ES2004465A6 - Procedimiento de preparcion de un nuevo derivado de diosmina - Google Patents

Procedimiento de preparcion de un nuevo derivado de diosmina

Info

Publication number
ES2004465A6
ES2004465A6 ES8702270A ES8702270A ES2004465A6 ES 2004465 A6 ES2004465 A6 ES 2004465A6 ES 8702270 A ES8702270 A ES 8702270A ES 8702270 A ES8702270 A ES 8702270A ES 2004465 A6 ES2004465 A6 ES 2004465A6
Authority
ES
Spain
Prior art keywords
preparation
diosmin
new
diosmine
derivate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8702270A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Faes Farma SA
Original Assignee
Fabrica Espanola de Productos Quimicos y Farmaceuticos FAES SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES554841A priority Critical patent/ES8707969A1/es
Priority to PT82827A priority patent/PT82827B/pt
Priority to FR8706508A priority patent/FR2598415B1/fr
Priority to IT8720444A priority patent/IT1215471B/it
Priority to DE3715447A priority patent/DE3715447C2/de
Application filed by Fabrica Espanola de Productos Quimicos y Farmaceuticos FAES SA filed Critical Fabrica Espanola de Productos Quimicos y Farmaceuticos FAES SA
Priority to EP87500053A priority patent/EP0302155B1/en
Priority to ES8702270A priority patent/ES2004465A6/es
Priority to AT0185388A priority patent/AT397504B/de
Priority to ZA885264A priority patent/ZA885264B/xx
Priority to NL8801840A priority patent/NL8801840A/nl
Priority to FI883508A priority patent/FI88924C/fi
Priority to LU87298A priority patent/LU87298A1/fr
Priority to US07/225,544 priority patent/US4894449A/en
Priority to KR1019880009540A priority patent/KR890002217A/ko
Priority to GR880100499A priority patent/GR880100499A/el
Priority to CA000573330A priority patent/CA1318317C/en
Priority to JP63189532A priority patent/JPS6463590A/ja
Priority to PT88158A priority patent/PT88158B/pt
Priority to AR88311551A priority patent/AR247216A1/es
Priority to NO883363A priority patent/NO171165C/no
Priority to SE8802755A priority patent/SE8802755L/xx
Priority to AU20128/88A priority patent/AU613386B2/en
Publication of ES2004465A6 publication Critical patent/ES2004465A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/07—Benzo[b]pyran-4-ones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A LA PREPARACION DE OCTASULFATO DE DIOSMINA Y ALUMINIO, UN NUEVO DERIVADO DE DIOSMINA, MEDIANTE REACCION DE DIOSMINA CON UN AGENTE SULFATANTE, TAL COMO COMPLEJO TRIOXIDO DE AZUFRE-PIRIDINA, COMPLEJO TRIOXIDO DE AZUFRE-TRIMETILAMINA Y COMPLEJO TRIOXIDO DE AZUFRE-TRIETILAMINA, A TEMPERATURA COMPRENDIDA ENTRE 40G Y 110GC, EN UN MEDIO ADECUADO, PREFERENTEMENTE PIRIDINA, DIMETILFORMAMIDA Y DIMETILACETAMIDA, Y ADICION FINAL DE HIDROXICLORURO DE ALUMINIO.
ES8702270A 1986-05-09 1987-07-31 Procedimiento de preparcion de un nuevo derivado de diosmina Expired ES2004465A6 (es)

Priority Applications (22)

