ES2004177A6 - PROCEDURE FOR OBTAINING ESTERS OF AZONIA SPIRONORTROPANOL - Google Patents

PROCEDURE FOR OBTAINING ESTERS OF AZONIA SPIRONORTROPANOL

Info

Publication number
ES2004177A6
ES2004177A6 ES8603662A ES8603662A ES2004177A6 ES 2004177 A6 ES2004177 A6 ES 2004177A6 ES 8603662 A ES8603662 A ES 8603662A ES 8603662 A ES8603662 A ES 8603662A ES 2004177 A6 ES2004177 A6 ES 2004177A6
Authority
ES
Spain
Prior art keywords
azonia
procedure
spironortropanol
esters
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8603662A
Other languages
Spanish (es)
Inventor
Wolf Grimminger
Klaus Gorler
Karl Peter Ondenthal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Madaus Holding GmbH
Original Assignee
Dr Madaus GmbH and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19853546165 external-priority patent/DE3546165A1/en
Priority claimed from DE19853546218 external-priority patent/DE3546218A1/en
Application filed by Dr Madaus GmbH and Co filed Critical Dr Madaus GmbH and Co
Publication of ES2004177A6 publication Critical patent/ES2004177A6/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCEDIMIENTO DE OBTENCION DE ESTERES DE AZONIAEPIRONORTROPANOL ASI COMO A NUEVOS ESTERES DE AZONIAESPIRONOTROPANOL Y A PRODUCTOS FARMACEUTICOS QUE CONTENGAN ESTOS NUEVOS COMPUESTOS. EL PROCEDIMIENTO DE OBTENCION PARTE DE LA TROPINA, POR DESMETILACION DE LA MISMA SE OBTIENE LA NORTROPINA, REACCION DE LA NORTROPINA CON DIHALUROS PARA OBTENER LOS COMPUESTOS AZONIA CORRESPONDIENTES Y ESTERIFICACION DE LOS COMPUESTOS AZONIA. LOS NUEVOS ESTERES AZONIAESPIRANORTROPANOL POSEEN UNA EXCELENTE ACCION ESPASMOLITICA.THE INVENTION IS RELATED TO A PROCESS FOR OBTAINING ESTERS OF AZONIAEPIRONORTROPANOL AS WELL AS NEW ESTERS OF AZONIA SPIRONOTROPANOL AND PHARMACEUTICAL PRODUCTS CONTAINING THESE NEW COMPOUNDS. THE PROCEDURE FOR OBTAINING PART OF TROPINA, BY DISTILLATION OF THE SAME, NORTROPINE IS OBTAINED, REACTION OF NORTROPINE WITH DIHALURES TO OBTAIN THE CORRESPONDING AZONIA COMPOUNDS AND ESTERIFICATION OF AZONIA COMPOUNDS. THE NEW ESTERES AZONIAESPIRANORTROPANOL HAVE AN EXCELLENT SPASMOLITICAL ACTION.

ES8603662A 1985-12-27 1986-12-24 PROCEDURE FOR OBTAINING ESTERS OF AZONIA SPIRONORTROPANOL Expired ES2004177A6 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19853546165 DE3546165A1 (en) 1985-12-27 1985-12-27 USE OF AZONIA SPIRONORTROPANOLESTERS AS ASTHMATHERAPEUTIC AND AS BRONCHOLYTIC
DE19853546218 DE3546218A1 (en) 1985-12-27 1985-12-27 AZONIA SPIRONORTROPANOLESTER, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENT

Publications (1)

Publication Number Publication Date
ES2004177A6 true ES2004177A6 (en) 1988-12-16

Family

ID=25839393

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8603662A Expired ES2004177A6 (en) 1985-12-27 1986-12-24 PROCEDURE FOR OBTAINING ESTERS OF AZONIA SPIRONORTROPANOL

Country Status (18)

