ES2019826A6 - Process for the preparation of quinazoline derivatives - Google Patents

Process for the preparation of quinazoline derivatives

Info

Publication number
ES2019826A6
ES2019826A6 ES9001130A ES9001130A ES2019826A6 ES 2019826 A6 ES2019826 A6 ES 2019826A6 ES 9001130 A ES9001130 A ES 9001130A ES 9001130 A ES9001130 A ES 9001130A ES 2019826 A6 ES2019826 A6 ES 2019826A6
Authority
ES
Spain
Prior art keywords
preparation
quinazoline derivatives
derivative
procedure
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES9001130A
Other languages
Spanish (es)
Inventor
Josef Reiter
Laszlo Pongo
Frigyes Gorgenyi
Marton Fekete
Margit Csorgo
Ilona Sztuhar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egyt Gyogyszervegyeszeti Gyar
Egis Pharmaceuticals PLC
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Egis Pharmaceuticals PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU193189A external-priority patent/HU203342B/en
Priority claimed from HU193089A external-priority patent/HU203333B/en
Application filed by Egyt Gyogyszervegyeszeti Gyar, Egis Pharmaceuticals PLC filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of ES2019826A6 publication Critical patent/ES2019826A6/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE DERIVADOS QUINAZOLINOS. LA INVENCION SE RELACIONA CON UN PROCEDIMIENTO DE PREPARACION DE DERIVADOS QUINAZOLINOS DE FORMULA GENERAL I, EN LA QUE RBS1 Y RBS2 PUEDEN SER IGUALES O DIFERENTES Y REPRESENTAN HIDROGENO O ALQUILO INFERIOR, O FORMAN CONJUNTAMENTE UN GRUPO ETILENO O TRIMETILENO, Y N ES 2 O 3, CARACTERIZADO POR LA REACCION DE UN DERIVADO 1,2 DIMETOXI FENIL 4 ISOTIOUREA, CON UN DERIVADO DIAMINCARBOXIFURANO, EVENTUALMENTE SUSTITUIDOS, Y POSTERIOR CICLACION, TERMICA O CATALITICA, DEL COMPUESTO ASI OBTENIDO. LA INVENCION SE RELACIONA ASIMISMO, CON LA PREPARACION DE LOS COMPUESTOS INTERMEDIOS DE REACCION. LOS COMPUESTOS OBJETO DE ESTA INVENCION TIENEN INTERESANTES PROPIEDADES FARMACEUTICAS COMO ANTIHIPERTENSIVOS Y BLOQUEADORES DE SI1 RECEPTORES.PROCEDURE FOR THE PREPARATION OF QUINAZOLINE DERIVATIVES. THE INVENTION IS RELATED TO A PROCEDURE FOR THE PREPARATION OF QUINAZOLINE DERIVATIVES OF GENERAL FORMULA I, IN WHICH RBS1 AND RBS2 MAY BE THE SAME OR DIFFERENT AND REPRESENT HYDROGEN OR LOWER ALKYL, OR ETHYL 3 OR THREE CHARACTERIZED BY THE REACTION OF A DERIVATIVE 1,2 DIMETOXI FENIL 4 ISOTIOUREA, WITH A DIAMINCARBOXIFURANO DERIVATIVE, EVENTUALLY SUBSTITUTED, AND SUBSEQUENT CYCLATION, THERMAL OR CATALYTICAL, OF THE COMPOUND SO OBTAINED. THE INVENTION IS ALSO RELATED TO THE PREPARATION OF THE INTERMEDIATE REACTION COMPOUNDS. THE COMPOUNDS SUBJECT TO THIS INVENTION HAVE INTERESTING PHARMACEUTICAL PROPERTIES AS ANTI-HYPERTENSIVE AND BLOCKERS OF SI1 RECEPTORS.

ES9001130A 1989-04-21 1990-04-20 Process for the preparation of quinazoline derivatives Expired - Lifetime ES2019826A6 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU193189A HU203342B (en) 1989-04-21 1989-04-21 Process for producing quinazoline deivatives
HU193089A HU203333B (en) 1989-04-21 1989-04-21 Process for producing n-cyano-carboxamidine derivatives

Publications (1)

Publication Number Publication Date
ES2019826A6 true ES2019826A6 (en) 1991-07-01

Family

ID=26317437

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9001130A Expired - Lifetime ES2019826A6 (en) 1989-04-21 1990-04-20 Process for the preparation of quinazoline derivatives

Country Status (16)

Country Link
JP (1) JPH02292282A (en)
KR (1) KR900016194A (en)
AT (1) AT398075B (en)
BG (1) BG91821A (en)
CA (2) CA2028953A1 (en)
CH (1) CH681300A5 (en)
DK (1) DK99090A (en)
ES (1) ES2019826A6 (en)
FI (1) FI902002A7 (en)
GB (1) GB2231571B (en)
GR (1) GR900100294A (en)
IT (1) IT1241128B (en)
PL (1) PL162976B1 (en)
RU (1) RU1838309C (en)
SE (1) SE9001402L (en)
YU (1) YU70890A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2096518A1 (en) * 1994-03-28 1997-03-01 Almirall Lab New anilines

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2077252C (en) * 1992-08-31 2001-04-10 Khashayar Karimian Methods of making ureas and guanidines, and intermediates therefor
WO2008015525A2 (en) * 2006-07-31 2008-02-07 Orchid Chemicals & Pharmaceuticals Limited An improved process for the preparation of alfuzosin hydrochloride
WO2008152514A2 (en) 2007-05-04 2008-12-18 Actavis Group Ptc Ehf Process for the preparation of alfuzosin and salts thereof
JP2010535185A (en) 2007-08-02 2010-11-18 シプラ・リミテッド Method for producing alfuzosin hydrochloride

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4026894A (en) * 1975-10-14 1977-05-31 Abbott Laboratories Antihypertensive agents
US4044135A (en) * 1975-10-14 1977-08-23 Abbott Laboratories Antihypertensive agents
GB1591490A (en) * 1977-08-04 1981-06-24 Abbott Lab 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride dihydrate
US4138561A (en) * 1977-09-30 1979-02-06 Bristol-Myers Company Cyanocarboxamidines and quinazoline process
FI56836C (en) * 1977-10-25 1980-04-10 Fermion Oy 4-SUBSTITUTES OF PIPERAZIN-1- (N-ARYL-N'-CYANO) -CARBOXIMIDAMIDER BUTTER OF THE BREAST PREPARATION WITH PHARMACOLOGICAL PROPERTIES 6,7-DIMETOXY-ELLER 6,7,8-TRIMETOXY-2-AMINO -SUBSTITUERADE-Piperazine-1-YL) -KINAZOLINER
FI57751C (en) * 1977-10-25 1980-10-10 Fermion Oy PROCEDURE FOR THE FRAMSTATION OF 6,7-DIMETOXY-ELLER 6,7,8-TRIMETOXY-4-AMINO-2- (4-SUBSTITUTES-PIPERAZIN-1-YL) -KINAZOLINE WITH BLODTRYCKSSAKANDE NETKAN
FR2421888A1 (en) * 1978-02-06 1979-11-02 Synthelabo ALKYLENE DIAMINE AMIDES AND THEIR APPLICATION IN THERAPEUTICS
FI59800C (en) * 1979-01-10 1981-10-12 Fermion Oy PROCEDURE FOR THE FRAMSTATION OF 6,7-DIMETOXY-4-AMINO-2- (4- (FURO-2-YL) -PIPERASIN-1-YL) -QUINAZOLINE
FI67699C (en) * 1979-01-31 1985-05-10 Orion Yhtymae Oy PROCEDURE FOR THE FRAMSTATION OF AV 6,7-DIMETOXY-4-AMINO-2- (4- (2-FUROYL) -1-PIPERAZINYL) QUINAZOLINE HYDROCHLORIDE WITH BLODTRYCKSSAENKANDE VERKAN
DE3375395D1 (en) * 1983-11-22 1988-02-25 Heumann Ludwig & Co Gmbh Process for the preparation of 4-amino-6,7-dimethoxy-2-(4-(furoyl-2)-piperazin-1-yl)-quinazoline and its physiologically acceptable salt

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2096518A1 (en) * 1994-03-28 1997-03-01 Almirall Lab New anilines

Also Published As

Publication number Publication date
PL162976B1 (en) 1994-01-31
GB9008941D0 (en) 1990-06-20
KR900016194A (en) 1990-11-12
RU1838309C (en) 1993-08-30
FI902002A7 (en) 1990-10-22
IT9020092A0 (en) 1990-04-20
YU70890A (en) 1992-05-28
IT9020092A1 (en) 1991-10-20
JPH02292282A (en) 1990-12-03
AT398075B (en) 1994-09-26
ATA93190A (en) 1994-01-15
SE9001402D0 (en) 1990-04-20
GR900100294A (en) 1991-09-27
DK99090D0 (en) 1990-04-20
IT1241128B (en) 1993-12-29
CA2028953A1 (en) 1990-10-22
CH681300A5 (en) 1993-02-26
DK99090A (en) 1990-10-22
GB2231571B (en) 1992-09-16
BG91821A (en) 1993-12-24
FI902002A0 (en) 1990-04-20
GB2231571A (en) 1990-11-21
SE9001402L (en) 1990-10-22
PL284860A1 (en) 1991-03-11
CA2015066A1 (en) 1990-10-21

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19990405