EP4716534A1 - Formulation d'analogue de nicotine synthétique pour le remplacement et l'amplification de nicotine - Google Patents

Formulation d'analogue de nicotine synthétique pour le remplacement et l'amplification de nicotine

Info

Publication number
EP4716534A1
EP4716534A1 EP24733434.5A EP24733434A EP4716534A1 EP 4716534 A1 EP4716534 A1 EP 4716534A1 EP 24733434 A EP24733434 A EP 24733434A EP 4716534 A1 EP4716534 A1 EP 4716534A1
Authority
EP
European Patent Office
Prior art keywords
nicotine
methylnicotine
synthetic
analogue
delivery systems
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24733434.5A
Other languages
German (de)
English (en)
Inventor
Michael KRIZNIC
Samuel BENAIM
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kriznic Michael Purple Sky LLC
Purple Sky LLC
Original Assignee
Kriznic Michael Purple Sky LLC
Purple Sky LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kriznic Michael Purple Sky LLC, Purple Sky LLC filed Critical Kriznic Michael Purple Sky LLC
Publication of EP4716534A1 publication Critical patent/EP4716534A1/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B13/00—Tobacco for pipes, for cigars, e.g. cigar inserts, or for cigarettes; Chewing tobacco; Snuff
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES OF CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
    • A24D1/00—Cigars; Cigarettes
    • A24D1/20—Cigarettes specially adapted for simulated smoking devices

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un remplacement de nicotine synthétique pour divers systèmes de distribution, en particulier pour une utilisation dans des systèmes de distribution de nicotine électroniques, par exemple, des vaporisateurs, des cigarettes électroniques, une combustion, des produits à base de tabac chauffé, des systèmes d'administration orale ou nasale de nicotine. La (S)-6-Méthylnicotine, également connue sous le nom de (S)-2-méthyl-5-(1-méthylpyrrolidin-2-yl)pyridine, est un dérivé de nicotine avec une substitution méthyle en position 6 du cycle pyridine. Des données empiriques préliminaires indiquent que (S)-6-Méthylnicotine est d'environ 4 à 5 fois plus puissante que la nicotine par unité de masse, et peut être à action plus rapide, fournissant une solution plus efficace pour gérer ou satisfaire les envies de nicotine. Des sels de carboxylate de celle-ci sont également appropriés. Cette résistance accrue permet à des individus de ressentir un soulagement des envies de nicotine de manière plus rapide et efficace, à l'aide de dosages beaucoup plus faibles, et induit une sensation de satisfaction subjective qui satisfait les envies. En plus d'autres avantages potentiels, cette puissance pharmacologique accrue permet l'utilisation d'une quantité réduite de principe actif par comparaison avec des formulations de nicotine synthétiques.
EP24733434.5A 2023-05-23 2024-05-22 Formulation d'analogue de nicotine synthétique pour le remplacement et l'amplification de nicotine Pending EP4716534A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202363468349P 2023-05-23 2023-05-23
US202363468351P 2023-05-23 2023-05-23
US202363468343P 2023-05-23 2023-05-23
PCT/US2024/030538 WO2024243290A1 (fr) 2023-05-23 2024-05-22 Formulation d'analogue de nicotine synthétique pour le remplacement et l'amplification de nicotine

Publications (1)

Publication Number Publication Date
EP4716534A1 true EP4716534A1 (fr) 2026-04-01

Family

ID=91580771

Family Applications (1)

Application Number Title Priority Date Filing Date
EP24733434.5A Pending EP4716534A1 (fr) 2023-05-23 2024-05-22 Formulation d'analogue de nicotine synthétique pour le remplacement et l'amplification de nicotine

Country Status (5)

Country Link
EP (1) EP4716534A1 (fr)
CN (1) CN121729230A (fr)
AU (1) AU2024274804A1 (fr)
MX (1) MX2025013818A (fr)
WO (1) WO2024243290A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20250241354A1 (en) * 2024-01-17 2025-07-31 Rai Strategic Holdings, Inc. Oral products
WO2025213000A1 (fr) * 2024-04-05 2025-10-09 ODS Products, LLC Poches comprenant des principes actifs

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012031220A2 (fr) * 2010-09-03 2012-03-08 University Of Florida Research Foundation, Inc. Composés de nicotine et leurs analogues, procédés de synthèse pour fabriquer les composés et procédés d'utilisation
WO2017117575A1 (fr) * 2015-12-30 2017-07-06 Next Generation Labs, LLC Produits de substitution de la nicotine comprenant une nicotine de synthèse
CN110384700A (zh) * 2019-09-03 2019-10-29 云南喜科科技有限公司 一种合成尼古丁的组合物
CN114437025B (zh) 2020-11-05 2023-08-25 上海零诺生物科技有限公司 消旋6-甲基烟碱及其制备方法、以及应用
CN114437031B (zh) * 2022-02-16 2023-06-27 深圳市真味生物科技有限公司 一种6-甲基尼古丁的合成方法

Also Published As

Publication number Publication date
WO2024243290A1 (fr) 2024-11-28
AU2024274804A1 (en) 2026-01-15
CN121729230A (zh) 2026-03-24
MX2025013818A (es) 2026-03-02

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