ES2026824A6 - Procedimiento de obtencion de eritromicina 9-(0-(2-metoxietoxi)metil)oxima). - Google Patents
Procedimiento de obtencion de eritromicina 9-(0-(2-metoxietoxi)metil)oxima).Info
- Publication number
- ES2026824A6 ES2026824A6 ES9100777A ES9100777A ES2026824A6 ES 2026824 A6 ES2026824 A6 ES 2026824A6 ES 9100777 A ES9100777 A ES 9100777A ES 9100777 A ES9100777 A ES 9100777A ES 2026824 A6 ES2026824 A6 ES 2026824A6
- Authority
- ES
- Spain
- Prior art keywords
- erythromycin
- oxime
- methoxyethoxy
- methyl
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- RXZBMPWDPOLZGW-XMRMVWPWSA-N (E)-roxithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=N/OCOCCOC)/[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 RXZBMPWDPOLZGW-XMRMVWPWSA-N 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 abstract 3
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229960005224 roxithromycin Drugs 0.000 abstract 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 2
- KYTWXIARANQMCA-PGYIPVOXSA-N (3r,4s,5s,6r,7r,9r,10z,11s,12r,13s,14r)-6-[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-10-hydroxyimino-4-[(2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradec Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=N\O)/[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 KYTWXIARANQMCA-PGYIPVOXSA-N 0.000 abstract 1
- 241000192125 Firmicutes Species 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 229960003276 erythromycin Drugs 0.000 abstract 1
- 239000003120 macrolide antibiotic agent Substances 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 238000010534 nucleophilic substitution reaction Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000003444 phase transfer catalyst Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO DE OBTENCION DE ERITROMICINA 9-[O-[(2-METOXI]METIL] OXIMA (ROXITROMICINA), EN EL QUE LA REACCION ENTRE ERITROMICINA 9-OXIMA Y UN COMPUESTO DE FORMULA CHSI3-O-CHSI2CHSI2-O-CHSI2-X*C (X ES UN GRUPO SALIENTE FRENTE A LA SUSTITUCION NUCLEOFILA), SE REALIZA AGITANDO A TEMPERATURA AMBIENTE UNA DISOLUCION DE AMBOS COMPUESTOS EN UN DISOLVENTE ORGANICO INMISCIBLE EN AGUA CON UNA DISOLUCION ACUOSA DE HIDOXIDO SODICO O POTASICO, EN PRESENCIA DE UN CATALIZADOR DE TRANSFERENCIA DE FASE. LA ROXITROMICINA ES UN MACROLIDO RELACIONADO CON LA ERITROMICINA, QUE MUESTRA ACTIVIDAD ANTIBIOTICA FRENTE A BACTERIAS GRAM POSITIVAS, ASI COMO TAMBIEN FRENTE A OTROS GERMENES.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9100777A ES2026824A6 (es) | 1991-03-26 | 1991-03-26 | Procedimiento de obtencion de eritromicina 9-(0-(2-metoxietoxi)metil)oxima). |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9100777A ES2026824A6 (es) | 1991-03-26 | 1991-03-26 | Procedimiento de obtencion de eritromicina 9-(0-(2-metoxietoxi)metil)oxima). |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2026824A6 true ES2026824A6 (es) | 1992-05-01 |
Family
ID=8271820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9100777A Expired - Fee Related ES2026824A6 (es) | 1991-03-26 | 1991-03-26 | Procedimiento de obtencion de eritromicina 9-(0-(2-metoxietoxi)metil)oxima). |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2026824A6 (es) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6204368B1 (en) | 1998-09-10 | 2001-03-20 | Hovione Inter Ltd. | Process for the purification of roxithromycin |
| ES2181546A1 (es) * | 1999-07-30 | 2003-02-16 | Biochemie Sa | Una eritromicina de oxima y un procedimiento para su obtencion. |
| EP1435359A1 (en) * | 2002-12-31 | 2004-07-07 | Alembic Limited | A process for the purification of roxithromycin |
| CN102887850A (zh) * | 2011-07-18 | 2013-01-23 | 海洋王照明科技股份有限公司 | 含吡咯烷离子液体、其制备方法和应用 |
-
1991
- 1991-03-26 ES ES9100777A patent/ES2026824A6/es not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6204368B1 (en) | 1998-09-10 | 2001-03-20 | Hovione Inter Ltd. | Process for the purification of roxithromycin |
| ES2181546A1 (es) * | 1999-07-30 | 2003-02-16 | Biochemie Sa | Una eritromicina de oxima y un procedimiento para su obtencion. |
| EP1435359A1 (en) * | 2002-12-31 | 2004-07-07 | Alembic Limited | A process for the purification of roxithromycin |
| CN102887850A (zh) * | 2011-07-18 | 2013-01-23 | 海洋王照明科技股份有限公司 | 含吡咯烷离子液体、其制备方法和应用 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20000201 |