ES2000382A6 - Production of substituted phenethylamine derivative - Google Patents

Production of substituted phenethylamine derivative

Info

Publication number
ES2000382A6
ES2000382A6 ES8600685A ES8600685A ES2000382A6 ES 2000382 A6 ES2000382 A6 ES 2000382A6 ES 8600685 A ES8600685 A ES 8600685A ES 8600685 A ES8600685 A ES 8600685A ES 2000382 A6 ES2000382 A6 ES 2000382A6
Authority
ES
Spain
Prior art keywords
formula
reduction
compound
lower alkoxy
reaction product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8600685A
Other languages
Spanish (es)
Inventor
Takashi Fujikura
Kunihiro Niigata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=17263445&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2000382(A6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Publication of ES2000382A6 publication Critical patent/ES2000382A6/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE:To obtain the titled compound useful as a blocking agent of alpha-receptor of sympathetic nervous system by a short process readily, by reacting a phenetylamine derivative with a substituted phenoxyacetaldehyde and reducing a reaction product. CONSTITUTION:A phenethylamine derivatibe shown by the formula I (R<1> is lower alkoxy R<2> is lower alkyl) is reacted with a substituted phenoxyacetaldehyde shown by formula II (R<3> is lower alkoxy) and the reaction product is reduced to give a compound shown by formula III or its salt. Catalytic reduction using platinum oxide as a catalyst or reduction using a metallic hydroxide such as sodium boron hydride, etc., may be applied as the reduction. The reaction process is shortened, the treatment and operation are simple and since racemization will not occur in the reaction process, the aimed compound keeping a corresponding optical activity can be obtained when an optically active substance of the compound shown by formula I is used.
ES8600685A 1985-11-13 1986-07-29 Production of substituted phenethylamine derivative Expired ES2000382A6 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP60254326A JPS62114952A (en) 1985-11-13 1985-11-13 Production of substituted phenethylamine derivative

Publications (1)

Publication Number Publication Date
ES2000382A6 true ES2000382A6 (en) 1988-02-16

Family

ID=17263445

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8600685A Expired ES2000382A6 (en) 1985-11-13 1986-07-29 Production of substituted phenethylamine derivative

Country Status (5)

Country Link
JP (1) JPS62114952A (en)
KR (1) KR940007746B1 (en)
AT (1) AT397960B (en)
CA (1) CA1282077C (en)
ES (1) ES2000382A6 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2200699A1 (en) * 2002-07-12 2004-03-01 Ragactives Sl Method of separating r(-)- and s(+)-5- 2- 2-(2-ethoxyphenoxy)ethyl amino propyl-2-methoxybenzene-sulphonamide

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4971990A (en) * 1988-02-19 1990-11-20 Hokuriku Pharmaceutical Co., Ltd. Phenoxyethylamine derivatives, for preparing the same and composition for exhibiting excellent α1 -blocking activity containing the same
US5288759A (en) * 1992-08-27 1994-02-22 Alcon Laboratories, Inc. Use of certain sulfamoyl-substituted phenethylamine derivatives to reverse drug-induced mydriasis
TW536402B (en) 1998-06-26 2003-06-11 Yamanouchi Pharma Co Ltd Pharmaceutical composition for the therapy of voiding dysfunction
KR100525493B1 (en) * 2001-02-23 2005-11-02 연성정밀화학(주) Process for preparing sulfamoyl-substituted phenethylamine derivatives
CZ291802B6 (en) * 2001-10-25 2003-05-14 Léčiva, A.S. Process for preparing (R)-(-)-5-[2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzene sulfonamide
WO2004016582A1 (en) * 2002-08-14 2004-02-26 Natco Pharma Limited An improved process for the preparation of tamsulosin hydrochloride
KR100503639B1 (en) 2003-02-12 2005-07-26 보령제약 주식회사 A purification process of Tamsulosin
JP2007513943A (en) 2003-12-09 2007-05-31 シージェイ コーポレーション Process for the preparation of optically pure phenethylamine derivatives
SI21656A (en) * 2003-12-29 2005-06-30 LEK farmacevtska družba d.d. Preparation of (r)-5-(2-(2-(2-ethoxyphenoxy)ethylamino)-1-propyl)-2-methoxybenzene sulphonamide hydrochloride of high chemical purity
SI21655A (en) * 2003-12-29 2005-06-30 LEK farmacevtska dru�ba d.d. Synthesis of optically pure (r)-5-(2-aminopropyl)-methoxybenzene sulphonamide
CZ2004197A3 (en) * 2004-02-05 2005-08-17 Zentiva, A. S. Process for the preparation of (R) - (-) - 5- (2-aminopropyl) -2-methoxybenzenesulfonamide
CA2560347A1 (en) * 2004-02-23 2005-09-01 Cadila Healthcare Limited Process for manufacturing optically pure (r) or (s)-5-(2-aminopropyl)-2-methoxybenzene sulfonamide
WO2006004093A1 (en) * 2004-07-07 2006-01-12 Hamari Chemicals, Ltd. Process for producing optically active phenylpropylamine derivative
CN100545148C (en) 2004-08-16 2009-09-30 神隆新加坡私人有限公司 Method for synthesizing tamsulosin medicine for resisting benign prostatic hyperplasia
US8273918B2 (en) 2005-09-12 2012-09-25 Avrobindo Pharma Ltd. Process for preparing tamsulosin hydrochloride
WO2008152653A2 (en) * 2007-06-11 2008-12-18 Matrix Laboratories Ltd An improved process for the preparation of tamsulosin hydrochloride
AU2010211725C1 (en) 2009-02-04 2014-10-16 Astellas Pharma Inc. Pharmaceutical composition for oral administration
EP2255793A1 (en) 2009-05-28 2010-12-01 Krka Tovarna Zdravil, D.D., Novo Mesto Pharmaceutical composition comprising tamsulosin
CA2772997A1 (en) * 2009-09-12 2011-03-17 Sandoz Ag Process for the preparation of indoline derivatives and their intermediates thereof
DE202023102187U1 (en) 2023-04-25 2023-05-02 Nusrath Anjum Derivative formulation based on tamsulosin

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1147342A (en) * 1977-10-12 1983-05-31 Kazuo Imai Process of producing novel phenylethanolamine derivatives
JPS56110665A (en) * 1980-02-08 1981-09-01 Yamanouchi Pharmaceut Co Ltd Sulfamoyl-substituted phenetylamine derivative and its preparation
US4558156A (en) * 1980-02-08 1985-12-10 Yamanouchi Pharmaceutical Co., Ltd. Sulfamoyl-substituted phenethylamine derivatives

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2200699A1 (en) * 2002-07-12 2004-03-01 Ragactives Sl Method of separating r(-)- and s(+)-5- 2- 2-(2-ethoxyphenoxy)ethyl amino propyl-2-methoxybenzene-sulphonamide
WO2004006829A3 (en) * 2002-07-12 2004-04-08 Ragactives Sl Method of separating r(-)- and s(+)-5-[2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl-2-methoxybenzene-sulphonamide
US7105698B2 (en) 2002-07-12 2006-09-12 Ragactives, S.L. Process for the separation of R(-)-and S(+)-5-[2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2- methoxybenzenesulfonamide

Also Published As

Publication number Publication date
JPH0137391B2 (en) 1989-08-07
KR870004949A (en) 1987-06-02
AT397960B (en) 1994-08-25
ATA203286A (en) 1993-12-15
JPS62114952A (en) 1987-05-26
CA1282077C (en) 1991-03-26
KR940007746B1 (en) 1994-08-24

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20060731