EP4713016A2 - Véhicule d'administration pour une administration ciblée à des cardiomyocytes - Google Patents

Véhicule d'administration pour une administration ciblée à des cardiomyocytes

Info

Publication number
EP4713016A2
EP4713016A2 EP24808012.9A EP24808012A EP4713016A2 EP 4713016 A2 EP4713016 A2 EP 4713016A2 EP 24808012 A EP24808012 A EP 24808012A EP 4713016 A2 EP4713016 A2 EP 4713016A2
Authority
EP
European Patent Office
Prior art keywords
lipid
disorder
disease
clnp
another embodiment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24808012.9A
Other languages
German (de)
English (en)
Inventor
Drew Weissman
Vladimir Muzykantov
Vladimir SHUVAEV
Ying K. Tam
Paulo Jia Ching LIN
Barbara Mui
Sean Semple
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Acuitas Therapeutics Inc
University of Pennsylvania Penn
Original Assignee
Acuitas Therapeutics Inc
University of Pennsylvania Penn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acuitas Therapeutics Inc, University of Pennsylvania Penn filed Critical Acuitas Therapeutics Inc
Publication of EP4713016A2 publication Critical patent/EP4713016A2/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne des compositions et des procédés pour l'administration efficace d'un agent thérapeutique à un cardiomyocyte. L'invention concerne également des procédés d'utilisation des procédés d'administration de l'invention pour le traitement de maladies et de troubles, comprenant le traitement de maladies et de troubles cardiaques.
EP24808012.9A 2023-05-15 2024-05-15 Véhicule d'administration pour une administration ciblée à des cardiomyocytes Pending EP4713016A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363502152P 2023-05-15 2023-05-15
PCT/US2024/029468 WO2024238658A2 (fr) 2023-05-15 2024-05-15 Véhicule d'administration pour une administration ciblée à des cardiomyocytes

Publications (1)

Publication Number Publication Date
EP4713016A2 true EP4713016A2 (fr) 2026-03-25

Family

ID=93520274

Family Applications (1)

Application Number Title Priority Date Filing Date
EP24808012.9A Pending EP4713016A2 (fr) 2023-05-15 2024-05-15 Véhicule d'administration pour une administration ciblée à des cardiomyocytes

Country Status (2)

Country Link
EP (1) EP4713016A2 (fr)
WO (1) WO2024238658A2 (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022081702A1 (fr) * 2020-10-13 2022-04-21 The Trustees Of The University Of Pennsylvania Ciblage in vivo de lymphocytes t cd4+ pour thérapeutique fondée sur l'arnm
JP2024503441A (ja) * 2021-01-20 2024-01-25 ビーム セラピューティクス インク． イオン化可能な脂質を含むナノ材料

Also Published As

Publication number Publication date
WO2024238658A3 (fr) 2024-12-26
WO2024238658A2 (fr) 2024-11-21

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