EP4688062A1 - Atomiseur - Google Patents

Atomiseur

Info

Publication number
EP4688062A1
EP4688062A1 EP24720577.6A EP24720577A EP4688062A1 EP 4688062 A1 EP4688062 A1 EP 4688062A1 EP 24720577 A EP24720577 A EP 24720577A EP 4688062 A1 EP4688062 A1 EP 4688062A1
Authority
EP
European Patent Office
Prior art keywords
opening
filter element
sectional area
holding
flow direction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24720577.6A
Other languages
German (de)
English (en)
Inventor
Mahmut Bilgic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neutec Inhaler Ilac Sanayi Ve Ticaret AS
Original Assignee
Neutec Inhaler Ilac Sanayi Ve Ticaret AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/IB2023/053508 external-priority patent/WO2024209239A1/fr
Priority claimed from PCT/IB2023/055905 external-priority patent/WO2024209254A1/fr
Priority claimed from PCT/IB2024/053151 external-priority patent/WO2024209333A1/fr
Application filed by Neutec Inhaler Ilac Sanayi Ve Ticaret AS filed Critical Neutec Inhaler Ilac Sanayi Ve Ticaret AS
Publication of EP4688062A1 publication Critical patent/EP4688062A1/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
    • A61M11/007—Syringe-type or piston-type sprayers or atomisers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/02—Membranes or pistons acting on the contents inside the container, e.g. follower pistons
    • B05B11/026—Membranes separating the content remaining in the container from the atmospheric air to compensate underpressure inside the container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/1001—Piston pumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B15/00—Details of spraying plant or spraying apparatus not otherwise provided for; Accessories
    • B05B15/40—Filters located upstream of the spraying outlets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/75—General characteristics of the apparatus with filters
    • A61M2205/7545—General characteristics of the apparatus with filters for solid matter, e.g. microaggregates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2207/00—Methods of manufacture, assembly or production

