ES2010286A6 - Nucleic acid derivatives - Google Patents

Nucleic acid derivatives

Info

Publication number
ES2010286A6
ES2010286A6 ES8802077A ES8802077A ES2010286A6 ES 2010286 A6 ES2010286 A6 ES 2010286A6 ES 8802077 A ES8802077 A ES 8802077A ES 8802077 A ES8802077 A ES 8802077A ES 2010286 A6 ES2010286 A6 ES 2010286A6
Authority
ES
Spain
Prior art keywords
bicatenary
procedure
nucleic acid
acid derivatives
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8802077A
Other languages
Spanish (es)
Inventor
Junichi Yano
Tadaaki Ohgi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shinyaku Co Ltd
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Publication of ES2010286A6 publication Critical patent/ES2010286A6/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR ACIDOS NUCLEICOS BICATENARIOS CON UN TAMAÑO MOLECULAR ENTRE 4 S Y 13 S COMO VALOR DE LA CONSTANTE DE SEDIMENTACION, COMPRENDIENDO DICHO PROCEDIMIENTO DISOLVER ARN BICATENARIO EN FORMAMIDA Y UNA SOLUCION ACUOSA DE CLORURO SODICO, CALENTAR LA SOLUCION A 50-90GC DURANTE 5 A 24 HORAS, DIALIZAR FRENTE A AGUA O TAMPON TRIS, Y LIOFILIZAR PARA OBTENER EL PRODUCTO DESEADO DE TAMAÑO CONTROLADO. LOS DERIVADOS OBTENIDOS SON UTILIZABLES COMO INGREDIENTE ACTIVO PARA UNA COMPOSICION ANTITUMORAL O COMPOSICION ANTIVIRICA DOTADA DE ALTA ACTIVIDAD FISIOLOGICA Y ESCASAMENTE TOXICA.PROCEDURE FOR PREPARING BICATENARY NUCLEIC ACIDS WITH A MOLECULAR SIZE BETWEEN 4 S AND 13 S AS THE VALUE OF THE SEDIMENTATION CONSTANT, UNDERSTANDING SUCH A PROCEDURE TO DISSOLVE BICATENARY ARN 5-SORCENT, 5-DURATED ALCOUR, 40 HOURS, DIALYZE AGAINST WATER OR TRIS BUFFER, AND FREEZE DRY TO OBTAIN THE DESIRED PRODUCT OF CONTROLLED SIZE. THE DERIVATIVES OBTAINED ARE USABLE AS AN ACTIVE INGREDIENT FOR AN ANTI-TUMORAL COMPOSITION OR ANTIVIRICAL COMPOSITION EQUIPPED WITH HIGH PHYSIOLOGICAL AND LITTLE TOXIC ACTIVITY.

ES8802077A 1987-07-03 1988-07-01 Nucleic acid derivatives Expired ES2010286A6 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16743387 1987-07-03

Publications (1)

Publication Number Publication Date
ES2010286A6 true ES2010286A6 (en) 1989-11-01

Family

ID=15849615

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8802077A Expired ES2010286A6 (en) 1987-07-03 1988-07-01 Nucleic acid derivatives

Country Status (19)

Country Link
KR (1) KR890002225A (en)
CN (1) CN1024350C (en)
AT (1) AT397657B (en)
AU (1) AU1864388A (en)
CH (1) CH676122A5 (en)
DE (1) DE3822405A1 (en)
DK (1) DK368988A (en)
ES (1) ES2010286A6 (en)
FI (1) FI883162A7 (en)
FR (1) FR2617486A1 (en)
GB (1) GB2207432A (en)
HU (1) HU199504B (en)
IL (1) IL86863A0 (en)
IT (1) IT1224503B (en)
NL (1) NL8801663A (en)
NO (1) NO882949L (en)
PT (1) PT87902A (en)
SE (1) SE8802479L (en)
ZA (1) ZA884700B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991005560A1 (en) * 1989-10-11 1991-05-02 Hem Research, Inc. PROTECTION FROM SHOCK SUBSEQUENT TO INJURY BY DOUBLE-STRANDED RNAs
JPH05163160A (en) * 1991-12-13 1993-06-29 Snow Brand Milk Prod Co Ltd Nutritional supplement for prevention and treatment of infectious diseases associated with immunity decline

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ194880A (en) * 1979-09-17 1983-07-15 Merck & Co Inc Interferon-inducing composition containing modified polyriboinosinic-polyribocytidylic acid

Also Published As

Publication number Publication date
ZA884700B (en) 1989-03-29
HU199504B (en) 1990-02-28
FI883162L (en) 1989-01-04
KR890002225A (en) 1989-04-10
PT87902A (en) 1989-06-30
CH676122A5 (en) 1990-12-14
FI883162A0 (en) 1988-07-01
DK368988A (en) 1989-01-04
CN1030423A (en) 1989-01-18
SE8802479L (en) 1989-01-04
NO882949L (en) 1989-01-04
GB8815263D0 (en) 1988-08-03
IT8848146A0 (en) 1988-07-01
IT1224503B (en) 1990-10-04
DE3822405A1 (en) 1989-01-12
CN1024350C (en) 1994-04-27
NO882949D0 (en) 1988-07-01
NL8801663A (en) 1989-02-01
FI883162A7 (en) 1989-01-04
IL86863A0 (en) 1988-11-30
HUT48271A (en) 1989-05-29
SE8802479D0 (en) 1988-07-01
FR2617486A1 (en) 1989-01-06
DK368988D0 (en) 1988-07-01
GB2207432A (en) 1989-02-01
ATA172788A (en) 1993-10-15
AT397657B (en) 1994-06-27
AU1864388A (en) 1989-04-27

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20010201