ES2007052A6 - Metodo de producir derivados de 1,1,2-triaril-1-buteno - Google Patents

Metodo de producir derivados de 1,1,2-triaril-1-buteno

Info

Publication number
ES2007052A6
ES2007052A6 ES8701742A ES8701742A ES2007052A6 ES 2007052 A6 ES2007052 A6 ES 2007052A6 ES 8701742 A ES8701742 A ES 8701742A ES 8701742 A ES8701742 A ES 8701742A ES 2007052 A6 ES2007052 A6 ES 2007052A6
Authority
ES
Spain
Prior art keywords
triaryl
butene
derivatives
acceptable salts
pharmacologically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8701742A
Other languages
English (en)
Inventor
Tesuji Asao
Setsuo Takeda
Yoshikazu Sugimoto
Toshiyuki Toko
Yuji Yamada
Kazuo Ogawa
Norio Unemi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Publication of ES2007052A6 publication Critical patent/ES2007052A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

METODO DE PRODUCIR DERIVADOS DE 1,1,2-TRIARIL-1-BUTENO DE LA FORMULA (TENIENDO R1, R2, R3 Y R4 LOS VALORES INDICADOS EN LA DESCRIPCIPON) O SUS SALES FARMACOLOGICAMENTE ACEPTABLES. EL METODO CONSISTE EN FOSFORILAR UN DERIVADO DE 1,1,2-TRIARIL-1-BUTENO Y, EN SU CASO, HACER REACCIONAR EL PRODUCTO RESULTANTE CON UN ACIDO O UNA BASE PARA FORMAR UNA DE SUS SALES FARMACOLOGICAMENTE ACEPTABLES. LOS DERIVADOS OBTENIDOS SE APLICAN AL TRATAMIENTO DE CANCER DE MAMA Y LA INFERTILIDAD ANOVULATORIA.
ES8701742A 1986-06-16 1987-06-12 Metodo de producir derivados de 1,1,2-triaril-1-buteno Expired ES2007052A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13989786 1986-06-16

Publications (1)

Publication Number Publication Date
ES2007052A6 true ES2007052A6 (es) 1989-06-01

Family

ID=15256159

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8701742A Expired ES2007052A6 (es) 1986-06-16 1987-06-12 Metodo de producir derivados de 1,1,2-triaril-1-buteno

Country Status (6)

Country Link
US (1) US4897503A (es)
EP (1) EP0272330B1 (es)
AU (1) AU611090B2 (es)
CA (1) CA1289570C (es)
ES (1) ES2007052A6 (es)
WO (1) WO1987007609A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1289570C (en) * 1986-06-16 1991-09-24 Tetsuji Asao 1,1,2-triaryl-1-alkene derivatives
US5681835A (en) * 1994-04-25 1997-10-28 Glaxo Wellcome Inc. Non-steroidal ligands for the estrogen receptor
CN1275911A (zh) 1997-08-15 2000-12-06 杜克大学 一种预防或治疗雌激素依赖性疾病及失调的方法
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE637389A (es) * 1962-09-13
GB1013907A (en) * 1962-09-13 1965-12-22 Ici Ltd Alkene derivatives
US3288806A (en) * 1964-03-23 1966-11-29 Parke Davis & Co Alpha-(aminoethoxyphenyl)-alpha-alkylstilbenes
GB1560274A (en) * 1977-02-28 1980-02-06 Ici Ltd Phenylbut 1-ene derivatives having antiostrogenicactivity
EP0002097B1 (en) * 1977-08-22 1981-08-05 Imperial Chemical Industries Plc Triphenylalkene derivatives, process for their preparation and pharmaceutical compositions containing them
GB2003855B (en) * 1977-08-22 1982-10-27 Ici Ltd Triphenylbut-1-ene derivatives
US4206234A (en) * 1977-08-22 1980-06-03 Imperial Chemical Industries Limited Triphenylbut-1-ene derivatives and pharmaceutical compositions and uses thereof
CA1289570C (en) * 1986-06-16 1991-09-24 Tetsuji Asao 1,1,2-triaryl-1-alkene derivatives

Also Published As

Publication number Publication date
EP0272330A4 (en) 1988-10-20
AU611090B2 (en) 1991-06-06
WO1987007609A1 (fr) 1987-12-17
US4897503A (en) 1990-01-30
EP0272330A1 (en) 1988-06-29
AU7519987A (en) 1988-01-11
JPH0557277B1 (es) 1993-08-23
EP0272330B1 (en) 1991-05-22
CA1289570C (en) 1991-09-24

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