EP4720681A1 - Détection d'antigènes - Google Patents

Détection d'antigènes

Info

Publication number
EP4720681A1
EP4720681A1 EP24730207.8A EP24730207A EP4720681A1 EP 4720681 A1 EP4720681 A1 EP 4720681A1 EP 24730207 A EP24730207 A EP 24730207A EP 4720681 A1 EP4720681 A1 EP 4720681A1
Authority
EP
European Patent Office
Prior art keywords
antibody
target
sample
detection
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24730207.8A
Other languages
German (de)
English (en)
Inventor
Michael Stockton
Mark Hooper
Michael Hausmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Qbd Qs Ip Ltd
Original Assignee
Qbd Qs Ip Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Qbd Qs Ip Ltd filed Critical Qbd Qs Ip Ltd
Publication of EP4720681A1 publication Critical patent/EP4720681A1/fr
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5761—Hepatitis B
    • G01N33/5764—Hepatitis B surface antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—DNA viruses
    • C07K16/082—Hepadnaviridae (F), e.g. hepatitis B virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne des dosages immunologiques d'une sensibilité exceptionnelle pour la détection d'antigènes cibles dans des échantillons. Dans un apprentissage, les étapes de capture et de détection relatives à ces dosages font appel à des anticorps recombinants. Les dosages immunologiques décrits peuvent trouver une application particulière dans la détection d'antigènes du VHB.
EP24730207.8A 2023-05-26 2024-05-24 Détection d'antigènes Pending EP4720681A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB2307938.7A GB202307938D0 (en) 2023-05-26 2023-05-26 Antigen detection
PCT/EP2024/064448 WO2024245965A1 (fr) 2023-05-26 2024-05-24 Détection d'antigènes

Publications (1)

Publication Number Publication Date
EP4720681A1 true EP4720681A1 (fr) 2026-04-08

Family

ID=87060949

Family Applications (1)

Application Number Title Priority Date Filing Date
EP24730207.8A Pending EP4720681A1 (fr) 2023-05-26 2024-05-24 Détection d'antigènes

Country Status (5)

Country Link
EP (1) EP4720681A1 (fr)
CN (1) CN121336112A (fr)
AU (1) AU2024283078A1 (fr)
GB (1) GB202307938D0 (fr)
WO (1) WO2024245965A1 (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2569561C (fr) * 2004-06-07 2014-08-12 Chiron Corporation Anticorps monoclonaux de lapin vis-a-vis des antigenes de surface de l'hepatite b et procedes d'utilisation
CN101762701A (zh) * 2009-06-24 2010-06-30 北京科美东雅生物技术有限公司 一种检测乙肝表面抗原的磁性免疫层析试纸条及其制备方法

Also Published As

Publication number Publication date
CN121336112A (zh) 2026-01-13
AU2024283078A1 (en) 2026-01-08
GB202307938D0 (en) 2023-07-12
WO2024245965A1 (fr) 2024-12-05

Similar Documents

Publication Publication Date Title
JP4931962B2 (ja) 抗ｈｃｖコア蛋白質モノクローナル抗体
EP0158973B1 (fr) Essai immunométrique multisite
US12399176B2 (en) Methods for reducing interferences
TWI809010B (zh) Ｂ型肝炎病毒ｓ抗原之測定方法及測定套組
CN117720650B (zh) 抗人呼吸道合胞病毒抗体及其应用
WO2022265066A1 (fr) Procédé de dosage immunologique du sars-cov-2 et kit de dosage immunologique
KR102390761B1 (ko) HBsAg의 정량적 검출을 위한 키트 및 방법
CN104126124A (zh) 用于慢性hbv患者的反应预测和疗法监测的hbv免疫复合物
US6489131B1 (en) Interference reduction by rheumatoid factors
CN117683121A (zh) 抗水痘-带状疱疹病毒抗体及其应用
EP1752768A1 (fr) Procede de detection du virus de l'hepatite b
JP4346798B2 (ja) Ｈｃｖコア抗原の検出または定量方法およびそれに用いる検出または定量試薬。
JP7141405B2 (ja) 検体検出イムノアッセイ
WO2022023461A1 (fr) Épitope amélioré pour la détection et/ou la quantification d'auto-anticorps contre l'alpha-fœtoprotéine
WO2019075109A1 (fr) Biomarqueurs dans une maladie hépatique auto-immune
EP4720681A1 (fr) Détection d'antigènes
JP2020506395A5 (fr)
CN118043666A (zh) 对定量药物和靶标浓度的测定
CN113196057B (zh) 病毒性肝癌的检测方法
CN101606066A (zh) 乙型肝炎病毒表面抗原的分析方法
US12442821B2 (en) Kit of in vitro quantifying large surface protein of hepatitis B virus (HBV), biomarker set for analyzing phases of HBV infection and hepatoma prognosis, and set of monoclonal antibodies for predicting, diagnosing or treating chronic liver disease
WO2025096611A1 (fr) Compositions de réactifs pour dosages immunologiques et leur utilisation dans la détection d'antigène cancéreux 19-9
JP2001116751A (ja) 新規な免疫複合体転移測定法
AU2004290800A1 (en) Methods and means relating to hepatitis B infection
HK1099361A1 (zh) 联合检测hbv前s1抗原和核心抗原的方法及诊断试剂盒

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: UNKNOWN

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20251219

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR