EP4713321A1 - Protac pour la dégradation de la protéine ask1 : préparation et utilisation associées - Google Patents

Protac pour la dégradation de la protéine ask1 : préparation et utilisation associées

Info

Publication number
EP4713321A1
EP4713321A1 EP24806801.7A EP24806801A EP4713321A1 EP 4713321 A1 EP4713321 A1 EP 4713321A1 EP 24806801 A EP24806801 A EP 24806801A EP 4713321 A1 EP4713321 A1 EP 4713321A1
Authority
EP
European Patent Office
Prior art keywords
compound
reaction mixture
carbamoyl
difluoro
triazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24806801.7A
Other languages
German (de)
English (en)
Inventor
Arindam Talukdar
Himadri Sekhar SARKAR
Partha Chakrabarti
Israful HOQUE
Abhishek Sen
Uddipta Ghosh DASTIDAR
Anindita DEY
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Council of Scientific and Industrial Research CSIR
Original Assignee
Council of Scientific and Industrial Research CSIR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Council of Scientific and Industrial Research CSIR filed Critical Council of Scientific and Industrial Research CSIR
Publication of EP4713321A1 publication Critical patent/EP4713321A1/fr
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne la préparation de composés de triazole-5-yl(pyridine-2-yl)benzamides substitués, ayant la structure I, sous forme libre ou sous forme de sel acceptable pour la dégradation ciblée de la kinase 1 régulant le signal d'apoptose (ASK 1) en tant que cible thérapeutique potentielle pour améliorer l'hépatopathie stéatosique non alcoolique (NAFLD)/la stéatohépatite non alcoolique (NASH). Plus particulièrement, l'invention concerne de petites molécules, R1, R2 et R3 étant tels que définis dans la description, aptes à une dégradation ciblée de ASK1, qui peuvent finalement être utilisées pour obtenir une santé humaine améliorée chez des patients atteints de fibrose hépatique. La présente invention représente le repère de cette technologie PROTAC pour une protéine cible thérapeutique potentielle ASK1 et apportera une percée dans la recherche NAFLD/NASH.
EP24806801.7A 2023-05-18 2024-05-13 Protac pour la dégradation de la protéine ask1 : préparation et utilisation associées Pending EP4713321A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN202311034982 2023-05-18
PCT/IN2024/050526 WO2024236595A1 (fr) 2023-05-18 2024-05-13 Protac pour la dégradation de la protéine ask1 : préparation et utilisation associées

Publications (1)

Publication Number Publication Date
EP4713321A1 true EP4713321A1 (fr) 2026-03-25

Family

ID=93518818

Family Applications (1)

Application Number Title Priority Date Filing Date
EP24806801.7A Pending EP4713321A1 (fr) 2023-05-18 2024-05-13 Protac pour la dégradation de la protéine ask1 : préparation et utilisation associées

Country Status (2)

Country Link
EP (1) EP4713321A1 (fr)
WO (1) WO2024236595A1 (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY34573A (es) * 2012-01-27 2013-06-28 Gilead Sciences Inc Inhibidor de la quinasa que regula la señal de la apoptosis
WO2019126731A1 (fr) * 2017-12-22 2019-06-27 Petra Pharma Corporation Dérivés d'aminopyridine utilisés en tant qu'inhibiteurs de la phosphatidylinositol phosphate kinase

Also Published As

Publication number Publication date
WO2024236595A1 (fr) 2024-11-21

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