ES2000502A6 - A PROCEDURE FOR THE PREPARATION OF DERIVATIVE POLY-4-AMINOPYROL-2-CARBOXAMIDE - Google Patents

A PROCEDURE FOR THE PREPARATION OF DERIVATIVE POLY-4-AMINOPYROL-2-CARBOXAMIDE

Info

Publication number
ES2000502A6
ES2000502A6 ES8600290A ES8600290A ES2000502A6 ES 2000502 A6 ES2000502 A6 ES 2000502A6 ES 8600290 A ES8600290 A ES 8600290A ES 8600290 A ES8600290 A ES 8600290A ES 2000502 A6 ES2000502 A6 ES 2000502A6
Authority
ES
Spain
Prior art keywords
reaction
procedure
preparation
organic solvent
carboxamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8600290A
Other languages
Spanish (es)
Inventor
Federico Arcamone
Nicola Mongelli
Sergio Pence
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858517922A external-priority patent/GB8517922D0/en
Priority claimed from GB868613594A external-priority patent/GB8613594D0/en
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Publication of ES2000502A6 publication Critical patent/ES2000502A6/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polyamides (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

UN PROCEDIMIENTO PARA LA PREPARACION DE POLI-4-AMINOPIRROL-2-CARBOXAMIDO DERIVADOS. LOS COMPUESTOS (I) EN QUE R, R1 Y R2 REPRESENTAN VARIOS RADICALES Y N EN O O UN NUMERO ENTERO DE 1 A 4 SE OBTIENEN POR : (A) REACCION DE (II) CON (III) EN UN DISOLVENTE ORGANICO INERTE DE 50JC A B50JC; O (B) REDUCCION DE (IV) POR HIDROGENACION CATALITICA; O (C) FORMILACION DE (V) CON UN AGENTE FORMILANTE PORTADOR DEL GRUPO -CHO; O (D) REACCION DE (V) CON (VI) EN UN DISOLVENTE ORGANICO INERTE DE 10JC A B25JC; O (E) REACCION DE (V) CON (VII) EN UN DISOLVENTE ORGANICO INERTE DE 50JC A B50JC; O (F) REACCION DE (V) CON (VIII) EN UN DISOLVENTE DE 20JC A B25JC. SON AGENTES ANTIVIRICOS Y ANTINEOPLASTICOS.A PROCEDURE FOR THE PREPARATION OF POLY-4-AMINOPYRROL-2-CARBOXAMIDE DERIVATIVES. THE COMPOUNDS (I) IN WHICH R, R1 AND R2 REPRESENT SEVERAL RADICALS AND N IN OO AN INTEGRAL NUMBER FROM 1 TO 4 ARE OBTAINED BY: (A) REACTION OF (II) WITH (III) IN AN INERT ORGANIC SOLVENT FROM 50JC TO B50JC ; OR (B) REDUCTION OF (IV) BY CATALYTIC HYDROGENATION; OR (C) FORMILATION OF (V) WITH A FORMILANT AGENT CARRIER OF THE -CHO GROUP; OR (D) REACTION OF (V) WITH (VI) IN AN INERT ORGANIC SOLVENT OF 10JC TO B25JC; OR (E) REACTION OF (V) WITH (VII) IN AN INERT ORGANIC SOLVENT OF 50JC TO B50JC; OR (F) REACTION OF (V) WITH (VIII) IN A SOLVENT FROM 20JC TO B25JC. THEY ARE ANTIVIRIC AND ANTINEOPLASTIC AGENTS.

ES8600290A 1985-07-16 1986-07-14 A PROCEDURE FOR THE PREPARATION OF DERIVATIVE POLY-4-AMINOPYROL-2-CARBOXAMIDE Expired ES2000502A6 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858517922A GB8517922D0 (en) 1985-07-16 1985-07-16 Carboxamido derivatives
GB868613594A GB8613594D0 (en) 1986-06-04 1986-06-04 Poly-4-aminopyrrole-2-carboxamido derivatives

Publications (1)

Publication Number Publication Date
ES2000502A6 true ES2000502A6 (en) 1988-03-01

Family

ID=26289538

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8600290A Expired ES2000502A6 (en) 1985-07-16 1986-07-14 A PROCEDURE FOR THE PREPARATION OF DERIVATIVE POLY-4-AMINOPYROL-2-CARBOXAMIDE

Country Status (26)

