EP4702014A1 - Bifunktionelle verbindungen zum braf-abbau über ubiquitin-proteosom-signalweg - Google Patents
Bifunktionelle verbindungen zum braf-abbau über ubiquitin-proteosom-signalwegInfo
- Publication number
- EP4702014A1 EP4702014A1 EP24730823.2A EP24730823A EP4702014A1 EP 4702014 A1 EP4702014 A1 EP 4702014A1 EP 24730823 A EP24730823 A EP 24730823A EP 4702014 A1 EP4702014 A1 EP 4702014A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- fluorophenyl
- piperidin
- sulfonamide
- pyridin
- dioxopiperidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202363462918P | 2023-04-28 | 2023-04-28 | |
| PCT/US2024/026679 WO2024227104A1 (en) | 2023-04-28 | 2024-04-26 | Bifunctional compounds for degrading braf via ubiquitin proteosome pathway |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP4702014A1 true EP4702014A1 (de) | 2026-03-04 |
Family
ID=91376068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP24730823.2A Pending EP4702014A1 (de) | 2023-04-28 | 2024-04-26 | Bifunktionelle verbindungen zum braf-abbau über ubiquitin-proteosom-signalweg |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP4702014A1 (de) |
| JP (1) | JP2026517764A (de) |
| KR (1) | KR20260005915A (de) |
| CN (1) | CN121548574A (de) |
| AU (1) | AU2024260700A1 (de) |
| IL (1) | IL323616A (de) |
| MX (1) | MX2025012819A (de) |
| WO (1) | WO2024227104A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3867242A1 (de) | 2018-10-15 | 2021-08-25 | Nurix Therapeutics, Inc. | Bifunktionelle verbindungen zum abbau von btk über den ubiquitin-proteosom-signalweg |
| EP3924350A1 (de) | 2019-02-13 | 2021-12-22 | Nurix Therapeutics, Inc. | Bifunktionelle verbindungen zum abbau von btk über den ubiquitin-proteosom-signalweg |
| CA3160713A1 (en) | 2019-12-04 | 2021-06-10 | Nurix Therapeutics, Inc. | Bifunctional compounds for degrading btk via ubiquitin proteosome pathway |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112812109B (zh) * | 2019-11-18 | 2022-06-21 | 中国科学院微生物研究所 | 化合物DaP-01及其制备方法和应用 |
| EP4232023A4 (de) * | 2020-10-26 | 2025-11-12 | Dana Farber Cancer Inst Inc | Verbindungen zum gezielten proteinabbau von kinasen |
| MX2023012981A (es) * | 2021-05-03 | 2024-01-11 | Nurix Therapeutics Inc | Compuestos para inhibir o degradar proteinas objetivo, composiciones que los comprenden, metodos para su preparacion y metodos para usarlos. |
-
2024
- 2024-04-26 CN CN202480042362.9A patent/CN121548574A/zh active Pending
- 2024-04-26 WO PCT/US2024/026679 patent/WO2024227104A1/en not_active Ceased
- 2024-04-26 EP EP24730823.2A patent/EP4702014A1/de active Pending
- 2024-04-26 KR KR1020257037277A patent/KR20260005915A/ko active Pending
- 2024-04-26 JP JP2025563017A patent/JP2026517764A/ja active Pending
- 2024-04-26 AU AU2024260700A patent/AU2024260700A1/en active Pending
-
2025
- 2025-09-28 IL IL323616A patent/IL323616A/en unknown
- 2025-10-27 MX MX2025012819A patent/MX2025012819A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2024260700A1 (en) | 2025-11-13 |
| KR20260005915A (ko) | 2026-01-12 |
| MX2025012819A (es) | 2025-12-01 |
| CN121548574A (zh) | 2026-02-17 |
| IL323616A (en) | 2025-11-01 |
| JP2026517764A (ja) | 2026-06-02 |
| WO2024227104A1 (en) | 2024-10-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7741282B2 (ja) | ユビキチンプロテオソーム経路を介してbtkを分解するための二官能性化合物 | |
| JP7687970B2 (ja) | Irak分解剤およびその使用 | |
| EP4334302A1 (de) | Verbindungen zur hemmung oder zum abbau von zielproteinen, zusammensetzungen damit, verfahren zu ihrer herstellung und verfahren zu ihrer verwendung | |
| AU2022349569A1 (en) | Pyridine derivative and use thereof | |
| KR20230143632A (ko) | Irak 분해제 및 이의 용도 | |
| KR20220112273A (ko) | 유비퀴틴 프로테오솜 경로를 통해 btk를 분해하기 위한 이작용성 화합물 | |
| AU2024260700A1 (en) | Bifunctional compounds for degrading braf via ubiquitin proteosome pathway | |
| US20240279202A1 (en) | Compounds for inhibiting or degrading itk, compositions, comprising the same methods of their making and methods of their use | |
| TW201919640A (zh) | 作為rsv抑制劑的組合藥劑 | |
| CN107108561A (zh) | 用作irak抑制剂的杂芳基化合物及其用途 | |
| EP2809652B1 (de) | Isochinolin- und naphthyridinderivate | |
| CA3078579A1 (en) | Pyrimidine tbk/ikk.epsilon. inhibitor compounds and uses thereof | |
| CA3235182A1 (en) | Bifunctional compounds for degrading itk via ubiquitin proteosome pathway | |
| OA21863A (en) | Indazole based compounds and associated methods of use. | |
| HK40081936A (en) | Bifunctional compounds for degrading btk via ubiquitin proteosome pathway | |
| HK1242303B (en) | Heteroaryl compounds as irak inhibitors and uses thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: UNKNOWN |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
| 17P | Request for examination filed |
Effective date: 20250930 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
| DAV | Request for validation of the european patent (deleted) | ||
| DAX | Request for extension of the european patent (deleted) |