EP4716528A1 - Préparation de nanoparticules de tolérance pour le traitement de la cholangite biliaire primitive - Google Patents

Préparation de nanoparticules de tolérance pour le traitement de la cholangite biliaire primitive

Info

Publication number
EP4716528A1
EP4716528A1 EP24734630.7A EP24734630A EP4716528A1 EP 4716528 A1 EP4716528 A1 EP 4716528A1 EP 24734630 A EP24734630 A EP 24734630A EP 4716528 A1 EP4716528 A1 EP 4716528A1
Authority
EP
European Patent Office
Prior art keywords
acid
pbc
particles
various embodiments
hydroxide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24734630.7A
Other languages
German (de)
English (en)
Inventor
Adam ELHOFY
Tushar MURTHY
Michael Boyne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cour Pharmaceuticals Development Co Inc
Original Assignee
Cour Pharmaceuticals Development Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cour Pharmaceuticals Development Co Inc filed Critical Cour Pharmaceuticals Development Co Inc
Publication of EP4716528A1 publication Critical patent/EP4716528A1/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6093—Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)

Abstract

La présente divulgation concerne un procédé de préparation de nanoparticules de modification immunitaire de tolérance encapsulant des antigènes associés à une cholangite biliaire primitive (PBC), des compositions comprenant les particules et leur utilisation pour le traitement de PBC.
EP24734630.7A 2023-05-23 2024-05-23 Préparation de nanoparticules de tolérance pour le traitement de la cholangite biliaire primitive Pending EP4716528A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363503771P 2023-05-23 2023-05-23
PCT/US2024/030775 WO2024243410A1 (fr) 2023-05-23 2024-05-23 Préparation de nanoparticules de tolérance pour le traitement de la cholangite biliaire primitive

Publications (1)

Publication Number Publication Date
EP4716528A1 true EP4716528A1 (fr) 2026-04-01

Family

ID=91585468

Family Applications (1)

Application Number Title Priority Date Filing Date
EP24734630.7A Pending EP4716528A1 (fr) 2023-05-23 2024-05-23 Préparation de nanoparticules de tolérance pour le traitement de la cholangite biliaire primitive

Country Status (9)

Country Link
EP (1) EP4716528A1 (fr)
KR (1) KR20260016937A (fr)
CN (1) CN121511079A (fr)
AR (1) AR132762A1 (fr)
AU (1) AU2024275807A1 (fr)
IL (1) IL324795A (fr)
MX (1) MX2025013817A (fr)
TW (1) TW202508618A (fr)
WO (1) WO2024243410A1 (fr)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2389613A1 (fr) * 1999-11-19 2001-05-25 Zycos Inc. Procede a debit continu permettant de produire des microparticules
CA2876495C (fr) 2012-06-21 2023-10-17 Northwestern University Particules conjuguees a des peptides
CN105555301B (zh) 2013-08-13 2021-04-16 西北大学 肽缀合颗粒
EP3393514A4 (fr) 2015-12-23 2019-08-14 Cour Pharmaceuticals Development Company Inc. Particules conjuguées par covalence de type polymère-antigène
JP6904959B2 (ja) 2016-01-04 2021-07-21 クール ファーマシューティカルズ ディベロップメント カンパニー インコーポレイテッド 結合エピトープを含有する融合タンパク質を封入する粒子
CA3015074C (fr) * 2016-02-18 2024-05-28 Cour Pharmaceuticals Development Company, Inc. Procede de preparation de particules immunomodulatrices induisant une tolerance
AU2022371668A1 (en) * 2021-10-21 2024-05-09 Cour Pharmaceuticals Development Company Inc. Treatment of primary biliary cholangitis (pbc) with tolerizing nanoparticles

Also Published As

Publication number Publication date
TW202508618A (zh) 2025-03-01
KR20260016937A (ko) 2026-02-04
CN121511079A (zh) 2026-02-10
IL324795A (en) 2026-01-01
MX2025013817A (es) 2026-01-07
WO2024243410A1 (fr) 2024-11-28
AR132762A1 (es) 2025-07-30
AU2024275807A1 (en) 2025-12-11

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