Country Link
JP (1) JPH0780843B2 (en)
KR (1) KR930010496B1 (en)
CN (1) CN1018825B (en)
AT (1) AT387013B (en)
AU (1) AU587841B2 (en)
BE (1) BE905110A (en)
CA (1) CA1285934C (en)
CH (1) CH674206A5 (en)
CS (1) CS276981B6 (en)
DE (1) DE3623880A1 (en)
DK (1) DK335986A (en)
ES (1) ES2000502A6 (en)
FI (1) FI83640C (en)
FR (1) FR2585018B1 (en)
GB (1) GB2178036B (en)
GR (1) GR861841B (en)
HU (1) HU205949B (en)
IE (1) IE59073B1 (en)
IL (1) IL79402A (en)
IT (1) IT1196488B (en)
NL (1) NL8601837A (en)
NO (1) NO168826C (en)
NZ (1) NZ216829A (en)
PH (1) PH24714A (en)
PT (1) PT82984B (en)
SE (1) SE468642B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN85103908A (en) * 1985-07-16 1986-11-05 法米塔利·卡洛·埃尔巴有限公司 A new method for preparing 4'-epodoxorubicin
GB8906709D0 (en) * 1989-03-23 1989-05-10 Creighton Andrew M Acryloyl substituted pyrrole derivatives
IT1243389B (en) * 1990-11-22 1994-06-10 Menarini Farma Ind POLYAMINE-PYRROLCARBOXIDE DERIVATIVES, PREPARATION PROCESSES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
AU1224392A (en) * 1991-02-06 1992-09-07 Synphar Laboratories, Inc. Oligopeptide antiretroviral agents
IT1247878B (en) * 1991-02-15 1995-01-05 Menarini Farma Ind POLY-4-AMINOPYRROL-2-CARBOXYXID DERIVATIVES, PREPARATION PROCESSES AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM
GB2260134A (en) * 1991-10-04 1993-04-07 Erba Carlo Spa Derivatives of poly-5-amino-3-carboxy-1-methyl compounds
IT1262921B (en) * 1992-01-10 1996-07-22 Federico Arcamone ANALOGUE AGENTS ANALOGUES OF PYROL-AMIDINE OLIGOPEPTIDES BACK TO PREPARATION PROCESSES AND PHARMACEUTICAL PRODUCTS CONTAINING THEM
GB9416005D0 (en) * 1994-08-08 1994-09-28 Erba Carlo Spa Peptidic compounds analogous to distamycin a and process for their preparation
US5717110A (en) * 1995-09-12 1998-02-10 Kyowa Hakko Kogyo Co., Ltd. UCH15 compounds
WO1997028123A1 (en) * 1996-02-02 1997-08-07 Pharmacia & Upjohn S.P.A. Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB9615692D0 (en) * 1996-07-25 1996-09-04 Pharmacia Spa Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB0011059D0 (en) 2000-05-08 2000-06-28 Pharmacia & Upjohn Spa Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
GB0015446D0 (en) 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites
GB0015447D0 (en) 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
GB0016447D0 (en) 2000-07-04 2000-08-23 Pharmacia & Upjohn Spa Process for preparing distamycin derivatives
US6969592B2 (en) 2001-09-26 2005-11-29 Pharmacia Italia S.P.A. Method for predicting the sensitivity to chemotherapy

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR86210E (en) * 1963-04-04 1966-03-23
DE1795539A1 (en) * 1963-07-26 1972-01-13 Farmaceutici Italia Process for the production of new pyrrole derivatives and their salts
US3420844A (en) * 1963-07-26 1969-01-07 Farmaceutici Italia Pyrrole-2-carboxamido-propionamidines
BE666612A (en) * 1963-07-26 1965-11-03
NL130086C (en) * 1964-07-14 1970-06-15
CN85103908A (en) * 1985-07-16 1986-11-05 法米塔利·卡洛·埃尔巴有限公司 A new method for preparing 4'-epodoxorubicin

Also Published As

Publication number Publication date
NZ216829A (en) 1989-03-29
CN1018825B (en) 1992-10-28
FI83640C (en) 1991-08-12
DK335986A (en) 1987-01-17
IT1196488B (en) 1988-11-16
FI862959A7 (en) 1987-01-17
PT82984B (en) 1989-01-30
GR861841B (en) 1986-11-18
CN86104787A (en) 1987-02-18
CA1285934C (en) 1991-07-09
FI862959A0 (en) 1986-07-16
NO168826B (en) 1991-12-30
HUT43088A (en) 1987-09-28
SE8603098D0 (en) 1986-07-11
FR2585018B1 (en) 1989-07-13
HU205949B (en) 1992-07-28
SE468642B (en) 1993-02-22
AU6020286A (en) 1987-01-22
FR2585018A1 (en) 1987-01-23
PT82984A (en) 1986-08-01
DK335986D0 (en) 1986-07-15
CS276981B6 (en) 1992-11-18
NL8601837A (en) 1987-02-16
ATA188886A (en) 1988-04-15
AT387013B (en) 1988-11-25
CS8605412A2 (en) 1991-03-12
KR930010496B1 (en) 1993-10-25
SE8603098L (en) 1987-01-17
IE861875L (en) 1987-01-16
JPH0780843B2 (en) 1995-08-30
CH674206A5 (en) 1990-05-15
JPS6277362A (en) 1987-04-09
DE3623880A1 (en) 1987-01-29
IT8621125A1 (en) 1988-01-15
IL79402A0 (en) 1986-10-31
AU587841B2 (en) 1989-08-31
PH24714A (en) 1990-10-01
NO862860D0 (en) 1986-07-15
FI83640B (en) 1991-04-30
GB2178036B (en) 1989-08-16
IE59073B1 (en) 1994-01-12
BE905110A (en) 1987-01-15
IL79402A (en) 1991-06-10
IT8621125A0 (en) 1986-07-15
GB8617292D0 (en) 1986-08-20
GB2178036A (en) 1987-02-04
NO168826C (en) 1992-04-08
KR870001201A (en) 1987-03-12
NO862860L (en) 1987-01-19

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Legal Events

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PC1A Transfer granted