ES2004268A6 - Procedimiento para preparar nuevos esteroides en un ciclo espiranico en posicion 17 - Google Patents

Procedimiento para preparar nuevos esteroides en un ciclo espiranico en posicion 17

Info

Publication number
ES2004268A6
ES2004268A6 ES8700832A ES8700832A ES2004268A6 ES 2004268 A6 ES2004268 A6 ES 2004268A6 ES 8700832 A ES8700832 A ES 8700832A ES 8700832 A ES8700832 A ES 8700832A ES 2004268 A6 ES2004268 A6 ES 2004268A6
Authority
ES
Spain
Prior art keywords
formula
spiranic
cycle
product
steroids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8700832A
Other languages
English (en)
Inventor
Francois Nique
Lucien Nedelec
Daniel Philibert
Martine Moguilewsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of ES2004268A6 publication Critical patent/ES2004268A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR NUEVOS ESTEROIDES CON UN CICLO ESPIRANICO EN POSICION 17 DE FORMULA:DONDE R1=ARILO, ARALQUILO, EVENTUALMENTE SUSTITUIDOS; R2=RADICAL HIDROCARBONADO C1-18 CON DOBLE ENLACE EVENTUAL EN 3'', 4''; A, B REPRESENTANDONDE R'' Y R''K=H O ALQUILO C1-4 Y RE=H, ALQUILO C1-6 EVENTUALMENTE SUSTITUIDO O ACILO, O A, B, C REPRESENTANEN QUE SE SOMETE UN PRODUCTO DE FORMULA:DONDE K=GRUPO PROTECTOR, A LA ACCION DE UN REACTIVO DE CICLISACION PARA OBTENER PRODUCTOS DE FORMULA:QUE SE SOMETEN A UN REACTIVO DE DESHIDRATACION SUSCEPTIBLE DE LIBERAR LA FUNCION CETONA PARA OBTENER UN PRODUCTO DE FORMULA:DONDE R''=R''K=H, O BIEN OBTENER DIRECTAMENTE DICHO PRODUCTO IA, QUE, SI SE DESEA, SE SOMETE A REACCIONES SUBSIGUIENTES PARA OBTENER LOS DEMAS PRODUCTOS DE FORMULA I. LOS COMPUESTOS OBTENIDOS SON UTILES COMO AGENTES ANTIPROGESTOMIMETICOS.
ES8700832A 1986-03-26 1987-03-25 Procedimiento para preparar nuevos esteroides en un ciclo espiranico en posicion 17 Expired ES2004268A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8604355A FR2596395B1 (fr) 1986-03-26 1986-03-26 Nouveaux steroides comportant un cycle spirannique en position 17, leur procede de preparation, leur application comme medicaments et les compositions les renfermant

Publications (1)

Publication Number Publication Date
ES2004268A6 true ES2004268A6 (es) 1988-12-16

Family

ID=9333576

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8700832A Expired ES2004268A6 (es) 1986-03-26 1987-03-25 Procedimiento para preparar nuevos esteroides en un ciclo espiranico en posicion 17

Country Status (27)

