EP4784593A2 - Oligonukleotidzusammensetzungen und verfahren dafür - Google Patents

Oligonukleotidzusammensetzungen und verfahren dafür

Info

Publication number
EP4784593A2
EP4784593A2 EP24873786.8A EP24873786A EP4784593A2 EP 4784593 A2 EP4784593 A2 EP 4784593A2 EP 24873786 A EP24873786 A EP 24873786A EP 4784593 A2 EP4784593 A2 EP 4784593A2
Authority
EP
European Patent Office
Prior art keywords
fl2r
ssp
oligonucleotide
nucleoside
oligonucleotides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24873786.8A
Other languages
English (en)
French (fr)
Inventor
Elizabeth Katherine WAGNER
Abbie Madeline MAGUIRE
Chandra Vargeese
Hsiu-Chiung Yang
Pachamuthu Kandasamy
Sruthi Madhukumar NAIR
Ann Fiegen DURBIN
Naoki Iwamoto
Michael John Byrne
Jayakanthan Kumarasamy
Sarah Diane LAMORE
Sharon Lee CHICKLAS
Jigar Desai
Fengjiao ZHANG
Jeonghoon Choi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wave Life Sciences Pte Ltd
Original Assignee
Wave Life Sciences Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wave Life Sciences Pte Ltd filed Critical Wave Life Sciences Pte Ltd
Publication of EP4784593A2 publication Critical patent/EP4784593A2/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP24873786.8A 2023-09-28 2024-09-27 Oligonukleotidzusammensetzungen und verfahren dafür Pending EP4784593A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363586381P 2023-09-28 2023-09-28
PCT/US2024/049133 WO2025072881A2 (en) 2023-09-28 2024-09-27 Oligonucleotide compositions and methods thereof

Publications (1)

Publication Number Publication Date
EP4784593A2 true EP4784593A2 (de) 2026-08-05

Family

ID=95201352

Family Applications (1)

Application Number Title Priority Date Filing Date
EP24873786.8A Pending EP4784593A2 (de) 2023-09-28 2024-09-27 Oligonukleotidzusammensetzungen und verfahren dafür

Country Status (4)

Country Link
EP (1) EP4784593A2 (de)
CN (1) CN122341621A (de)
AU (1) AU2024351975A1 (de)
WO (2) WO2025072881A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014010250A1 (en) 2012-07-13 2014-01-16 Chiralgen, Ltd. Asymmetric auxiliary group
MA46427A (fr) 2015-10-09 2018-08-15 Wave Life Sciences Ltd Compositions d'oligonucléotides et procédés associés
MX2021012981A (es) 2019-04-25 2022-01-18 Wave Life Sciences Ltd Composiciones de oligonucleotido y metodos de uso de las mismas.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019392928A1 (en) * 2018-12-06 2021-06-17 Wave Life Sciences Ltd. Oligonucleotide compositions and methods thereof
EP3978608A1 (de) * 2020-10-05 2022-04-06 SQY Therapeutics Oligomere verbindung zur dystrophinrettung in dmd-patienten während des skipping exon-51
JP2023548584A (ja) * 2020-11-08 2023-11-17 ウェイブ ライフ サイエンシズ リミテッド オリゴヌクレオチド組成物及びその方法

Also Published As

Publication number Publication date
WO2025072881A9 (en) 2025-05-15
WO2026073042A8 (en) 2026-05-28
AU2024351975A1 (en) 2026-04-16
CN122341621A (zh) 2026-07-03
WO2025072881A2 (en) 2025-04-03
WO2026073042A1 (en) 2026-04-02
WO2025072881A3 (en) 2025-06-12

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