EP4698272A1 - Utilisation d'ions d'air chargés dans des traitements esthétiques - Google Patents

Utilisation d'ions d'air chargés dans des traitements esthétiques

Info

Publication number
EP4698272A1
EP4698272A1 EP24719214.9A EP24719214A EP4698272A1 EP 4698272 A1 EP4698272 A1 EP 4698272A1 EP 24719214 A EP24719214 A EP 24719214A EP 4698272 A1 EP4698272 A1 EP 4698272A1
Authority
EP
European Patent Office
Prior art keywords
skin
ionized gas
gas molecules
treatment
area
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24719214.9A
Other languages
German (de)
English (en)
Inventor
Matthias Rudolph
Carsten SEMARK
Anders Berglund
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wetling Ip Aeam Ltd
Original Assignee
Wetling Ip Aeam Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wetling Ip Aeam Ltd filed Critical Wetling Ip Aeam Ltd
Publication of EP4698272A1 publication Critical patent/EP4698272A1/fr
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/44—Applying ionised fluids

Definitions

  • the present invention relates to the field of cosmetic treatment.
  • the present invention relates to the use of non-contact eletrostimulation (ES) as a means for effecting rejuvenation of skin as well as general and specific improvements in skin appearance.
  • ES non-contact eletrostimulation
  • the invention also relates to to combination of non-contact ES and topical administration of cosmetic or pharmaceutical substances.
  • Electrostimulation also termed electrostimulation or ES
  • electrotherapy is a well-known technology, which has been used in treatment of a large number of pathologies - when used for medical treatment, ES is often termed electrotherapy.
  • ES involves the transfer of electric current through an applied surface electrode pad that is in electrolytic contact with the external skin surface and the area to receive the effect.
  • at least two electrodes (a lead and a discharge electrode) are required to complete the electric circuit.
  • ES has been used as a therapeutic means in a number of conditions, notably in the treatment of various types of wounds, such as acute wounds, burns, chronic wounds including pressure ulcers, diabetic ulcers, venous ulcers, and arterial ulcers.
  • microcurrent can deliver an electrical current to muscles and skin cells.
  • This microcurrent builds up muscles in the face and/or lifts and tightens the skin tissue.
  • the establishment of a microcurrent also facilitates delivery of active compounds commonly used for beauty treatments into the lower layers of the skin, whereby their beneficial effects are enhanced.
  • the present invention relates to a method for cosmetic treatment of a surface area of the skin of a human subject, the method comprising projection of ionized gas molecules onto the area of the skin so as to establish an electric current, which is driven by the projection of the ionized gas molecules, in or over the area of the skin, wherein the human subject optionally has at least one discharge electrode attached to an area of the body remote from the surface area of the skin so as to sustain the electric current.
  • the present invention relates to ionized gas molecules for use in a method of treatment of an area of the skin of a human, the method being selected from redness relief, sensitivity relief, acne reduction, sun damage and/or photo damage prevention or repair, anti-inflammatory treatment of skin, treatment to ameliorate effects of laser treatment, treatment to ameliorate effects of cryolipolysis, and reduction in scar and pigmentation post-surgery, wherein the method comprises that ionized gas molecules are projected onto the area of the skin so as to establish an electric current, which is driven by the projection of the ionized gas molecules, in or over the area of the skin, wherein the human subject optionally has at least one discharge electrode attached to an area of the body remote from the surface area of the skin so as to sustain the electric current.
  • the present invention relates to a method for therapeutic treatment of a surface area of the skin of a human subject by topic application on the skin of an active drug substance or composition comprising said substance, the method comprising projection of ionized gas molecules onto the area of the skin so as to establish an electric current, which is driven by the projection of the ionized gas molecules, in or over the area of the skin, wherein the human subject optionally has at least one discharge electrode attached to an area of the body remote from the surface area of the skin so as to sustain the electric current, and wherein the projection of the ionized gas molecules enhances the uptake and/or the therapeutic effect of the administered active drug substance or composition.
  • a part of the third aspect relates to the same basic principle but in a non-therapeutic setting, and thus provides a method for non-therapeutic cosmetic treatment of a surface area of the skin of a human subject by topic application on the skin of a cosmetically active substance or composition comprising said active substance, the method comprising projection of ionized gas molecules onto the area of the skin so as to establish an electric current, which is driven by the projection of the ionized gas molecules, in or over the area of the skin, wherein the human subject optionally has at least one discharge electrode attached to an area of the body remote from the surface area of the skin so as to sustain the electric current, and wherein the projection of the ionized gas molecules enhances the uptake and/or the cosmetic effect of the administered active cosmetic substance or composition.
