ES2006109A6 - Un procedimiento para preparar un conjugado de inmunoglobulina. - Google Patents

Un procedimiento para preparar un conjugado de inmunoglobulina.

Info

Publication number
ES2006109A6
ES2006109A6 ES8800719A ES8800719A ES2006109A6 ES 2006109 A6 ES2006109 A6 ES 2006109A6 ES 8800719 A ES8800719 A ES 8800719A ES 8800719 A ES8800719 A ES 8800719A ES 2006109 A6 ES2006109 A6 ES 2006109A6
Authority
ES
Spain
Prior art keywords
preparing
procedure
immunoglobulin conjugate
antigen
immunoglobulin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8800719A
Other languages
English (en)
Inventor
Ian Farquhar Mckenzie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Carlo Erba SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL, Carlo Erba SpA filed Critical Farmitalia Carlo Erba SRL
Publication of ES2006109A6 publication Critical patent/ES2006109A6/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/44—Antibodies bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UN PROCEDIMIENTO PARA PREPARAR UN CONJUGADO DE INMUNOGLOBULINA. LOS CONJUGADOS DE INMUNOGLOBULINAS, FORMADOS POR IDARRUBICINA (IDA) CONJUGADA A UN ANTICUERPO O FRAGMENTO DE ANTICUERPO MONOCLONAL QUE CONTIENE POR LO MENOS UNO DE LOS SITIOS DE FIJACION DEL ANTIGENO EN EL ANTICUERPO, SON UTILES PARA TRATAR UN SER HUMANO O UN ANIMAL ENFERMOS DE CANCER O PARA ELIMINAR UNA SUBPOBLACION DE LINFOCITOS T DE UNA POBLACION DE CELULAS.
ES8800719A 1987-03-11 1988-03-10 Un procedimiento para preparar un conjugado de inmunoglobulina. Expired ES2006109A6 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPI080387 1987-03-11
AUPI295587 1987-07-07

Publications (1)

Publication Number Publication Date
ES2006109A6 true ES2006109A6 (es) 1989-04-01

Family

ID=25643244

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8800719A Expired ES2006109A6 (es) 1987-03-11 1988-03-10 Un procedimiento para preparar un conjugado de inmunoglobulina.

Country Status (29)

Country Link
US (1) US5798097A (es)
JP (1) JP2736255B2 (es)
KR (1) KR0130906B1 (es)
CN (1) CN1045621C (es)
AT (1) AT395375B (es)
AU (1) AU622105B2 (es)
BE (1) BE1001051A4 (es)
CA (1) CA1329156C (es)
CH (1) CH678815A5 (es)
CZ (1) CZ281193B6 (es)
DE (1) DE3808166C2 (es)
DK (1) DK173792B1 (es)
ES (1) ES2006109A6 (es)
FI (1) FI98706C (es)
FR (1) FR2612074B1 (es)
GB (1) GB2203154B (es)
GR (1) GR1000059B (es)
HU (1) HU205266B (es)
IE (1) IE64781B1 (es)
IL (1) IL85688A0 (es)
IT (1) IT8819746A0 (es)
MY (1) MY103231A (es)
NL (1) NL8800610A (es)
NO (1) NO178954C (es)
NZ (1) NZ223834A (es)
PT (1) PT86960B (es)
RU (1) RU2106147C1 (es)
SE (1) SE503402C2 (es)
YU (1) YU46858B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6824777B1 (en) * 1992-10-09 2004-11-30 Licentia Ltd. Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy
JP4841724B2 (ja) * 1998-10-09 2011-12-21 ベジェニクス ピーティーワイ リミテッド 腫瘍イメージングおよび抗腫瘍治療の標的としてのＦｌｔ４（ＶＥＲＧ−３）
AU2002216864A1 (en) * 2000-12-21 2002-07-01 Mcgill University Conjugates of antibodies and anticancer drugs
JP4669984B2 (ja) * 2001-01-19 2011-04-13 ベジェニクス リミテッド 腫瘍画像化のターゲットとしてのＦ１ｔ４（ＶＥＧＦＲ−３）および抗腫瘍療法
US7592143B2 (en) * 2003-04-18 2009-09-22 Cytovia, Inc. Methods of treating diseases responsive to induction of apoptosis and screening assays
GB0511266D0 (en) * 2005-06-02 2005-07-13 Trust Chemical compounds
US20080108138A1 (en) * 2006-06-13 2008-05-08 Vermette Patrick Bioactive compositions and their use in cell patterning
CN103443125B (zh) 2010-11-30 2019-05-03 霍夫曼-拉罗奇有限公司 低亲和力血脑屏障受体抗体及其用途
MY170528A (en) 2013-02-18 2019-08-09 Vegenics Pty Ltd Vegfr-3 ligand binding molecules and uses thereof
EP4157241A4 (en) * 2020-05-29 2025-01-08 The Regents of the University of California AGENTS AND METHODS FOR THE TREATMENT OF TAUOPATHIES

