ES2007121A6 - Un rpocedimiento para obtener derivados 2,4-disustituidos de tetrahidrofurado y 5-oxotetrahidrofurado. - Google Patents
Un rpocedimiento para obtener derivados 2,4-disustituidos de tetrahidrofurado y 5-oxotetrahidrofurado.Info
- Publication number
- ES2007121A6 ES2007121A6 ES8702900A ES8702900A ES2007121A6 ES 2007121 A6 ES2007121 A6 ES 2007121A6 ES 8702900 A ES8702900 A ES 8702900A ES 8702900 A ES8702900 A ES 8702900A ES 2007121 A6 ES2007121 A6 ES 2007121A6
- Authority
- ES
- Spain
- Prior art keywords
- derivs
- substd
- new
- alkyl
- furan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 title abstract 3
- HVAUUPRFYPCOCA-AREMUKBSSA-N 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCOC[C@@H](OC(C)=O)COP([O-])(=O)OCC[N+](C)(C)C HVAUUPRFYPCOCA-AREMUKBSSA-N 0.000 title 1
- 206010020772 Hypertension Diseases 0.000 title 1
- 206010061218 Inflammation Diseases 0.000 title 1
- 108010003541 Platelet Activating Factor Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 208000006673 asthma Diseases 0.000 title 1
- 230000004054 inflammatory process Effects 0.000 title 1
- 230000003389 potentiating effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- -1 halide Chemical class 0.000 abstract 3
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 150000007942 carboxylates Chemical class 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 125000005179 haloacetyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
EN LA PRESENTE INVENCION SE DESCRIBE UN PROCEDIMIENTO PARA OBTENER DERIVADOS 2,4-DISUSTITUIDOS DE TETRAHIDROFURANO Y 5-OXOTETRAHIDROFURANO, DE FORMULA (I) DONDE R REPRESENTA UN GRUPO ALQUILO DE CADENA LARGA; X ES UN GRUPO CH2 O UN GRUPO C=O; Y ES UN ENLACE COVALENTE O BIEN ES UN GRUPO CARBONILO, CARBOXILO, CARBAMOILO O UN GRUPO -P(=O)(OY)O-; Y ES UNA CARGA NEGATIVA (-) CUANDO Q VALE CERO, O Y ES UN ATOMO DE HIDROGENO CUANDO Q VALE 1; N ES UN NUMERO ENTERO DE 2 A 10; R1, R2 Y R3 SON GRUPOS ALQUILO INFERIOR O R1R2R3N+ REPRESENTA UN GRUPO AMONIO CICLICO DE TIPO AROMATICO, O R1R2R3N+ REPRESENTA UN GRUPO AMONIO CICLICO DE TIPO NO AROMATICO EN EL QUE DOS DE LOS GRUPOS (R1R2 O R3) FORMAN UN ANILLO JUNTO CON EL ATOMO DE N CUATERNARIO Y Z- ES UN ANION FARMACEUTICAMENTE ACEPTABLE. DICHOS COMPUESTOS SON INHIBIDORES IN VITRO DE LA AGREGACION PLAQUETARIA INDUCIDA POR EL FACTOR ACTIVADOR DE LAS PLAQUETAS (PAF) Y, POR LO TANTO, SON UTILES EN EL TRATAMIENTO DE LAS ENFERMEDADES EN LAS QUE DICHA SUSTANCIA SE ENCUENTRA INVOLUCRADA. POR OTRA PARTE, ALGUNOS DE DICHOS COMPUESTOS POSEEN ACTIVIDAD HIPOTENSORA SIN PROVOCAR ACTIVACION DE LAS PLAQUETAS.
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES8702900A ES2007121A6 (es) | 1987-10-13 | 1987-10-13 | Un rpocedimiento para obtener derivados 2,4-disustituidos de tetrahidrofurado y 5-oxotetrahidrofurado. |
| JP63258321A JPH01132582A (ja) | 1987-10-13 | 1988-10-13 | テトラヒドロフランの２，４−二置換誘導体 |
| US07/257,205 US4997843A (en) | 1987-10-13 | 1988-10-13 | 2,4-disubstituted derivatives of tetrahydrofuran useful for the treatment of PAF mediated illnesses |
| AT88116989T ATE76872T1 (de) | 1987-10-13 | 1988-10-13 | 2,4-disubstituierte tetrahydrofuranderivate. |
| DE8888116989T DE3871705T2 (de) | 1987-10-13 | 1988-10-13 | 2,4-disubstituierte tetrahydrofuranderivate. |
| EP88116989A EP0312040B1 (en) | 1987-10-13 | 1988-10-13 | 2,4-disubstituted derivatives of tetrahydrofuran |
| GR920401023T GR3004793T3 (es) | 1987-10-13 | 1992-06-04 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES8702900A ES2007121A6 (es) | 1987-10-13 | 1987-10-13 | Un rpocedimiento para obtener derivados 2,4-disustituidos de tetrahidrofurado y 5-oxotetrahidrofurado. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2007121A6 true ES2007121A6 (es) | 1989-06-01 |
Family
ID=8252809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8702900A Expired ES2007121A6 (es) | 1987-10-13 | 1987-10-13 | Un rpocedimiento para obtener derivados 2,4-disustituidos de tetrahidrofurado y 5-oxotetrahidrofurado. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2007121A6 (es) |
-
1987
- 1987-10-13 ES ES8702900A patent/ES2007121A6/es not_active Expired
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| SA6 | Expiration date (snapshot 920101) |
Free format text: 2007-10-13 |
|
| FD1A | Patent lapsed |
Effective date: 20001009 |