EP4716530A2 - Nouvelle composition pour le traitement de troubles inflammatoires - Google Patents

Nouvelle composition pour le traitement de troubles inflammatoires

Info

Publication number
EP4716530A2
EP4716530A2 EP24810574.4A EP24810574A EP4716530A2 EP 4716530 A2 EP4716530 A2 EP 4716530A2 EP 24810574 A EP24810574 A EP 24810574A EP 4716530 A2 EP4716530 A2 EP 4716530A2
Authority
EP
European Patent Office
Prior art keywords
acid
disease
inflammatory
dfo
metal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24810574.4A
Other languages
German (de)
English (en)
Inventor
Vladimir Vinokur
Dror CHEVION
Itzchak Angel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP4716530A2 publication Critical patent/EP4716530A2/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/315—Zinc compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)

Abstract

Sont divulguées dans la description des compositions comprenant des complexes de déféroxamine (tels que DFO B) avec au moins un métal, par exemple avec Zn2+ ou Ga3+ ou de l'argent ou de l'or ou toute combinaison associée, et un tensioactif non ionique hydrophile comprenant du polyéthylène glycol (PEG) et un copolymère triséquencé non ionique comprenant des poloxamères. Le tensioactif peut en outre comprendre des copolymères triséquencés non ioniques composés d'une chaîne hydrophobe centrale de polyoxypropylène (poly(oxyde de propylène)) flanquée de deux chaînes hydrophiles de polyoxyéthylène (poly(oxyde d'éthylène)). Sont également divulgués des procédures pour la préparation des complexes et des compositions pharmaceutiques comprenant lesdits complexes ou toute combinaison desdits complexes, ainsi que des procédés utilisant les compositions et les complexes divulgués dans la modulation de niveaux de cytokine chez un sujet, et ainsi dans le traitement de troubles inflammatoires.
EP24810574.4A 2023-05-22 2024-05-22 Nouvelle composition pour le traitement de troubles inflammatoires Pending EP4716530A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363468018P 2023-05-22 2023-05-22
PCT/IB2024/054991 WO2024241250A2 (fr) 2023-05-22 2024-05-22 Nouvelle composition pour le traitement de troubles inflammatoires

Publications (1)

Publication Number Publication Date
EP4716530A2 true EP4716530A2 (fr) 2026-04-01

Family

ID=93590398

Family Applications (1)

Application Number Title Priority Date Filing Date
EP24810574.4A Pending EP4716530A2 (fr) 2023-05-22 2024-05-22 Nouvelle composition pour le traitement de troubles inflammatoires

Country Status (7)

Country Link
EP (1) EP4716530A2 (fr)
KR (1) KR20260015873A (fr)
CN (1) CN121793956A (fr)
AU (1) AU2024275726A1 (fr)
IL (1) IL324797A (fr)
MX (1) MX2025013957A (fr)
WO (1) WO2024241250A2 (fr)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2008013405A (es) * 2006-04-18 2009-03-09 Ekr Therapeutics Inc Composiciones farmaceuticas premezcladas listas para uso.
EP2467135B1 (fr) * 2009-08-19 2017-02-01 Mordechai Chevion Complexes desferrioxamine-métal pour le traitement de troubles liés à l'immunité
CA2971824A1 (fr) * 2014-12-22 2016-06-30 Mordechai Chevion Nouveaux complexes metalliques de nocardamine et leur utilisation dans des compositions pharmaceutiques

Also Published As

Publication number Publication date
WO2024241250A2 (fr) 2024-11-28
IL324797A (en) 2026-01-01
MX2025013957A (es) 2026-03-02
AU2024275726A1 (en) 2025-12-11
CN121793956A (zh) 2026-04-03
KR20260015873A (ko) 2026-02-03
WO2024241250A3 (fr) 2025-01-02

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