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1500421A (en) * 1975-01-22 1978-02-08 Farmaceutici Italia Optically active anthracyclinones
AT346838B (de) * 1975-01-22 1978-11-27 Farmaceutici Italia Verfahren zur herstellung von neuen optisch aktiven anthracyclinonen
AT343811B (de) * 1975-01-22 1978-06-26 Farmaceutici Italia Verfahren zur herstellung von neuen optisch aktiven anthracyclinonen
AT343812B (de) * 1975-01-22 1978-06-26 Farmaceutici Italia Verfahren zur herstellung von neuen optisch aktiven daunosaminylderivaten von anthracyclinonen
GB1511680A (en) 1975-11-18 1978-05-24 Farmaceutici Italia Daunosaminyl anthracyclinones
GB1541436A (en) * 1976-02-02 1979-02-28 Searle & Co Immunological materials
US5162512A (en) * 1982-03-09 1992-11-10 Cytogen Corporation Amine derivatives of anthracycline antibodies
US4867973A (en) * 1984-08-31 1989-09-19 Cytogen Corporation Antibody-therapeutic agent conjugates
US4950738A (en) * 1984-09-13 1990-08-21 Cytogen Corporation Amine derivatives of anthracycline antibiotics
JPS59186924A (ja) * 1983-04-08 1984-10-23 Kureha Chem Ind Co Ltd ヒト免疫グロブリン結合抗腫瘍剤
US4545985A (en) * 1984-01-26 1985-10-08 The United States Of America As Represented By The Secretary, Dept. Of Health And Human Services Pseudomonas exotoxin conjugate immunotoxins
GB8413464D0 (en) * 1984-05-25 1984-07-04 Erba Farmitalia Anthracycline-anionic polymer conjugates
JPS61155334A (ja) * 1984-12-28 1986-07-15 Teijin Ltd 殺細胞性修飾免疫グロブリン及びその製造方法
FR2584293B1 (fr) * 1985-07-04 1989-03-17 Ire Celltarg Sa Anticorps utiles comme agents de pilotage et conjugues les incorporant

