EP4724099A2 - Interleukin-15-fusionsprotein und verfahren zur verwendung - Google Patents

Interleukin-15-fusionsprotein und verfahren zur verwendung

Info

Publication number
EP4724099A2
EP4724099A2 EP24819810.3A EP24819810A EP4724099A2 EP 4724099 A2 EP4724099 A2 EP 4724099A2 EP 24819810 A EP24819810 A EP 24819810A EP 4724099 A2 EP4724099 A2 EP 4724099A2
Authority
EP
European Patent Office
Prior art keywords
fusion protein
cells
sequence
protein
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24819810.3A
Other languages
English (en)
French (fr)
Inventor
Jianwei Zhu
Shusheng Wang
Kaiyong YANG
Haiqiu HUANG
Yueqing XIE
Hua Jiang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jecho Laboratories Inc
Original Assignee
Jecho Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jecho Laboratories Inc filed Critical Jecho Laboratories Inc
Publication of EP4724099A2 publication Critical patent/EP4724099A2/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5443—IL-15
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP24819810.3A 2023-06-06 2024-05-30 Interleukin-15-fusionsprotein und verfahren zur verwendung Pending EP4724099A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363471370P 2023-06-06 2023-06-06
PCT/US2024/031723 WO2024253944A2 (en) 2023-06-06 2024-05-30 Interleukin-15 fusion protein and methods of use

Publications (1)

Publication Number Publication Date
EP4724099A2 true EP4724099A2 (de) 2026-04-15

Family

ID=93794629

Family Applications (1)

Application Number Title Priority Date Filing Date
EP24819810.3A Pending EP4724099A2 (de) 2023-06-06 2024-05-30 Interleukin-15-fusionsprotein und verfahren zur verwendung

Country Status (3)

Country Link
EP (1) EP4724099A2 (de)
CN (1) CN121240886A (de)
WO (1) WO2024253944A2 (de)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2619229B1 (de) * 2010-09-21 2016-04-06 Altor BioScience Corporation Lösliche, multimere il-15- fusionsmoleküle sowie verfahren zu ihrer herstellung und verwendung
ES2608835T3 (es) * 2011-04-13 2017-04-17 Bristol-Myers Squibb Company Proteínas de fusión Fc que comprenden nuevos enlazadores o disposiciones
JP7516254B2 (ja) * 2018-04-18 2024-07-16 ゼンコア インコーポレイテッド Ｉｌ－１５／ｉｌ－１５ｒａヘテロ二量体ｆｃ融合タンパク質およびその使用
AU2020329301A1 (en) * 2019-08-15 2022-02-17 Igm Biosciences, Inc. Immunostimulatory multimeric binding molecules
WO2021142476A1 (en) * 2020-01-12 2021-07-15 Dragonfly Therapeutics, Inc. Single-chain polypeptides

Also Published As

Publication number Publication date
WO2024253944A3 (en) 2025-01-09
WO2024253944A2 (en) 2024-12-12
CN121240886A (zh) 2025-12-30

Similar Documents

Publication Publication Date Title
AU2022204946A1 (en) Molecules that selectively activate regulatory t cells for the treatment of autoimmune disease
US11535657B2 (en) Molecules that selectively activate regulatory T cells for the treatment of autoimmune diseases
AU731583B2 (en) Fusion proteins with an immunoglobulin hinge region linker
EP2619229B1 (de) Lösliche, multimere il-15- fusionsmoleküle sowie verfahren zu ihrer herstellung und verwendung
CA2429384C (en) Concatameric immunoadhesion
WO1997020062A1 (en) Il-12 p40 subunit fusion polypeptides and uses thereof
EP4090354A1 (de) Il2-muteine
WO2024253944A2 (en) Interleukin-15 fusion protein and methods of use
US20220267434A1 (en) Long-Acting Therapeutic Fusion Proteins
US20240092851A1 (en) Il-7 fusion protein and related methods
CN116685345A (zh) Il-7融合蛋白及相关方法
WO2025085590A1 (en) Multifunctional pd1 fusion proteins
HK1190729A (en) Multimeric il-15 soluble fusion molecules and methods of making and using same
HK1190729B (en) Multimeric il-15 soluble fusion molecules and methods of making and using same

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20251113

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR