ES2017246A6 - Improvements to patent of invention number 8702020 for a new process for the preparation of famotidine polymorphs - Google Patents

Improvements to patent of invention number 8702020 for a new process for the preparation of famotidine polymorphs

Info

Publication number
ES2017246A6
ES2017246A6 ES8800888A ES8800888A ES2017246A6 ES 2017246 A6 ES2017246 A6 ES 2017246A6 ES 8800888 A ES8800888 A ES 8800888A ES 8800888 A ES8800888 A ES 8800888A ES 2017246 A6 ES2017246 A6 ES 2017246A6
Authority
ES
Spain
Prior art keywords
melting point
apparent density
famotidine
preparation
new process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES8800888A
Other languages
Spanish (es)
Inventor
Rodes Montserrat Ballester
Nicolau Francisco E Palomo
Coll Antonio Luis Palomo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MARAGA PARA LA INVESTIGACION S
Original Assignee
MARAGA PARA LA INVESTIGACION S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MARAGA PARA LA INVESTIGACION S filed Critical MARAGA PARA LA INVESTIGACION S
Priority to ES8800888A priority Critical patent/ES2017246A6/en
Priority to NO882037A priority patent/NO882037L/en
Priority to IL86330A priority patent/IL86330A0/en
Priority to FI882329A priority patent/FI882329A7/en
Priority to US07/197,329 priority patent/US5021582A/en
Priority to CN88103190A priority patent/CN1030077A/en
Priority to JP63134279A priority patent/JPH01100162A/en
Priority to AT88500054T priority patent/ATE69052T1/en
Priority to DE8888500054T priority patent/DE3865899D1/en
Priority to EP88500054A priority patent/EP0297019B1/en
Priority to AU17672/88A priority patent/AU1767288A/en
Priority to KR1019880007442A priority patent/KR920000308B1/en
Priority to CA000569954A priority patent/CA1322760C/en
Priority to DK342988A priority patent/DK342988A/en
Publication of ES2017246A6 publication Critical patent/ES2017246A6/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Abstract

Improvements to patent of invention number 8702020 for a new process for the preparation of famotidine polymorphs. A high melting point or high apparent density polymorph or mixtures thereof is caused to react with an inorganic acid, preferably hydrochloric acid, in an alcohol, preferably methanol, and then an organic base, preferably DBU, is added and a variety of famotidine with a low melting point and a relatively low apparent density is added to the resulting solution dissolved in a chlorinated solvent and heated, which encourages formation of the low melting point low apparent density polymorph which is distinguished from the others by its physical and chemical properties and bioactive behaviour.
ES8800888A 1987-06-22 1988-03-23 Improvements to patent of invention number 8702020 for a new process for the preparation of famotidine polymorphs Expired - Fee Related ES2017246A6 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
ES8800888A ES2017246A6 (en) 1988-03-23 1988-03-23 Improvements to patent of invention number 8702020 for a new process for the preparation of famotidine polymorphs
NO882037A NO882037L (en) 1987-06-22 1988-05-10 FAMOTIDINE, POLYMERIC FORMS AND MANUFACTURING THEREOF.
IL86330A IL86330A0 (en) 1987-06-22 1988-05-10 Famotidine polymorphic forms and their preparation
FI882329A FI882329A7 (en) 1987-06-22 1988-05-18 POLYMORFISKA FORMER AV FAMOTIDIN OCH FOERFARANDE FOER FRAMSTAELLNING DAERAV.
US07/197,329 US5021582A (en) 1987-06-22 1988-05-23 Famotidine polymorphic forms and their preparation process
CN88103190A CN1030077A (en) 1987-06-22 1988-05-25 Famotidine polymorph and preparation method thereof
JP63134279A JPH01100162A (en) 1987-06-22 1988-05-31 Famotidine polymorphs and their production method
AT88500054T ATE69052T1 (en) 1987-06-22 1988-06-01 POLYMORPHOUS FORM OF FAMOTIDINE AND ITS PRODUCTION PROCESS.
DE8888500054T DE3865899D1 (en) 1987-06-22 1988-06-01 POLYMORPHIC FORM OF FAMOTIDINE AND THEIR PRODUCTION PROCESS.
EP88500054A EP0297019B1 (en) 1987-06-22 1988-06-01 Famotidine polymorphic form and preparation thereof
AU17672/88A AU1767288A (en) 1987-06-22 1988-06-14 Famotidine polymorphic forms and their preparation process
KR1019880007442A KR920000308B1 (en) 1987-06-22 1988-06-20 Famotidine polymorphic forms and their preparation process
CA000569954A CA1322760C (en) 1987-06-22 1988-06-21 Famotidine polymorphic forms and their preparation process
DK342988A DK342988A (en) 1987-06-22 1988-06-22 POLYMORPH PHAMOTIDE INFORMATION AND PROCEDURES FOR PREPARING IT

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES8800888A ES2017246A6 (en) 1988-03-23 1988-03-23 Improvements to patent of invention number 8702020 for a new process for the preparation of famotidine polymorphs

Publications (1)

Publication Number Publication Date
ES2017246A6 true ES2017246A6 (en) 1991-01-16

Family

ID=8255497

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8800888A Expired - Fee Related ES2017246A6 (en) 1987-06-22 1988-03-23 Improvements to patent of invention number 8702020 for a new process for the preparation of famotidine polymorphs

Country Status (1)

Country Link
ES (1) ES2017246A6 (en)

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