ES2001867A6 - Metodo y equipo de preparacion de un complejo de coordinacion de un ligando isonitrilo y un metal radiactivo - Google Patents

Metodo y equipo de preparacion de un complejo de coordinacion de un ligando isonitrilo y un metal radiactivo

Info

Publication number
ES2001867A6
ES2001867A6 ES8600875A ES8600875A ES2001867A6 ES 2001867 A6 ES2001867 A6 ES 2001867A6 ES 8600875 A ES8600875 A ES 8600875A ES 8600875 A ES8600875 A ES 8600875A ES 2001867 A6 ES2001867 A6 ES 2001867A6
Authority
ES
Spain
Prior art keywords
isonitrile
league
preparation
equipment
coordination complex
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8600875A
Other languages
English (en)
Inventor
Carpenter Alan Purdom
Karen Elise Linder
Leo John Mahue
Michael Alan Atz
Vinayakam Subramanyam
Thompson Jeffery Scott
Tulip Thomas Hunt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25064908&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2001867(A6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of ES2001867A6 publication Critical patent/ES2001867A6/es
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G07—CHECKING-DEVICES
    • G07F—COIN-FREED OR LIKE APPARATUS
    • G07F15/00—Coin-freed apparatus with meter-controlled dispensing of liquid, gas or electricity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/06—Cobalt compounds
    • C07F15/065—Cobalt compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0476—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from monodendate ligands, e.g. sestamibi
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/005—Compounds containing elements of Groups 1 or 11 of the Periodic Table without C-Metal linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F11/00—Compounds containing elements of Groups 6 or 16 of the Periodic Table
    • C07F11/005—Compounds containing elements of Groups 6 or 16 of the Periodic Table compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/006—Palladium compounds
    • C07F15/0066—Palladium compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0073—Rhodium compounds
    • C07F15/008—Rhodium compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/04—Nickel compounds
    • C07F15/045—Nickel compounds without a metal-carbon linkage
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G5/00—Alleged conversion of chemical elements by chemical reaction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Optics & Photonics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Ladders (AREA)

Abstract

METODO Y EQUIPO DE PREPARACION DE UN COMPLEJO DE COORDINACION DE UN LIGANDO ISONITRILO Y UN METAL RADIACTIVO. EL METODO COMPRENDE LA COMBINACION DE UN ADUCTO SOLUBLE DE UN METAL DESPLAZABLE NO RADIACTIVO DEL LIGANDO ISONITRILO, CON UN METAL RADIACTIVO EN UN DISOLVENTE ADECUADO PARA SUSTITUIR EL METAL DESPLAZABLE POR EL RADIACTIVO. COMO METALES NO RADIACTIVOS SE EMPLEAN: CU, MO, PD, CO, NI, CR, AG Y RH. COMO METALES RADIACTIVOS SE EMPLEAN ISOTOPOS RADIACTIVOS DE TC, RU, CO, PT, FE, OS, IR, W, RE, CR, MO, MU, NI, RH, PD, NB Y TA. EL EQUIPO TIENE UNA CANTIDAD PREDETERMINADA DE (A) UN ADUCTO DE UN COMPLEJO METALICO NO RADIACTIVO Y LIGANDO ISONITRILO Y DE (B) UN AGENTE REDUCTOR. LOS COMPLEJOS ISONITRILICOS DE RADIONUCLIDOS OBTENIDOS SON AGENTES RADIOISOTOPICOS FORMADORES DE IMAGEN Y MARCADORES Y SON UTILES PARA MARCAR CELULAS, MEDIR FUNCIONES FISIOLOGICAS Y FORMAR IMAGENES DE CIERTOS TEJIDOS.
ES8600875A 1985-08-05 1986-08-05 Metodo y equipo de preparacion de un complejo de coordinacion de un ligando isonitrilo y un metal radiactivo Expired ES2001867A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US76239285A 1985-08-05 1985-08-05

Publications (1)

Publication Number Publication Date
ES2001867A6 true ES2001867A6 (es) 1988-07-01

Family

ID=25064908

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8600875A Expired ES2001867A6 (es) 1985-08-05 1986-08-05 Metodo y equipo de preparacion de un complejo de coordinacion de un ligando isonitrilo y un metal radiactivo

Country Status (18)

