EP4719457A2 - Fusionierte il10-polypeptide - Google Patents

Fusionierte il10-polypeptide

Info

Publication number
EP4719457A2
EP4719457A2 EP24816600.1A EP24816600A EP4719457A2 EP 4719457 A2 EP4719457 A2 EP 4719457A2 EP 24816600 A EP24816600 A EP 24816600A EP 4719457 A2 EP4719457 A2 EP 4719457A2
Authority
EP
European Patent Office
Prior art keywords
polypeptide
hil10
fused
amino acid
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24816600.1A
Other languages
English (en)
French (fr)
Inventor
Andrew Morin
Mahalakshmi RAMADASS
Tatjana PETOJEVIC
Bhargavi JAYARAMAN
Sandro VIVONA
Patrick Lupardus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthekine Inc
Original Assignee
Synthekine Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthekine Inc filed Critical Synthekine Inc
Publication of EP4719457A2 publication Critical patent/EP4719457A2/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5428—IL-10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
EP24816600.1A 2023-06-02 2024-05-31 Fusionierte il10-polypeptide Pending EP4719457A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363506000P 2023-06-02 2023-06-02
PCT/US2024/032054 WO2024249898A2 (en) 2023-06-02 2024-05-31 Fused il10 polypeptides

Publications (1)

Publication Number Publication Date
EP4719457A2 true EP4719457A2 (de) 2026-04-08

Family

ID=93658529

Family Applications (1)

Application Number Title Priority Date Filing Date
EP24816600.1A Pending EP4719457A2 (de) 2023-06-02 2024-05-31 Fusionierte il10-polypeptide

Country Status (8)

Country Link
EP (1) EP4719457A2 (de)
KR (1) KR20260034078A (de)
CN (1) CN121620382A (de)
AU (1) AU2024282178A1 (de)
IL (1) IL324786A (de)
MX (1) MX2025014405A (de)
TW (1) TW202502807A (de)
WO (1) WO2024249898A2 (de)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030186386A1 (en) * 2000-02-11 2003-10-02 Hansen Christian Karsten Interleukin 10
WO2015117930A1 (en) * 2014-02-06 2015-08-13 F. Hoffmann-La Roche Ag Interleukine 10 immunoconjugates
WO2015175957A1 (en) * 2014-05-16 2015-11-19 Baylor Research Institute Methods and compositions for treating autoimmune and inflammatory conditions
WO2018005226A2 (en) * 2016-06-22 2018-01-04 Alkermes, Inc. Compositions and methods for modulating il-10 immunostimulatory and anti-inflammatory properties
EP3927728A2 (de) * 2019-02-21 2021-12-29 Xencor, Inc. Ungezielte und zielgerichtete il-10-fc-fusionsproteine

Also Published As

Publication number Publication date
CN121620382A (zh) 2026-03-06
TW202502807A (zh) 2025-01-16
WO2024249898A3 (en) 2025-03-06
KR20260034078A (ko) 2026-03-10
MX2025014405A (es) 2026-03-02
AU2024282178A1 (en) 2025-11-27
WO2024249898A2 (en) 2024-12-05
IL324786A (en) 2026-01-01

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