  • Projection of ionized gas molecules means that a sufficient amount of electrical charge in the form of electrically charged gas molecules is provided a surface area on the skin, so as to allow an electric current to be established between the surface area to surrounding tissue. It should be emphasized that the electric current, which passes from the surface area to the surrounding tissue cannot be established precisely - when discussing this electrical current in quantitative terms in the present application, the quantity (measured in Ampere or micro Ampere) is the one which may be measured in discharge electrode(s), which return(s) current from the treated human to the device that delivers the ionized gas molecules.
  • Ionized gas molecules broadly refers to gas molecules which carry a net electrical charge. Typical examples are negatively charged oxygen molecules and positively charged Nitrogen molecules because of the abundancy of oxygen and nitrogen in atmospheric air, but any gas molecule capable of carrying a net charge is useful in the practice of the present invention, as long as such ionized ga molecules do not provide unacceptable adverse or toxic effects on the human subjects treated.
  • a “discharge electrode” is an electrode attached to a treated subject which ensures that the ionized gas molecules do not simply build up a static charge in the subject but instead establishes an electrical current which passes through the subject to the discharge electrode.
  • Such an electrode will be in the form of a strap, but any convenient physical form may be useful.
  • a special example of a discharge electrode is a "return electrode", which is connected (optionally via a control unit) to the device which supplies the ionized gas ions - this enables that a return current may be measured (cf. above) and this in turn enables full control over the current sent through the treated subject as a consequence of the delivery of the ionized gas molecules.
  • a "gas ion transmitting device” is a device or apparatus, which is capable of generating a stream, jet or flux of ionized gas molecules having a net electrical positive or negative charge and where the direction of the stream, jet or flux may optionally may be controlled with respect to dosage, intensity and direction. Specifics concerning such devices are discussed in the patent application publications referenced in the Background of the Invention section above.
  • the projection of gas ions (and optionally light) onto the skin surface area can be carried out as set forth in WO 2009/135896 and WO 2015/052170, where the treatments are directed to various pathological states.
  • details concerning timing of treatments, dosage of gas ions (in terms of the pA applied), shifting of current direction and ionized gas molecule charges disclosed in these patent publications apply mutatis mutandis to the present invention.
  • the first aspect of the invention relates to method for cosmetic treatment of a surface area of the skin of a human subject, the method comprising projection of ionized gas molecules onto the area of the skin so as to establish an electric current, which is driven by the projection of the ionized gas molecules, in or over the area of the skin, wherein the human subject optionally has at least one discharge electrode attached to an area of the body remote from the surface area of the skin so as to sustain the electric current.
  • the charge of the ionized gas molecules can be both negative and positive, depending on the selection of apparatus for air ion generation.
  • the ionized gas molecules predominantly are negatively charged, such as negatively charged oxygen molecules (O 2 ) (but as mentioned the ionized gas molecules can instead predominantly be positively charged, such as positively charged Nitrogen molecules (N 2 + )).
  • the ionized gas molecules are derived from atmospheric air.
  • the projection of the ionized gas molecules preferably that an electrical current is established between the surface area of the skin and underlying tissue.
  • the electrical current is typically at least 0.1 pA and at most 100 pA.
  • any amperage in this interval can be used, e.g. about 0.2 pA, about 0.3 pA, about 0.4 pA, about 0.5 pA, about 0.6 pA, about 0.7 pA, about 0.8 pA, about 0.9, about 1 pA pA 2 pA, about 3 pA, about 4 pA, about 5 pA, about 6 pA, about 7 pA, about 8 pA, about 9 pA, about 10 pA, about 11 pA, about 12 pA, about 13 pA, about 14 pA, about 15 pA, about 16 pA, about 17 pA, about 18 pA, about 19 pA, about 20 pA, about 21 pA, about 22 pA, about 23 pA, about 24 pA, about 25 pA, about 26 pA, about
  • the treatment time is preferably at least 1 second and at most 100 minutes, but any treatment time in this interval is considered useful in the exercise of the invention.
  • the treatment time can hence be about 2 s, about 3 s, about 4 s, about 5 s, about 6 s, about 7 s, about 8 s, about 9 s, about 10 s, about 11 s, about 12 s, about 13 s, about 14 s, about 15 s, about 16 s, about 17 s, about 18 s, about 19 s, about 20 s, about 21 s, about 22 s, about 23 s, about 24 s, about 25 s, about 26 s, about 27 s, about 28 s, about 29 s, about 30 s, about 31 s, about 32 s, about 33 s, about 34 s, about 35 s, about 36 s, about 37 s, about 38 s, about 39 s, about 40 s, about 41
  • the treatment detailed above is carried out in combination with light treatment - for details on useful light treatment modes, reference is e.g. given to WO 2015/052170.
  • Embodiments of the invention further entail that method of the first aspect comprises that the ionized gas molecules are projected by a gas ion transmitting device, which optionally can further be equipped with a camera and/or a light emitting means.
