ES2021907A6 - Process for preparation of a 1-piperazine-ethoxyacetic acid - Google Patents

Process for preparation of a 1-piperazine-ethoxyacetic acid

Info

Publication number
ES2021907A6
ES2021907A6 ES8903975A ES8903975A ES2021907A6 ES 2021907 A6 ES2021907 A6 ES 2021907A6 ES 8903975 A ES8903975 A ES 8903975A ES 8903975 A ES8903975 A ES 8903975A ES 2021907 A6 ES2021907 A6 ES 2021907A6
Authority
ES
Spain
Prior art keywords
preparation
piperazine
ethoxyacetic acid
acid
phenylmethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES8903975A
Other languages
Spanish (es)
Inventor
Eric Cossement
Genevieve Motte
Guy Bodson
Jean Gobert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB SA
Original Assignee
UCB SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB SA filed Critical UCB SA
Publication of ES2021907A6 publication Critical patent/ES2021907A6/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A process for the preparation of 2-[2-4-[(4-chlorophenyl) phenylmethyl]-1-piperazinyl]ethoxy]-acetic acid and its dihydrochloride, wherein 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-acetonitrile is hydrolysed in an aqueous, alcoholic or aqueous-alcoholic medium by a base or by an acid, and, if desired, the acid thus obtained is converted into its dihydrochloride. The compound < IMAGE > is claimed per se.o
ES8903975A 1988-11-23 1989-11-22 Process for preparation of a 1-piperazine-ethoxyacetic acid Expired - Lifetime ES2021907A6 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888827391A GB8827391D0 (en) 1988-11-23 1988-11-23 Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride

Publications (1)

Publication Number Publication Date
ES2021907A6 true ES2021907A6 (en) 1991-11-16

Family

ID=10647347

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8903975A Expired - Lifetime ES2021907A6 (en) 1988-11-23 1989-11-22 Process for preparation of a 1-piperazine-ethoxyacetic acid

Country Status (16)

Country Link
KR (1) KR970009728B1 (en)
AT (1) AT398971B (en)
CA (1) CA1317300C (en)
CY (1) CY1671A (en)
DK (1) DK174543B1 (en)
ES (1) ES2021907A6 (en)
FI (1) FI91862C (en)
GB (2) GB8827391D0 (en)
GR (1) GR1000553B (en)
HK (1) HK95892A (en)
HU (1) HU205094B (en)
NO (1) NO172342C (en)
PH (1) PH25982A (en)
PL (1) PL161379B1 (en)
PT (1) PT92364B (en)
SG (1) SG89492G (en)

Families Citing this family (38)