Application Number Priority Date Filing Date Title
ES554841A ES8707969A1 (es) 1986-05-09 1986-05-09 Procedimiento de preparacion de una mezcla estandar de o-(b-hidroxietil)-diosminas
PT82827A PT82827B (pt) 1986-05-09 1986-06-23 Processo de preparacao duma mistura padrao de o-(beta-hidroxietil)-diosminas
FR8706508A FR2598415B1 (fr) 1986-05-09 1987-05-07 Procede de preparation d'un melange standard de mono-0-(b-hydroxy-ethyl)-diosmines et de di-0-(b-hydroxyethyl)-diosmine
IT8720444A IT1215471B (it) 1986-05-09 1987-05-08 Processo per la preparazione di una miscela standard di o-(beta -idrossietil)-diosmine.
DE3715447A DE3715447C2 (de) 1986-05-09 1987-05-08 Verfahren zur Herstellung einer Mischung von O-(beta-Hydroxyethyl)-diosminen
EP87500053A EP0302155B1 (en) 1986-05-09 1987-07-31 Preparation of a new diosmine derivate
ES8702270A ES2004465A6 (es) 1986-05-09 1987-07-31 Procedimiento de preparcion de un nuevo derivado de diosmina
AT0185388A AT397504B (de) 1987-07-31 1988-07-19 Diosminderivat und verfahren zu dessen herstellung
ZA885264A ZA885264B (en) 1986-05-09 1988-07-20 Preparation of a new diosmine derivative
NL8801840A NL8801840A (nl) 1986-05-09 1988-07-20 Bereiding van een nieuw diosmine derivaat.
FI883508A FI88924C (fi) 1987-07-31 1988-07-26 Foerfarande foer framstaellning av nytt diosminderivat
LU87298A LU87298A1 (fr) 1986-05-09 1988-07-27 Nouveau derive de diosmine et sa preparation
US07/225,544 US4894449A (en) 1986-05-09 1988-07-28 Diosmin octakis (hydrogen sulfate) aluminum complex
KR1019880009540A KR890002217A (ko) 1987-07-31 1988-07-28 신규 디오스민 유도체의 제조
GR880100499A GR880100499A (el) 1987-07-31 1988-07-28 Μεθοδος παρασκευης νεου παραγωγου διοσμινης.
CA000573330A CA1318317C (en) 1987-07-31 1988-07-28 Preparation of a new diosmine derivative
JP63189532A JPS6463590A (en) 1987-07-31 1988-07-28 Novel diosmine derivative and its production
PT88158A PT88158B (pt) 1986-05-09 1988-07-29 Processo para a preparacao de um novo derivado de diosmina
AR88311551A AR247216A1 (es) 1987-07-31 1988-07-29 Procedimiento de preparacion de octasulfato de aluminio y diosmina.
NO883363A NO171165C (no) 1987-07-31 1988-07-29 Analogifremgangsmaate for fremstilling av et terapeutisk aktivt diosmin-octakis-(hydrogensulfat)-aluminiumkompleks
SE8802755A SE8802755L (sv) 1986-05-09 1988-07-29 Framstaellning av ett nytt diosminderivat
AU20128/88A AU613386B2 (en) 1987-07-31 1988-07-29 Preparation of a new diosmine derivative

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES554841A ES8707969A1 (es) 1986-05-09 1986-05-09 Procedimiento de preparacion de una mezcla estandar de o-(b-hidroxietil)-diosminas
ES8702270A ES2004465A6 (es) 1986-05-09 1987-07-31 Procedimiento de preparcion de un nuevo derivado de diosmina

Publications (1)

Publication Number Publication Date
ES2004465A6 true ES2004465A6 (es) 1989-01-01

Family

ID=39671968

Family Applications (2)

Application Number Title Priority Date Filing Date
ES554841A Expired ES8707969A1 (es) 1986-05-09 1986-05-09 Procedimiento de preparacion de una mezcla estandar de o-(b-hidroxietil)-diosminas
ES8702270A Expired ES2004465A6 (es) 1986-05-09 1987-07-31 Procedimiento de preparcion de un nuevo derivado de diosmina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES554841A Expired ES8707969A1 (es) 1986-05-09 1986-05-09 Procedimiento de preparacion de una mezcla estandar de o-(b-hidroxietil)-diosminas

Country Status (11)

Country Link
US (1) US4894449A (es)
EP (1) EP0302155B1 (es)
DE (1) DE3715447C2 (es)
ES (2) ES8707969A1 (es)
FR (1) FR2598415B1 (es)
IT (1) IT1215471B (es)
LU (1) LU87298A1 (es)
NL (1) NL8801840A (es)
PT (2) PT82827B (es)
SE (1) SE8802755L (es)
ZA (1) ZA885264B (es)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2041216A1 (es) * 1992-02-25 1993-11-01 Espanola Prod Quimicos Procedimiento de preparacion de un nuevo derivado sulfatado de diosmina.
ES2158774A1 (es) * 1999-04-12 2001-09-01 Faes Fabrica Espanola De Produ Nuevo procedimiento para la preparacion industrial de dosmalfato en povo.

