ES2009210A6 - Un procedimiento para la obtencion de nuevos polipeptidos que proporcionan anticuerpos frente a virus de sida, yno reaccionantes con anticuerpos sida. - Google Patents

Un procedimiento para la obtencion de nuevos polipeptidos que proporcionan anticuerpos frente a virus de sida, yno reaccionantes con anticuerpos sida.

Info

Publication number
ES2009210A6
ES2009210A6 ES8602630A ES8602630A ES2009210A6 ES 2009210 A6 ES2009210 A6 ES 2009210A6 ES 8602630 A ES8602630 A ES 8602630A ES 8602630 A ES8602630 A ES 8602630A ES 2009210 A6 ES2009210 A6 ES 2009210A6
Authority
ES
Spain
Prior art keywords
aids
antibodies
reactionants
procedure
obtaining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8602630A
Other languages
English (en)
Inventor
Wilhelm Bannwarth
Ulrich Certa
Jan Mous
Dietrich Stuber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES2009210A6 publication Critical patent/ES2009210A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

UN PROCEDIMIENTO PARA LA OBTENCION DE NUEVOS POLIPEPTIDOS QUE PROPORCIONAN ANTICUERPOS FRENTE A VIRUS DE SIDA. LOS POLIPEPTIDOS TIENEN UNA SECUENCIA DE AMINOACIDO REPRESENTADA POR LA FORMULA (I). EL PROCEDIMIENTO REFERIDO CONSISTE EN SINTETIZAR FRAGMENTOS OLIGONUCLEOTIDOS QUE, CUANDO SE ENSAMBLAN CORRECTAMENTE, FORMAN UN GEN SINTETICO QUE SINTETIZA UN POLIPEPTIDO. LOS FRAGMENTOS PUEDEN HIBRIDIZARSE Y LIGARSE EN ETAPAS PREDETERMINADAS PARA CONSTRUIR EL GEN SINTETICO. ESTE PUEDE PROPORCIONARSE CON SITIOS DE ENZIMA DE RESTRICCION APROPIADOS Y CLONARSE EN VECTORES ESPECIFICAMENTE DESIGNADOS PARA CUAXIMIZAR LA EXPRESION DEL GEN SINTETICO. LOS FRAGMENTOS OLIGONUCLEOTIDOS PUEDEN OBTENERSE CON METODOS NORMALES EN LA QUIMICA DE DNA INCLUYENDO SINTESIS TOTAL DE LA SECUENCIA OLIGONUCLEOTIDA. DE ESTA FORMA, EL PROCEDIMIENTO COMPRENDE HACER QUE UN CULTIVO DE UN MICROORGANISMO, TRANSFORMADO CON UN VECTOR DE EXPRESION CAPAZ DE EXPRESAR DICHO POLIPEPTIDO, SE DESARROLLE Y EXPRESE DICHO POLIPEPTIDO Y EXTRAERY AISLAR DICHO POLIPEPTIDO. ESTOS POLIPEPTIDOS PROPORCIONAN ANTICUERPOS FRENTE A VIRUS DE SIDA Y/O REACCIONAN CON SIDA-ANTICUERPOS.
ES8602630A 1985-10-17 1986-10-16 Un procedimiento para la obtencion de nuevos polipeptidos que proporcionan anticuerpos frente a virus de sida, yno reaccionantes con anticuerpos sida. Expired ES2009210A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858525615A GB8525615D0 (en) 1985-10-17 1985-10-17 Polypeptides

Publications (1)

Publication Number Publication Date
ES2009210A6 true ES2009210A6 (es) 1989-09-16

Family

ID=10586812

Family Applications (7)

Application Number Title Priority Date Filing Date
ES8602630A Expired ES2009210A6 (es) 1985-10-17 1986-10-16 Un procedimiento para la obtencion de nuevos polipeptidos que proporcionan anticuerpos frente a virus de sida, yno reaccionantes con anticuerpos sida.
ES8801338A Expired ES2009906A6 (es) 1985-10-17 1988-04-29 Procedimiento de preparacion de transformantes bacterianos.
ES8801340A Expired ES2006925A6 (es) 1985-10-17 1988-04-29 Procedimiento para la preparacion de vectores de expresion.
ES8801342A Expired ES2010538A6 (es) 1985-10-17 1988-04-29 Procedimiento para la preparacion de un gen sintetico.
ES8801337A Expired ES2009905A6 (es) 1985-10-17 1988-04-29 Procedimiento para la preparacion de anticuerpos frente a virus de sida.
ES8801341A Expired - Lifetime ES2014527A6 (es) 1985-10-17 1988-04-29 Procedimiento para la determinacion de virus sida.
ES8801339A Expired ES2009907A6 (es) 1985-10-17 1988-04-29 Procedimiento para detectar en sangre humana la presencia de anticuerpos frente al virus sida.