Country Link
KR (1) KR930000113B1 (en)
AT (1) AT397962B (en)
AU (1) AU584266B2 (en)
BE (1) BE906054A (en)
CA (1) CA1304369C (en)
CH (1) CH677793A5 (en)
ES (1) ES2004177A6 (en)
FI (1) FI865295A7 (en)
FR (1) FR2598417B1 (en)
GB (1) GB2184726B (en)
HU (1) HU201930B (en)
IT (1) IT1198263B (en)
NL (1) NL193184C (en)
PL (1) PL150843B1 (en)
PT (1) PT84022B (en)
SE (1) SE8605531L (en)
SU (1) SU1711674A3 (en)
YU (1) YU46038B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69527839T2 (en) * 1994-04-19 2003-01-02 Neurosearch A/S, Ballerup TROPAN-2-ALDOXIME DERIVATIVES AS A NEW RED TRANSMITTER "REUPTAKE" INHIBITORS
WO2005046655A1 (en) * 2003-11-04 2005-05-26 Shire Laboratories, Inc. Sustained release of positively charged pharmacologically active molecules from a matrix containing polymers with polarized oxygen atoms
US8709476B2 (en) * 2003-11-04 2014-04-29 Supernus Pharmaceuticals, Inc. Compositions of quaternary ammonium compounds containing bioavailability enhancers
CN101684117B (en) * 2008-09-27 2013-06-12 宁波市医药技术研究有限公司 Method for preparing nor-tropine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1194422B (en) * 1963-03-05 1965-06-10 Robert Pfleger Chem Fab Dr Process for the production of azonia spironortropane derivatives
US3480626A (en) * 1967-05-18 1969-11-25 Chem Fab Dr R Pfleger Certain azoniaspironortropine derivatives
DE1670258C3 (en) * 1967-08-04 1976-01-02 C.H. Boehringer Sohn, 6507 Ingelheim Process for the preparation of norscopolamine by dealkylation of tertiary, cyclic amines
IT1140998B (en) * 1980-06-18 1986-10-10 Valeas Ind Chimica E Farmaceut ENDO-8-METHYL-8-SIN-ALCHIL-8-AZONIABICYCLE OPEN SALTS PAR. SQUARE 3.2.1. CLOSED PAR. QUADRATA-OTTAN-3-ALCHILCARBOSSILATI, PROCESS FOR THEIR PREPARATION AND THERAPEUTIC COMPOSITIONS THAT CONTAIN THEM AS AN ACTIVE INGREDIENT

Also Published As

Publication number Publication date
FI865295L (en) 1987-06-28
SE8605531L (en) 1987-06-28
PL150843B1 (en) 1990-07-31
ATA339286A (en) 1993-12-15
NL193184B (en) 1998-10-01
YU224986A (en) 1988-04-30
SU1711674A3 (en) 1992-02-07
HU201930B (en) 1991-01-28
GB2184726B (en) 1990-10-03
GB2184726A (en) 1987-07-01
IT1198263B (en) 1988-12-21
IT8622877A1 (en) 1988-06-24
CA1304369C (en) 1992-06-30
PT84022B (en) 1989-07-31
FI865295A7 (en) 1987-06-28
IT8622877A0 (en) 1986-12-24
PT84022A (en) 1987-01-01
HUT43060A (en) 1987-09-28
AU6698586A (en) 1987-07-02
AT397962B (en) 1994-08-25
BE906054A (en) 1987-06-29
PL263216A1 (en) 1988-04-14
FR2598417A1 (en) 1987-11-13
KR870005998A (en) 1987-07-08
NL8603303A (en) 1987-07-16
SE8605531D0 (en) 1986-12-22
AU584266B2 (en) 1989-05-18
NL193184C (en) 1999-02-02
KR930000113B1 (en) 1993-01-09
FR2598417B1 (en) 1993-10-29
FI865295A0 (en) 1986-12-23
CH677793A5 (en) 1991-06-28
YU46038B (en) 1992-12-21
GB8630809D0 (en) 1987-02-04

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2006-12-24