ES2002729A6 - Un procedimiento para la preparacion de hidroxialquil-fenoxi-propan-2-olaminas y nuevos esteres de los mismas - Google Patents

Un procedimiento para la preparacion de hidroxialquil-fenoxi-propan-2-olaminas y nuevos esteres de los mismas

Info

Publication number
ES2002729A6
ES2002729A6 ES8601453A ES8601453A ES2002729A6 ES 2002729 A6 ES2002729 A6 ES 2002729A6 ES 8601453 A ES8601453 A ES 8601453A ES 8601453 A ES8601453 A ES 8601453A ES 2002729 A6 ES2002729 A6 ES 2002729A6
Authority
ES
Spain
Prior art keywords
blockers
alkyl
formulations containing
oculoselective
ophthalmic formulations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8601453A
Other languages
English (en)
Inventor
John J Baldwin
Gerald S Ponticello
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES2002729A6 publication Critical patent/ES2002729A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Medicinal Preparation (AREA)
  • Luminescent Compositions (AREA)
  • Steroid Compounds (AREA)
  • Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
  • Paper (AREA)

Abstract

UN PROCEDIMIENTO PARA LA PREPARACION DE HIDROXIALQUILFENOXI-PROPAN-2-OLAMINAS Y NUEVOS ESTERES DE LAS MISMAS, DE FORMULA (I), DONDE R Y R2 SON INDEPENDIENTEMENTE H O R5-CO- (DONDE R5 ES ALQUILO C1-5); R1 ES ALQUILO C1-5; R3 Y R4 INDEPENDIENTEMENTE SON H, ALQUILO C1-5, ALCOXI C1-5, HALOGENO O CIANO Y N ES 1 A 5. EL PROCEDIMIENTO COMPRENDE LA APERTURA DEL ANILLO DE UNA OXAZOLIDINA (II) MEDIANTE EL TRATAMIENTO CON UN ACIDO MINERAL. LOS PRODUCTOS OBTENIDOS SON B)BLOQUEADORES OCULOSELECTIVOS UTILES PARA EL TRATAMIENTO DE LA PRESION INTEROCULAR ELEVADA Y TIENEN UN REDUCIDO O AUSENTE EFECTO SOBRE EL SISTEMA PULMONAR O CARDIOVASCULAR.
ES8601453A 1985-08-29 1986-08-28 Un procedimiento para la preparacion de hidroxialquil-fenoxi-propan-2-olaminas y nuevos esteres de los mismas Expired ES2002729A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/770,479 US4665094A (en) 1985-08-29 1985-08-29 Oculoselective beta-blockers for treatment of elevated intraocular pressure

Publications (1)

Publication Number Publication Date
ES2002729A6 true ES2002729A6 (es) 1988-10-01

Family

ID=25088683

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8601453A Expired ES2002729A6 (es) 1985-08-29 1986-08-28 Un procedimiento para la preparacion de hidroxialquil-fenoxi-propan-2-olaminas y nuevos esteres de los mismas

Country Status (18)

Country Link
US (1) US4665094A (es)
EP (1) EP0221788B1 (es)
JP (1) JPS6251649A (es)
KR (1) KR900003508B1 (es)
CN (1) CN86105229A (es)
AT (1) ATE53006T1 (es)
AU (1) AU6202686A (es)
CA (1) CA1286313C (es)
DE (1) DE3671429D1 (es)
DK (1) DK409186A (es)
ES (1) ES2002729A6 (es)
FI (1) FI863384A7 (es)
GR (1) GR862186B (es)
IL (1) IL79794A0 (es)
NO (1) NO863448L (es)
NZ (1) NZ217281A (es)
PT (1) PT83247B (es)
ZA (1) ZA866530B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5229127A (en) * 1989-03-03 1993-07-20 Mckinzie James W Rapid miosis with control of intraocular pressure using a mixture of a cetylcholine and carbachol derivatives
TW275614B (es) * 1993-02-15 1996-05-11 Senju Pharma Co
JPH0797373A (ja) * 1994-03-07 1995-04-11 Torcan Chem Ltd フェノールエーテルの製造のための環状中間体
CN103864653A (zh) * 2012-12-10 2014-06-18 韩冰 一类降低眼压的化合物及其用途