Family Applications After (6)

Application Number Title Priority Date Filing Date
ES8801338A Expired ES2009906A6 (es) 1985-10-17 1988-04-29 Procedimiento de preparacion de transformantes bacterianos.
ES8801340A Expired ES2006925A6 (es) 1985-10-17 1988-04-29 Procedimiento para la preparacion de vectores de expresion.
ES8801342A Expired ES2010538A6 (es) 1985-10-17 1988-04-29 Procedimiento para la preparacion de un gen sintetico.
ES8801337A Expired ES2009905A6 (es) 1985-10-17 1988-04-29 Procedimiento para la preparacion de anticuerpos frente a virus de sida.
ES8801341A Expired - Lifetime ES2014527A6 (es) 1985-10-17 1988-04-29 Procedimiento para la determinacion de virus sida.
ES8801339A Expired ES2009907A6 (es) 1985-10-17 1988-04-29 Procedimiento para detectar en sangre humana la presencia de anticuerpos frente al virus sida.

Country Status (11)

Country Link
EP (1) EP0219106A3 (es)
JP (1) JPS6299398A (es)
AU (1) AU602315B2 (es)
BR (1) BR8605053A (es)
DK (1) DK496486A (es)
ES (7) ES2009210A6 (es)
GB (1) GB8525615D0 (es)
IL (1) IL80304A0 (es)
NO (1) NO864139L (es)
NZ (1) NZ217895A (es)
ZA (1) ZA867748B (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL76082A (en) * 1984-08-22 1991-07-18 Us Health Molecular clones of the genome of htlv-iii and a process for the preparation thereof
US4879212A (en) * 1986-04-02 1989-11-07 United Biomedical Inc. Peptide composition and method for the detection of antibodies to HTLV-III
US4925784A (en) * 1986-04-04 1990-05-15 Hoffmann-La Roche Inc. Expression and purification of an HTLV-III gag/env gene protein
DE3789633T2 (de) * 1986-05-27 1994-08-04 Hoffmann La Roche HTLV-III(LAV)Decke-Peptide.
JPH01501547A (ja) * 1986-06-12 1989-06-01 バイオジェン　ナームローズ　ベンノットシャップ Ｈｉｖ感染の病因に関するペプチド
US5087557A (en) * 1986-06-23 1992-02-11 Genetic Systems Corporation Human monoclonal antibody to lymphadenopathy-associated virus
US5166050A (en) * 1986-08-20 1992-11-24 Bristol-Myers Squibb Company Monoclonal antibodies and peptides useful in treating and diagnosing HIV infections
NZ221440A (en) * 1986-08-20 1991-11-26 Genetic Systems Corp Composition containing monoclonal antibodies/peptides useful in treating and diagnosing hiv infections
NO881151L (no) * 1987-03-27 1988-09-28 Syntello Ab Syntetisk hiv-1-antigen.
GB8714802D0 (en) * 1987-06-24 1987-07-29 Proteus Biotech Ltd Synthetic polypeptides
IL87391A0 (en) * 1987-08-27 1989-01-31 Repligen Corp Hiv proteins and peptides,dna coding therefor,vectors comprising such dna,the use of the proteins and peptides in diagnosis of aids and vaccine compositions containing them
SE8704185L (sv) * 1987-10-28 1989-04-29 Ferring Ab Nya peptider, artificiella antigener och immunoanalystestsatser
EP0323157A3 (en) * 1987-12-24 1990-07-25 The University Of Melbourne Antiviral compounds and methods
US6210874B1 (en) 1988-01-27 2001-04-03 Biochem Immunosystems, Inc. Synthetic peptides and mixtures thereof for detecting HIV antibodies
US5241047A (en) * 1988-12-08 1993-08-31 Biochem Pharma Inc. Synthetic peptides and mixtures thereof for detecting HIV antibodies
US6214537B1 (en) 1988-01-27 2001-04-10 Biochem Immunosystems, Inc. Synthetic peptides and mixtures thereof for detecting HIV antibodies