Definitions

  • the invention relates to an atomizer for a fluid located in a container, with an atomizer nozzle and a housing, wherein a pump body with a first through-opening having a first opening cross-sectional area is arranged in the housing, wherein a hollow piston with a check valve and a filter element are arranged in the first through-opening, wherein a holding region is also provided for holding the filter element in a flow direction of the fluid in the first through-opening, wherein further in the flow direction after the filter element an atomizing part is arranged, which is received in an extension region of the pump body adjoining the first through-opening in the flow direction.
  • Nebulizers of the type in question which are also referred to as inhalers, are known, for example, from WO 2007/022898 A2 (US 7823584 B2) and further, for example, from WO 2012/160052 A1 (US 9827384 B2) or from WO 2017/080895 A1 (US 2017/0128681 A1).
  • the filter part designed there as a fine filter is made of metal and is arranged downstream of a pre-filter made of plastic in the through-opening in the flow direction.
  • the invention is concerned with the task of specifying an atomizer which, with an advantageous construction, has a favorable arrangement of a filter element.
  • the filter element is arranged in the first through-opening in the flow direction in front of the holding device in which a second through-opening is provided, wherein the second through-opening has a second opening cross-sectional area, and that the second opening cross-sectional area is smaller than the first opening cross-sectional area in such a way that a secure holding of the filter element is provided with otherwise as unhindered a flow as possible.
  • the second opening cross-sectional area can vary depending on which material is used for the filter element. Possible materials are explained in more detail below. If the filter material is comparatively soft, the second opening cross-sectional area is preferably smaller than for a hard material such as a metallic material.
  • the filter element is preferably a depth filter. Compared to surface filters, depth filters have a high filter capacity, while at the same time also being able to withstand high pressure and also preferably being able to withstand pressure and/or having a lower impact on a pressure drop with increasing amounts of filtered-out substance.
  • the holding device is provided after the filter element in the direction of flow, a favorable holding of the filter element in the first through-opening with a high supporting effect is achieved.
  • the holding device is preferably a plastic part or is formed on a plastic part, in particular the pump body. If the filter element is made of a comparatively soft material, it cannot push through the second through-opening or be extruded through it under the pressure drop that occurs during inhalation or spray activation. It can, preferably, be an effective and optionally soft filter element as the sole filter element alongside the microfilter integrated in the atomization part in the nozzle area. In this case, in particular, it is a sole filter element in front of the atomization part. In such a case, it is correspondingly one-piece and is available as a one-piece filter element.
  • the second opening cross-sectional area is smaller, it is preferably also selected such that no additional, relevant flow resistance is created in relation to the largest flow resistance in the atomizing part. If the atomizing part, ultimately the nozzle outlet of the atomizing part, has, for example, (only) one opening area between approx.
  • the second opening cross-sectional area should preferably be at least approx. 100 times the largest assumed cross-section of the nozzle outlet in the sense of a low flow resistance, i.e. 12,000 m 2 or 0.012 mm 2 , which would correspond to a minimum diameter of the second through opening of approx. 0.12 mm. In terms of manufacturing technology, this diameter can still be easily produced by mechanical drilling or laser drilling.
  • the upper limit of the second through opening is determined by the strength of the filter.
  • a through hole of 20% to 40%, preferably 30% of the filter diameter or the first through hole has proven to be effective.
  • the cross section of the second through-opening can also be close to the cross section of the first and preferably amount to approximately four fifths or less of the first opening cross-sectional area. This would correspond to a diameter of the second opening of preferably approximately 1.3 mm compared to a diameter of the first opening of preferably 1.5 mm in the above example.
  • a number of 200 doses corresponds, for example, to a standard monthly pack. This result is also evident when ethanol solutions are used as the active ingredient.
  • the choice of material for the filter element is subject to very few restrictions.
  • it can also be a soft material.
  • the filter element can be designed to suit a filtering requirement.
  • it can be made of a relatively soft, porous material in one piece.
  • the filter element can also be made of a material such as glass, ceramic, plastic, metal or a semiconductor such as silicon. In terms of production, it can be sintered from a powder, woven as a fleece and structured by etching or ion bombardment. Last but not least, it can also be manufactured by additive manufacturing.
  • the holding area can be designed solely by a taper integrated into the pump body with respect to the second through-opening.
  • the taper can be stepped or, for example, conical.
  • a manufacturing process for the pump body which is usually an injection molding process for large quantities, in the event that the resulting through-opening, as a combination of the first and second through-openings, is disadvantageously small (and long) for the given length, it can also be designed by first producing the part without the second through-opening with the second opening cross-sectional area and then introducing this into the injection molded part in a further processing by removing processes such as boring, lasering, punching or the like.
  • a separate mounting part can also be provided. This is particularly advantageous in that the injection molding of the pump body does not have to be carried out with a significantly reduced or transitionally complex opening in view of the comparatively long through-opening.
  • the holding part is preferably a plastic part. It can also preferably be produced by injection molding, for example from polypropylene. Except for the second through-opening, it is preferably not permeable to flow.
  • the holding part can be essentially cylindrical or conical. However, it can also be disc-shaped, but also, regardless of the specific design, can be designed as a support structure through which flow can pass and in a sieve-like manner.
  • it is preferably a plastic part, it can also be a metal part, a ceramic part, a glass part, a silicon part and the like.
  • the holding part can be seated in a tapered region of the first through-opening.
  • the holding part further reduces the size of the first through-opening despite a tapered region, the first tapered region can still be formed comparatively inexpensively on the pump body in terms of injection molding technology.
  • the holding part is further preferably seated with a press fit or transition fit in the first through-opening and preferably also in the said tapering region.
