EP4727929A2 - Monomères modifiés en 5', oligonucléotides et arn double brin - Google Patents

Monomères modifiés en 5', oligonucléotides et arn double brin

Info

Publication number
EP4727929A2
EP4727929A2 EP24824200.0A EP24824200A EP4727929A2 EP 4727929 A2 EP4727929 A2 EP 4727929A2 EP 24824200 A EP24824200 A EP 24824200A EP 4727929 A2 EP4727929 A2 EP 4727929A2
Authority
EP
European Patent Office
Prior art keywords
oligonucleotide
compound
optionaly
nucleotide
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24824200.0A
Other languages
German (de)
English (en)
Inventor
Dhrubajyoti Datta
Muthiah Manoharan
Juan SALINAS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alnylam Pharmaceuticals Inc
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of EP4727929A2 publication Critical patent/EP4727929A2/fr
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La technologie présentement décrite concerne des nucléosides, des nucléotides, des oligonucléotides et des ARN double brin modifiés en 5', par exemple, des ARNsi, et des kits les comprenant et des méthodes d'utilisation de ceux-ci pour inhiber des gènes cibles.
EP24824200.0A 2023-06-15 2024-06-14 Monomères modifiés en 5', oligonucléotides et arn double brin Pending EP4727929A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363521256P 2023-06-15 2023-06-15
PCT/US2024/033953 WO2024259190A2 (fr) 2023-06-15 2024-06-14 Monomères modifiés en 5', oligonucléotides et arn double brin

Publications (1)

Publication Number Publication Date
EP4727929A2 true EP4727929A2 (fr) 2026-04-22

Family

ID=93852914

Family Applications (1)

Application Number Title Priority Date Filing Date
EP24824200.0A Pending EP4727929A2 (fr) 2023-06-15 2024-06-14 Monomères modifiés en 5', oligonucléotides et arn double brin

Country Status (3)

Country Link
EP (1) EP4727929A2 (fr)
CN (1) CN121335889A (fr)
WO (1) WO2024259190A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2026006107A1 (fr) * 2024-06-24 2026-01-02 Eli Lilly And Company Nouveaux oligonucléotides portant une liaison internucléotidique "2-propyle"

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008100447A2 (fr) * 2007-02-09 2008-08-21 Gilead Sciences, Inc. Analogues nucléosidiques pour traitement antiviral
WO2018045317A1 (fr) * 2016-09-02 2018-03-08 Dicerna Pharmaceuticals, Inc. Analogues de 4'-phosphate et oligonucléotides comprenant ceux-ci
EP4419536A4 (fr) * 2021-10-19 2026-04-15 Alnylam Pharmaceuticals Inc Oligonucléotides à nucléotides 2'-désoxy-2'-f-2'-c-méthyle

Also Published As

Publication number Publication date
WO2024259190A2 (fr) 2024-12-19
WO2024259190A3 (fr) 2025-03-27
CN121335889A (zh) 2026-01-13

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