AU629528B2 (en) * 1988-01-27 1992-10-08 Biochem Pharma Inc. Synthetic peptides and mixtures thereof for detecting hiv antibodies
US6218102B1 (en) * 1988-01-27 2001-04-17 Biochem Immunosystems, Inc. Synthetic peptides and mixtures thereof for detecting HIV antibodies
SE8802176D0 (sv) * 1988-06-10 1988-06-10 Kabigen Ab Fusion protein and its use
FI902151A7 (fi) * 1988-08-30 1990-04-27 Applied Res Systems Ars Holding Yhdistelmä-DNA-fuusioproteiineja hormonierityksen muuttamiseksi
EP0361749B1 (en) * 1988-09-27 1995-02-08 Dana Farber Cancer Institute A vector comprising a replication competent HIV-I provirus and a heterologous gene
US6228608B1 (en) * 1991-02-28 2001-05-08 Aquila Biopharmaceuticals, Inc. Recombinant FIV glycoprotein 160 and P24 gag protein
EP0645454A3 (en) * 1993-06-22 1997-01-15 Vladimir Glebovich Lunin Chimeric somatostatin-containing protein and encoding DNA, immunogen compositions, and methods of increasing farm animal production.
IT1271486B (it) * 1993-10-12 1997-05-28 Italfarmaco Spa Oligopeptidi immunomodulatori derivati di frammenti della proteina c- reattiva
DE4405810A1 (de) 1994-02-23 1995-08-24 Behringwerke Ag Von einem Retrovirus aus der HIV-Gruppe abgeleitete Peptide und deren Verwendung
FR2732346B1 (fr) * 1995-03-27 1997-05-30 Centre Nat Rech Scient Proteines mutees, codees par un gene env mute de lentivirus, fragments peptidiques inclus dans lesdites proteines, vecteurs d'expression exprimant lesdites proteines mutees et leurs applications
CA2288869A1 (en) * 1998-03-04 1999-09-10 Mary Ann Childs Rapid confirmatory test for microbial infections
ES2366185T3 (es) * 2003-04-11 2011-10-18 Institut Pasteur Vacunas de péptidos sintéticas para vih: el epítopo de cbd como un inmunógeno eficaz para provocar anticuerpos ampliamente neutralizantes contra el vih.
AU2005247943A1 (en) 2004-05-23 2005-12-08 Gerard M. Housey Theramutein modulators
US8431110B2 (en) 2005-05-23 2013-04-30 Hmi Medical Innovations, Llc. Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8324800D0 (en) * 1983-09-15 1983-10-19 Pasteur Institut Antigens
WO1986002383A1 (en) * 1984-10-18 1986-04-24 Institut Pasteur Envelope antigens of lymphadenopathy associated virus and their applications
AU600658B2 (en) * 1984-12-24 1990-08-23 Genentech Inc. Molecularly cloned acquired immunodeficiency syndrome polypeptides and their methods of use
US4774175A (en) * 1985-03-01 1988-09-27 Centocor, Inc. Immunochemical methods for the detection of antibody against HTLV-III
KR910002374B1 (ko) * 1985-04-29 1991-04-20 제네틱 시스템즈 코포레이션 Aids 관련질병의 검출을 위한 합성항원

Also Published As

Publication number Publication date
NZ217895A (en) 1991-05-28
NO864139L (no) 1987-04-21
ES2009906A6 (es) 1989-10-16
IL80304A0 (en) 1987-01-30
JPS6299398A (ja) 1987-05-08
ES2009907A6 (es) 1989-10-16
ES2006925A6 (es) 1989-05-16
AU6399786A (en) 1987-04-30
NO864139D0 (no) 1986-10-16
EP0219106A2 (en) 1987-04-22
GB8525615D0 (en) 1985-11-20
BR8605053A (pt) 1987-07-14
AU602315B2 (en) 1990-10-11
ES2014527A6 (es) 1990-07-16
DK496486A (da) 1987-04-18
ES2009905A6 (es) 1989-10-16
EP0219106A3 (en) 1989-02-08
DK496486D0 (da) 1986-10-16
ES2010538A6 (es) 1989-11-16
ZA867748B (en) 1987-07-29

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2006-10-16