein the fluid circuit further includes a vent.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un système de distribution de fluide pour distribuer un fluide entre une pluralité de récipients. Le système comprend un circuit de fluide, des robinets d'arrêt et des récipients de fluide, les robinets d'arrêt étant configurés pour commander l'écoulement de fluide à travers le circuit de fluide et la distribution de fluide entre la pluralité de récipients.
EP24745069.5A 2023-01-20 2024-01-16 Système automatisé de distribution et de dosage de volume Pending EP4652510A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363480750P 2023-01-20 2023-01-20
PCT/US2024/011629 WO2024155598A1 (fr) 2023-01-20 2024-01-16 Système automatisé de distribution et de dosage de volume

Publications (1)

Publication Number Publication Date
EP4652510A1 true EP4652510A1 (fr) 2025-11-26

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Application Number Title Priority Date Filing Date
EP24745069.5A Pending EP4652510A1 (fr) 2023-01-20 2024-01-16 Système automatisé de distribution et de dosage de volume

Country Status (2)

Country Link
EP (1) EP4652510A1 (fr)
WO (1) WO2024155598A1 (fr)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5868177A (en) * 1995-07-27 1999-02-09 Chemical Control Systems, Inc. Method and apparatus for injecting additives
US6723062B1 (en) * 1999-09-03 2004-04-20 Baxter International Inc. Fluid pressure actuated blood pumping systems and methods with continuous inflow and pulsatile outflow conditions
US8392029B2 (en) * 2006-04-11 2013-03-05 Tokyo Institute Of Technology Odor blender, odor recorder, odor reproducer, and odor recording and reproducing system

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WO2024155598A1 (fr) 2024-07-25

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