Country Link
US (1) US4900725A (es)
EP (1) EP0262188B1 (es)
JP (2) JP2684180B2 (es)
KR (1) KR880701244A (es)
CN (1) CN1021445C (es)
AU (1) AU604692B2 (es)
CA (1) CA1299169C (es)
DK (1) DK174211B1 (es)
ES (1) ES2004268A6 (es)
FI (1) FI87078C (es)
FR (1) FR2596395B1 (es)
GR (1) GR870471B (es)
HU (1) HU198509B (es)
IE (1) IE60143B1 (es)
IL (1) IL82004A0 (es)
MA (1) MA20918A1 (es)
MX (1) MX5712A (es)
NZ (1) NZ219776A (es)
OA (1) OA08505A (es)
PH (1) PH25612A (es)
PT (1) PT84554B (es)
SU (1) SU1715205A3 (es)
TN (1) TNSN87042A1 (es)
TR (1) TR23117A (es)
WO (1) WO1987005908A1 (es)
YU (1) YU53387A (es)
ZA (1) ZA872130B (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0306846A3 (de) * 1987-09-11 1990-05-02 Dr. Karl Thomae GmbH Neue synergistische Kombination bestehend aus einem Phosphodiesterase-Hemmer und einem Thromboxan-A2-Antagonisten und deren Verwendung bzw. Herstellung
FR2620707B1 (fr) * 1987-09-18 1989-12-08 Roussel Uclaf Nouveaux steroides comportant un cycle spirannique a 3, 4 ou 6 chainons en position 17, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
DE3921059A1 (de) * 1989-06-23 1991-01-10 Schering Ag 11(beta)-aryl-4-estrene, verfahren zu ihrer herstellung sowie deren verwendung als arzneimittel
FR2651233B1 (fr) * 1989-08-23 1991-12-13 Roussel Uclaf Nouveaux acides omega-phenylamino alcanouiques substitues sur le noyau aromatique par un radical derive de 19-norsterouides, leur procede de preparation, leur application a titre de medicaments et les compositions les renfermant.
FR2654337B1 (fr) * 1989-11-15 1994-08-05 Roussel Uclaf Nouvelles microspheres injectables biodegradables procede de preparation et suspensions injectables les renfermant.
DE4018168A1 (de) * 1990-06-01 1991-12-05 Schering Ag Ausgangsverbindungen fuer die herstellung von 10ss-h-steroiden und ein verfahren zur herstellung dieser ausgangsverbindungen
ZA929315B (en) * 1991-12-20 1993-05-24 Akzo Nv 17-spirofuran-3'-ylidene steroids.
CA2100514C (en) * 1992-07-29 2005-03-29 Johannes A. M. Hamersma 17-spiromethylene steroids
IL115659A (en) * 1994-10-27 2000-06-01 Akzo Nobel Nv Steroids with a 17-spiromethylene lactone or lactol group process for their preparation and pharmaceutical compositions containing them
FR2757399B1 (fr) * 1996-12-23 1999-12-17 Hoechst Marion Roussel Inc Application de composes steroides substitues en 11 pour la fabrication de medicaments ayant une activite estrogene dissociee
US6020328A (en) * 1998-03-06 2000-02-01 Research Triangle Institute 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
ATE473759T1 (de) 1998-05-22 2010-07-15 Univ Leland Stanford Junior Bifunktionelle moleküle sowie darauf basierende therapien.
US6262042B1 (en) 1998-05-29 2001-07-17 Research Triangle Institute 17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US5962444A (en) * 1998-05-29 1999-10-05 Research Triangle Institute 17β-nitro-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
FR2789393B1 (fr) * 1999-02-05 2001-10-12 Centre Nat Rech Scient Lactol steroidique
EP2392258B1 (en) 2005-04-28 2014-10-08 Proteus Digital Health, Inc. Pharma-informatics system
US9062126B2 (en) 2005-09-16 2015-06-23 Raptor Pharmaceuticals Inc. Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
DE102006054535A1 (de) * 2006-11-15 2008-05-21 Bayer Schering Pharma Aktiengesellschaft Progesteronrezeptorantagonisten
GB0711948D0 (en) * 2007-06-20 2007-08-01 Bionature E A Ltd Neurosteriod compounds
PL3395372T3 (pl) 2009-02-20 2022-07-25 EnhanX Biopharm Inc. Układ do dostarczania leków na bazie glutationu
CN102458374A (zh) 2009-05-06 2012-05-16 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其使用方法
DE102009034368A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-acyloxyalkylenphenyl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034367A1 (de) * 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102009034366A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-methylenoxyalkylenaryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034362A1 (de) * 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034526A1 (de) * 2009-07-21 2011-02-10 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-ethinylphenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102009034525A1 (de) 2009-07-21 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
CN102711769A (zh) * 2009-09-11 2012-10-03 生态自然E·A有限公司 甾体化合物在炎性和自身免疫疾病中的应用
DE102010007719A1 (de) 2010-02-10 2011-08-11 Bayer Schering Pharma Aktiengesellschaft, 13353 Progesteronrezeptorantagonisten
DE102010007722A1 (de) 2010-02-10 2011-08-11 Bayer Schering Pharma Aktiengesellschaft, 13353 Progesteronrezeptorantagonisten
US9096641B2 (en) * 2013-06-05 2015-08-04 Evestra, Inc. Imidazolyl progesterone antagonists
WO2023000135A1 (en) * 2021-07-19 2023-01-26 Context Biopharma Inc. Processes of making onapristone and intermediates thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3509135A (en) * 1968-07-26 1970-04-28 Searle & Co 3-oxygenated 4'-5 - dihydrospiro(estra-4,9-diene-17,2'(3'h)-furans) and congeners
US3764596A (en) * 1971-06-22 1973-10-09 Sandoz Ag 17-dihydrofuranyl-substituted steroids
FR2496669A1 (fr) * 1980-12-23 1982-06-25 Roussel Uclaf Nouveaux derives steroides 3-ceto4 ou1-4 substitues en position 7, leur procede de preparation et leur application comme medicaments
FR2528434B1 (fr) * 1982-06-11 1985-07-19 Roussel Uclaf Nouveaux 19-nor steroides substitues en 11b et eventuellement en 2, leur procede de preparation et leur application comme medicament
ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
DE3410880A1 (de) * 1984-03-21 1985-10-03 Schering AG, Berlin und Bergkamen, 1000 Berlin 17-substituierte estradiene und estratriene

Also Published As

Publication number Publication date
TNSN87042A1 (fr) 1990-01-01
DK174211B1 (da) 2002-09-23
IE60143B1 (en) 1994-06-01
GR870471B (en) 1987-07-30
FR2596395B1 (fr) 1989-05-26
EP0262188B1 (fr) 1990-11-14
TR23117A (tr) 1989-04-03
HUT46037A (en) 1988-09-28
HU198509B (en) 1989-10-30
FI875202L (fi) 1987-11-25
FI87078C (fi) 1992-11-25
SU1715205A3 (ru) 1992-02-23
CN87103193A (zh) 1988-01-13
KR880701244A (ko) 1988-07-26
JP2652007B2 (ja) 1997-09-10
ZA872130B (en) 1988-05-25
FR2596395A1 (fr) 1987-10-02
WO1987005908A1 (fr) 1987-10-08
OA08505A (fr) 1988-07-29
YU53387A (en) 1988-08-31
DK618287D0 (da) 1987-11-25
CN1021445C (zh) 1993-06-30
PH25612A (en) 1991-08-08
PT84554B (pt) 1989-11-10
PT84554A (fr) 1987-04-01
MX5712A (es) 1993-11-01
JPH08311094A (ja) 1996-11-26
JPS63502902A (ja) 1988-10-27
EP0262188A1 (fr) 1988-04-06
AU604692B2 (en) 1991-01-03
IE870772L (en) 1987-09-26
US4900725A (en) 1990-02-13
IL82004A0 (en) 1987-10-20
FI875202A0 (fi) 1987-11-25
FI87078B (fi) 1992-08-14
DK618287A (da) 1988-01-22
JP2684180B2 (ja) 1997-12-03
AU7167487A (en) 1987-10-20
CA1299169C (fr) 1992-04-21
MA20918A1 (fr) 1987-10-01
NZ219776A (en) 1990-03-27

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