  • the holding part is preferably seated in the first through-opening in the manner of a plug.
  • the mounting part can be inserted into the first through hole from below. It can then be pressed into its final seat.
  • the filter element is the only discrete filter element of the atomizer, in addition to the microfilter integrated in the atomization part. It can be designed in several stages, with different porosities, e.g. porosity decreasing in the direction of flow.
  • a favorable, sealed design can be achieved with a comparatively favorable number of components.
  • the tolerance chain for pre-tensioning the nozzle seal is reduced.
  • the pressurized surfaces of the nozzle holder can advantageously be reduced.
  • the mounting area is formed in one piece in the pump body, the components involved in the filtering, i.e. without nozzle holder, atomizing element and screw cap, can be reduced to three parts, the filter element, the nozzle seal and the pump body itself. If a mounting part (made of plastic) is added, there are four parts.
  • Fig. 1 the atomizer in perspective view, with a cover cap attached;
  • Fig. 2 shows the atomizer in a section along the plane II-II in Figure 1;
  • FIG. 3 shows an enlarged upper region of the illustration according to Fig. 2, in a first embodiment
  • Fig. 4 shows the enlarged upper area of the illustration according to Figure 2, in a second embodiment
  • FIG. 5 shows the enlarged area of the illustration according to Figure 2, in a third embodiment
  • Fig. 6 shows the enlarged area of the illustration according to Figure 2 in a fourth embodiment.
  • the atomizer 1 is preferably designed as a portable inhaler, more preferably with an elongated, round or oval cross-section. Viewed in the direction of a housing longitudinal axis x, the atomizer 1 can have a length of about 80 to about 200 mm. The length is preferably about 100 to about 150 mm. A width or diameter transverse to the housing longitudinal axis can be in the range of 20 to 60 mm, preferably about 25 to 50 mm. The atomizer 1 can thus be held and used in one hand to carry out an inhalation process.
  • the fluid 3 is preferably a therapeutic or pharmaceutical product to be inhaled by the user during an inhalation process. Such inhalation is preferably carried out without propellant gas.
  • the fluid 3 is preferably sucked from the container 2 into a pressure chamber 4 and, as a result of pressurization, atomized via a mouthpiece 5.
  • the atomization processes carried out can be counted using a counter 6 arranged on the housing side.
  • the fluid 3 is present as an ethanolic solution, alternatively also as an aqueous solution.
  • the atomizer 1 further comprises a housing 7 in which a pump body 8 ( Figure 2) is arranged.
  • the pump body 8 comprises a first through-opening 9.
  • a hollow piston 10, a check valve 11 and a filter element 12 are arranged in the first through-opening 9 (see also Figures 3, 4).
  • the hollow piston 10 is, as is known and usual for such atomizers.
  • a mounting area 13 is also provided for mounting the filter element 12 in a flow direction r of the fluid 3 expelled for atomization in front of a nozzle holder 14, wherein further in the flow direction r after the filter element 12 there is an atomization part 17 with an integrated microfilter, which is accommodated in an extension area of the pump body 8 adjoining the first through-opening 9.
  • the atomization part 17 is held in the mouthpiece 5 by the nozzle holder 14, preferably a metal part.
  • the nozzle holder 14 can also be a plastic part.
  • the nozzle holder 14 is in turn covered by a screw cap 19, which is preferably held on the pump body 8.
  • the nozzle holder 14 further covers a sealing element 15 made of plastic or elastomer, which is preferably seated with a certain radial and axial preload between the nozzle holder 14, the pump body 8 and the atomizing part 17.
  • the support region 13 can preferably be formed integrally in the pump body 8. This is illustrated in Figure 5.
  • a second through opening 16 is formed in the holding area 13.
  • a holding part 18 is provided for holding the filter element 12 in the flow direction r of the fluid 3 expelled for atomization in front of the atomization part 17.
  • the filter element 12 is accommodated in the first through-opening 9 in the flow direction r in front of a holding area 13.
  • the holding area 13 can, as already stated, be formed by the pump body 8 itself or by the holding part 18 accommodated in the first through-opening 9.
  • the holding area 13 or the holding part 18 has the second through-opening 16.
  • the second through-opening 16 is a continuation of the first through-opening 9, i.e. a partial area thereof.
  • the second through-opening 16 has a second opening cross-sectional area that is smaller than the first opening cross-sectional area. The difference is chosen so that the filter element is held securely, with the flow otherwise being as unhindered as possible.
  • the second opening cross-sectional area can correspond to four fifths or less of the first cross-sectional area.
  • the first or second opening cross-sectional area is the free area of the first or second through-opening 9, 16 measured perpendicular to the housing longitudinal axis x.
  • the filter element 12 is preferably a depth filter, more preferably designed as a sintered part with a certain porosity.
  • the material used can be conventional thermoplastics such as PP, PBT or HT (high-temperature) thermoplastics such as PEEK, but also corrosion-resistant, inert materials such as glass, ceramics or metals (VA, titanium).
  • the holder part 18 is preferably a plastic part, manufactured by injection molding, e.g. from PP or integrated in the pump body, but can also consist of other materials, such as HT thermoplastics, preferably PEEK (polyetheretherketone).
  • the pump body 8 can be manufactured in the same way.
  • the holding part 18 is further preferably seated in a tapered region of the first through-opening 9.
  • the holding part 18 is also preferably formed so as to be shaped to match the tapered region of the first through-opening 9.
  • the holding part 18 is press-fitted into the first through-opening 9 in order to be axially secured.
  • the filter element 12 is further preferably provided as the sole filter element in addition to the microfilter of the atomizer 1 integrated in the atomization part 17.
  • a stepped design with different porosities is also possible.
  • the nozzle seal 15 and/or the nozzle holder 14 sit directly sealingly on an end face of the pump body 8.
  • An intermediate O-ring or the like is preferably not provided.
  • FIG. 6 an embodiment according to Figure 3 or Figure 4 is shown, further enlarged, in which the mounting part 18 is formed in a disk-like manner.
  • a stepped design is shown and in the right half, a conical design is shown in relation to the housing longitudinal axis x, i.e. in principle corresponding to Figure 4 or Figure 3.
  • the design is uniformly stepped or uniformly conical. It is indicated in dashed lines that instead of the specifically drawn stepped design of the pump body 8 in this regard, a conical design can also be provided, corresponding to Figure 3.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Mechanical Engineering (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)

