EP4728045A2 - Systèmes de bioréacteur modulaire pour applications de médecine régénérative - Google Patents

Systèmes de bioréacteur modulaire pour applications de médecine régénérative

Info

Publication number
EP4728045A2
EP4728045A2 EP24840361.0A EP24840361A EP4728045A2 EP 4728045 A2 EP4728045 A2 EP 4728045A2 EP 24840361 A EP24840361 A EP 24840361A EP 4728045 A2 EP4728045 A2 EP 4728045A2
Authority
EP
European Patent Office
Prior art keywords
bioreactor
module
tissue
housing
modular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24840361.0A
Other languages
German (de)
English (en)
Inventor
Thomas SHUPE
James Yoo
Anthony Atala
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wake Forest University Health Sciences
Original Assignee
Wake Forest University Health Sciences
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wake Forest University Health Sciences filed Critical Wake Forest University Health Sciences
Publication of EP4728045A2 publication Critical patent/EP4728045A2/fr
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/42—Integrated assemblies, e.g. cassettes or cartridges
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/44—Multiple separable units; Modules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/48—Holding appliances; Racks; Supports
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C12M41/14—Incubators; Climatic chambers

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Mechanical Engineering (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • External Artificial Organs (AREA)

Abstract

La présente divulgation concerne un système de bioréacteur modulaire. Le système comprend un boîtier ; une pluralité de modules de bioréacteur interchangeables, chaque module étant conçu pour être reçu à l'intérieur du boîtier, la pluralité de modules de bioréacteur interchangeables comprenant un module de bioréacteur uniaxial, un module de bioréacteur biaxial, un module de bioréacteur pulsatile, un module de bioréacteur de remplissage de vide et/ou un module de bioréacteur de perfusion ; un sous-système d'échangeur de milieux conçu pour être connecté à l'un de la pluralité de modules de bioréacteur interchangeables reçus à l'intérieur du boîtier ; un module de surveillance de capteur conçu pour être connecté au sous-système d'échangeur de milieux et à l'un de la pluralité de modules de bioréacteur interchangeables reçus à l'intérieur du boîtier, le module de surveillance de capteur étant éventuellement conçu pour être reçu à l'intérieur du boîtier ; et un dispositif de commande associé de manière fonctionnelle au boîtier, à la pluralité de modules de bioréacteur interchangeables, au module de surveillance de capteur et au sous-système d'échangeur de milieux.
EP24840361.0A 2023-07-11 2024-07-08 Systèmes de bioréacteur modulaire pour applications de médecine régénérative Pending EP4728045A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363512974P 2023-07-11 2023-07-11
PCT/US2024/037004 WO2025014852A2 (fr) 2023-07-11 2024-07-08 Systèmes de bioréacteur modulaire pour applications de médecine régénérative

Publications (1)

Publication Number Publication Date
EP4728045A2 true EP4728045A2 (fr) 2026-04-22

Family

ID=94216302

Family Applications (1)

Application Number Title Priority Date Filing Date
EP24840361.0A Pending EP4728045A2 (fr) 2023-07-11 2024-07-08 Systèmes de bioréacteur modulaire pour applications de médecine régénérative

Country Status (3)

Country Link
EP (1) EP4728045A2 (fr)
AU (1) AU2024293440A1 (fr)
WO (1) WO2025014852A2 (fr)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7591786B2 (en) * 2003-01-31 2009-09-22 Sonosite, Inc. Dock for connecting peripheral devices to a modular diagnostic ultrasound apparatus
DE102015210609B3 (de) * 2015-06-10 2016-01-14 OSPIN GmbH Modulares Bioreaktorsystem
WO2017048852A1 (fr) * 2015-09-14 2017-03-23 Reflexion Medical, Inc. Détecteur dynamique à haute résolution pour imagerie et dosimétrie en thérapie par rayonnement mégavolt
EP3359641B1 (fr) * 2015-10-09 2020-01-08 DEKA Products Limited Partnership Système de bioréacteur et de pompage de fluide
US11069012B2 (en) * 2017-12-28 2021-07-20 Cilag Gmbh International Interactive surgical systems with condition handling of devices and data capabilities

Also Published As

Publication number Publication date
WO2025014852A2 (fr) 2025-01-16
WO2025014852A3 (fr) 2025-04-24
AU2024293440A1 (en) 2026-01-15

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