ES2010939A6 - Sintesis enzimatica de derivados del dipeptido tyr-arg (kyotorphin) - Google Patents
Sintesis enzimatica de derivados del dipeptido tyr-arg (kyotorphin)Info
- Publication number
- ES2010939A6 ES2010939A6 ES8901398A ES8901398A ES2010939A6 ES 2010939 A6 ES2010939 A6 ES 2010939A6 ES 8901398 A ES8901398 A ES 8901398A ES 8901398 A ES8901398 A ES 8901398A ES 2010939 A6 ES2010939 A6 ES 2010939A6
- Authority
- ES
- Spain
- Prior art keywords
- tyrosine
- arginine
- deriv
- prepn
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000004475 Arginine Substances 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- JXNRXNCCROJZFB-UHFFFAOYSA-N Tyrosyl-Arginine Chemical compound NC(N)=NCCCC(C(O)=O)NC(=O)C(N)CC1=CC=C(O)C=C1 JXNRXNCCROJZFB-UHFFFAOYSA-N 0.000 abstract 2
- 108010016626 Dipeptides Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 1
- JXNRXNCCROJZFB-RYUDHWBXSA-N Tyr-Arg Chemical compound NC(=N)NCCC[C@@H](C(O)=O)NC(=O)[C@@H](N)CC1=CC=C(O)C=C1 JXNRXNCCROJZFB-RYUDHWBXSA-N 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 108010053037 kyotorphin Proteins 0.000 abstract 1
- 239000012429 reaction media Substances 0.000 abstract 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
EN UNA PRIMERA ETAPA SE ESTERIFICA LA TIROSINA Y SE PROTEGE SU GRUPO 01-AMINO Y ADEMAS SE ESTERIFICA Y/O AMIDA LA ARGININA. EN UNA SEGUNDA ETAPA SE HACE REACCIONAR EL DERIVADO DE LA TIROSINA CON EL DE LA ARGININA MEDIANTE QUIMOTERIPSINA YA SEA LIBRE O INMOVILIZADA EN UN MEDIO DE REACCION CONTENIENDO ENTRE 20-60% DEL DEIMETILFORMAMIDA. EN UNA TERCERA ETAPA OPCIONAL SE DESPROTEGE EL DIPEPTIDO, YA SEA POR HIDROGENACION CATALITICA, TRATAMIENTO ACIDO O BASICO O ENZIMATICO, PARA OBTENER LOS DIPEPTIDOS DE FORMULA GENERAL DESCRITA.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES8901398A ES2010939A6 (es) | 1989-04-21 | 1989-04-21 | Sintesis enzimatica de derivados del dipeptido tyr-arg (kyotorphin) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES8901398A ES2010939A6 (es) | 1989-04-21 | 1989-04-21 | Sintesis enzimatica de derivados del dipeptido tyr-arg (kyotorphin) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2010939A6 true ES2010939A6 (es) | 1989-12-01 |
Family
ID=8261602
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8901398A Expired ES2010939A6 (es) | 1989-04-21 | 1989-04-21 | Sintesis enzimatica de derivados del dipeptido tyr-arg (kyotorphin) |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2010939A6 (es) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009123487A1 (en) | 2008-04-01 | 2009-10-08 | Bioalvo - Serviços, Investigação E Desenvolvimento Em Biotecnologia S.A. | Compounds for treating pain |
-
1989
- 1989-04-21 ES ES8901398A patent/ES2010939A6/es not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009123487A1 (en) | 2008-04-01 | 2009-10-08 | Bioalvo - Serviços, Investigação E Desenvolvimento Em Biotecnologia S.A. | Compounds for treating pain |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| SA6 | Expiration date (snapshot 920101) |
Free format text: 2009-04-21 |
|
| FD1A | Patent lapsed |
Effective date: 20000922 |