Abstract

L'invention concerne un atomiseur (1) pour un fluide (3) contenu dans un récipient (2), comprenant une buse d'atomiseur et un boîtier (7), un corps de pompe (8) avec une première ouverture traversante (9) présentant une première surface de section transversale d'ouverture étant disposé dans le boîtier (7), un piston creux (10) avec un clapet antiretour (11) et un élément filtrant (12) étant agencés dans la première ouverture traversante (9), une région de retenue (13) étant également prévue pour maintenir l'élément filtrant (12) dans une direction d'écoulement (r) du fluide (3) dans la première ouverture traversante (9), une partie d'atomisation (17) étant également agencée en aval de l'élément filtrant (12) dans la direction d'écoulement (r), laquelle partie d'atomisation étant logée dans une région d'extension du corps de pompe (8) adjacente à la première ouverture traversante (9) dans la direction d'écoulement (r). Dans un mode de réalisation avantageux, l'élément filtrant (12) est agencé dans la première ouverture traversante (9) dans la direction d'écoulement (r) en amont de la région de retenue (13), dans lequel une seconde ouverture traversante (16) est ménagée, la seconde ouverture traversante (16) présentant une seconde surface de section transversale d'ouverture, et la seconde surface de section transversale d'ouverture étant plus petite que la première surface de section transversale d'ouverture de telle sorte que l'élément filtrant soit solidement maintenu tandis que l'écoulement se fait par ailleurs de la manière la plus libre possible.
EP24720577.6A 2023-04-06 2024-04-05 Atomiseur Pending EP4688062A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
PCT/IB2023/053508 WO2024209239A1 (fr) 2023-04-06 2023-04-06 Nébuliseur et récipient pour nébuliseur
PCT/IB2023/055693 WO2024209253A1 (fr) 2023-04-06 2023-06-02 Nébuliseur pour un fluide contenu dans un récipient
PCT/IB2023/055905 WO2024209254A1 (fr) 2023-04-06 2023-06-08 Nébuliseur pour un fluide contenu dans un récipient
PCT/IB2024/053151 WO2024209333A1 (fr) 2023-04-06 2024-04-01 Nébuliseur pour un fluide contenu dans un récipient
PCT/IB2024/053343 WO2024209414A1 (fr) 2023-04-06 2024-04-05 Atomiseur

Publications (1)

Publication Number Publication Date
EP4688062A1 true EP4688062A1 (fr) 2026-02-11

Family

ID=90825594

Family Applications (1)

Application Number Title Priority Date Filing Date
EP24720577.6A Pending EP4688062A1 (fr) 2023-04-06 2024-04-05 Atomiseur

Country Status (5)

Country Link
EP (1) EP4688062A1 (fr)
JP (1) JP2026511424A (fr)
CN (1) CN121194811A (fr)
GB (1) GB2644493A (fr)
WO (1) WO2024209414A1 (fr)

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB688161A (en) * 1950-12-13 1953-02-25 Eclipse Spraying Company Ltd Improvements in sprayer nozzles
DE19536902A1 (de) * 1995-10-04 1997-04-10 Boehringer Ingelheim Int Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung
DE10300983A1 (de) * 2003-01-14 2004-07-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Düsensystem für eine Ausbringungsvorrichtung für Flüssigkeiten bestehend aus Düse und Düsenhalter und/oder Überwurfmutter
EP1917108B1 (fr) 2005-08-24 2012-10-03 Boehringer Ingelheim International GmbH Atomiseur
EP2275160A1 (fr) * 2009-07-13 2011-01-19 Boehringer Ingelheim International Gmbh Chambre haute pression
EP2593164B1 (fr) 2010-07-16 2017-03-22 Boehringer Ingelheim International GmbH Système de filtre conçu pour être utilisé dans des appareils médicaux
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
EP3157681A1 (fr) * 2014-06-20 2017-04-26 Medspray B.V. Aérosol ou dispositif de pulvérisation, unité de buse de pulvérisation et procédé de fabrication associé
WO2017080895A1 (fr) 2015-11-09 2017-05-18 Boehringer Ingelheim International Gmbh Nébuliseur et récipient
ES2879863T3 (es) * 2017-04-27 2021-11-23 Aptar France Sas Cabezal de dispensación de producto fluido
GB202104736D0 (en) * 2021-04-01 2021-05-19 Ttp Plc Micro-nozzle

Also Published As

Publication number Publication date
JP2026511424A (ja) 2026-04-14
WO2024209414A1 (fr) 2024-10-10
GB2644493A (en) 2026-04-15
CN121194811A (zh) 2025-12-23

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