Also Published As

Publication number Publication date
JP2736255B2 (ja) 1998-04-02
KR880010775A (ko) 1988-10-24
MY103231A (en) 1993-05-29
NO178954C (no) 1996-07-10
NO178954B (no) 1996-04-01
US5798097A (en) 1998-08-25
FI881158L (fi) 1988-09-12
HUT46547A (en) 1988-11-28
IE64781B1 (en) 1995-09-06
YU46858B (sh) 1994-06-24
DE3808166C2 (de) 1997-08-28
FI98706C (fi) 1997-08-11
GB2203154B (en) 1991-06-26
FI881158A0 (fi) 1988-03-11
YU48288A (en) 1989-08-31
NO881105D0 (no) 1988-03-11
CN1045621C (zh) 1999-10-13
DE3808166A1 (de) 1988-09-22
NZ223834A (en) 1990-05-28
KR0130906B1 (ko) 1998-04-23
CH678815A5 (es) 1991-11-15
SE8800886D0 (sv) 1988-03-11
AT395375B (de) 1992-12-10
IL85688A0 (en) 1988-08-31
JPS63301832A (ja) 1988-12-08
GB8805865D0 (en) 1988-04-13
FR2612074B1 (fr) 1991-06-21
GR880100148A (en) 1989-01-31
PT86960A (pt) 1988-04-01
SE8800886L (sv) 1989-09-12
GR1000059B (el) 1990-06-27
HU205266B (en) 1992-04-28
SE503402C2 (sv) 1996-06-10
BE1001051A4 (fr) 1989-06-20
NL195078C (es) 2003-07-30
DK173792B1 (da) 2001-11-05
DK131588D0 (da) 1988-03-11
GB2203154A (en) 1988-10-12
PT86960B (pt) 1992-06-30
NL8800610A (nl) 1988-10-03
CZ161288A3 (en) 1996-07-17
FI98706B (fi) 1997-04-30
IT8819746A0 (it) 1988-03-11
CN88101810A (zh) 1988-11-09
CA1329156C (en) 1994-05-03
CZ281193B6 (cs) 1996-07-17
ATA67488A (de) 1992-05-15
NO881105L (no) 1988-09-12
AU1288188A (en) 1988-09-15
RU2106147C1 (ru) 1998-03-10
DK131588A (da) 1988-09-12
FR2612074A1 (fr) 1988-09-16
IE880701L (en) 1988-09-11
AU622105B2 (en) 1992-04-02

Similar Documents

Publication Publication Date Title
AU563356B2 (en) Conjugate of enzyme and antibody
MY104946A (en) Antigen antibody conjugate.
GB9009548D0 (en) Chimeric antibody and method
EP0597829A4 (en) MONOCLONAL ANTIBODIES AGAINST A NEW ANTIQUE ASSOCIATED WITH HUMAN TUMORS.
DE69221147D1 (de) Nicht glycosylierter Anti-CD3-IgG-Antikörper
NO963168D0 (no) Immunstimulatoriske monoklonale antistoffer
PT743856E (pt) Heteropolimeros a base de antigenes e metodo para o tratamento de doencas auto-imunes utilizando esses heteropolimeros
ES8506091A1 (es) Un procedimiento para obtener un polidoma
NO862641D0 (no) Monoklonalt antistoff for et antigen tilknyttet human karsinoma tumor.
FI913891A7 (fi) Uusi monoklonaalinen vasta-aine uutta antigeenia vastaan, joka liittyy ihmisen kasvaimiin
NO863974D0 (no) Monoklonale antihuman brystkreftantistoffer.
CA2078118A1 (en) Cc-1065 analogs
NO901986D0 (no) Nytt antistoff-leveringssystem for biologisk respons-modifiserende midler.
IL89823A0 (en) Antibody hetero conjugates and pharmaceutical compositions containing them
GR3020610T3 (en) Monoclonal antibodies against tumor associated antigen, their preparation and use
DK167884D0 (da) Immunoglobulinkonjugater
SE8800886D0 (sv) Immunoglobulin conjugates
EP0683822A4 (en) PRODUCTION OF PHOTOPROTEIN CONJUGATES AND METHOD FOR USE THEREOF.
EP0352722A3 (en) Adenocarcinoma antigen binding methods and reagents
PT733903E (pt) Processo de dosagem imunologica de cortisol nomeadamente urinario e reagentes utilizados
ATE131069T1 (de) Composition comprising at least two different antibodies or fragments thereof.
WO1987007302A3 (en) MONOCLONAL ANTIBODIES TO HUMAN LYMPHOCYTE IgE RECEPTORS, HYBRIDOMAS PRODUCING SUCH ANTIBODIES, AND KITS FOR USING SUCH ANTIBODIES
NZ314010A (en) A method of targeting intracellular binding proteins using a lipidized antibody
ATE14937T1 (de) Monoklonaler hybridoma-antikoerper spezifisch fuer karzinoembryonisches antigen mit hohem molekulargewicht.

Legal Events

Date Code Title Description
PC1A Transfer granted
PC1A Transfer granted
FD1A Patent lapsed

Effective date: 20080311