EP4732017A1 - Verfahren zur diagnose von nichtalkoholischer steatotischer hepatitis - Google Patents

Verfahren zur diagnose von nichtalkoholischer steatotischer hepatitis

Info

Publication number
EP4732017A1
EP4732017A1 EP24735977.1A EP24735977A EP4732017A1 EP 4732017 A1 EP4732017 A1 EP 4732017A1 EP 24735977 A EP24735977 A EP 24735977A EP 4732017 A1 EP4732017 A1 EP 4732017A1
Authority
EP
European Patent Office
Prior art keywords
nash
patient
patients
values
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24735977.1A
Other languages
English (en)
French (fr)
Inventor
Thierry Poynard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biopredictive
Original Assignee
Biopredictive
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP23305987.2A external-priority patent/EP4481388A1/de
Priority claimed from EP23305989.8A external-priority patent/EP4481390A1/de
Priority claimed from EP23305988.0A external-priority patent/EP4481389A1/de
Application filed by Biopredictive filed Critical Biopredictive
Publication of EP4732017A1 publication Critical patent/EP4732017A1/de
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • G01N33/723—Glycosylated haemoglobin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/728—Bilirubin; including biliverdin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/775—Apolipopeptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/91188—Transferases (2.) transferring nitrogenous groups (2.6)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
    • G01N2405/02—Triacylglycerols
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/08—Hepato-biliairy disorders other than hepatitis
    • G01N2800/085—Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP24735977.1A 2023-06-21 2024-06-20 Verfahren zur diagnose von nichtalkoholischer steatotischer hepatitis Pending EP4732017A1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP23305987.2A EP4481388A1 (de) 2023-06-21 2023-06-21 Verfahren zur diagnose von lebersteatose
EP23305989.8A EP4481390A1 (de) 2023-06-21 2023-06-21 Verfahren zur diagnose von leberfibrose
EP23305988.0A EP4481389A1 (de) 2023-06-21 2023-06-21 Verfahren zur diagnose von nichtalkoholischer steatotischer hepatitis
PCT/EP2024/067359 WO2024261198A1 (en) 2023-06-21 2024-06-20 Method of diagnosis of non-alcoholic steatotic hepatitis

Publications (1)

Publication Number Publication Date
EP4732017A1 true EP4732017A1 (de) 2026-04-29

Family

ID=91663885

Family Applications (3)

Application Number Title Priority Date Filing Date
EP24735977.1A Pending EP4732017A1 (de) 2023-06-21 2024-06-20 Verfahren zur diagnose von nichtalkoholischer steatotischer hepatitis
EP24735976.3A Pending EP4732016A1 (de) 2023-06-21 2024-06-20 Verfahren zur diagnose von lebersteatose
EP24735630.6A Pending EP4732015A1 (de) 2023-06-21 2024-06-20 Verfahren zur diagnose von leberfibrose

Family Applications After (2)

Application Number Title Priority Date Filing Date
EP24735976.3A Pending EP4732016A1 (de) 2023-06-21 2024-06-20 Verfahren zur diagnose von lebersteatose
EP24735630.6A Pending EP4732015A1 (de) 2023-06-21 2024-06-20 Verfahren zur diagnose von leberfibrose

Country Status (2)

Country Link
EP (3) EP4732017A1 (de)
WO (3) WO2024261197A1 (de)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2420089C (en) 2000-08-21 2009-04-14 Assistance Publique-Hopitaux De Paris Diagnosis method of fibrotic disease using biochemical markers
WO2014049131A1 (en) 2012-09-28 2014-04-03 Université d'Angers Accurate blood test for the non-invasive diagnosis of non-alcoholic steatohepatitis
GB201614455D0 (en) 2016-08-24 2016-10-05 Univ Oxford Innovation Ltd Biomarkers
EP3296744A1 (de) 2016-09-16 2018-03-21 Biopredictive Verfahren zur diagnose nichtalkoholischer fettlebererkrankungen
EP3599615A1 (de) 2018-07-27 2020-01-29 Biopredictive Verfahren zur diagnose von lebersteatose

Also Published As

Publication number Publication date
WO2024261199A1 (en) 2024-12-26
EP4732016A1 (de) 2026-04-29
EP4732015A1 (de) 2026-04-29
WO2024261197A1 (en) 2024-12-26
WO2024261198A1 (en) 2024-12-26

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EP4481389A1 (de) Verfahren zur diagnose von nichtalkoholischer steatotischer hepatitis
EP4481388A1 (de) Verfahren zur diagnose von lebersteatose
EP4481390A1 (de) Verfahren zur diagnose von leberfibrose
Azarboo et al. The association between cardiometabolic index (CMI) and metabolic dysfunction-associated steatotic liver disease (MASLD): a systematic review and meta-analysis
EP4732017A1 (de) Verfahren zur diagnose von nichtalkoholischer steatotischer hepatitis

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