EP4720162A1 - Oligo(imidazolium) cationique à chaîne principale formant du carbène n-hétérocyclique pour tuer efficacement des bactéries dans un environnement complexe - Google Patents

Oligo(imidazolium) cationique à chaîne principale formant du carbène n-hétérocyclique pour tuer efficacement des bactéries dans un environnement complexe

Info

Publication number
EP4720162A1
EP4720162A1 EP24816028.5A EP24816028A EP4720162A1 EP 4720162 A1 EP4720162 A1 EP 4720162A1 EP 24816028 A EP24816028 A EP 24816028A EP 4720162 A1 EP4720162 A1 EP 4720162A1
Authority
EP
European Patent Office
Prior art keywords
oim1
compound
nmr
mmol
oim
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24816028.5A
Other languages
German (de)
English (en)
Inventor
Bee Eng Mary Chan
Kevin Pethe
Angelika GRÜNDLING
Chong Hui KOH
Mallikharjuna Rao LAMBU
Zhi Yuan KOK
Guangmin WEI
Madhu Babu TATINA
Paula Hammond Cunningham
Kaixi ZHANG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ip2ipo Innovations Ltd
Nanyang Technological University
Massachusetts Institute of Technology
Original Assignee
Imperial College Innovations Ltd
Nanyang Technological University
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial College Innovations Ltd, Nanyang Technological University, Massachusetts Institute of Technology filed Critical Imperial College Innovations Ltd
Publication of EP4720162A1 publication Critical patent/EP4720162A1/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P3/00—Fungicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L79/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing nitrogen with or without oxygen or carbon only, not provided for in groups C08L61/00 - C08L77/00
    • C08L79/04—Polycondensates having nitrogen-containing heterocyclic rings in the main chain; Polyhydrazides; Polyamide acids or similar polyimide precursors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
    • C08G73/0605—Polycondensates containing five-membered rings, not condensed with other rings, with nitrogen atoms as the only ring hetero atoms
    • C08G73/0616—Polycondensates containing five-membered rings, not condensed with other rings, with nitrogen atoms as the only ring hetero atoms with only two nitrogen atoms in the ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Environmental Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Agronomy & Crop Science (AREA)
  • Polymers & Plastics (AREA)
  • Birds (AREA)
  • Dentistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente divulgation concerne un composé selon la formule Ia : La présente divulgation concerne également une composition pharmaceutique comprenant le composé tel que mentionné ci-dessus, l'utilisation du composé tel que mentionné ci-dessus, une méthode de traitement d'une infection microbienne et/ou d'une infection fongique comprenant l'étape d'administration d'une quantité pharmaceutiquement efficace du composé tel que mentionné ci-dessus ou de la composition pharmaceutique telle que mentionnée ci-dessus, et une composition détergente antimicrobienne et/ou antifongique comprenant le composé tel que mentionné ci-dessus, et un tensioactif.
EP24816028.5A 2023-06-01 2024-06-03 Oligo(imidazolium) cationique à chaîne principale formant du carbène n-hétérocyclique pour tuer efficacement des bactéries dans un environnement complexe Pending EP4720162A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SG10202301554P 2023-06-01
PCT/SG2024/050366 WO2024248739A1 (fr) 2023-06-01 2024-06-03 Oligo(imidazolium) cationique à chaîne principale formant du carbène n-hétérocyclique pour tuer efficacement des bactéries dans un environnement complexe

Publications (1)

Publication Number Publication Date
EP4720162A1 true EP4720162A1 (fr) 2026-04-08

Family

ID=93658745

Family Applications (1)

Application Number Title Priority Date Filing Date
EP24816028.5A Pending EP4720162A1 (fr) 2023-06-01 2024-06-03 Oligo(imidazolium) cationique à chaîne principale formant du carbène n-hétérocyclique pour tuer efficacement des bactéries dans un environnement complexe

Country Status (3)

Country Link
EP (1) EP4720162A1 (fr)
CN (1) CN121866291A (fr)
WO (1) WO2024248739A1 (fr)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2773991B1 (fr) * 1998-01-26 2000-05-26 Oreal Utilisation a titre d'agent protecteur des fibres keratiniques de polymeres de polyammonium quaternaire heterocyclique et compositions cosmetiques
WO2019004940A1 (fr) * 2017-06-30 2019-01-03 Agency For Science, Technology And Research Oligomère d'imidazolium dégradable et polymère pour applications antimicrobiennes
US20230131111A1 (en) * 2020-05-26 2023-04-27 Nanyang Technological University Biodegradable polyimidazoliums and oligoimidazoliums

Also Published As

Publication number Publication date
WO2024248739A1 (fr) 2024-12-05
CN121866291A (zh) 2026-04-14

Similar Documents

Publication Publication Date Title
JP7203385B2 (ja) 抗菌性ポリ（アルキル化イミダゾリウム）塩
US7087632B2 (en) Benzimidazole derivatives as therapeutic agents
US12325678B2 (en) Anti-fungals compounds targeting the synthesis of fungal sphingolipids
CN115836103B (zh) 可生物降解的聚咪唑鎓和低聚咪唑鎓
EA020466B1 (ru) Агонисты гуанилатциклазы, пригодные для лечения желудочно-кишечных нарушений, воспаления, рака и других заболеваний
US11707442B2 (en) Antibacterial and antifungal compounds
RU2694624C2 (ru) Производные пирролидинона в качестве ингибиторов метар-2
EP3600286B1 (fr) Composés et procédés pour le traitement de maladies parasitaires
CN114599371A (zh) 作为癌症靶向药物载体的磷脂醚缀合物
Murcia-Galán et al. Antifungal activity of Co (II) and Cu (II) complexes containing 1, 3-bis (benzotriazol-1-yl)-propan-2-ol on the growth and virulence traits of fluconazole-resistant Candida species: synthesis, DFT calculations, and biological activity
Koh et al. Carbene formation as a mechanism for efficient intracellular uptake of cationic antimicrobial carbon acid polymers
CA3186027A1 (fr) Composes capables de se lier a des proteines et conjugues obtenus a partir de ces composes
WO2024248739A1 (fr) Oligo(imidazolium) cationique à chaîne principale formant du carbène n-hétérocyclique pour tuer efficacement des bactéries dans un environnement complexe
EP3013812B1 (fr) Agonistes opioïdes kappa et leurs utilisations
EP4038052B1 (fr) Antagonistes du récepteur ep4 prostaglandine e2 (pge2)
CN113166084A (zh) 用于治疗细菌感染的茚满衍生物
EP3572411A1 (fr) Dérivés de thiazole comme inhibiteurs de métallo-bêta-lactamases
US20240246920A1 (en) Triazole derivatives with antifungal activity
CN116836083A (zh) 丙氨酸及脯氨酸氨基酸的功能性衍生物化合物及包含其的药学组合物
EP1937257B1 (fr) Antibiotiques innovants comprenant des dérivés de bis(1-aryl-5-tétrazolyl) méthane
EP3230259A1 (fr) Anti-fongiques ciblant la synthèse de shingolipides fongiques
HK40076200B (en) Prostaglandin e2 (pge2) ep4 receptor antagonists
HK40076200A (en) Prostaglandin e2 (pge2) ep4 receptor antagonists
HK40015340B (en) Compounds and methods for the treatment of parasitic diseases
HK40015340A (en) Compounds and methods for the treatment of parasitic diseases

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20251217

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR