ES2003195A6 - 4, 5-diphenyl-2-oxazole propionic acid derivative and its production - Google Patents
4, 5-diphenyl-2-oxazole propionic acid derivative and its productionInfo
- Publication number
- ES2003195A6 ES2003195A6 ES8603653A ES8603653A ES2003195A6 ES 2003195 A6 ES2003195 A6 ES 2003195A6 ES 8603653 A ES8603653 A ES 8603653A ES 8603653 A ES8603653 A ES 8603653A ES 2003195 A6 ES2003195 A6 ES 2003195A6
- Authority
- ES
- Spain
- Prior art keywords
- production
- compounds
- propionic acid
- diphenyl
- acid derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- OFPXSFXSNFPTHF-UHFFFAOYSA-N oxaprozin Chemical class O1C(CCC(=O)O)=NC(C=2C=CC=CC=2)=C1C1=CC=CC=C1 OFPXSFXSNFPTHF-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- -1 alkali metal cation Chemical class 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000001760 anti-analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
The invention relates to 4,5-di(phenyl)oxazole-2-propionic acid derivatives of the general formula < IMAGE > in which R<+> stands for an alkali metal cation or an amino acid or aminoglucoside cation in each case having an amine radical which contains a quaternary nitrogen atom, and to a process for their preparation and medicaments containing these compounds. In contrast to the original free acid, these compounds are distinguished by a remarkable water solubility and are therefore also suitable for the production of pharmaceutical preparations to be administered parenterally. The compounds have an appreciable anti-inflammatory and analgesic activity.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT19005/86A IT1204751B (en) | 1986-01-03 | 1986-01-03 | WATER SOLUBLE ACID DERIVATIVES 4,5 -DIPHENYL-2 -XSAZOLPROPIONIC, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2003195A6 true ES2003195A6 (en) | 1988-10-16 |
Family
ID=11153779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8603653A Expired ES2003195A6 (en) | 1986-01-03 | 1986-12-31 | 4, 5-diphenyl-2-oxazole propionic acid derivative and its production |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS6322085A (en) |
| KR (1) | KR870007143A (en) |
| DE (1) | DE3700158A1 (en) |
| ES (1) | ES2003195A6 (en) |
| IT (1) | IT1204751B (en) |
| YU (1) | YU45310B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69733752T2 (en) * | 1996-05-20 | 2006-06-01 | G.D. Searle Llc, Chicago | DRUGS CONTAINING OXAPROCINE SODIUM SALT, CALIUM SALT, OR TRIS (HYDROXYMETHYL) AMINOMETHANE SALT |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL28803A (en) * | 1966-11-18 | 1974-05-16 | Wyeth John & Brother Ltd | Oxazole and thiazole compounds,their preparation and pharmaceutical compositions containing them |
| JPS4938267A (en) * | 1972-08-18 | 1974-04-09 | ||
| ES412429A1 (en) * | 1973-03-08 | 1976-01-01 | Gallardo Antonio Sa | Soluble salt of a cephalosporin |
| IN160683B (en) * | 1981-06-01 | 1987-07-25 | Pfizer |
-
1986
- 1986-01-03 IT IT19005/86A patent/IT1204751B/en active
- 1986-03-13 YU YU374/86A patent/YU45310B/en unknown
- 1986-12-26 JP JP61315970A patent/JPS6322085A/en active Pending
- 1986-12-29 KR KR860011424A patent/KR870007143A/en not_active Ceased
- 1986-12-31 ES ES8603653A patent/ES2003195A6/en not_active Expired
-
1987
- 1987-01-05 DE DE19873700158 patent/DE3700158A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| IT1204751B (en) | 1989-03-10 |
| IT8619005A0 (en) | 1986-01-03 |
| JPS6322085A (en) | 1988-01-29 |
| KR870007143A (en) | 1987-08-17 |
| YU37486A (en) | 1988-02-29 |
| YU45310B (en) | 1992-05-28 |
| DE3700158A1 (en) | 1987-07-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| SA6 | Expiration date (snapshot 920101) |
Free format text: 2006-12-31 |