  • the cosmetic treatment is in embodiments of the invention selected from the group consisting of wrinkle depth reduction, skin tightening, skin rejuvenation, skin elasticity enhancement, skin hydration enhancement, collagen stimulation, skin peeling, scar revision, dermabrasion, anti-aging, skin discoloration reduction, fine line improvement, redness relief, sensitivity relief, exfoliation, acne reduction, youth glow induction, sun damage and/or photo damage prevention or repair, anti-inflammatory treatment of skin, treatment to ameliorate effects of laser treatment, treatment to ameliorate effects of cryolipolysis, and reduction in scar and pigmentation post-surgery.
  • the cosmetic treatment is selected from the group consisting of wrinkle depth reduction, skin tightening, skin rejuvenation, skin elasticity enhancement, skin hydration enhancement, collagen stimulation, skin peeling, scar revision, dermabrasion, anti-aging, skin discoloration reduction, fine line improvement, exfoliation, and youth glow induction.
  • the cosmetic treatment method is carried out in combination with topical administration of at least one cosmetically active substance or composition.
  • the delivery of the at least one cosmetically active substance or composition is preferably enhanced by the projection of the ionized gas molecules and/or the activity of the at least one cosmetically active substance is enhanced by the projection of the ionized gas molecules.
  • cosmetically active substances are for instance vitamins and vitamin precursors, metal salts, moisturizing agents, lipids, fats or fatty acids, e.g. in liposomal form, peptides or polypeptides, amino acids.
  • the at least on cosmetically active substance is preferably selected from the group consisting of beta carotene and/or other carotenoids, selenium or a selenium salt, manganese or a manganese salt, one or more anti-oxidants, glutathione, coenzyme Q10, lipoic acid, one or more flavonoids, one or more phenolic compounds (such as phenolic compounds selected from Quercetin, one more catechins, resveratrol, coumaric acid, one or more anthocyanins, one or more polyphenols, and one or more phytoestrogens), one or more vitamins (e.g.
  • vitamin A selected from the group consisting of vitamin A, retinol, B3, vitamin C, vitamin E, and vitamin D
  • iron or an iron salt magnesium or a magnesium salt
  • one or more peptides including synthetic peptides, such as Matrixyl 3000®
  • one or more proteins one or more amino acids, one or more essential oils or fats, platelet-rich plasma (PRP), collagen, snail mucin, and hyaluronic acid.
  • PRP platelet-rich plasma
  • This aspect relates to ionized gas molecules for use in a method of therapeutic treatment of an area of the skin of a human, the method being selected from redness relief, sensitivity relief, acne reduction, sun damage and/or photo damage prevention or repair, antiinflammatory treatment of skin, treatment to ameliorate effects of laser treatment, treatment to ameliorate effects of cryolipolysis, and reduction in scar and pigmentation post-surgery, wherein the method comprises that ionized gas molecules are projected onto the area of the skin so as to establish an electric current, which is driven by the projection of the ionized gas molecules, in or over the area of the skin, wherein the human subject optionally has at least one discharge electrode attached to an area of the body remote from the surface area of the skin so as to sustain the electric current.
  • the method in question hence relates to a subset of the treatments detailed in the 1 st aspect of the invention as well as the embodiments thereof discussed above.
  • This aspect relates to a) a method for therapeutic treatment of a surface area of the skin of a human subject by topic application on the skin of an active drug substance or composition comprising said substance, the method comprising projection of ionized gas molecules onto the area of the skin so as to establish an electric current, which is driven by the projection of the ionized gas molecules, in or over the area of the skin, wherein the human subject optionally has at least one discharge electrode attached to an area of the body remote from the surface area of the skin so as to sustain the electric current, and wherein the projection of the ionized gas molecules enhances the uptake and/or the therapeutic effect of the administered active drug substance or composition, or b) a method for non-therapeutic cosmetic treatment of a surface area of the skin of a human subject by topic application on the skin of a cosmetically active substance or composition comprising said active substance, the method comprising projection of ionized gas molecules onto the area of the skin so as to establish an electric current, which is driven by the projection of the ionized gas molecules, in
  • the projection of the ionized gas can enhance the effects of a topically applied substance, be it a drug substance or a substance applied for cosmetic purposes.
  • the cosmetic substance can be any one of the cosmetic substances discussed above in the context of the first aspect of the invention.
  • the active drug substance is in the relevant cases selected from the group consisting of an antibiotic substance, an anti-inflammatory substance, a cytostatic or cytotoxic anti-cancer substance, a cytokine, a chemokine, a hormone, a receptor stimulant or activator, a receptor antagonist, a vasoactive substance, an analgesic, and an anaesthetic substance.
  • compositions therapeutic or cosmetic
  • a composition will typically be selected from the group consisting of a suspension, an o/w emulsion, a w/o emulsion, and a suspoemulsion.
  • the active principle or the composition can be in the form of or is incorporated in a delivery system selected from a cream, a foam, a gel, a lotion, an ointment, a paste, a powder, a shake lotion, a solid, a sponge, a tape, a tincture, a solution, and a transdermal patch.
