ES2003642A6 - A PROCEDURE FOR THE PREPARATION OF 1,5-BENZOTIAZEPINE DERIVATIVES - Google Patents

A PROCEDURE FOR THE PREPARATION OF 1,5-BENZOTIAZEPINE DERIVATIVES

Info

Publication number
ES2003642A6
ES2003642A6 ES8603613A ES8603613A ES2003642A6 ES 2003642 A6 ES2003642 A6 ES 2003642A6 ES 8603613 A ES8603613 A ES 8603613A ES 8603613 A ES8603613 A ES 8603613A ES 2003642 A6 ES2003642 A6 ES 2003642A6
Authority
ES
Spain
Prior art keywords
group
hydrogen atom
compounds
alcanoyl
benzotiazepine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8603613A
Other languages
Spanish (es)
Inventor
Nirozumi Inoue
Hisao Ohtsuka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Pharma Corp
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Publication of ES2003642A6 publication Critical patent/ES2003642A6/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LOS COMPUESTOS DE FORMULA (I) EN LA QUE R1 ES UN GRUPO ALQUILO INFERIOR, R2 ES UN ATOMO DE HIDROGENO O UN GRUPO ALCANOILO INFERIOR Y X1 ES UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO INFERIOR, O UNA SAL DEL MISMO, SE OBTIENEN POR ALQUILACION DE LOS COMPUESTOS DE FORMULA (II) EN LA QUE R3 ES UN ATOMO DE HIDROGENO O UN GRUPO ALCANOILO INFERIOR Y X2 ES UN ATOMO DE HIDROGENO, UN GRUPO ALCANOILO INFERIOR O UN GRUPO PROTECTOR, SEGUIDO DE ELIMINACION OPCIONAL DEL GRUPO PROTECTOR Y/O DEL GRUPO ALCANOILO INFERIOR Y/O DE SALIFICACION. LOS COMPUESTOS (I) Y SUS SALES SON POTENTES AGENTES HIPOTENSIVOS, VASODILATADORES CORONARIOS O CEREBRALES O INHIBIDORES DE LA AGREGACION DE LAS PLAQUETAS.THE COMPOUNDS OF FORMULA (I) IN WHICH R1 IS A LOWER ALKYL GROUP, R2 IS A HYDROGEN ATOM OR A LOWER ALCANOYL GROUP AND X1 IS A HYDROGEN ATOM OR A LOWER ALKYL GROUP, OR A SALT OF THE SAME IS OBTAINED ALKYLATION OF THE COMPOUNDS OF FORMULA (II) IN WHICH R3 IS A HYDROGEN ATOM OR A LOWER ALKANOYL GROUP AND X2 IS A HYDROGEN ATOM, A LOWER ALCANOYL GROUP OR A PROTECTIVE GROUP, FOLLOWED BY ELIMINATION OR OPTIONAL PROTECTION OF THE GROUP OF THE LOWER ALCANOYL GROUP AND / OR SALIFICATION. THE COMPOUNDS (I) AND THEIR SALTS ARE POWERFUL HYPOTENSIVE AGENTS, CORONARY OR BRAIN VASODILATORS OR PLATELET AGGREGATION INHIBITORS.

ES8603613A 1986-01-07 1986-12-29 A PROCEDURE FOR THE PREPARATION OF 1,5-BENZOTIAZEPINE DERIVATIVES Expired ES2003642A6 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP61001845A JPS62161776A (en) 1986-01-07 1986-01-07 Production of 1,5-benzothiazepine derivative

Publications (1)

Publication Number Publication Date
ES2003642A6 true ES2003642A6 (en) 1988-11-01

Family

ID=11512884

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8603613A Expired ES2003642A6 (en) 1986-01-07 1986-12-29 A PROCEDURE FOR THE PREPARATION OF 1,5-BENZOTIAZEPINE DERIVATIVES

Country Status (14)

Country Link
JP (1) JPS62161776A (en)
KR (1) KR910002879B1 (en)
CN (1) CN1030388C (en)
AT (1) AT394367B (en)
BG (1) BG46747A3 (en)
CA (1) CA1291134C (en)
DD (1) DD257426A5 (en)
ES (1) ES2003642A6 (en)
FI (1) FI865343A7 (en)
HU (1) HU198031B (en)
IE (1) IE59359B1 (en)
IL (1) IL81039A (en)
PT (1) PT84036B (en)
SU (1) SU1544187A3 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5580867A (en) * 1994-09-09 1996-12-03 Universite De Montreal Myocardial protection during ischemia and reperfusion

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57169476A (en) * 1981-04-13 1982-10-19 Hamari Yakuhin Kogyo Kk Novel preparation of benzothiazepine derivative
JPS57175182A (en) * 1981-04-22 1982-10-28 Hamari Yakuhin Kogyo Kk Novel preparation of benzothiazepin derivative
JPS58113186A (en) * 1981-12-28 1983-07-05 Hamari Yakuhin Kogyo Kk Novel preparation of benzothiazepin derivative
JPS58116476A (en) * 1981-12-29 1983-07-11 Hamari Yakuhin Kogyo Kk Novel preparation of benzothiazepine derivative
US4567175A (en) * 1983-06-03 1986-01-28 Tanabe Seiyaku Co., Ltd. 8-Chloro-1,5-benzothiazepine derivatives
US4585768A (en) * 1984-04-10 1986-04-29 Tanabe Seiyaku Co., Ltd. 1,5-benzothiazepine derivatives and processes for preparing the same

Also Published As

Publication number Publication date
BG46747A3 (en) 1990-02-15
PT84036B (en) 1989-01-17
IL81039A0 (en) 1987-03-31
KR910002879B1 (en) 1991-05-09
AT394367B (en) 1992-03-25
SU1544187A3 (en) 1990-02-15
FI865343A0 (en) 1986-12-30
FI865343L (en) 1987-07-08
IE863269L (en) 1987-07-07
KR870007147A (en) 1987-08-17
DD257426A5 (en) 1988-06-15
CN87100139A (en) 1987-08-12
CA1291134C (en) 1991-10-22
JPH0573749B2 (en) 1993-10-15
HUT45242A (en) 1988-06-28
IE59359B1 (en) 1994-02-09
IL81039A (en) 1991-07-18
PT84036A (en) 1987-01-01
ATA1687A (en) 1991-09-15
FI865343A7 (en) 1987-07-08
CN1030388C (en) 1995-11-29
JPS62161776A (en) 1987-07-17
HU198031B (en) 1989-07-28

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2006-12-29