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AU703690B2 (en) * 1992-09-24 1999-04-01 Sepracor, Inc. Methods for treating allergic disorders using optically pure (+)cetirizine
DE10199031I2 (en) * 1992-09-24 2004-09-23 Sepracor Inc Use of (-) cetrizine to treat allergic rhinitis and asthma.
EP0885611A3 (en) * 1992-09-24 1999-01-07 Sepracor, Inc. Methods and compositions for treating allergic disorders using optically pure (+) cetirizine
GB9305282D0 (en) 1993-03-15 1993-05-05 Ucb Sa Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine
US6469009B1 (en) 1996-04-08 2002-10-22 Ucb, S.A. Pharmaceutical compositions for the treatment of rhinitis
BE1010095A3 (en) * 1996-04-10 1997-12-02 Ucb Sa METHOD OF PREPARATION OF ACID 2- [2- [4 - [(4-Chlorophenyl) phenylmethyl] -1-PIPERAZINYL] ETHOXY] acetic acid AND ITS SALTS.
BE1010094A3 (en) * 1996-04-10 1997-12-02 Ucb Sa NEW [2- (1-piperazinyl) ethoxy] SUBSTITUTED.
DE69818079T2 (en) 1997-06-04 2004-06-03 Azwell Inc. METHOD FOR PRODUCING PIPERAZINE SULFONAMIDE DERIVATIVES AND THEIR SALTS
EP0919550A1 (en) * 1997-11-26 1999-06-02 Ucb, S.A. Pseudopolymorphic forms of 2-2-4-bis(4-fluorophenyl)methyl-1-piperazinyl-ethoxy acetic acid dihydrochloride
IL124195A (en) * 1998-04-23 2000-08-31 Chemagis Ltd Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid
GR990100135A (en) * 1999-04-22 2000-12-29 Genepharm �.�. Method of preparation 2-(2-{4-[(4-chlorophenyl)(phenyl)methhyl]piperasine}-ethoxy)acetic acid and its bihydrochloric salt
JP2002249487A (en) 2001-02-22 2002-09-06 Sumitomo Chem Co Ltd A 4- (tert-butoxycarbonyl) piperazine derivative, an optically active acid addition salt thereof, a method for producing them, and a method for producing optically active 1-[(substituted phenyl) phenylmethyl] piperazine using the same.
US6977301B1 (en) 2001-05-29 2005-12-20 Ucb, S.A. Process for preparing (S) and (R)—2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
US7199241B1 (en) 2001-05-29 2007-04-03 Ucb, S.A. Process for preparing (S) and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
CA2514145A1 (en) * 2003-01-23 2004-08-05 Ucb Farchim Sa Piperazine derivatives and their use as synthesis intermediates
KR100503443B1 (en) 2004-02-02 2005-07-22 한림제약(주) Processes for preparing an optically active cetirizine or its salt
CN101128446B (en) * 2005-03-03 2010-12-08 Ucb法奇姆股份有限公司 Pyroglutamate salts and their use in optical resolution of intermediates for the synthesis of dextrocetirizine and levocetirizine
HU227325B1 (en) * 2005-12-08 2011-03-28 Egis Gyogyszergyar Nyrt Process for the production of an intermediate of (dextro- and levo)- cetirizine
SI22489A (en) * 2007-03-12 2008-10-31 Krka, Tovarna Zdravil, D.D., Novo Mesto New procedure for preparation of levocetirizine and its intermediates
EP2121643B1 (en) 2007-03-12 2013-10-23 Krka, tovarna zdravil, d.d., Novo mesto New process for the preparation of levocetirizine and intermediates thereof
US8084606B2 (en) 2007-06-15 2011-12-27 Symed Labs Limited Process for preparation of substantially optically pure levorotatory and dextrorotatory enantiomers of cetirizine using novel intermediates
WO2009062036A2 (en) * 2007-11-09 2009-05-14 Dr. Reddy's Laboratories Ltd. Processes for preparing levocetirizine and pharmaceutically acceptable salts thereof
PL2062881T3 (en) 2007-11-21 2011-07-29 Synthon Bv Process for making N-(diphenylmethyl)piperazines
US7989623B2 (en) 2007-11-21 2011-08-02 Synthon Bv Process for making n-(diphenylmethyl)piperazines
CA2724887A1 (en) 2008-06-02 2009-12-10 Cipla Limited Processes for the synthesis of levocetirizine and intermediates for use therein
WO2009150147A1 (en) * 2008-06-11 2009-12-17 Krka, Tovarna Zdravil, D.D., Novo Mesto New process for the preparation of levocetirizine and intermediates thereof
KR100998067B1 (en) 2008-09-08 2010-12-03 주식회사 삼오제약 Bis (1-[(4-chlorophenyl) phenylmethyl] piperazin) -2,3-dibenzoyl tartaric acid novel intermediate salt and optically pure 1-[(4-chlorophenyl) phenylmethyl] piperazin using the same How to separate
US20110172425A1 (en) 2008-09-17 2011-07-14 Calyx Chemicals And Pharmaceuticals Pvt. Ltd. Novel water based process for the preparation of substituted diphenylmethyl piperazines
WO2010107404A1 (en) 2009-03-16 2010-09-23 Mahmut Bilgic Stable pharmaceutical combinations
TR201007652A2 (en) 2010-09-20 2012-04-24 Bi̇lgi̇ç Mahmut Synergistic effect.
TR201009398A2 (en) 2010-11-11 2012-05-21 Bi̇lgi̇ç Mahmut Tablet formulations with improved physical properties
WO2012101475A1 (en) 2011-01-27 2012-08-02 Jubilant Life Sciences Limited An improved process for the preparation of antihistaminic drugs via a novel carbamate intermediate
CN103044355A (en) * 2011-10-13 2013-04-17 湖南九典制药有限公司 Key intermediate for synthesizing levocetirizine and preparation method thereof
KR101418404B1 (en) 2012-01-06 2014-07-10 한미약품 주식회사 Stable pharmaceutical formulation for oral administration comprising levocetirizine or a pharmaceutically acceptable salt thereof, and montelukast or a pharmaceutically acceptable salt thereof
KR102226833B1 (en) 2013-06-28 2021-03-12 한미약품 주식회사 Complex granule formulation having improved stability comprising levocetirizine and montelukast
CN104045607B (en) * 2014-05-21 2016-04-13 丽珠医药集团股份有限公司 A kind of purification process of cetrizine hcl
CN105924409B (en) * 2016-05-12 2019-01-08 浙江永宁药业股份有限公司 The method for splitting of one kind (R) -1- ((2- chlorphenyl)-(phenyl)-methyl)-piperazine
CN111205247B (en) * 2020-04-22 2020-08-14 湖南九典宏阳制药有限公司 The preparation method of levocetirizine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO155805C (en) * 1981-02-06 1987-06-10 Ucb Sa ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVITY 2- (4- (DIPHENYLMETHYL) -1-PIPERAZINYL) -ACDIC ACIDS AND THEIR AMIDS AND NON-TOXIC SALTS.

Also Published As

Publication number Publication date
DK586789D0 (en) 1989-11-22
PT92364A (en) 1990-05-31
GB2225321A (en) 1990-05-30
KR970009728B1 (en) 1997-06-17
GR890100770A (en) 1990-12-31
PT92364B (en) 1995-07-18
DK174543B1 (en) 2003-05-19
PH25982A (en) 1992-01-13
NO894651D0 (en) 1989-11-22
HU896131D0 (en) 1990-02-28
PL161379B1 (en) 1993-06-30
FI91862C (en) 1994-08-25
FI895564A0 (en) 1989-11-22
FI91862B (en) 1994-05-13
GB8926243D0 (en) 1990-01-10
HUT53627A (en) 1990-11-28
KR900007825A (en) 1990-06-02
AT398971B (en) 1995-02-27
ATA266589A (en) 1994-07-15
NO172342C (en) 1993-07-07
CA1317300C (en) 1993-05-04
DK586789A (en) 1990-05-24
GB2225321B (en) 1992-04-08
NO894651L (en) 1990-05-25
HU205094B (en) 1992-03-30
SG89492G (en) 1992-12-04
HK95892A (en) 1992-12-11
CY1671A (en) 1993-05-14
GB8827391D0 (en) 1988-12-29
NO172342B (en) 1993-03-29
GR1000553B (en) 1992-08-26

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2009-11-22

FD1A Patent lapsed

Effective date: 20100803