  • the whole face was initially treated with a cleansing serum (In this case a "Deep Cleanser” from FUSION MESO) for 5 minutes, followed by a massage, all over the face, with a serum cocktail, containing octapeptides, pentapeptides and low-molecular weight hyaluronic acid (in this case FUSION F-BTX).
  • a cleansing serum In this case a "Deep Cleanser” from FUSION MESO
  • a serum cocktail containing octapeptides, pentapeptides and low-molecular weight hyaluronic acid (in this case FUSION F-BTX).
  • Microcurrent was applied with a Wetling W200 device (available i.a. from Wetling EU ApS in Denmark) for 10 min, only on the left side of the face.
  • the Device was adjusted to emit 1.5 pA without any light.
  • Electrostimulation as described in Rozhanets AR et al. 2010, Vopr Kurortol Fizioter Lech Fiz Kult. Jul-Aug;(4) :26-30. Russian. PMID: 21086592 and Paj ⁇ k et a/. Int J Environ Res Public Health. 2022 Jul 25; 19(15) :9055. doi: 10.3390/ijerphl9159055. PMID: 35897441, has shown promising effects in reducing wrinkle depth and rejuvenating aging skin. In the study by Rozhanets et al., the combined application of electric myo-stimulation and meso-therapy demonstrated significant improvements in age-related facial changes.
  • Electric myostimulation likely enhances muscle tone and circulation, contributing to a more youthful appearance.
  • Paj ⁇ k et a/. highlight the role of micro-needling in neck and cleavage rejuvenation, suggesting that it stimulates collagen production and enhances the penetration of skincare products.
  • these techniques are by the present inventors believed to target different aspects of skin aging, leading to comprehensive wrinkle reduction and skin rejuvenation.
  • Xu et al.'s study provides understanding on how electrical stimulation influences the skin surface, potentially promoting collagen synthesis, improving blood circulation, and stimulating nerve activity, all of which contribute to enhanced skin elasticity. Additionally, Tangerino Filho et al.'s investigation into microcurrent therapy suggests that electrical stimulation can have positive effects on tissue repair and regeneration, which may extend to enhancing the elasticity of the skin. Furthermore, Gerasimenko et al.'s (supra) discussion of electrostimulation after cheilorhinoplasty implies its potential role in promoting tissue healing and possibly aiding in skin elasticity enhancement. These findings collectively support that electrostimulation holds promise as a non-invasive method for improving skin elasticity, offering potential benefits for skin health and appearance.
  • electrostimulation may promote tissue repair and regeneration, which are essential aspects of anti-aging interventions.
  • electrostimulation is believed to contribute to the restoration of youthful skin characteristics, such as elasticity and firmness.
  • Zacarias et al.'s research on the association of Arnica montana L. with microcurrent in accelerating dermis reorganization implies that electrostimulation may facilitate the repair of skin lesions and the rejuvenation of aging skin.
  • electrostimulation may modulate skin functions and inflammatory processes relevant to acne pathogenesis. Through its potential to regulate sebum production, reduce inflammation, and promote tissue repair, electrostimulation could contribute to mitigating acne symptoms and promoting clearer skin, thus providing a sound basis for the application of the presently disclosed electrostimulation in acne treatment.
  • Sun damage and/or photo damage prevention or repair
  • electrostimulation By suppressing the activity of memory T cells, electrostimulation likely plays a role in dampening the inflammatory cascade associated with psoriasis and other inflammatory skin conditions. This supports that electrostimulation according to the present invention may have broader implications in managing inflammation in dermatological disorders beyond psoriasis.
  • microcurrent stimulation primarily investigates the effects of wireless microcurrent stimulation on improving blood flow in burn wounds, it has been realized by the present inventors that it indirectly hints at the potential of electrostimulation in mitigating laser damage.
  • Laser treatment particularly ablative and nonablative procedures, can induce tissue damage and inflammation in the skin.
  • microcurrent stimulation may have the potential to accelerate the healing process and mitigate the adverse effects of laser damage.
  • Enhanced blood flow facilitates the delivery of oxygen and nutrients to the affected area, supporting tissue regeneration and reducing inflammation. Therefore, while not directly addressing laser damage, the findings from Tsolakidis et al.'s study support that microcurrent stimulation according to the present invention could have implications for improving wound healing and tissue recovery, including in scenarios involving laser-induced damage to the skin.
  • micro-current stimulation demonstrates potential effects in promoting hair growth, both in vitro on human hair follicle- derived papilla cells and in an animal model. Hair loss, whether due to genetic factors, hormonal imbalances, or environmental influences, is a common concern for many individuals. Micro-current stimulation has emerged as a non-invasive and promising approach to addressing this issue.
  • micro-current stimulation may stimulate hair follicle activity, promote blood circulation, and enhance nutrient delivery to the hair follicles. These effects can potentially prolong the anagen (growth) phase of the hair cycle, resulting in thicker, denser hair growth over time.
