ES2007802A6 - Bis-tri:fluoro-ethoxy piperidinyl-methyl benzamide acetate prepn. - Google Patents
Bis-tri:fluoro-ethoxy piperidinyl-methyl benzamide acetate prepn.Info
- Publication number
- ES2007802A6 ES2007802A6 ES888800830A ES8800830A ES2007802A6 ES 2007802 A6 ES2007802 A6 ES 2007802A6 ES 888800830 A ES888800830 A ES 888800830A ES 8800830 A ES8800830 A ES 8800830A ES 2007802 A6 ES2007802 A6 ES 2007802A6
- Authority
- ES
- Spain
- Prior art keywords
- bis
- trifluoroetoxi
- prepn
- piperidinyl
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 fluoro-ethoxy piperidinyl-methyl benzamide acetate Chemical compound 0.000 title 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 229960000583 acetic acid Drugs 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- KXDAEFPNCMNJSK-UHFFFAOYSA-N benzene carboxamide Natural products NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 abstract 1
- 239000012362 glacial acetic acid Substances 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
UN PROCEDIMIENTO PARA LA OBTENCION DEL ACETATO DE 2,5-BIS-(2,2,2-TRIFLUOROETOXI)-N-(2-PIPERIDILMETIL)-BENZAMIDA. UN PROCEDIMIENTO PARA LA OBTENCION DEL ACETATO DE 2,5-BIS-(2,2,2-TRIFLUOROETOXI)-N-(2-PIPERIDILMETIL)-BENZAMIDA, CARACTERIZADO PORQUE SE HACE REACCIONAR EL ACIDO 2,5-BIS-(2,2,2-TRIFLUOROETOXI)-BENZOIDO EN SU FORMA ACTIVA, CON LA OCTAHIDROIMIDAZO- 1,5-A -PIRIDINA O 2- AZAINDOLIZIDINA, PARA OBRTENER EL INTERMEDIO HIDROCLORURO DE 3- 2,5-BIS-(2,2,2-TRIFLUOROETOXI)-BENZOIL -OCTAHIDROIMIDAZO 1,5-A -PIRIDINA, EL CUAL POR HIDROLISIS SELECTIVA CONDUCE A LA SAL DE LA BASE 2,5-BIS-(2,2,2-TRIFLUOROETOXI)-N-(2-PIPERIDILMETIL)-BENZAMIDA, QUE TRATADA CON ACIDO ACETICO GLACIAL DA LUGAR AL ACETATO DE 2,5-BIS-(2,2,2-TRIFLUOROETOXI)-N-(2-PIPERIDILMETIL)-BENZAMIDA, DE FORMULAA PROCEDURE FOR OBTAINING 2,5-BIS- (2,2,2-TRIFLUOROETOXI) -N- (2-PIPERIDYL METHYL) -BENZAMIDE ACETATE. A PROCEDURE FOR OBTAINING 2,5-BIS- (2,2,2-TRIFLUOROETOXI) -N- (2-PIPERIDYL METHYL) -BENZAMIDE, CHARACTERIZED BECAUSE THE 2,5-BIS ACID IS REACTED- (2, 2,2-TRIFLUOROETOXI) -BENZOIDE IN ITS ACTIVE FORM, WITH OCTAHIDROIMIDAZO- 1,5-A -PIRIDINA OR 2- AZAINDOLIZIDINA, TO OBTAIN THE INTERMEDIATE HYDROCHLORIDE OF 3- 2,5-BIS- (2,2,2- TRIFLUOROETOXI) -BENZOIL -OCTAHIDROIMIDAZO 1,5-A -PIRIDINA, WHICH BY SELECTIVE HYDROLYSIS LEADS TO THE SALT OF THE BASE 2,5-BIS- (2,2,2-TRIFLUOROETOXI) -N- (2-PIPERIDILMETIL) - BENZAMIDE, WHICH TREATED WITH GLACIAL ACETIC ACID, GIVES PLACE TO 2,5-BIS- (2,2,2-TRIFLUOROETOXI) -N- (2-PIPERIDYL METHYL) -BENZAMIDE, FROM FORMULA
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES888800830A ES2007802A6 (en) | 1988-03-18 | 1988-03-18 | Bis-tri:fluoro-ethoxy piperidinyl-methyl benzamide acetate prepn. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES888800830A ES2007802A6 (en) | 1988-03-18 | 1988-03-18 | Bis-tri:fluoro-ethoxy piperidinyl-methyl benzamide acetate prepn. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2007802A6 true ES2007802A6 (en) | 1989-07-01 |
Family
ID=8255418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES888800830A Expired ES2007802A6 (en) | 1988-03-18 | 1988-03-18 | Bis-tri:fluoro-ethoxy piperidinyl-methyl benzamide acetate prepn. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2007802A6 (en) |
-
1988
- 1988-03-18 ES ES888800830A patent/ES2007802A6/en not_active Expired
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20080319 |