EP4724433A2 - Médicaments psychoactifs et leur utilisation pour le traitement de pathologies et de troubles psychiatriques et neurologiques - Google Patents

Médicaments psychoactifs et leur utilisation pour le traitement de pathologies et de troubles psychiatriques et neurologiques

Info

Publication number
EP4724433A2
EP4724433A2 EP24819953.1A EP24819953A EP4724433A2 EP 4724433 A2 EP4724433 A2 EP 4724433A2 EP 24819953 A EP24819953 A EP 24819953A EP 4724433 A2 EP4724433 A2 EP 4724433A2
Authority
EP
European Patent Office
Prior art keywords
methylone
subject
disorder
neuropsychiatric illness
dose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24819953.1A
Other languages
German (de)
English (en)
Inventor
Blake MANDELL
Martin Stogniew
Jennifer Louise SCHMIDT
Markus SEELIG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Transcend Therapeutics Inc
Original Assignee
Transcend Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transcend Therapeutics Inc filed Critical Transcend Therapeutics Inc
Priority claimed from PCT/US2024/032615 external-priority patent/WO2024254190A2/fr
Publication of EP4724433A2 publication Critical patent/EP4724433A2/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne des médicaments psychoactifs comprenant du méthylone, du 2C-B, de la MBDB, leurs sels, métabolites, isomères, énantiomères, solvates, isotopologues et isotopomères, polymorphes, promédicaments et analogues respectifs (série 2C et cathinones) ; leur préparation, leurs formulations, leurs intermédiaires, leurs voies d'administration, leur dosage et leur calendrier destinés à des usages médicaux pour des pathologies et des troubles psychiatriques et neurologiques.
EP24819953.1A 2023-06-06 2024-06-05 Médicaments psychoactifs et leur utilisation pour le traitement de pathologies et de troubles psychiatriques et neurologiques Pending EP4724433A2 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202363471412P 2023-06-06 2023-06-06
US202363602904P 2023-11-27 2023-11-27
US202363605729P 2023-12-04 2023-12-04
US202363607702P 2023-12-08 2023-12-08
US202463553788P 2024-02-15 2024-02-15
US202463649653P 2024-05-20 2024-05-20
PCT/US2024/032615 WO2024254190A2 (fr) 2023-06-06 2024-06-05 Médicaments psychoactifs et leur utilisation pour le traitement de pathologies et de troubles psychiatriques et neurologiques

Publications (1)

Publication Number Publication Date
EP4724433A2 true EP4724433A2 (fr) 2026-04-15

Family

ID=98099691

Family Applications (1)

Application Number Title Priority Date Filing Date
EP24819953.1A Pending EP4724433A2 (fr) 2023-06-06 2024-06-05 Médicaments psychoactifs et leur utilisation pour le traitement de pathologies et de troubles psychiatriques et neurologiques

Country Status (4)

Country Link
EP (1) EP4724433A2 (fr)
AU (1) AU2024284688A1 (fr)
IL (1) IL324918A (fr)
MX (1) MX2025014366A (fr)

Also Published As

Publication number Publication date
IL324918A (en) 2026-01-01
AU2024284688A1 (en) 2025-12-11
MX2025014366A (es) 2026-02-03

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