  • the findings from Hwang et al.'s study have been found by the present inventors to suggest that micro-current stimulation according to the present invention holds promise as a hair loss treatment modality.
  • micro-current stimulation offers a potential non-pharmacological approach to combating hair loss. Additionally, its non-invasive nature and minimal side effects make it an attractive option for individuals seeking alternative hair restoration methods. Capability to facilitate drug delivery and/or efficacy
  • electroporation By inducing transient pores in cell membranes, electroporation enables the efficient uptake of therapeutic molecules, including drugs and nucleic acids, thereby enhancing their delivery and efficacy.
  • Guillet et al. (2017) introduce a hydrogel/carbon-nanotube needle- free device for electrostimulated skin drug delivery. This innovative approach leverages electrostimulation to facilitate the penetration of drugs through the skin barrier, offering a non-invasive and potentially more effective alternative to traditional drug delivery methods.
  • Gunathilake et al. (2020) explore electro-stimulated release of poorly water- soluble drugs from poly(lactic acid)/carboxymethyl cellulose/ZnO nanocomposite film.
  • micro-current stimulation according to the present invention has the potential to stimulate hair follicle- derived papilla cells and promote hair growth, demonstrating its therapeutic potential beyond traditional drug delivery applications.
  • a method for cosmetic treatment of a surface area of the skin of a human subject comprising projection of ionized gas molecules onto the area of the skin so as to establish an electric current, which is driven by the projection of the ionized gas molecules, in or over the area of the skin, wherein the human subject optionally has at least one discharge electrode attached to an area of the body remote from the surface area of the skin so as to sustain the electric current.
  • Treatment to ameliorate effects of laser treatment Treatment to ameliorate effects of cryolipolysis, and Reduction in scar and pigmentation post-surgery.
  • Beta carotene and/or other carotenoids Selenium or a selenium salt, Manganese or a manganese salt, One or more anti-oxidants, Glutathione, Coenzyme Q10, Lipoic acid, One or more flavonoids, One or more phenolic compounds, One or more vitamins, Iron or an iron salt, Magnesium or a magnesium salt, One or more peptides, including synthetic peptides, such as Matrixyl 3000, One or more proteins, One or more amino acids,
  • One or more essential oils or fats are one or more essential oils or fats,
  • Plant stem cells or other stem cells are Plant stem cells or other stem cells
  • the one or more phenolic compounds are selected from the group consisting of Quercetin, one more catechins, resveratrol, coumaric acid, one or more anthocyanins, one or more polyphenols, and one or more phytoestrogens.
  • Ionized gas molecules for use in a method of therapeutic treatment of an area of the skin of a human, the method being selected from
  • the method comprises that ionized gas molecules are projected onto the area of the skin so as to establish an electric current, which is driven by the projection of the ionized gas molecules, in or over the area of the skin, wherein the human subject optionally has at least one discharge electrode attached to an area of the body remote from the surface area of the skin so as to sustain the electric current.
  • a method for therapeutic treatment of a surface area of the skin of a human subject by topic application on the skin of an active drug substance or composition comprising said substance comprising projection of ionized gas molecules onto the area of the skin so as to establish an electric current, which is driven by the projection of the ionized gas molecules, in or over the area of the skin, wherein the human subject optionally has at least one discharge electrode attached to an area of the body remote from the surface area of the skin so as to sustain the electric current, and wherein the projection of the ionized gas molecules enhances the uptake and/or the therapeutic effect of the administered active drug substance or composition.
  • a method for non-therapeutic cosmetic treatment of a surface area of the skin of a human subject by topic application on the skin of a cosmetically active substance or composition comprising said active substance comprising projection of ionized gas molecules onto the area of the skin so as to establish an electric current, which is driven by the projection of the ionized gas molecules, in or over the area of the skin, wherein the human subject optionally has at least one discharge electrode attached to an area of the body remote from the surface area of the skin so as to sustain the electric current, and wherein the projection of the ionized gas molecules enhances the uptake and/or the cosmetic effect of the administered active cosmetic substance or composition.
  • E26 The method according to numbered embodiment E22 or the active drug substance or composition for the use according to numbered embodiment E25, wherein the active drug substance is selected from the group consisting of an antibiotic substance, an anti-inflammatory substance, a cytostatic or cytotoxic anti-cancer substance, a cytokine, a chemokine, a hormone, a receptor stimulant or activator, a receptor antagonist, a vasoactive substance, an analgesic, and an anaesthetic substance.
  • the active drug substance is selected from the group consisting of an antibiotic substance, an anti-inflammatory substance, a cytostatic or cytotoxic anti-cancer substance, a cytokine, a chemokine, a hormone, a receptor stimulant or activator, a receptor antagonist, a vasoactive substance, an analgesic, and an anaesthetic substance.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