Country Link
EP (1) EP0211424B1 (es)
JP (1) JPH0751593B2 (es)
KR (1) KR970000807B1 (es)
AT (1) ATE63311T1 (es)
AU (1) AU587484B2 (es)
CA (1) CA1293729C (es)
DE (1) DE3679116D1 (es)
DK (1) DK174300B1 (es)
ES (1) ES2001867A6 (es)
FI (1) FI85859C (es)
GR (1) GR862061B (es)
IE (1) IE58717B1 (es)
IL (1) IL79602A (es)
MX (1) MX171979B (es)
NO (1) NO172693C (es)
NZ (1) NZ217075A (es)
PT (1) PT83136B (es)
ZA (1) ZA865828B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4735793A (en) * 1985-08-30 1988-04-05 Massachusetts Institute Of Technology Carboxy, carboalkoxy and carbamile substituted isonitrile radionuclide complexes
US4885100A (en) * 1987-09-11 1989-12-05 E. I. Du Pont De Nemours And Company Tris(isonitrile)copper(I) adducts for preparing radionuclide complexes
US5008418A (en) * 1987-09-11 1991-04-16 E. I. Du Pont De Nemours And Company Tris(isonitrile)copper(I) adducts for preparing radionuclide complexes
US5028699A (en) * 1987-09-11 1991-07-02 E. I. Du Pont De Nemours And Company Process for preparing Tc-99m tris(isonitrile) copper complexes
US5808091A (en) * 1991-10-29 1998-09-15 Bracco International B.V. Rhenium and technetium complexes containing a hypoxia localizing moiety
WO1997026922A1 (en) * 1996-01-24 1997-07-31 The Du Pont Merck Pharmaceutical Company 99mTc-TERTIARY-BUTYL ISONITRILE AND ANALOGS AS BREAST TUMOR IMAGING AGENTS
DE102008036247A1 (de) * 2008-08-04 2010-02-11 Merck Patent Gmbh Elektronische Vorrichtungen enthaltend Metallkomplexe
CN118126096B (zh) * 2024-03-15 2025-04-15 南华大学 一种内质网靶向型铑(i)配合物、制备方法及应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4707352A (en) * 1984-01-30 1987-11-17 Enzo Biochem, Inc. Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
AU4311085A (en) * 1984-06-01 1985-12-05 E.I. Du Pont De Nemours And Company Copper salt and ligand containing composition
US4707544A (en) * 1984-11-28 1987-11-17 President And Fellows Of Harvard College Metal-isonitrile adducts for preparing radionuclide complexes for labelling and imaging agents

Also Published As

Publication number Publication date
MX171979B (es) 1993-11-26
IE58717B1 (en) 1993-11-03
FI863171L (fi) 1987-02-06
EP0211424A2 (en) 1987-02-25
PT83136B (pt) 1989-03-30
IL79602A (en) 1995-11-27
JPS6233194A (ja) 1987-02-13
ATE63311T1 (de) 1991-05-15
DK174300B1 (da) 2002-11-25
IE862063L (en) 1987-02-05
DE3679116D1 (de) 1991-06-13
FI85859C (fi) 1992-06-10
IL79602A0 (en) 1986-11-30
DK371186A (da) 1987-02-06
NO863145D0 (no) 1986-08-04
KR970000807B1 (en) 1997-01-20
DK371186D0 (da) 1986-08-04
EP0211424B1 (en) 1991-05-08
NO172693C (no) 1993-08-25
CA1293729C (en) 1991-12-31
FI863171A0 (fi) 1986-08-04
NO172693B (no) 1993-05-18
FI85859B (fi) 1992-02-28
AU587484B2 (en) 1989-08-17
EP0211424A3 (en) 1987-04-15
PT83136A (en) 1986-09-01
NO863145L (no) 1987-02-06
ZA865828B (en) 1988-04-27
KR870002598A (ko) 1987-03-31
NZ217075A (en) 1989-11-28
JPH0751593B2 (ja) 1995-06-05
GR862061B (en) 1986-12-24
AU6087886A (en) 1987-02-12

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Legal Events

Date Code Title Description
PC1A Transfer granted

Owner name: THE DU PONT MERCK PHARMACEUTICAL COMPANY

FD1A Patent lapsed

Effective date: 20060807