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5202123A (en) * 1990-04-20 1993-04-13 Somerville Technology Group, Inc. Surface modified aluminum and aluminum-zirconium salts
US7034054B2 (en) * 2000-12-15 2006-04-25 Galileo Pharmaceuticals, Inc. Methods for the prevention and treatment of cerebral ischemia using non-alpha tocopherols
US6384271B1 (en) * 2001-05-04 2002-05-07 E.I. Du Pont De Nemours And Company Sulfonation, sulfation and sulfamation
CN103408621B (zh) * 2013-08-16 2015-09-30 李玉山 一种海曲司明的合成工艺
CN108992456B (zh) * 2018-07-19 2021-05-04 湘北威尔曼制药股份有限公司 含有香叶木苷硫酸酯衍生物的药物组合物及其应用
EP3949972A4 (en) 2019-05-05 2022-06-15 Guangzhou Century Clinical Research Co., Ltd COMPOUND FOR REGULATING AN IMBALANCE OF BODY WEIGHT, COMPOSITION THEREOF AND APPLICATION THEREOF

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3432489A (en) * 1965-11-05 1969-03-11 Chugai Pharmaceutical Co Ltd Disaccharide polysulfate aluminium compound and method
FR6967M (es) * 1968-01-22 1969-05-19
ES469101A1 (es) * 1978-04-25 1978-11-16 Espanola Prod Quimicos Procedimiento de obtencion de eteres hidrosolubles de hidro-xiflavonas.
US4334058A (en) * 1979-07-31 1982-06-08 American Cyanamid Company Rutin poly(H--)sulfate salts and related compounds
CH644374A5 (en) * 1981-05-18 1984-07-31 Espanola Prod Quimicos Water-soluble hydroxyflavone ethers and medicaments containing them
US4342753A (en) * 1981-06-15 1982-08-03 American Cyanamid Company Carboxyalkyl derivatives of rutin poly(H-)sulfate
EP0075626A1 (en) * 1981-09-29 1983-04-06 American Cyanamid Company Novel rutin nona- and deca(H-)sulfate salts, methods of preparing novel salts, and use of novel salts of complement inhibitors

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2041216A1 (es) * 1992-02-25 1993-11-01 Espanola Prod Quimicos Procedimiento de preparacion de un nuevo derivado sulfatado de diosmina.
ES2158774A1 (es) * 1999-04-12 2001-09-01 Faes Fabrica Espanola De Produ Nuevo procedimiento para la preparacion industrial de dosmalfato en povo.

Also Published As

Publication number Publication date
NL8801840A (nl) 1989-02-16
SE8802755D0 (sv) 1988-07-29
SE8802755L (sv) 1989-02-01
ZA885264B (en) 1989-07-26
ES8707969A1 (es) 1987-10-01
PT82827A (en) 1986-07-01
IT8720444A0 (it) 1987-05-08
DE3715447A1 (de) 1988-02-11
US4894449A (en) 1990-01-16
PT88158B (pt) 1995-03-01
EP0302155A1 (en) 1989-02-08
EP0302155B1 (en) 1993-10-27
DE3715447C2 (de) 1998-09-03
LU87298A1 (fr) 1989-02-02
FR2598415A1 (fr) 1987-11-13
PT88158A (pt) 1989-06-30
ES554841A0 (es) 1987-10-01
FR2598415B1 (fr) 1994-05-27
PT82827B (pt) 1988-04-21
IT1215471B (it) 1990-02-14

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001009