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3459782A (en) * 1963-08-26 1969-08-05 Boehringer Sohn Ingelheim 1-substituted phenoxy-2-hydroxy-3-isopropylamino-propanes
US3541130A (en) * 1967-02-06 1970-11-17 Boehringer Sohn Ingelheim 1-(cyanophenoxy)-2-hydroxy-3-tert.-butylamine propanes
DE1593762A1 (de) * 1967-02-06 1972-06-08 Boehringer Sohn Ingelheim Verfahren zur Herstellung von neuen substituierten 1-Phenoxy-2-hydroxy-3-alkylaminopropanen
DE1643262C3 (de) * 1967-12-13 1975-06-26 C.H. Boehringer Sohn, 6507 Ingelheim i-Phenoxy^-hydroxy-S-alklyaminopropane, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
SE358382B (es) * 1967-12-18 1973-07-30 Boehringer Sohn Ingelheim
GB1285038A (en) * 1969-02-21 1972-08-09 Ici Ltd Alkanolamine derivatives
DE1966513A1 (de) * 1969-08-19 1973-05-24 Boehringer Sohn Ingelheim 1-(3-hydroxymethyl-phenoxy)-2hydroxy-3-sek.-butylaminopropan, dessen saeureadditionssalze, verfahren zu deren herstellung und diese enthaltende praeparate
FR2119844B1 (es) * 1970-12-28 1974-03-22 Laroche Navarro Labo
JPS4911847A (es) * 1972-05-20 1974-02-01
SE386892B (sv) * 1972-07-06 1976-08-23 Haessle Ab Forfarande for framstellning av oxaminoforeningar
US4066768A (en) * 1973-12-27 1978-01-03 Cassella Farbwerke Mainkur Aktiengesellschaft Derivatives of 1-phenoxy-3-amino-propan-2-ol
BE833291A (fr) * 1974-09-12 1976-03-11 Nouveaux derives cycloaklyles de 1-aryloxy-3-amino-2-propanols, leurs procedes de preparation, et leurs utilisations therapeutiques
DE2645710C2 (de) * 1976-10-09 1985-06-27 Merck Patent Gmbh, 6100 Darmstadt Phenoxy-amino-propanole, Verfahren zu ihrer Herstellung und pharmazeutische Zubereitung
FI59985C (fi) * 1980-05-26 1982-01-08 Farmos Oy Foerfarande foer framstaellning av terapeutiskt aktiv 1-isopropylamino-3-(4-(2-metoxietyl)fenoxi)-2-propanol samt dess syra-additionssalter
FR2512443A1 (fr) * 1981-09-10 1983-03-11 Synthelabo Derives de phenoxy-3 propanol-2, leur preparation et leur application en therapeutique
DE3151201A1 (de) * 1981-12-23 1983-07-28 Beiersdorf Ag, 2000 Hamburg Substituierte phenoxyalkanolamine und phenoxyalkanol-cycloalkylamine, verfahren zu ihrer herstellung, diese verbindungen enthaltende pharmazeutische zubereitungen und zwischenprodukte
US4450172A (en) * 1982-03-10 1984-05-22 E. I. Du Pont De Nemours And Company Antihypertensive polyhalohydroxyisopropyl phenylalka(e)noic acid esters of alkylaminohydroxypropyloxyphenylalkyl alcohols
EP0105996A1 (en) * 1982-10-15 1984-04-25 Merck & Co. Inc. Ophthalmic compositions for treating elevated intraocular pressure

Also Published As

Publication number Publication date
CN86105229A (zh) 1987-04-22
NZ217281A (en) 1989-10-27
EP0221788B1 (en) 1990-05-23
FI863384L (fi) 1987-03-01
DK409186A (da) 1987-03-01
GR862186B (en) 1986-12-23
FI863384A7 (fi) 1987-03-01
US4665094A (en) 1987-05-12
PT83247A (en) 1986-09-01
ZA866530B (en) 1987-04-29
PT83247B (pt) 1989-03-30
ATE53006T1 (de) 1990-06-15
IL79794A0 (en) 1986-11-30
DK409186D0 (da) 1986-08-28
NO863448D0 (no) 1986-08-28
FI863384A0 (fi) 1986-08-21
KR870002050A (ko) 1987-03-28
NO863448L (no) 1987-03-02
EP0221788A1 (en) 1987-05-13
AU6202686A (en) 1987-03-05
DE3671429D1 (de) 1990-06-28
JPS6251649A (ja) 1987-03-06
CA1286313C (en) 1991-07-16
KR900003508B1 (ko) 1990-05-21

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980504