ES2021943A6 - Procedimiento para la sintesis de peptidos para neutralizar la infectividad del virus del sida (vhs) - Google Patents
Procedimiento para la sintesis de peptidos para neutralizar la infectividad del virus del sida (vhs)Info
- Publication number
- ES2021943A6 ES2021943A6 ES9000400A ES9000400A ES2021943A6 ES 2021943 A6 ES2021943 A6 ES 2021943A6 ES 9000400 A ES9000400 A ES 9000400A ES 9000400 A ES9000400 A ES 9000400A ES 2021943 A6 ES2021943 A6 ES 2021943A6
- Authority
- ES
- Spain
- Prior art keywords
- hiv
- peptides
- aids
- individuals
- infection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 241000700605 Viruses Species 0.000 title 1
- 230000003472 neutralizing effect Effects 0.000 title 1
- 208000015181 infectious disease Diseases 0.000 abstract 2
- 208000030507 AIDS Diseases 0.000 abstract 1
- 208000012124 AIDS-related disease Diseases 0.000 abstract 1
- 101710104895 DNA replication protein 17 Proteins 0.000 abstract 1
- 102100037593 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta Human genes 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000010353 genetic engineering Methods 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000007790 solid phase Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70514—CD4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
PROCEDIMIENTO PARA LA SINTESIS DE PEPTIDOS PARA NEUTRALIZAR LA INFECTIVIDAD DEL VIRUS DEL SIDA (VIH). SE DESCRIBE LA SINTESIS DE UN NUEVO PEPTIDO CORRESPONDIENTE A LA SECUENCIA DE AMINOACIDOS FYIFFVEDQKEEDD O A SUS VARIANTES X1YIX2X3VEDQKX4X5DD (X1CT O F, X2CC O F, X3=E O F, X4=E O F, X5= E O F) CON ACTIVIDAD IN VITRO FRENTE A LA INFECCION POR VIRUS VIH QUE PERMITE, A LA CONCENTRACION 164 MICRA/MOLAR INHIBIR EN UN 91% LA CAPACIDAD DEL VIRUS VIH DE FORMAR CELULAS GIGANTES (SINCITIOS) CON CELULAS MOLT-3 Y EN UN 75% SU CAPACIDAD DE SINTETIZAR LA PROTEINA P17 DEL CORE. ESTOS PEPTIDOS POSEEN POTENCIAL TERAPEUTICO NO SOLO EN SUJETOS CON SIDA SINO TAMBIEN EN LOS CUADROS RELACIONADOS CON EL SIDA. LA SINTESIS SE REALIZA MEDIANTE EL METODO EN FASE SOLIDA, UTILIZANDO UNA VARIANTE EN LA QUE NO SE HACE USO DEL GRUPO PROTECTOR BENCILO, CON LO QUE SE PERMITE ASEGURAR QUE NINGUNO DE LOS AMINOACIDOS DEL PEPTIDO SINTETICO CONTIENE ESTE GRUPO.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9000400A ES2021943A6 (es) | 1990-02-09 | 1990-02-09 | Procedimiento para la sintesis de peptidos para neutralizar la infectividad del virus del sida (vhs) |
| PCT/ES1991/000009 WO1991012271A1 (es) | 1990-02-09 | 1991-02-04 | Peptidos sinteticos para neutralizar la infectividad del virus del sida (vih) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9000400A ES2021943A6 (es) | 1990-02-09 | 1990-02-09 | Procedimiento para la sintesis de peptidos para neutralizar la infectividad del virus del sida (vhs) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2021943A6 true ES2021943A6 (es) | 1991-11-16 |
Family
ID=8265874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9000400A Expired - Lifetime ES2021943A6 (es) | 1990-02-09 | 1990-02-09 | Procedimiento para la sintesis de peptidos para neutralizar la infectividad del virus del sida (vhs) |
Country Status (2)
| Country | Link |
|---|---|
| ES (1) | ES2021943A6 (es) |
| WO (1) | WO1991012271A1 (es) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989003420A1 (en) * | 1987-10-13 | 1989-04-20 | Genelabs Incorporated | Anti-retroviral agent |
| EP0462229A4 (en) * | 1989-05-02 | 1992-03-11 | Genelabs Incorporated | Chemically modified cd4 peptide fragments having anti-retroviral properties |
-
1990
- 1990-02-09 ES ES9000400A patent/ES2021943A6/es not_active Expired - Lifetime
-
1991
- 1991-02-04 WO PCT/ES1991/000009 patent/WO1991012271A1/es not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO1991012271A1 (es) | 1991-08-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20031122 |