Sont ici divulguées des méthodes de traitement de problèmes de la peau et des méthodes de traitement esthétique utilisant l'électrostimulation sans contact (ES) qui est utilisée en tant que moyen pour effectuer un rajeunissement de la peau ainsi que des améliorations générales et spécifiques de l'aspect de la peau. Dans des modes de réalisation préférés, l'électrostimulation est effectuée par application d'ions de gaz ionisé. Un autre mode de réalisation concerne la combinaison de l'électrostimulation sans contact et de l'administration topique de substances cosmétiques ou pharmaceutiques dont les effets sont augmentés par l'électrostimulation sans contact.
EP24719214.9A 2023-04-20 2024-04-22 Utilisation d'ions d'air chargés dans des traitements esthétiques Pending EP4698272A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP23169045 2023-04-20
PCT/EP2024/060921 WO2024218387A1 (fr) 2023-04-20 2024-04-22 Utilisation d'ions d'air chargés dans des traitements esthétiques

Publications (1)

Publication Number Publication Date
EP4698272A1 true EP4698272A1 (fr) 2026-02-25

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EP24719214.9A Pending EP4698272A1 (fr) 2023-04-20 2024-04-22 Utilisation d'ions d'air chargés dans des traitements esthétiques

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Country Link
EP (1) EP4698272A1 (fr)
CN (1) CN121240906A (fr)
WO (1) WO2024218387A1 (fr)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000010640A1 (fr) * 1998-08-19 2000-03-02 Gal-Ion Blaze Ltd. Procede et dispositif d'administration topique de substances
EP1800711A4 (fr) * 2004-09-07 2008-04-02 Yugen Kaisha Beauty Clinical Appareil cosmétique
WO2007042029A1 (fr) 2005-10-07 2007-04-19 Iolife International Limited Dispositif transmetteur d’ions
AU2009245742B2 (en) 2008-05-09 2014-06-19 Wetling IP TWIG Ltd. Ionized gas for medical treatment
WO2015052170A1 (fr) 2013-10-07 2015-04-16 Wetling Holding Aps Dispositif et méthode de traitement d'un site affecté par une pathologie chez un sujet
ITUB20160508A1 (it) * 2016-01-22 2017-07-22 Bios S R L Unipersonale Dispositivo a radiofrequenza per la lassità e il rimodellamento vaginale

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CN121240906A (zh) 2025-12-30

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